Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A, et al. Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2021;71(3):209–49.
Strandberg TE, Pyorala K, Cook TJ, Wilhelmsen L, Faergeman O, Thorgeirsson G, Pedersen TR, Kjekshus J, Group S. Mortality and incidence of cancer during 10-year follow-up of the scandinavian simvastatin survival study (4S). Lancet. 2004;364:771–7.
Article CAS PubMed Google Scholar
Buranrat B, Senggunprai L, Prawan A, Kukongviriyapan V. Simvastatin and atorvastatin as inhibitors of proliferation and inducers of apoptosis in human cholangiocarcinoma cells. Life Sci. 2016;153:41–9.
Article CAS PubMed Google Scholar
Guterres FA, Martinez GR, Rocha ME, Winnischofer SM. Simvastatin rises reactive oxygen species levels and induces senescence in human Melanoma cells by activation of p53/p21 pathway. Exp Cell Res. 2013;319:2977–88.
Duarte JA, de Barros ALB, Leite EA. The potential use of simvastatin for cancer treatment: a review. Biomed Pharmacother. 2021;141:111858.
Article CAS PubMed Google Scholar
Karagkounis G, DeVecchio J, Ferrandon S, Kalady MF. Simvastatin enhances radiation sensitivity of Colorectal cancer cells. Surg Endosc. 2018;32:1533–9.
Lee J, Lee I, Han B, Park JO, Jang J, Park C, Kang WK. Effect of simvastatin on cetuximab resistance in human Colorectal cancer with KRAS mutations. J Natl Cancer Inst. 2011;103:674–88.
Article CAS PubMed Google Scholar
Lu L, Huang W, Hu W, Jiang L, Li Y, Wu X, Yuan D, Li M. Kruppel-like factor 2 mediated anti-proliferative and anti-metastasis effects of simvastatin in p53 mutant colon Cancer. Biochem Biophys Res Commun. 2019;511:772–9.
Article CAS PubMed Google Scholar
Li G, Zheng J, Xu B, Ling J, Qiu W, Wang Y. Simvastatin inhibits Tumor angiogenesis in HER2-overexpressing human Colorectal cancer. Biomed Pharmacother. 2017;85:418–24.
Article CAS PubMed Google Scholar
Pardee AB, Li CJ. Two controls of cell proliferation underlie cancer relapse. J Cell Physiol. 2018;233:8437–40.
Article CAS PubMed Google Scholar
Wang S, Zhang Y, Liu Y, Zheng R, Wu Z, Fan Y, Li M, Li M, Li T, Li Y, et al. Inhibition of CSRP2 promotes Leukemia Cell Proliferation and correlates with relapse in adults with Acute Myeloid Leukemia. Onco Targets Ther. 2020;13:12549–60.
Article CAS PubMed PubMed Central Google Scholar
Qiu P, Liu J, Zhao L, Zhang P, Wang W, Shou D, Ji J, Li C, Chai K, Dong Y. Inoscavin A, a pyrone compound isolated from a Sanghuangporus Vaninii extract, inhibits colon Cancer cell growth and induces cell apoptosis via the hedgehog signaling pathway. Phytomedicine. 2022;96:153852.
Article CAS PubMed Google Scholar
Ye S, Xu M, Zhu T, Chen J, Shi S, Jiang H, Zheng Q, Liao Q, Ding X, Xi Y. Cytoglobin promotes sensitivity to ferroptosis by regulating p53-YAP1 axis in colon Cancer cells. J Cell Mol Med. 2021;25:3300–11.
Article CAS PubMed PubMed Central Google Scholar
Hsu SK, Li CY, Lin IL, Syue WJ, Chen YF, Cheng KC, Teng YN, Lin YH, Yen CH, Chiu CC. Inflammation-related pyroptosis, a novel programmed cell death pathway, and its crosstalk with immune therapy in cancer treatment. Theranostics. 2021;11:8813–35.
Article CAS PubMed PubMed Central Google Scholar
Huang Y, Wang JW, Huang J, Tang L, Xu YH, Sun H, et al. Pyroptosis, a target for cancer treatment? Apoptosis. 2022;27(1–2):1–13.
Article CAS PubMed Google Scholar
Ju X, Yang Z, Zhang H, Wang Q. Role of pyroptosis in cancer cells and clinical applications. Biochimie. 2021;185:78–86.
Article CAS PubMed Google Scholar
Wang F, Liu W, Ning J, Wang J, Lang Y, Jin X, Zhu K, Wang X, Li X, Yang F, et al. Simvastatin suppresses Proliferation and Migration in Non-small Cell Lung Cancer via Pyroptosis. Int J Biol Sci. 2018;14:406–17.
Article CAS PubMed PubMed Central Google Scholar
Yang S, Xie C, Guo T, Li H, Li N, Zhou S, Wang X, Xie C. Simvastatin inhibits Tumor Growth and Migration by Mediating Caspase-1-dependent pyroptosis in Glioblastoma Multiforme. World Neurosurg; 2022.
Liu L, Chen W, Li Y, Fu P, Cao Y, Li Z, Xiong J, Jie Z. Comprehensive analysis of pyroptosis-related long noncoding RNA Immune Infiltration and Prediction of Prognosis in patients with Colon Cancer. J Oncol. 2022;2022:2035808.
