Trépo C, Chan HL, Lok A. Hepatitis B virus infection. Lancet. 2014;384(9959):2053–63.

Article  PubMed  Google Scholar 

Hatzakis A, Van Damme P, Alcorn K, Gore C, Benazzouz M, Berkane S, et al. The state of hepatitis B and C in the Mediterranean and Balkan countries: report from a summit conference. J Viral Hepat. 2013;20(Suppl 2):1–20.

Article  PubMed  Google Scholar 

Ruan LL, Chen MX, Adu-Gyamfi EA, Geng LH, Fu LJ, Wan Q, et al. Maternal Hepatitis B Virus Infection and Pregnancy Outcomes of Freeze-Thaw Embryo Transfer. JAMA Netw Open. 2023;6(7): e2323495.

Article  PubMed  PubMed Central  Google Scholar 

Cui AM, Cheng XY, Shao JG, Li HB, Wang XL, Shen Y, et al. Maternal hepatitis B virus carrier status and pregnancy outcomes: a prospective cohort study. BMC Pregnancy Childbirth. 2016;16:87.

Article  PubMed  PubMed Central  Google Scholar 

Zheng S, Zhang H, Chen R, Yan J, Han Q. Pregnancy complicated with hepatitis B virus infection and preterm birth: a retrospective cohort study. BMC Pregnancy Childbirth. 2021;21(1):513.

Article  PubMed  PubMed Central  Google Scholar 

Nguyen MH, Wong G, Gane E, Kao JH, Dusheiko G. Hepatitis B virus: advances in prevention, diagnosis, and therapy. Clin Microbiol Rev. 2020;33(2):e00046–19.

Rehermann B. Pathogenesis of chronic viral hepatitis: differential roles of T cells and NK cells. Nat Med. 2013;19(7):859–68.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hann HW, Hann RS, Maddrey WC. Hepatitis B virus infection in 6,130 unvaccinated Korean-Americans surveyed between 1988 and 1990. Am J Gastroenterol. 2007;102(4):767–72.

Article  PubMed  Google Scholar 

Hadchouel M, Scotto J, Huret JL, Molinie C, Villa E, Degos F, et al. Presence of HBV DNA in spermatozoa: a possible vertical transmission of HBV via the germ line. J Med Virol. 1985;16(1):61–6.

Article  CAS  PubMed  Google Scholar 

Huang JM, Huang TH, Qiu HY, Fang XW, Zhuang TG, Liu HX, et al. Effects of hepatitis B virus infection on human sperm chromosomes. World J Gastroenterol. 2003;9(4):736–40.

Article  PubMed  PubMed Central  Google Scholar 

Huang JM, Huang TH, Qiu HY, Fang XW, Zhuang TG, Qiu JW. Studies on the integration of hepatitis B virus DNA sequence in human sperm chromosomes. Asian J Androl. 2002;4(3):209–12.

CAS  PubMed  Google Scholar 

Wang S, Peng G, Li M, Xiao H, Jiang P, Zeng N, et al. Identification of hepatitis B virus vertical transmission from father to fetus by direct sequencing. Southeast Asian J Trop Med Public Health. 2003;34(1):106–13.

CAS  PubMed  Google Scholar 

Cai QX, Zhu YY. Is hepatitis B virus transmitted via the male germ line? A seroepidemiological study in fetuses. Int J Infect Dis. 2013;17(1):e54–8.

Article  PubMed  Google Scholar 

Xiong Y, Liu C, Wei W, Huang S, Wang J, Qi Y, et al. The impact of biparental hepatitis B virus infection on pregnancy outcomes in patients undergoing assisted reproductive technology treatment: a systematic review and meta-analysis. Arch Gynecol Obstet. 2022;306(4):1253–66.

Article  PubMed  Google Scholar 

Lorusso F, Palmisano M, Chironna M, Vacca M, Masciandaro P, Bassi E, et al. Impact of chronic viral diseases on semen parameters. Andrologia. 2010;42(2):121–6.

Article  CAS  PubMed  Google Scholar 

Heck JE, Wu CK, Huang X, Chew KW, Tong M, Federman N, et al. Cohort study of familial viral hepatitis and risks of paediatric cancers. Int J Epidemiol. 2022;51(2):448–57.

