Integrated analysis of MYC expression, 8q24.21 copy number, and recurrence patterns in astrocytoma, IDH-mutant

Chen P, Guo X, Zhang L et al (2017) MiR-200c is a cMyc-activated miRNA that promotes nasopharyngeal carcinoma by downregulating PTEN. Oncotarget 8:5206–5218. https://doi.org/10.18632/oncotarget.14123

Article  PubMed  Google Scholar 

Dammert MA, Brägelmann J, Olsen RR et al (2019) MYC paralog-dependent apoptotic priming orchestrates a spectrum of vulnerabilities in small cell lung cancer. Nat Commun 10:3485. https://doi.org/10.1038/s41467-019-11371-x

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hirose Y, Sasaki H, Miwa T et al (2011) Whole genome analysis from microdissected tissue revealed adult supratentorial grade II-III gliomas are divided into clinically relevant subgroups by genetic profile. Neurosurgery 69:376–390. https://doi.org/10.1227/NEU.0b013e318212bcd8

Article  PubMed  Google Scholar 

Ho JSL, Ma W, Mao DYL et al (2005) p53-Dependent transcriptional repression of c-myc is required for G1 cell cycle arrest. Mol Cell Biol 25:7423–7431. https://doi.org/10.1128/MCB.25.17.7423-7431.2005

Article  CAS  PubMed  PubMed Central  Google Scholar 

Huppi K, Pitt JJ, Wahlberg BM et al (2018) The 8q24 gene desert: an oasis of non-coding transcriptional activity. Front Genet 3:69. https://doi.org/10.3389/fgene.2012.00069

Article  Google Scholar 

Jenkins RB, Xiao Y, Sicotte H et al (2012) A low-frequency variant at 8q24.21 is strongly associated with risk of oligodendroglial tumors and astrocytomas with IDH1 or IDH2 mutation. Nat Genet 44:1122–1125. https://doi.org/10.1038/ng.2388

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kahlert UD, Maciaczyk D, Doostkam S et al (2012) Activation of canonical WNT/β-catenin signaling enhances in vitro motility of glioblastoma cells by activation of ZEB1 and other activators of epithelial-to-mesenchymal transition. Cancer Lett 325:42–53. https://doi.org/10.1016/j.canlet.2012.05.024

Article  CAS  PubMed  Google Scholar 

Lecarpentier Y, Schussler O, Hébert JL et al (2019) Multiple Targets of the Canonical WNT/beta-Catenin Signaling in Cancers. Front Oncol 9:1248. https://doi.org/10.3389/fonc.2019.01248

Article  PubMed  PubMed Central  Google Scholar 

Liu Z, Chen SS, Clarke S et al (2021) Targeting MYCN in Pediatric and Adult Cancers. Front Oncol 10:623679. https://doi.org/10.3389/fonc.2020.623679

Article  PubMed  PubMed Central  Google Scholar 

Louis D, Perry A, Reifenberger G et al (2016) The 2016 World Health Organization Classification of Tumors of the Central Nervous System: a summary. Acta Neuropathol 131:803–820. https://doi.org/10.1007/s00401-016-1545-1

Article  PubMed  Google Scholar 

Mundo L, Ambrosio MR, Raimondi F et al (2019) Molecular switch from MYC to MYCN expression in MYC protein negative Burkitt lymphoma cases. Blood Cancer J 9:91. https://doi.org/10.1038/s41408-019-0252-2

Article  PubMed  PubMed Central  Google Scholar 

Mehrazin R, Dulaimi E, Uzzo RG et al (2017) The correlation between gain of chromosome 8q and survival in patients with clear and papillary renal cell carcinoma. Ther Adv Urol 10:3–10. https://doi.org/10.1177/1756287217732660

Article  CAS  PubMed  PubMed Central  Google Scholar 

Nakae S, Sasaki H, Hayashi S et al (2015) PCR-based simple subgrouping is validated for classification of gliomas and defines negative prognostic copy number aberrations in IDH mutant gliomas. PLoS ONE 10(11):e0142750. https://doi.org/10.1371/journal.pone.0142750

