Rimoldi M, Chieppa M, Salucci V, Avogadri F, Sonzogni A, Sampietro GM, et al. Intestinal immune homeostasis is regulated by the crosstalk between epithelial cells and dendritic cells. Nat Immunol. 2005;6:507–14.
Article CAS PubMed Google Scholar
Okumura R, Kurakawa T, Nakano T, Kayama H, Kinoshita M, Motooka D, et al. Lypd8 promotes the segregation of flagellated microbiota and colonic epithelia. Nature. 2016;532:117–21.
Article CAS PubMed Google Scholar
Okumura R, Takeda K. Roles of intestinal epithelial cells in the maintenance of gut homeostasis. Exp Mol Med. 2017;49:e338. https://doi.org/10.1038/emm.2017.20.
Gonnella PA, Wilmore DW. Co-localization of class II antigen and exogenous antigen in the rat enterocyte. J Cell Sci. 1993;106(Pt 3):937–40. https://doi.org/10.1242/jcs.106.3.937.
Article CAS PubMed Google Scholar
Hirata I, Austin LL, Blackwell WH, Weber JR, Dobbins WO. Immunoelectron microscopic localization of HLA-DR antigen in control small intestine and colon and in inflammatory bowel disease. Dig Dis Sci. 1986;31:1317–30. https://doi.org/10.1007/BF01299810.
Article CAS PubMed Google Scholar
Roche PA, Marks MS, Cresswell P. Formation of a nine-subunit complex by HLA class II glycoproteins and the invariant chain. Nature. 1991;354:392–94. https://doi.org/10.1038/354392a0.
Article CAS PubMed Google Scholar
Hershberg RM, Cho DH, Youakim A, Bradley MB, Lee JS, Framson PE, et al. Highly polarized HLA class II antigen processing and presentation by human intestinal epithelial cells. J Clin Invest. 1998;102:792–803.
Article CAS PubMed PubMed Central Google Scholar
Heuberger C, Pott J, Maloy KJ. Why do intestinal epithelial cells express MHC class II? Immunology. 2021;162:357–67. https://doi.org/10.1111/imm.13270
Thelemann C, Eren RO, Coutaz M, Brasseit J, Bouzourene H, Rosa M, et al. Interferon-γ induces expression of MHC class II on intestinal epithelial cells and protects mice from colitis. PLoS One. 2014;9(1):e86844. https://doi.org/10.1371/journal.pone.0086844.
Article CAS PubMed PubMed Central Google Scholar
Wosen JE, Ilstad-Minnihan A, Co JY, Jiang W, Mukhopadhyay D, Fernandez-Becker NQ, et al. Human intestinal enteroids model MHC-II in the gut epithelium. Front Immunol. 2019;10:https://doi.org/10.3389/fimmu.2019.01970.
Farin HF, Karthaus WR, Kujala P, Rakhshandehroo M, Schwank G, Vries RGJ, et al. Paneth cell extrusion and release of antimicrobial products is directly controlled by immune cell–derived IFN-γ. J Exp Med. 2014;211:1393–405.
Article CAS PubMed PubMed Central Google Scholar
Peiravan A, Allenspach K, Boag AM, Soutter F, Holder A, Catchpole B, et al. Single nucleotide polymorphisms in major histocompatibility class II haplotypes are associated with potential resistance to inflammatory bowel disease in German shepherd dogs. Vet Immunol Immunopathol. 2016;182:101–05.
Article CAS PubMed Google Scholar
Nakazawa M, Miyamae J, Okano M, Kanemoto H, Katakura F, Shiina T, et al. Dog leukocyte antigen (DLA) class II genotypes associated with chronic enteropathy in French bulldogs and miniature dachshunds. Vet Immunol Immunopathol. 2021;237:110271.
Article CAS PubMed Google Scholar
German AJ, Bland PW, Hall EJ, Day MJ. Expression of major histocompatibility complex class II antigens in the canine intestine. Vet Immunol Immunopathol. 1998;61:171–80. https://doi.org/10.1016/s0165-2427(97)00144-x.
Article CAS PubMed Google Scholar
German AJ, Hall EJ, Kelly DF, Watson ADJ, Day MJ. An immunohistochemical study of histiocytic ulcerative colitis in boxer dogs. J Comp Pathol. 2000;122:163–75. https://doi.org/10.1053/jcpa.1999.0353.
Article CAS PubMed Google Scholar
Kol A, Arzi B, Athanasiou KA, Farmer DL, Nolta JA, Rebhun RB, et al. Companion animals: translational scientist’s new best friends. Sci Transl Med. 2015;7:https://doi.org/10.1126/scitranslmed.aaa9116.
Sato T, Vries RG, Snippert HJ, Van De Wetering M, Barker N, Stange DE, et al. Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche. Nature. 2009;459:262–65.
Article CAS PubMed Google Scholar
Kawasaki M, Goyama T, Tachibana Y, Nagao I, Ambrosini YM. Farm and companion animal organoid models in translational research: a powerful tool to bridge the gap between mice and humans. Front Med Technol. 2022;4. https://doi.org/10.3389/fmedt.2022.895379.
