Eiras MC, Pinheiro DP, Romcy KAM, Ferriani RA, Reis RMD, Furtado CLM. Polycystic ovary syndrome: the epigenetics behind the disease. Reprod Sci. 2022;29:680–94. https://doi.org/10.1007/s43032-021-00516-3.
Kujanpää L, Arffman RK, Pesonen P, Hurskainen E, Järvelin M-R, Franks S, et al. Polycystic ovary syndrome presents as a multimorbid condition by age 50: birth cohort linkage to national register data. Eur J Endocrinol. 2024;190:409–20. https://doi.org/10.1093/ejendo/lvae057.
Article CAS PubMed Google Scholar
Sharma P, Bilkhiwal N, Chaturvedi P, Kumar S, Khetarpal P. Potential environmental toxicant exposure, metabolizing gene variants and risk of PCOS-a systematic review. Reprod Toxicol. 2021;103:124–32. https://doi.org/10.1016/j.reprotox.2021.06.005.
Article CAS PubMed Google Scholar
Chaudhary H, Patel J, Jain NK, Joshi R. The role of polymorphism in various potential genes on polycystic ovary syndrome susceptibility and pathogenesis. J Ovarian Res. 2021;14:125. https://doi.org/10.1186/s13048-021-00879-w.
Article CAS PubMed PubMed Central Google Scholar
Stener-Victorin E, Deng Q. Epigenetic inheritance of polycystic ovary syndrome — challenges and opportunities for treatment. Nat Rev Endocrinol. 2021;17:521–33. https://doi.org/10.1038/s41574-021-00517-x.
Combs JC, Hill MJ, Decherney AH. Polycystic ovarian syndrome genetics and epigenetics. Clin Obstet Gynecol. 2021;64:20–5. https://doi.org/10.1097/GRF.0000000000000581.
Article PubMed PubMed Central Google Scholar
Li S, Zhu D, Duan H, Ren A, Glintborg D, Andersen M, et al. Differential DNA methylation patterns of polycystic ovarian syndrome in whole blood of Chinese women. Oncotarget. 2017;8:20656–66. https://doi.org/10.18632/oncotarget.9327.
Vázquez-Martínez ER, Gómez-Viais YI, García-Gómez E, Reyes-Mayoral C, Reyes-Muñoz E, Camacho-Arroyo I, et al. DNA methylation in the pathogenesis of polycystic ovary syndrome. Reproduction. 2019;158:R27–40. https://doi.org/10.1530/REP-18-0449.
Loscalzo J, Handy DE. Epigenetic modifications: basic mechanisms and role in cardiovascular disease (2013 Grover Conference Series). Pulm Circ. 2014;4:169–74. https://doi.org/10.1086/675979.
Article CAS PubMed PubMed Central Google Scholar
Cao P, Yang W, Wang P, Li X, Nashun B. Characterization of DNA methylation and screening of epigenetic markers in polycystic ovary syndrome. Front Cell Dev Biol. 2021;9:664843. https://doi.org/10.3389/fcell.2021.664843.
Article PubMed PubMed Central Google Scholar
Zhang J, Xu Y, Liu H, Pan Z. Micrornas in ovarian follicular atresia and granulosa cell apoptosis. Reprod Biol Endocrinol. 2019;17:9. https://doi.org/10.1186/s12958-018-0450-y.
Article PubMed PubMed Central Google Scholar
Echiburú B, Milagro F, Crisosto N, Pérez-Bravo F, Flores C, Arpón A, et al. DNA methylation in promoter regions of genes involved in the reproductive and metabolic function of children born to women with PCOS. Epigenetics. 2020;15(11):1178–94. https://doi.org/10.1080/15592294.2020.1754674.
Article PubMed PubMed Central Google Scholar
Amiri M, Hatoum S, Hopkins D, Buyalos RP, Ezeh U, Pace LA, et al. The association between obesity and polycystic ovary syndrome: an epidemiologic study of observational data. J Clin Endocrinol Metab. 2024;109:2640–57. https://doi.org/10.1210/clinem/dgae488.
Article CAS PubMed Google Scholar
Guay S-P, Brisson D, Lamarche B, Biron S, Lescelleur O, Biertho L, et al. ADRB3 gene promoter DNA methylation in blood and visceral adipose tissue is associated with metabolic disturbances in men. Epigenomics. 2014;6:33–43. https://doi.org/10.2217/epi.13.82.
Article CAS PubMed Google Scholar
Nilsson E, Benrick A, Kokosar M, Krook A, Lindgren E, Källman T, et al. Transcriptional and epigenetic changes influencing skeletal muscle metabolism in women with polycystic ovary syndrome. J Clin Endocrinol Metab. 2018;103:4465–77. https://doi.org/10.1210/jc.2018-00935.
