Cui Y, Liu W, Zhao S, Zhao Y, Dai J. Advances in microgravity directed tissue engineering. Adv Healthc Mater. 2023;12(23):e2202768.

Article  PubMed  Google Scholar 

Ratushnyy AY, Buravkova LB. Microgravity effects and aging physiology: similar changes or common mechanisms. Biochem (Mosc). 2023;88(11):1763–77.

Article  CAS  Google Scholar 

Van Ombergen A, Jillings S, Jeurissen B, et al. Brain tissue-volume changes in cosmonauts. N Engl J Med. 2018;379(17):1678–80.

Article  PubMed  Google Scholar 

Liu Z, Wan Y, Zhang L, et al. Alterations in the heart rate and activity rhythms of three orbital astronauts on a space mission. Life Sci Space Res (Amst). 2015;4:62–6.

PubMed  Google Scholar 

Shen M, Frishman WH. Effects of spaceflight on cardiovascular physiology and health. Cardiol Rev. 2019;27(3):122–6.

Article  PubMed  Google Scholar 

Nowacki D, Klinger FG, Mazur G, De Felici M. Effect of culture in simulated microgravity on the development of mouse embryonic testes. Adv Clin Exp Med. 2015;24(5):769–74.

Article  PubMed  Google Scholar 

Zhou DX, Qiu SD, Wang ZY, Zhang J. Effect of tail-suspension on the reproduction of adult male rats. Natl J Androl. 2006;12(4):326–9.

CAS  Google Scholar 

Hogg SJ, Beavis PA, Dawson MA, Johnstone RW. Targeting the epigenetic regulation of antitumour immunity. Nat Rev Drug Discov. 2020;19(11):776–800.

Article  CAS  PubMed  Google Scholar 

Kim M, Costello J. DNA methylation: an epigenetic mark of cellular memory. Exp Mol Med. 2017;49(4):e322.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Boxer LD, Renthal W, Greben AW, et al. MeCP2 represses the rate of transcriptional initiation of highly methylated long genes. Mol Cell. 2020;77(2):294–e3099.

Article  CAS  PubMed  Google Scholar 

Schmidt A, Zhang H, Cardoso MC. 2020. MeCP2 and chromatin compartmentalization. Cells 9(4).

Sandweiss AJ, Brandt VL, Zoghbi HY. Advances in understanding of Rett syndrome and MECP2 duplication syndrome: prospects for future therapies. Lancet Neurol. 2020;19(8):689–98.

Article  CAS  PubMed  Google Scholar 

Qian J, Guan X, Xie B, et al. Multiplex epigenome editing of MECP2 to rescue Rett syndrome neurons. Sci Transl Med. 2023;15(679):eadd4666.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Oliveri RS, Kalisz M, Schjerling CK, Andersen CY, Borup R, Byskov AG. Evaluation in mammalian oocytes of gene transcripts linked to epigenetic reprogramming. Reproduction. 2007;134(4):549–58.

Article  CAS  PubMed  Google Scholar 

Ren P, Tong X, Li J, et al. CRL4(DCAF13) E3 ubiquitin ligase targets MeCP2 for degradation to prevent DNA hypermethylation and ensure normal transcription in growing oocytes. Cell Mol Life Sci. 2024;81(1):165.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wang J, Xiao Y, Liu C, et al. Emerging physiological and pathological roles of MeCP2 in non-neurological systems. Arch Biochem Biophys. 2021;700:108768.

Article  CAS  PubMed  Google Scholar 

Morey-Holton E, Globus RK, Kaplansky A, Durnova G. The hindlimb unloading rat model: literature overview, technique update and comparison with space flight data. Adv Space Biol Med. 2005;10:7–40.