Article  CAS  PubMed  PubMed Central  Google Scholar 

Nakae S, Murayama K, Sasaki H et al (2017) Prediction of genetic subgroups in adult supratentorial gliomas by pre- and intraoperative parameters. J Neurooncol 131:403–412. https://doi.org/10.1007/s11060-016-2313-8

Article  CAS  PubMed  Google Scholar 

Nakae S, Kato T, Murayama K et al (2017) Remote intracranial recurrence of IDH mutant gliomas is associated with TP53 mutations and an 8q gain. Oncotarget 8:84729–84742. https://doi.org/10.18632/oncotarget.20951

Article  PubMed  PubMed Central  Google Scholar 

Pfaff E, Remke M, Sturm D et al (2010) TP53 mutation is frequently associated with CTNNB1 mutation or MYCN amplification and is compatible with long-term survival in medulloblastoma. J Clin Oncol 28:5188–5196. https://doi.org/10.1200/JCO.2010.31.1670

Article  CAS  PubMed  Google Scholar 

Prochownik EV (2008) c-Myc: linking transformation and genomic instability. Curr Mol Med 8:446–458. https://doi.org/10.2174/156652408785747988

Article  CAS  PubMed  Google Scholar 

Reiner AS, Lobaugh SM, Gonen S et al (2022) A population-based study of treatment and survival in older glioma patients. JNCI Cancer Spectr 6:pkac010. https://doi.org/10.1093/jncics/pkac010

Article  PubMed  PubMed Central  Google Scholar 

Sareddy GR, Panigrahi M, Challa S et al (2009) Activation of Wnt/beta-catenin/Tcf signaling pathway in human astrocytomas. Neurochem Int 55:307–317. https://doi.org/10.1016/j.neuint.2009.03.016

Article  CAS  PubMed  Google Scholar 

Schüle R, Dictus C, Campos B et al (2012) Potential canonical wnt pathway activation in high-grade astrocytomas. ScientificWorldJournal 2012:697313. https://doi.org/10.1100/2012/697313

Article  CAS  PubMed  PubMed Central  Google Scholar 

Shirahara M, Ono T, Stichel D et al (2018) Novel, improved grading system(s) for IDH-mutant astrocytic gliomas. Acta Neuropathol 136:153–166. https://doi.org/10.1007/s00401-018-1849-4

Article  CAS  Google Scholar 

Simeone P, Trerotola M, Urbanella A et al (2014) A unique four-hub protein cluster associates to glioblastoma progression. PLoS ONE 9(7):e103030. https://doi.org/10.1371/journal.pone.0103030

Article  PubMed  PubMed Central  Google Scholar 

van den Bent MJ, Chang SM (2018) Grade II and III oligodendroglioma and astrocytoma. Neurol Clin 36:467–484. https://doi.org/10.1016/j.ncl.2018.04.005

Article  PubMed  Google Scholar 

van den Bent MJ, Smits M, Kros JM et al (2017) Diffuse infiltrating oligodendroglioma and astrocytoma. J Clin Oncol 35:2394–2401. https://doi.org/10.1200/JCO.2017.72.6737

Article  PubMed  Google Scholar 

Wu C, Su J, Long W et al (2020) LINC00470 promotes tumour proliferation and invasion, and attenuates chemosensitivity through the LINC00470/miR-134/Myc/ABCC1 axis in glioma. J Cell Mol Med 24:12094–12106. https://doi.org/10.1111/jcmm.15846

Article  CAS  PubMed  PubMed Central  Google Scholar 

Yu X, Xiao F, Wei Y et al (2022) Elevated β-catenin and C-myc promote malignancy, relapse, and indicate poor prognosis in patients with relapsed glioma. J Cancer Res Ther 18:553–559. https://doi.org/10.4103/jcrt.jcrt_246_22

Article  CAS  PubMed  Google Scholar 

Zhang L-Y, Jiang L-N, Li F-F et al (2010) Reduced beta-catenin expression is associated with good prognosis in Astrocytoma. Pathol Oncol Res 16:253–257. https://doi.org/10.1007/s12253-009-9219-0

Article  CAS  PubMed  Google Scholar 

Comments (0)

No login
gif