How Many Blastocysts Are Needed for PGT-A to Benefit RPL Patients? A 7-Year Retrospective Cohort Study

Practice Committee of the American Society for Reproductive Medicine. Evaluation and treatment of recurrent pregnancy loss: a committee opinion. Fertil Steril. 2012;98(5):1103–11.

Article  Google Scholar 

ESHRE Guideline Group on RPL, Bender Atik R, Christiansen OB, Elson J, Kolte AM, Lewis S, et al. ESHRE guideline: recurrent pregnancy loss: an update in 2022. Hum Reprod Open. 2023;2023(1):hoad002.

Article  Google Scholar 

Baek KH, Lee EJ, Kim YS. Recurrent pregnancy loss: the key potential mechanisms. Trends Mol Med. 2007;13(7):310–7.

Article  CAS  PubMed  Google Scholar 

Dimitriadis E, Menkhorst E, Saito S, Kutteh WH, Brosens JJ. Recurrent pregnancy loss. Nat Rev Dis Primers. 2020;6(1):98.

Article  PubMed  Google Scholar 

van Dijk MM, Kolte AM, Limpens J, Kirk E, Quenby S, van Wely M, et al. Recurrent pregnancy loss: diagnostic workup after two or three pregnancy losses? A systematic review of the literature and meta-analysis. Hum Reprod Update. 2020;26(3):356–67.

Article  PubMed  PubMed Central  Google Scholar 

Sullivan EA, Wang YA, Hayward I, Chambers GM, Illingworth P, McBain J, et al. Single embryo transfer reduces the risk of perinatal mortality, a population study. Hum Reprod. 2012;27(12):3609–15.

Article  PubMed  Google Scholar 

Gardner DK, Meseguer M, Rubio C, Treff NR. Diagnosis of human preimplantation embryo viability. Hum Reprod Update. 2015;21(6):727–47.

Article  CAS  PubMed  Google Scholar 

Verlinsky Y, Kuliev A. Preimplantation genetics. J Assist Reprod Genet. 1998;15(5):215–8.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Munne S, Chen S, Fischer J, Colls P, Zheng X, Stevens J, et al. Preimplantation genetic diagnosis reduces pregnancy loss in women aged 35 years and older with a history of recurrent miscarriages. Fertil Steril. 2005;84(2):331–5.

Article  PubMed  Google Scholar 

Rodrigo L, Mateu E, Mercader A, Cobo AC, Peinado V, Milan M, et al. New tools for embryo selection: comprehensive chromosome screening by array comparative genomic hybridization. Biomed Res Int. 2014;2014:517125.

Article  PubMed  PubMed Central  Google Scholar 

Rubio C, Bellver J, Rodrigo L, Bosch E, Mercader A, Vidal C, et al. Preimplantation genetic screening using fluorescence in situ hybridization in patients with repetitive implantation failure and advanced maternal age: two randomized trials. Fertil Steril. 2013;99(5):1400–7.

Article  PubMed  Google Scholar 

Morita K, Ono Y, Takeshita T, Sugi T, Fujii T, Yamada H, et al. Risk factors and outcomes of recurrent pregnancy loss in Japan. J Obstet Gynaecol Res. 2019;45(10):1997–2006.

Article  CAS  PubMed  Google Scholar 

Scott RT Jr., Upham KM, Forman EJ, Hong KH, Scott KL, Taylor D, et al. Blastocyst biopsy with comprehensive chromosome screening and fresh embryo transfer significantly increases in vitro fertilization implantation and delivery rates: a randomized controlled trial. Fertil Steril. 2013;100(3):697–703.

Article  PubMed  Google Scholar 

Yang Z, Liu J, Collins GS, Salem SA, Liu X, Lyle SS, et al. Selection of single blastocysts for fresh transfer via standard morphology assessment alone and with array CGH for good prognosis IVF patients: results from a randomized pilot study. Mol Cytogenet. 2012;5(1):24.

Article  PubMed  PubMed Central  Google Scholar 

Chang J, Boulet SL, Jeng G, Flowers L, Kissin DM. Outcomes of in vitro fertilization with preimplantation genetic diagnosis: an analysis of the United States assisted reproductive technology surveillance data, 2011–2012. Fertil Steril. 2016;105(2):394–400.

Article  PubMed  Google Scholar 

Munne S, Kaplan B, Frattarelli JL, Child T, Nakhuda G, Shamma FN, et al. Preimplantation genetic testing for aneuploidy versus morphology as selection criteria for single frozen-thawed embryo transfer in good-prognosis patients: a multicenter randomized clinical trial. Fertil Steril. 2019;112(6):1071-9 e7.

