Aran V, Devalle S, Meohas W, Heringer M, Caruso AC, Aguiar DP et al (2021) Osteosarcoma, chondrosarcoma and Ewing sarcoma: clinical aspects, biomarker discovery and liquid biopsy. Crit Rev Oncol Hematol 162:103340

Article  PubMed  Google Scholar 

Hattinger CM, Patrizio MP, Fantoni L, Casotti C, Riganti C, Serra M (2021) Drug resistance in osteosarcoma: emerging biomarkers, therapeutic targets and treatment strategies. Cancer 13(12):2878

Article  CAS  Google Scholar 

Ambrosio L, Raucci MG, Vadalà G, Ambrosio L, Papalia R, Denaro V (2021) Innovative biomaterials for the treatment of bone cancer. Int J Mol Sci 22(15):8214

Article  CAS  PubMed  PubMed Central  Google Scholar 

Nafar S, Nouri N, Alipour M, Fallahi J, Zare F, Tabei SMB (2022) Exosome as a target for cancer treatment. J Investig Med 70(5):1212–1218

Article  PubMed  Google Scholar 

Batista IA, Machado JC, Melo SA (2024) Advances in exosomes utilization for clinical applications in cancer. Trends Cancer 10:947–968. https://www.cell.com/trends/cancer/abstract/S2405-8033(24)00158-4?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS2405803324001584%3Fshowall%3Dtrue

Shimbo K, Miyaki S, Ishitobi H, Kato Y, Kubo T, Shimose S et al (2014) Exosome-formed synthetic microRNA-143 is transferred to osteosarcoma cells and inhibits their migration. Biochem Biophys Res Commun 445(2):381–387

Article  CAS  PubMed  Google Scholar 

Huang X, Wu W, Jing D, Yang L, Guo H, Wang L et al (2022) Engineered exosome as targeted lncRNA MEG3 delivery vehicles for osteosarcoma therapy. J Control Release 343:107–117

Article  CAS  PubMed  Google Scholar 

Luongo M, Laurenziello P, Cesta G, Bochicchio AM, Omer LC, Falco G et al (2024) The molecular conversations of sarcomas: exosomal non-coding RNAs in tumor’s biology and their translational prospects. Mol Cancer 23(1):172

Article  PubMed  PubMed Central  Google Scholar 

Yuan X, Qian N, Ling S, Li Y, Sun W, Li J et al (2021) Breast cancer exosomes contribute to pre-metastatic niche formation and promote bone metastasis of tumor cells. Theranostics 11(3):1429

Article  CAS  PubMed  PubMed Central  Google Scholar 

Sadu L, Krishnan RH, Akshaya R, Das UR, Satishkumar S, Selvamurugan N (2022) Exosomes in bone remodeling and breast cancer bone metastasis. Prog Biophys Mol Biol 175:120–130

Article  CAS  PubMed  Google Scholar 

Nam GH, Choi Y, Kim GB, Kim S, Kim SA, Kim IS (2020) Emerging prospects of exosomes for cancer treatment: from conventional therapy to immunotherapy. Adv Mater 32(51):2002440

Article  CAS  Google Scholar 

Huang C, Li J, Xie Z, Hu X, Huang Y (2025) Relationship between exosomes and cancer: formation, diagnosis, and treatment. Int J Biol Sci 21(1):40

Article  PubMed  PubMed Central  Google Scholar 

Oveili E, Vafaei S, Bazavar H, Eslami Y, Mamaghanizadeh E, Yasamineh S et al (2023) The potential use of mesenchymal stem cells-derived exosomes as microRNAs delivery systems in different diseases. Cell Commun Signal 21(1):20

Article  CAS  PubMed  PubMed Central  Google Scholar 

Han Q-F, Li W-J, Hu K-S, Gao J, Zhai W-L, Yang J-H et al (2022) Exosome biogenesis: machinery, regulation, and therapeutic implications in cancer. Mol Cancer 21(1):207

Article  PubMed  PubMed Central  Google Scholar 

Gurunathan S, Kang M-H, Jeyaraj M, Qasim M, Kim J-H (2019) Review of the isolation, characterization, biological function, and multifarious therapeutic approaches of exosomes. Cells 8(4):307

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ansari MA, Thiruvengadam M, Venkidasamy B, Alomary MN, Salawi A, Chung I-M et al (2022) Exosome-based nanomedicine for cancer treatment by targeting inflammatory pathways: current status and future perspectives. In: Seminars in cancer biology. Elsevier, pp 678–696