Chandra L, Borcherding DC, Kingsbury D, Atherly T, Ambrosini YM, Bourgois-Mochel A, et al. Derivation of adult canine intestinal organoids for translational research in gastroenterology. BMC Biol. 2019;17:1–21.
Kim MB, Hwangbo S, Jang S, Jo YK. Bioengineered Co-culture of organoids to recapitulate host-microbe interactions. Mater Today Bio. 2022;16:100345. https://doi.org/10.1016/j.mtbio.2022.100345.
Article CAS PubMed PubMed Central Google Scholar
Hammoudi N, Hamoudi S, Bonnereau J, Bottois H, Pérez K, Bezault M, et al. Autologous organoid co-culture model reveals T cell-driven epithelial cell death in Crohn’s Disease. Front Immunol. 2022;13:1008456.
Article CAS PubMed PubMed Central Google Scholar
Heijmans J, Van Lidth de Jeude JF, Koo BK, Rosekrans SL, Wielenga MCB, Van De Wetering M, et al. ER stress causes rapid loss of intestinal epithelial stemness through activation of the unfolded protein response. Cell Rep. 2013;3:1128–39.
Article CAS PubMed Google Scholar
Sato T, Stange DE, Ferrante M, Vries RGJ, Van Es JH, Van Den Brink S, et al. Long-term expansion of epithelial organoids from human colon, adenoma, adenocarcinoma, and Barrett’s epithelium. Gastroenterology. 2011;141:1762–72.
Article CAS PubMed Google Scholar
Sato T, Van Es JH, Snippert HJ, Stange DE, Vries RG, Van Den Born M, et al. Paneth cells constitute the niche for Lgr5 stem cells in intestinal crypts. Nature. 2011;469:415–18.
Article CAS PubMed Google Scholar
German AJ, Helps CR, Hall EJ, Day MJ. Cytokine mRNA expression in mucosal biopsies from German shepherd dogs with small intestinal enteropathies. Dig Dis Sci. 2000;45:7–17. https://doi.org/10.1023/a:1005436721798.
Article CAS PubMed Google Scholar
Sanchez-Muñoz F, Dominguez-Lopez A, Yamamoto-Furusho JK. Role of cytokines in inflammatory bowel disease. World J Gastroenterol. 2008;14:4280–88. https://doi.org/10.3748/wjg.14.4280.
Article CAS PubMed PubMed Central Google Scholar
Konstantinidis AO, Adamama-Moraitou KK, Pardali D, Dovas CI, Brellou GD, Papadopoulos T, et al. Colonic mucosal and cytobrush sample cytokine mRNA expression in canine inflammatory bowel disease and their correlation with disease activity, endoscopic and histopathologic score. PLoS One. 2021;16:https://doi.org/10.1371/journal.pone.0245713.
Onozato D, Akagawa T, Kida Y, Ogawa I, Hashita T, Iwao T, et al. Application of human induced pluripotent stem cell-derived intestinal organoids as a model of epithelial damage and fibrosis in inflammatory bowel disease. Biol Pharm Bull. 2020;43:1088–95.
Article CAS PubMed Google Scholar
Lee C, Hong SN, Kim ER, Chang DK, Kim YH. Epithelial regeneration ability of crohn’s disease assessed using patient-derived intestinal organoids. Int J Mol Sci. 2021;22. https://doi.org/10.3390/ijms22116013.
Saito Y, Shimizu M, Iwatsuki K, Hanyu H, Tadaishi M, Sugita-Konishi Y, et al. Effect of short-time treatment with TNF-α on stem cell activity and barrier function in enteroids. Cytotechnology. 2021;73:669–82.
Article CAS PubMed PubMed Central Google Scholar
Ambrosini YM, Park Y, Jergens AE, Shin W, Min S, Atherly T, et al. Recapitulation of the accessible interface of biopsy-derived canine intestinal organoids to study epithelial-luminal interactions. PLoS One. 2020;15:https://doi.org/10.1371/journal.pone.0231423.
Nowak M, Aslan S, Kowalewski MP. Determination of novel reference genes for improving gene expression data normalization in selected canine reproductive tissues—a multistudy analysis. BMC Vet Res. 2020;16. https://doi.org/10.1186/s12917-020-02635-6.
Soileau AM, Quick CN, Moeller CE, Schaumburg JC, Withers SS. the effect of arginase on canine T-lymphocyte functions and its modulation by all-trans retinoid acid (ATRA) in canine monocyte-derived macrophages. Vet Sci. 2022;9. https://doi.org/10.3390/vetsci9070374.
Nagao I, Nakazawa M, Goyama T, Court MH, Ambrosini YM. Assessment of cytochrome P450 induction in canine intestinal organoid models. Xenobiotica. 2024;54(5):217–25. https://doi.org/10.1080/00498254.2024.2326973.
Article CAS PubMed Google Scholar
Peters IR, Peeters D, Helps CR, Day MJ. Development and application of multiple internal reference (housekeeper) gene assays for accurate normalisation of canine gene expression studies. Vet Immunol Immunopathol. 2007;117:55–66. https://doi.org/10.1016/j.vetimm.2007.01.011.
Comments (0)