Li Z, Lin L, Wu H et al (2021) Global, regional, and national death, and disability-adjusted life-years (DALYs) for cardiovascular disease in 2017 and trends and risk analysis from 1990 to 2017 using the global burden of disease study and implications for prevention. Front Public Health 9:559751. https://doi.org/10.3389/fpubh.2021.559751

Article  PubMed  PubMed Central  Google Scholar 

Rastogi A, Sudhayakumar A, Schaper NC, Jude EB (2023) A paradigm shift for cardiovascular outcome evaluation in diabetes: major adverse cardiovascular events (MACE) to major adverse vascular events (MAVE). Diabetes Metab Syndr 17:102875. https://doi.org/10.1016/j.dsx.2023.102875

Article  CAS  PubMed  Google Scholar 

Fan W, Wu C, Wong ND (2025) Lipoprotein(a) atherosclerotic cardiovascular disease risk score development and prediction in primary prevention from real-world data. Circ Genom Precis Med 18:e004631. https://doi.org/10.1161/CIRCGEN.124.004631

Article  CAS  PubMed  Google Scholar 

Morgan CL, Durand A, McCormack T et al (2023) Risk of major adverse cardiovascular events associated with elevated low-density lipoprotein cholesterol in a population with atherosclerotic cardiovascular disease with and without type 2 diabetes: a UK database analysis using the clinical practice research datalink. BMJ Open 13:e064541. https://doi.org/10.1136/bmjopen-2022-064541

Article  PubMed  PubMed Central  Google Scholar 

Esau D, Abramson BL (2022) Approach to risk stratification of atherosclerotic cardiovascular disease: use of biomarkers and imaging in a Canadian context. Can Fam Physician 68:654–660. https://doi.org/10.46747/cfp.6809654

Article  PubMed  PubMed Central  Google Scholar 

Barkas F, Sener YZ, Golforoush PA et al (2024) Advancements in risk stratification and management strategies in primary cardiovascular prevention. Atherosclerosis 395:117579. https://doi.org/10.1016/j.atherosclerosis.2024.117579

Article  CAS  PubMed  Google Scholar 

Alexandratou M, Papachristodoulou A, Li X et al (2022) Advances in noninvasive carotid wall imaging with ultrasound: a narrative review. J Clin Med 11:6196. https://doi.org/10.3390/jcm11206196

Article  PubMed  PubMed Central  Google Scholar 

Martinsson A, Östling G, Persson M et al (2014) Carotid plaque, intima-media thickness, and incident aortic stenosis: a prospective cohort study. Arterioscler Thromb Vasc Biol 34:2343–2348. https://doi.org/10.1161/ATVBAHA.114.304015

Article  CAS  PubMed  Google Scholar 

Ebrahim S, Papacosta O, Whincup P (1999) Carotid plaque, intima media thickness, cardiovascular risk factors, and prevalent cardiovascular disease in men and women: the British regional heart study. Stroke 30:841–850. https://doi.org/10.1161/01.str.30.4.841

Article  CAS  PubMed  Google Scholar 

Zhang Y, Fang X, Hua Y et al (2018) Carotid artery plaques, carotid intima-media thickness, and risk of cardiovascular events and all-cause death in older adults: a 5-year prospective, community-based study. Angiology 69:120–129. https://doi.org/10.1177/0003319717716842

Article  PubMed  Google Scholar 

Su T-C, Jeng J-S, Hwang B-S, Liau C-S (2007) Application of intima-media thickness and early atherosclerosis at carotid arteries as a window for cardiovascular diseases in preventive cardiology. J Med Ultrasound 15:112–125. https://doi.org/10.1016/S0929-6441(08)60029-6

Article  Google Scholar 

Kolaszyńska O, Lorkowski J (2023) Symmetry and asymmetry in atherosclerosis. Int J Occup Med Environ Health 36(6):693–703. https://doi.org/10.13075/ijomeh.1896.02171

Article  PubMed  PubMed Central  Google Scholar 

Liu C, Xie S, Li Y et al (2024) Asymmetry in circulation system and cardiovascular diseases. Medicine in Novel Technology and Devices 21:100283. https://doi.org/10.1016/j.medntd.2023.100283

Article  Google Scholar 

Peng Z, Shu B, Zhang Y, Wang M (2019) Endothelial response to pathophysiological stress. Arterioscler Thromb Vasc Biol 39:e233–e243. https://doi.org/10.1161/ATVBAHA.119.312580

Article  CAS  PubMed  Google Scholar 

Zhang X, Feng H, Han Y et al (2024) Plaque stabilization and regression, from mechanisms to surveillance and clinical strategies. Rev Cardiovasc Med 25:459. https://doi.org/10.31083/j.rcm2512459

Article  CAS  PubMed  PubMed Central  Google Scholar 

Tsai T-Y, Revaiah PC, Aldujeli A et al (2025) Cumulative plaque burden analysis for phenotyping epicardial coronary artery disease. Int J Cardiol 430:133173. https://doi.org/10.1016/j.ijcard.2025.133173

Article  PubMed  Google Scholar 

Sarraju A, Nissen SE (2024) Atherosclerotic plaque stabilization and regression: a review of clinical evidence. Nat Rev Cardiol 21:487–497. https://doi.org/10.1038/s41569-023-00979-8

Article  CAS  PubMed  Google Scholar 

Bellien J, Iacob M, Richard V et al (2021) Evidence for wall shear stress-dependent t-PA release in human conduit arteries: role of endothelial factors and impact of high blood pressure. Hypertens Res 44:310–317. https://doi.org/10.1038/s41440-020-00554-5

Article  CAS  PubMed  Google Scholar 

Villines TC, Robinson AA (2020) Will plaque quantification on coronary CTA end our infatuation with lumen stenosis? JACC Cardiovasc Imaging 13:1718–1720. https://doi.org/10.1016/j.jcmg.2020.06.007

Article  PubMed  Google Scholar 

Yu Y, Yin W, Feng J, Qian S (2025) Development and validation of a risk model for effective immune and stromal related signature predicting prognosis of patients with ovarian cancer. Sci Rep 15:16556. https://doi.org/10.1038/s41598-025-01212-x

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kolaszyńska O, Lorkowski J (2023) Symmetry and asymmetry in atherosclerosis. Int J Occup Med Environ Health 36(6):693–703. https://doi.org/10.13075/ijomeh.1896.02171

Article  PubMed  PubMed Central  Google Scholar 

Bartels S, Franco AR, Rundek T (2012) Carotid intima-media thickness (cIMT) and plaque from risk assessment and clinical use to genetic discoveries. Perspectives in Medicine 1:139–145. https://doi.org/10.1016/j.permed.2012.01.006

Article  Google Scholar 

Liu M, Jia J, Fan F et al (2021) Association of depressive symptoms with the progression of carotid intima-media thickness in a community-based cohort in Beijing, China. BMJ Open 11:e050254. https://doi.org/10.1136/bmjopen-2021-050254

Article  PubMed  PubMed Central  Google Scholar 

de Winther MPJ, Bäck M, Evans P et al (2023) Translational opportunities of single-cell biology in atherosclerosis. Eur Heart J 44:1216–1230. https://doi.org/10.1093/eurheartj/ehac686

Article  CAS  PubMed  Google Scholar 

Newby AC (2005) Dual role of matrix metalloproteinases (matrixins) in intimal thickening and atherosclerotic plaque rupture. Physiol Rev 85:1–31. https://doi.org/10.1152/physrev.00048.2003

Article  CAS  PubMed  Google Scholar