Google Scholar 

Tan F, Li X, Wang Z, Li J, Shahzad K, Zheng J (2024) Clinical applications of stem cell-derived exosomes. Signal Transduct Target Ther 9(1):17

Article  PubMed  PubMed Central  Google Scholar 

Panigrahi AR, Srinivas L, Panda J (2022) Exosomes: insights and therapeutic applications in cancer. Transl Oncol 21:101439

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bai S, Wang Z, Wang M, Li J, Wei Y, Xu R et al (2022) Tumor-derived exosomes modulate primary site tumor metastasis. Front Cell Dev Biol 10:752818

Article  PubMed  PubMed Central  Google Scholar 

Hazrati A, Soudi S, Malekpour K, Mahmoudi M, Rahimi A, Hashemi SM et al (2022) Immune cells-derived exosomes function as a double-edged sword: role in disease progression and their therapeutic applications. Biomark Res 10(1):30

Article  PubMed  PubMed Central  Google Scholar 

Easwaran VB, Pai KMS, Pai KSR (2025) Mesenchymal stem cell-derived exosomes in cancer resistance against therapeutics. Cancer 17(5):831

Article  CAS  Google Scholar 

Potdar PD, Jethmalani YD (2015) Human dental pulp stem cells: applications in future regenerative medicine. World J Stem Cells 7(5):839

Article  PubMed  PubMed Central  Google Scholar 

Kiarashi M, Bayat H, Shahrtash SA, Etajuri EA, Khah MM, Al-Shaheri NA et al (2024) Mesenchymal stem cell-based scaffolds in regenerative medicine of dental diseases. Stem Cell Rev Rep 20(3):688–721

Article  PubMed  Google Scholar 

Zhang L, Jiao G, Ren S, Zhang X, Li C, Wu W et al (2020) Exosomes from bone marrow mesenchymal stem cells enhance fracture healing through the promotion of osteogenesis and angiogenesis in a rat model of nonunion. Stem Cell Res Ther 11:1–15

Google Scholar 

Huang Y, Liu W, He B, Wang L, Zhang F, Shu H et al (2020) Exosomes derived from bone marrow mesenchymal stem cells promote osteosarcoma development by activating oncogenic autophagy. J Bone Oncol 21:100280

Article  PubMed  PubMed Central  Google Scholar 

Xu Z, Zhou X, Wu J, Cui X, Wang M, Wang X et al (2020) Mesenchymal stem cell-derived exosomes carrying microRNA-150 suppresses the proliferation and migration of osteosarcoma cells via targeting IGF2BP1. Transl Cancer Res 9(9):5323

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lotfy A, AboQuella NM, Wang H (2023) Mesenchymal stromal/stem cell (MSC)-derived exosomes in clinical trials. Stem Cell Res Ther 14(1):66

Article  PubMed  PubMed Central  Google Scholar 

Xu Z, Zeng S, Gong Z, Yan Y (2020) Exosome-based immunotherapy: a promising approach for cancer treatment. Mol Cancer 19:1–16

Article  Google Scholar 

Lahouty M, Fadaee M, Shanehbandi D, Kazemi T (2025) Exosome-driven nano-immunotherapy: revolutionizing colorectal cancer treatment. Mol Biol Rep 52(1):1–18

Article  Google Scholar 

Si C, Gao J, Ma X (2024) Natural killer cell-derived exosome-based cancer therapy: from biological roles to clinical significance and implications. Mol Cancer 23(1):134

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ran X-M, Yang J, Wang Z-Y, Xiao L-Z, Deng Y-P, Zhang K-Q (2024) M2 macrophage-derived exosomal circTMCO3 acts through miR-515-5p and ITGA8 to enhance malignancy in ovarian cancer. Commun Biol 7(1):583

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wang Y, Zhang J, Shi H, Wang M, Yu D, Fu M et al (2024) M2 tumor-associated macrophages-derived exosomal MALAT1 promotes glycolysis and gastric cancer progression. Adv Sci 11(24):2309298

Article  CAS  Google Scholar 

Pitt JM, André F, Amigorena S, Soria J-C, Eggermont A, Kroemer G et al (2016) Dendritic cell–derived exosomes for cancer therapy. J Clin Invest 126(4):1224–1232

Article  PubMed