NSAID-Induced acute kidney injury risk in patients on renin-angiotensin system inhibitors and diuretics: nationwide cohort study

Thomas MC, Diuretics. ACE inhibitors and NSAIDs–the triple whammy. Med J Aust. 2000;172:184–5.

PubMed  CAS  Google Scholar 

Katarzyna KL, Gillian MS. Drug combinations and impaired renal function – the ‘triple whammy’. Br J Clin Pharmacol. 2005;59:239–43.

Google Scholar 

Boyd IW, Mathew TH, Thomas MC. COX-2 inhibitors and renal failure: the triple whammy revisited. Med J Aust. 2000;173:274.

PubMed  CAS  Google Scholar 

Lapi F, Azoulay L, Yin H, Nessim SJ, Suissa S. Concurrent use of diuretics, angiotensin converting enzyme inhibitors, and angiotensin receptor blockers with non-steroidal anti-inflammatory drugs and risk of acute kidney injury: nested case-control study. BMJ. 2013;346:e8525.

PubMed  PubMed Central  Google Scholar 

Kunitsu Y, Isono T, Hira D, Terada T. Chronic effects on kidney function by triple whammy (Combination of Renin and angiotensin type inhibitor, diuretic drug and nonsteroidal Anti-inflammatory drug). Yakugaku Zasshi. 2019;139:1457–62.

PubMed  CAS  Google Scholar 

Kunitsu Y, Hira D, Morikochi A, Ueda T, Isono T, Morita S-Y, et al. Time until onset of acute kidney injury by combination therapy with triple whammy drugs obtained from Japanese adverse drug event report database. PLoS ONE. 2022;17:e0263682.

PubMed  PubMed Central  CAS  Google Scholar 

Camin RMG, Cols M, Chevarria JL, García Osuna R, Carreras M, Lisbona JM, et al. Acute kidney injury secondary to a combination of renin-angiotensin system inhibitors, diuretics and NSAIDS: the triple whammy. Nefrología (English Edition). 2015;35:197–206.

Google Scholar 

Swan SK, Rudy DW, Lasseter KC, Ryan CF, Buechel KL, Lambrecht LJ, et al. Effect of cyclooxygenase-2 Inhibition on renal function in elderly persons receiving a low-salt diet. A randomized, controlled trial. Ann Intern Med. 2000;133:1–9.

PubMed  CAS  Google Scholar 

Ruschitzka F, Borer JS, Krum H, Flammer AJ, Yeomans ND, Libby P, et al. Differential blood pressure effects of ibuprofen, naproxen, and celecoxib in patients with arthritis: the PRECISION-ABPM (Prospective randomized evaluation of celecoxib integrated safety versus ibuprofen or Naproxen ambulatory blood pressure Measurement) trial. Eur Heart J. 2017;38:3282–92.

PubMed  PubMed Central  CAS  Google Scholar 

Obeid S, Libby P, Husni E, Wang Q, Wisniewski LM, Davey DA, et al. Cardiorenal risk of celecoxib compared with Naproxen or ibuprofen in arthritis patients: insights from the PRECISION trial. Eur Heart J Cardiovasc Pharmacother. 2022;8:611–21.

PubMed  Google Scholar 

Nissen SE, Yeomans ND, Solomon DH, Lüscher TF, Libby P, Husni ME, et al. Cardiovascular safety of celecoxib, naproxen, or ibuprofen for arthritis. N Engl J Med. 2016;375:2519–29.

PubMed  CAS  Google Scholar 

Cabassi A, Tedeschi S, Perlini S, Verzicco I, Volpi R, Gonzi G, et al. Non-steroidal anti-inflammatory drug effects on renal and cardiovascular function: from physiology to clinical practice. Eur J Prev Cardiol. 2020;27:850–67.

PubMed  Google Scholar 

Hörl WH. Nonsteroidal Anti-Inflammatory drugs and the kidney. Pharmaceuticals. 2010;3:2291–321.

PubMed  PubMed Central  Google Scholar 

Sato S, Sasabuchi Y, Okada A, Yasunaga H. Do Orally Disintegrating Tablets Facilitate Medical Adherence and Clinical Outcomes in Patients with Post-stroke Dysphagia? Dysphagia. 2024;40:381–7.

Okada A, Yasunaga H. Prevalence of noncommunicable diseases in Japan using a newly developed administrative claims database covering young, Middle-aged, and elderly people. Jma J. 2022;5:190–8.

PubMed  PubMed Central  Google Scholar 

Lim CC, Tan NC, Teo EPS, Kadir HBA, Kwek JL, Bee YM, et al. Non-Steroidal Anti-Inflammatory drugs and risk of acute kidney injury and hyperkalemia in older adults: A retrospective cohort study and external validation of a clinical risk model. Drugs & Aging; 2021;39:75–82.

Hwang YJ, Shariff SZ, Gandhi S, Wald R, Clark E, Fleet JL, et al. Validity of the international classification of diseases, tenth revision code for acute kidney injury in elderly patients at presentation to the emergency department and at hospital admission. BMJ Open. 2012;2:e001821.

PubMed  PubMed Central  Google Scholar 

Bihorac A, Yavas S, Subbiah S, Hobson CE, Schold JD, Gabrielli A, et al. Long-term risk of mortality and acute kidney injury during hospitalization after major surgery. Ann Surg. 2009;249:851–8.

PubMed  Google Scholar 

Grams ME, Sang Y, Ballew SH, Gansevoort RT, Kimm H, Kovesdy CP, et al. A Meta-analysis of the association of estimated GFR, albuminuria, age, race, and sex with acute kidney injury. Am J Kidney Dis. 2015;66:591–601.