PubMed PubMed Central Google Scholar
Yang L, Liu G, Li X, Xia Z, Wang Y, Lin W, Zhang W, Zhang W, Li X. Small GTPase RAB6 deficiency promotes alveolar progenitor cell renewal and attenuates PM2.5-induced lung injury and fibrosis. Cell Death Dis. 2020;11:827.
Article CAS PubMed PubMed Central Google Scholar
Boudreau DM, Yu O, Johnson J. Statin use and cancer risk: a comprehensive review. Expert Opin Drug Saf. 2010;9:603–21.
Article CAS PubMed PubMed Central Google Scholar
Horiguchi A, Sumitomo M, Asakuma J, Asano T, Asano T, Hayakawa M. 3-hydroxy-3-methylglutaryl-coenzyme a reductase inhibitor, fluvastatin, as a novel agent for prophylaxis of renal cancer Metastasis. Clin Cancer Res. 2004;10:8648–55.
Article CAS PubMed Google Scholar
Xiao Y, Liu Q, Peng N, Li Y, Qiu D, Yang T, Kang R, Usmani A, Amadasu E, Borlongan CV, Yu G. Lovastatin inhibits RhoA to suppress canonical Wnt/beta-Catenin signaling and alternative Wnt-YAP/TAZ signaling in Colon Cancer. Cell Transpl. 2022;31:9636897221075749.
Sroda-Pomianek K, Michalak K, Palko-Labuz A, Uryga A, Szczesniak-Siega B, Wesolowska O. Simvastatin strongly augments Proapoptotic, anti-inflammatory and cytotoxic activity of oxicam derivatives in doxorubicin-resistant Colon Cancer cells. Anticancer Res. 2019;39:727–34.
Article CAS PubMed Google Scholar
Barbalata CI, Porfire AS, Sesarman A, Rauca VF, Banciu M, Muntean D, et al. A screening study for the development of simvastatin-doxorubicin liposomes, a Co-formulation with future perspectives in Colon Cancer therapy. Pharmaceutics. 2021;13(10):1526.
Article CAS PubMed PubMed Central Google Scholar
Zhuang Z, Cai H, Lin H, Guan B, Wu Y, Zhang Y, et al. Development and validation of a robust pyroptosis-related signature for predicting prognosis and immune status in patients with colon cancer. J Oncol. 2021;2021:5818512.
Wei R, Li S, Yu G, Guan X, Liu H, Quan J, Jiang Z, Wang X. Deciphering the pyroptosis-related prognostic signature and Immune Cell infiltration characteristics of Colon Cancer. Front Genet. 2021;12:755384.
Article CAS PubMed PubMed Central Google Scholar
Tang Z, Ji L, Han M, Xie J, Zhong F, Zhang X, Su Q, Yang Z, Liu Z, Gao H, Jiang G. Pyroptosis is involved in the inhibitory effect of FL118 on growth and Metastasis in Colorectal cancer. Life Sci. 2020;257:118065.
Article CAS PubMed Google Scholar
Lee C, Do HTT, Her J, Kim Y, Seo D, Rhee I. Inflammasome as a promising therapeutic target for cancer. Life Sci. 2019;231:116593.
Article CAS PubMed Google Scholar
Tan G, Huang C, Chen J, Zhi F. HMGB1 released from GSDME-mediated pyroptotic epithelial cells participates in the tumorigenesis of colitis-associated Colorectal cancer through the ERK1/2 pathway. J Hematol Oncol. 2020;13:149.
Article PubMed PubMed Central Google Scholar
Liu Z, Li Y, Zhu Y, Li N, Li W, Shang C, Song G, Li S, Cong J, Li T, et al. Apoptin induces pyroptosis of Colorectal cancer cells via the GSDME-dependent pathway. Int J Biol Sci. 2022;18:717–30.
Article CAS PubMed PubMed Central Google Scholar
Yu J, Li S, Qi J, Chen Z, Wu Y, Guo J, Wang K, Sun X, Zheng J. Cleavage of GSDME by caspase-3 determines lobaplatin-induced pyroptosis in colon Cancer cells. Cell Death Dis. 2019;10:193.
Article PubMed PubMed Central Google Scholar
Wang Y, Xu SL, Wu YZ, Zhao MS, Xu WJ, Yang HY, Li YX. Simvastatin induces caspase-dependent apoptosis and activates P53 in OCM-1 cells. Exp Eye Res. 2013;113:128–34.
Article CAS PubMed Google Scholar
Ganesh K, Wu C, O’Rourke KP, Szeglin BC, Zheng Y, Sauve CG, Adileh M, Wasserman I, Marco MR, Kim AS, et al. A rectal cancer organoid platform to study individual responses to chemoradiation. Nat Med. 2019;25:1607–14.
Article CAS PubMed PubMed Central Google Scholar
Farin HF, Mosa MH, Ndreshkjana B, Grebbin BM, Ritter B, Menche C, et al. Colorectal cancer organoid-stroma biobank allows subtype-specific assessment of individualized therapy responses. Cancer Discov. 2023;13(10):2192–211.
Comments (0)