Article  CAS  PubMed  Google Scholar 

Sato T, Sugiura-Ogasawara M, Ozawa F, Yamamoto T, Kato T, Kurahashi H, et al. Preimplantation genetic testing for aneuploidy: a comparison of live birth rates in patients with recurrent pregnancy loss due to embryonic aneuploidy or recurrent implantation failure. Hum Reprod. 2020;35(1):255.

Article  PubMed  Google Scholar 

Bhatt SJ, Marchetto NM, Roy J, Morelli SS, McGovern PG. Pregnancy outcomes following in vitro fertilization frozen embryo transfer (IVF-FET) with or without preimplantation genetic testing for aneuploidy (PGT-A) in women with recurrent pregnancy loss (RPL): a SART-CORS study. Hum Reprod. 2021;36(8):2339–44.

Article  CAS  PubMed  Google Scholar 

Murugappan G, Shahine LK, Perfetto CO, Hickok LR, Lathi RB. Intent to treat analysis of in vitro fertilization and preimplantation genetic screening versus expectant management in patients with recurrent pregnancy loss. Hum Reprod. 2016;31(8):1668–74.

Article  PubMed  Google Scholar 

Gardner DK, Lane M, Stevens J, Schlenker T, Schoolcraft WB. Blastocyst score affects implantation and pregnancy outcome: towards a single blastocyst transfer. Fertil Steril. 2000;73(6):1155–8.

Article  CAS  PubMed  Google Scholar 

Zhao S, Lyu C, Liu Y, Wang X, Zhang Z, Lv H, et al. Preimplantation genetic testing for aneuploidy could not improve cumulative live birth rate among 1003 couples with recurrent pregnancy loss. Chin Med J (Engl). 2024;137(17):2134–6.

Article  PubMed  Google Scholar 

Pantou A, Mitrakos A, Kokkali G, Petroutsou K, Tounta G, Lazaros L, et al. The impact of preimplantation genetic testing for aneuploidies (PGT-A) on clinical outcomes in high risk patients. J Assist Reprod Genet. 2022;39(6):1341–9.

Article  PubMed  PubMed Central  Google Scholar 

Viotti M, Greco E, Grifo JA, Madjunkov M, Librach C, Cetinkaya M, et al. Chromosomal, gestational, and neonatal outcomes of embryos classified as a mosaic by preimplantation genetic testing for aneuploidy. Fertil Steril. 2023;120(5):957–66.

Article  CAS  PubMed  Google Scholar 

Mastenbroek S, Twisk M, van Echten-Arends J, Sikkema-Raddatz B, Korevaar JC, Verhoeve HR, et al. In vitro fertilization with preimplantation genetic screening. N Engl J Med. 2007;357(1):9–17.

Article  CAS  PubMed  Google Scholar 

Gleicher N, Barad DH, Patrizio P, Orvieto R. We have reached a dead end for preimplantation genetic testing for aneuploidy. Hum Reprod. 2022;37(12):2730–4.

Article  PubMed  Google Scholar 

Magnus MC, Wilcox AJ, Morken NH, Weinberg CR, Haberg SE. Role of maternal age and pregnancy history in risk of miscarriage: prospective register based study. BMJ. 2019;364:l869.

Article  PubMed  PubMed Central  Google Scholar 

Ma S, Peng Y, Hu L, Wang X, Xiong Y, Tang Y, et al. Comparisons of benefits and risks of single embryo transfer versus double embryo transfer: a systematic review and meta-analysis. Reprod Biol Endocrinol. 2022;20(1):20.

Article  PubMed  PubMed Central  Google Scholar 

Peng Y, Ma S, Hu L, Wang X, Xiong Y, Yao M, et al. Effectiveness and safety of two consecutive cycles of single embryo transfer compared with one cycle of double embryo transfer: a systematic review and meta-analysis. Front Endocrinol (Lausanne). 2022;13:920973.

Article  PubMed  Google Scholar 

Rubio C, Bellver J, Rodrigo L, Castillon G, Guillen A, Vidal C, et al. In vitro fertilization with preimplantation genetic diagnosis for aneuploidies in advanced maternal age: a randomized, controlled study. Fertil Steril. 2017;107(5):1122–9.

Article  PubMed  Google Scholar 

Verpoest W, Staessen C, Bossuyt PM, Goossens V, Altarescu G, Bonduelle M, et al. Preimplantation genetic testing for aneuploidy by microarray analysis of polar bodies in advanced maternal age: a randomized clinical trial. Hum Reprod. 2018;33(9):1767–76.

Article  CAS  PubMed  Google Scholar 

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