Liu Y-N, Qin Y, Wu B, Peng H, Li M, Luo H, et al. DNA methylation in polycystic ovary syndrome: emerging evidence and challenges. Reprod Toxicol. 2022;111:11–9. https://doi.org/10.1016/j.reprotox.2022.04.010.
Article CAS PubMed Google Scholar
Rawat K, Sandhu A, Gautam V, Saha PK, Saha L. Role of genomic DNA methylation in PCOS pathogenesis: a systematic review and meta-analysis involving case-controlled clinical studies. Mol Hum Reprod. 2022;28:gaac024. https://doi.org/10.1093/molehr/gaac024.
Article CAS PubMed Google Scholar
Wells G, Wells G, Shea B, Shea B, O’Connell D, Peterson J, Welch V, Losos M, Tugwell P, Ga SW, Zello G, Petersen J. The Newcastle-Ottawa scale (NOS) for assessing the quality of nonrandomised studies in meta-analyses. 2014. https://www.semanticscholar.org/paper/The-Newcastle-Ottawa-Scale-(NOS)-for-Assessing-the-Wells-Wells/c293fb316b6176154c3fdbb8340a107d9c8c82bf. Accessed December 11, 2024
Ge SX, Jung D, Yao R. ShinyGO: a graphical gene-set enrichment tool for animals and plants. Bioinformatics. 2020;36:2628–9. https://doi.org/10.1093/bioinformatics/btz931.
Article CAS PubMed Google Scholar
Szklarczyk D, Kirsch R, Koutrouli M, Nastou K, Mehryary F, Hachilif R, et al. The STRING database in 2023: protein–protein association networks and functional enrichment analyses for any sequenced genome of interest. Nucleic Acids Res. 2023;51:638–46. https://doi.org/10.1093/nar/gkac1000.
Xu J, Bao X, Peng Z, Wang L, Du L, Niu W, et al. Comprehensive analysis of genome-wide DNA methylation across human polycystic ovary syndrome ovary granulosa cell. Oncotarget. 2016;7:27899–909. https://doi.org/10.18632/oncotarget.8544.
Article PubMed PubMed Central Google Scholar
Qu F, Wang F-F, Yin R, Ding G-L, El-Prince M, Gao Q, et al. A molecular mechanism underlying ovarian dysfunction of polycystic ovary syndrome: hyperandrogenism induces epigenetic alterations in the granulosa cells. J Mol Med (Berl). 2012;90:911–23. https://doi.org/10.1007/s00109-012-0881-4.
Article CAS PubMed Google Scholar
Ting W, Yanyan Q, Jian H, Keqin H, Duan M. The relationship between insulin resistance and CpG island methylation of LMNA gene in polycystic ovary syndrome. Cell Biochem Biophys. 2013;67:1041–7. https://doi.org/10.1007/s12013-013-9602-z.
Article CAS PubMed Google Scholar
Yu Y-Y, Sun C-X, Liu Y-K, Li Y, Wang L, Zhang W. Promoter methylation of CYP19A1 gene in Chinese polycystic ovary syndrome patients. Gynecol Obstet Invest. 2013;76:209–13. https://doi.org/10.1159/000355314.
Article CAS PubMed Google Scholar
Yu Y-Y, Sun C-X, Liu Y-K, Li Y, Wang L, Zhang W. Genome-wide screen of ovary-specific DNA methylation in polycystic ovary syndrome. Fertil Steril. 2015;104:145-153.e6. https://doi.org/10.1016/j.fertnstert.2015.04.005.
Article CAS PubMed Google Scholar
Sang Q, Zhang S, Zou S, Wang H, Feng R, Li Q, et al. Quantitative analysis of follistatin (FST) promoter methylation in peripheral blood of patients with polycystic ovary syndrome. Reprod Biomed Online. 2013;26:157–63. https://doi.org/10.1016/j.rbmo.2012.10.011.
Article CAS PubMed Google Scholar
Sang Q, Li X, Wang H, Wang H, Zhang S, Feng R, et al. Quantitative methylation level of the EPHX1 promoter in peripheral blood DNA is associated with polycystic ovary syndrome. PLoS One. 2014;9:e88013. https://doi.org/10.1371/journal.pone.0088013.
Article CAS PubMed PubMed Central Google Scholar
Shen H, Qiu L, Zhang Z, Qin Y, Cao C, Di W. Genome-wide methylated DNA immunoprecipitation analysis of patients with polycystic ovary syndrome. PLoS One. 2013;8:e64801. https://doi.org/10.1371/journal.pone.0064801.
Comments (0)