PubMed  PubMed Central  CAS  Google Scholar 

James MT, Grams ME, Woodward M, Elley CR, Green JA, Wheeler DC, et al. A Meta-analysis of the association of estimated GFR, albuminuria, diabetes mellitus, and hypertension with acute kidney injury. Am J Kidney Dis. 2015;66:602–12.

PubMed  PubMed Central  Google Scholar 

Mehta RL, Cerdá J, Burdmann EA, Tonelli M, García-García G, Jha V, et al. International society of nephrology’s 0by25 initiative for acute kidney injury (zero preventable deaths by 2025): a human rights case for nephrology. Lancet. 2015;385:2616–43.

PubMed  Google Scholar 

Grams ME, Sang Y, Coresh J, Ballew S, Matsushita K, Molnar MZ, et al. Acute kidney injury after major surgery: A retrospective analysis of veterans health administration data. Am J Kidney Dis. 2016;67:872–80.

PubMed  Google Scholar 

Sharma K, Slawski B. Renal disease and the surgical patient: minimizing the impact. Cleve Clin J Med. 2018;85:559–67.

PubMed  Google Scholar 

El-Ahmadi A, Abassi MS, Andersson HB, Engstrøm T, Clemmensen P, Helqvist S, et al. Acute kidney injury - A frequent and serious complication after primary percutaneous coronary intervention in patients with ST-segment elevation myocardial infarction. PLoS ONE. 2019;14:e0226625.

PubMed  PubMed Central  CAS  Google Scholar 

Ronsin C, Chaba A, Suchanek O, Coindre JP, Kerleau C, Garandeau C, et al. Incidence, risk factors and outcomes of kidney and liver cyst infection in kidney transplant recipient with ADPKD. Kidney Int Rep. 2022;7:867–75.

PubMed  PubMed Central  Google Scholar 

Yoshikawa T, Yanagita M. Single-Cell analysis provides new insights into the roles of tertiary lymphoid structures and immune cell infiltration in kidney injury and chronic kidney disease. Am J Pathol. 2024;195:40–54.

PubMed  PubMed Central  Google Scholar 

Usui J, Yamagata K, Imai E, Okuyama H, Kajiyama H, Kanamori H, et al. Clinical practice guideline for drug-induced kidney injury in Japan 2016: digest version. Clin Exp Nephrol. 2016;20:827–31.

PubMed  PubMed Central  Google Scholar 

Ikuta K, Nakagawa S, Momo K, Yonezawa A, Itohara K, Sato Y, et al. Association of proton pump inhibitors and concomitant drugs with risk of acute kidney injury: a nested case–control study. BMJ Open. 2021;11:e041543.

PubMed  PubMed Central  Google Scholar 

Peduzzi P, Concato J, Kemper E, Holford TR, Feinstein AR. A simulation study of the number of events per variable in logistic regression analysis. J Clin Epidemiol. 1996;49:1373–9.

PubMed  CAS  Google Scholar 

Dreischulte T, Morales DR, Bell S, Guthrie B. Combined use of nonsteroidal anti-inflammatory drugs with diuretics and/or renin-angiotensin system inhibitors in the community increases the risk of acute kidney injury. Kidney Int. 2015;88:396–403.

PubMed  CAS  Google Scholar 

Calvo DM, Saiz LC, Leache L, Celaya MC, Gutiérrez-Valencia M, Alonso A, et al. Effect of the combination of diuretics, renin-angiotensin-aldosterone system inhibitors, and non-steroidal anti-inflammatory drugs or metamizole (triple whammy) on hospitalisation due to acute kidney injury: a nested case-control study. Pharmacoepidemiol Drug Saf. 2023;32:898–909.

PubMed  CAS  Google Scholar 

Biesheuvel CJ, Vergouwe Y, Oudega R, Hoes AW, Grobbee DE, Moons KG. Advantages of the nested case-control design in diagnostic research. BMC Med Res Methodol. 2008;8:48.

PubMed  PubMed Central  Google Scholar 

Rothman KJ, Greenland S, Lash T. Modern epidemiology. Third Edition: Lippincott Williams & Wilkins, Philadelphia;; 2008.

Google Scholar 

Maclure M. The case-crossover design: a method for studying transient effects on the risk of acute events. Am J Epidemiol. 1991;133:144–53.

PubMed  CAS  Google Scholar 

Mittleman MA, Maclure M, Robins JM. Control sampling strategies for case-crossover studies: an assessment of relative efficiency. Am J Epidemiol. 1995;142:91–8.

PubMed  CAS  Google Scholar 

Rutjes AW, Reitsma JB, Vandenbroucke JP, Glas AS, Bossuyt PM. Case-control and two-gate designs in diagnostic accuracy studies. Clin Chem. 2005;51:1335–41.

PubMed  CAS  Google Scholar 

Zhang X, Donnan PT, Bell S, Guthrie B. Non-steroidal anti-inflammatory drug induced acute kidney injury in the community dwelling general population and people with chronic kidney disease: systematic review and meta-analysis. BMC Nephrol. 2017;18:256.

PubMed  PubMed Central  Google Scholar 

Baker M, Perazella MA. NSAIDs in CKD: are they safe?? Am J Kidney Dis. 2020;76:546–57.

PubMed  CAS  Google Scholar 

Guthrie B, Mccowan C, Davey P, Simpson CR, Dreischulte T, Barnett K. High risk prescribing in primary care patients particularly vulnerable to adverse drug events: cross sectional population database analysis in Scottish general practice. BMJ. 2011;342:d3514.

PubMed  Google Scholar 

Arakawa T, Fujiwara Y, Sollano JD, Zhu Q, Kachintorn U, Rani AA, et al. A questionnaire-based survey on the prescription of non-steroidal anti-inflammatory drugs by physicians in East Asian countries in 2007. Digestion. 2009;79:177–85.

Comments (0)

No login
gif