Article  PubMed  Google Scholar 

Dai S, Kong F, Liu C, et al. Effect of simulated microgravity conditions of hindlimb unloading on mice hematopoietic and mesenchymal stromal cells. Cell Biol Int. 2020;44(11):2243–52.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Turner RT, Branscum AJ, Wong CP, Iwaniec UT, Morey-Holton E. Studies in microgravity, simulated microgravity and gravity do not support a gravitostat. J Endocrinol. 2020;247(3):273–82.

Article  PubMed  Google Scholar 

Wang N, Zuo Z, Meng T, Liu Y, Zheng X, Ma Y. Salidroside alleviates simulated microgravity-induced bone loss by activating the Nrf2/HO-1 pathway. J Orthop Surg Res. 2024;19(1):531.

Article  PubMed  PubMed Central  Google Scholar 

Zhang J, Wang X, Fu Z, et al. Long-term simulated microgravity fosters carotid aging-like changes via Piezo1. Cardiovasc Res. 2024;120(5):548–59.

Article  CAS  PubMed  Google Scholar 

Pang D, Laferriere C. Review of intraperitoneal injection of sodium pentobarbital as a method of euthanasia in laboratory rodents. J Am Assoc Lab Anim Sci. 2020;59(3):346.

PubMed  Google Scholar 

Ge P, Zhang X, Yang YQ, et al. Rno_circRNA_016194 might be involved in the testicular injury induced by long-term formaldehyde exposure via rno-miR-449a-5p mediated Atg4b activation. Food Chem Toxicol. 2021;155:112409.

Article  CAS  PubMed  Google Scholar 

Zhou DX, Qiu SD, Zhang J, Tian H, Wang HX. The protective effect of vitamin E against oxidative damage caused by formaldehyde in the testes of adult rats. Asian J Androl. 2006;8(5):584–8.

Article  CAS  PubMed  Google Scholar 

Zhang HF, Liu HM, Xiang JY, et al. Alpha lipoamide inhibits diabetic kidney fibrosis via improving mitochondrial function and regulating RXRα expression and activation. Acta Pharmacol Sin. 2023;44(5):1051–65.

Article  CAS  PubMed  Google Scholar 

Cai X, Deng J, Zhou X, et al. Comprehensive analysis of cuproptosis-related genes involved in immune infiltration and their use in the diagnosis of hepatic ischemia-reperfusion injury: an experimental study. Int J Surg. 2025;111(1):242–56.

Article  PubMed  Google Scholar 

Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, et al. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res. 2024;52(D1):D174–82.

Article  CAS  PubMed  Google Scholar 

Bong D, Sohn J, Lee SV. Brief guide to RT-qPCR. Mol Cells. 2024;47(12):100141.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Sule R, Rivera G, Gomes AV. Western blotting (immunoblotting): history, theory, uses, protocol and problems. Biotechniques. 2023;75(3):99–114.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Nay K, Koechlin-Ramonatxo C, Rochdi S, et al. Simulated microgravity disturbs iron metabolism and distribution in humans: lessons from dry immersion, an innovative ground-based human model. FASEB J. 2020;34(11):14920–9.

Article  CAS  PubMed  Google Scholar 

Trudel G, Shafer J, Laneuville O, Ramsay T. Characterizing the effect of exposure to microgravity on anemia: more space is worse. Am J Hematol. 2020;95(3):267–73.

Article  CAS  PubMed  Google Scholar 

Horeau M, Ropert M, Mulder E, et al. Iron metabolism regulation in females and males exposed to simulated microgravity: results from the randomized trial artificial gravity bed Rest-European space agency (AGBRESA). Am J Clin Nutr. 2022;116(5):1430–40.

Article  CAS  PubMed  Google Scholar 

Ricci G, Esposito R, Catizone A, Galdieri M. Direct effects of microgravity on testicular function: analysis of hystological, molecular and physiologic parameters. J Endocrinol Invest. 2008;31(3):229–37.

Article  CAS  PubMed  Google Scholar 

Mishra B, Luderer U. Reproductive hazards of space travel in women and men. Nat Rev Endocrinol. 2019;15(12):713–30.