Article  PubMed  Google Scholar 

Zhong C, Lu H, Han T, Tan X, Li P, Huang J, et al. CpG methylation participates in regulation of hepatitis B virus gene expression in host sperm and sperm-derived embryos. Epigenomics. 2017;9(2):123–5.

Article  CAS  PubMed  Google Scholar 

Koumbi L, Karayiannis P. The Epigenetic Control of Hepatitis B Virus Modulates the Outcome of Infection. Front Microbiol. 2015;6:1491.

PubMed  Google Scholar 

Cheng Q, Zhao B, Huang Z, Su Y, Chen B, Yang S, et al. Epigenome-wide study for the offspring exposed to maternal HBV infection during pregnancy, a pilot study. Gene. 2018;658:76–85.

Article  CAS  PubMed  Google Scholar 

World Health Organization: WHO Laboratory Manual for the Examination and Processing of Human Semen, 6th ed..https://www.who.int/publications/i/item/9789240030787 (2021). Accessed 17 Nov 2023.

Tucci V, Isles AR, Kelsey G, Ferguson-Smith AC. Genomic Imprinting and Physiological Processes in Mammals. Cell. 2019;176(5):952–65.

Article  CAS  PubMed  Google Scholar 

Rotondo JC, Borghi A, Selvatici R, Magri E, Bianchini E, Montinari E, et al. Hypermethylation-Induced Inactivation of the IRF6 Gene as a Possible Early Event in Progression of Vulvar Squamous Cell Carcinoma Associated With Lichen Sclerosus. JAMA Dermatol. 2016;152(8):928–33.

Article  PubMed  Google Scholar 

Keyhan S, Burke E, Schrott R, Huang Z, Grenier C, Price T, et al. Male obesity impacts DNA methylation reprogramming in sperm. Clin Epigenetics. 2021;13(1):17.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Moretti E, Federico MG, Giannerini V, Collodel G. Sperm ultrastructure and meiotic segregation in a group of patients with chronic hepatitis B and C. Andrologia. 2008;40(5):286–91.

Article  CAS  PubMed  Google Scholar 

Zhou XL, Sun PN, Huang TH, Xie QD, Kang XJ, Liu LM. Effects of hepatitis B virus S protein on human sperm function. Hum Reprod. 2009;24(7):1575–83.

Article  CAS  PubMed  Google Scholar 

Rando OJ, Simmons RA. I’m eating for two: parental dietary effects on offspring metabolism. Cell. 2015;161(1):93–105.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Peters J. The role of genomic imprinting in biology and disease: an expanding view. Nat Rev Genet. 2014;15(8):517–30.

Article  CAS  PubMed  Google Scholar 

Rotondo JC, Lanzillotti C, Mazziotta C, Tognon M, Martini F. Epigenetics of Male Infertility: The Role of DNA Methylation. Front Cell Dev Biol. 2021;9: 689624.

Article  PubMed  PubMed Central  Google Scholar 

Huang J, Sengupta R, Espejo AB, Lee MG, Dorsey JA, Richter M, et al. p53 is regulated by the lysine demethylase LSD1. Nature. 2007;449(7158):105–8.

Article  CAS  PubMed  Google Scholar 

Feng S, Jacobsen SE, Reik W. Epigenetic reprogramming in plant and animal development. Science. 2010;330(6004):622–7.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wang L, Zhang J, Duan J, Gao X, Zhu W, Lu X, et al. Programming and inheritance of parental DNA methylomes in mammals. Cell. 2014;157(4):979–91.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hopf LVM, Baek K, Klügel M, von Gronau S, Xiong Y, Schulman BA. Structure of CRL7(FBXW8) reveals coupling with CUL1-RBX1/ROC1 for multi-cullin-RING E3-catalyzed ubiquitin ligation. Nat Struct Mol Biol. 2022;29(9):854–62.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lopez-Sainz A, Dominguez F, Lopes LR, Ochoa JP, Barriales-Villa R, Climent V, et al. Clinical Features and Natural History of PRKAG2 Variant Cardiac Glycogenosis. J Am Coll Cardiol. 2020;76(2):186–97.

Article  CAS