Chronic Abdominal Pain in Patients with Inflammatory Bowel Disease in Remission: A Continuing Challenge for Clinicians

Coates MD, Johri A, Gorrepati VS et al. Abdominal pain in quiescent inflammatory bowel disease. Int J Colorectal Dis 2021;36:93–102.

Article  PubMed  Google Scholar 

Nicholas M, Vlaeyen JWS, Rief W et al. The IASP Taskforce for the Classification of Chronic Pain. The IASP classification of chronic pain for ICD-11: chronic primary pain. Pain 2019;160:28–37.

Article  PubMed  Google Scholar 

Drewes AM, Olesen AE, Farmer AD et al. Gastrointestinal pain. Nat Rev Dis Primers 2020;6:1.

Article  PubMed  Google Scholar 

Dunleavy KA, Cross RK, Raffals LE. Causes, diagnostic testing, and treatment of residual symptoms in patients with IBD with quiescent disease. Am J Gastroenterol 2023;118:1909–1914.

Article  CAS  PubMed  Google Scholar 

Lim J, Rezaie A. Irritable bowel syndrome-like symptoms in quiescent inflammatory bowel disease: a practical approach to diagnosis and treatment of organic causes. Dig Dis Sci 2023;68:4081–4097. https://doi.org/10.1007/s10620-023-08095-w.

Article  PubMed  PubMed Central  Google Scholar 

Coates MD, Clarke K, Williams E et al. Abdominal pain in inflammatory bowel disease: an evidence-based, multidisciplinary review. Crohn’s Colitis 360 2023;5:1–18.

Google Scholar 

Shah A, Morrison M, Burger D et al. Systematic review with meta-analysis: the prevalence of small intestinal bacterial overgrowth in inflammatory bowel disease. Aliment Pharmacol Ther 2018;49:624–635.

Article  Google Scholar 

Halpin SJ, Ford AC. Prevalence of symptoms meeting criteria for irritable bowel syndrome in inflammatory bowel disease: systematic review and meta-analysis. Am J Gastroenterol 2012;107:1474–1482.

Article  PubMed  Google Scholar 

Fairbrass KM, Costantino SJ, Gracie DJ, Ford AC. Prevalence of irritable bowel syndrome-type symptoms in patients with inflammatory bowel disease in remission: a systematic review and meta-analysis. Lancet Gastroenterol Hepatol 2020;5:1053–1062.

Article  PubMed  Google Scholar 

Gracie DJ, Hamlin PJ, Ford AC. The influence of the brain–gut axis in inflammatory bowel disease and possible implications for treatment. Lancet Gastroenterol Hepatol 2019;4:632–642.

Article  PubMed  Google Scholar 

Coates MD, Dalessio S, Walter V et al. Lifestyle factors associated with abdominal pain in quiescent inflammatory bowel disease. Dig Dis Sci 2023;68:4156–4165. https://doi.org/10.1007/s10620-023-08075-0.

Article  CAS  PubMed  Google Scholar 

Abdalla MII, Sandler RS, Kappelman MD et al. Prevalence and impact of inflammatory bowel disease-irritable bowel syndrome on patient-reported outcomes in CCFA partners. Inflamm Bowel Dis 2017;23:325–331.

Article  PubMed  Google Scholar 

Bosman MHMA, Weerts ZZRM, Snijkers JTW et al. The socioeconomic impact of irritable bowel syndrome: an analysis of direct and indirect health care costs. Clin Gastroenterol Hepatol 2023;21:2660–2669.

Article  PubMed  Google Scholar 

Kuenzig ME, Im JHB, Coward S et al. The 2023 impact of inflammatory bowel disease in Canada: indirect (individual and societal) and direct out-of-pocket costs. J Can Assoc Gastroenterol 2023;6:S16–S22.

Article  PubMed  PubMed Central  Google Scholar 

Bogale K, Maheshwari P, Kang M et al. Symptoms associated with healthcare resource utilization in the setting of inflammatory bowel disease. Sci Rep 2022;12:1–8.

Article  Google Scholar 

Al Khoury A, Balram B, Bessissow T et al. Patient perspectives and expectations in inflammatory bowel disease: a systematic review. Dig Dis Sci 2022;67:1956–1974. https://doi.org/10.1007/s10620-021-07025-y.

Article  PubMed  Google Scholar 

Gregor JC, Williamson M, Dajnowiec D, Sattin B, Sabot E, Salh B. Inflammatory bowel disease patients prioritize mucosal healing, symptom control, and pain when choosing therapies: results of a prospective cross-sectional willingness-to-pay study. Patient Prefer Adherence 2018;12:505–513.

Article  PubMed  PubMed Central  Google Scholar 

Louis E, Siegel CA, James B, Heidenreich S, Krucien N, Ghosh S. Patients with inflammatory bowel disease have heterogeneous treatment preferences that are largely determined by the avoidance of abdominal pain and side effects [P-POWER IBD Study]. J Crohn’s Colitis 2023;17:231–239.

Article  Google Scholar 

Balbale SN, Iroz CB, Schäfer WLA, Johnson JK, Stulberg JJ. A missing piece of the puzzle: patient and provider perspectives on pain management needs and opioid prescribing in inflammatory bowel disease care. Crohn’s Colitis 2022;360:1–15.

Google Scholar 

Weaver E, Szigethy E. Managing pain and psychosocial care in IBD: a primer for the practicing gastroenterologist. Curr Gastroenterol Rep 2020;22:20.

Article  PubMed  Google Scholar 

Colombel JF, Shin A, Gibson PR. AGA clinical practice update on functional gastrointestinal symptoms in patients with inflammatory bowel disease: expert review. Clin Gastroenterol Hepatol 2019;17:380-390.e1.

Article  PubMed  Google Scholar 

Quigley EMM. Overlapping irritable bowel syndrome and inflammatory bowel disease: less to this than meets the eye? Ther Adv Gastroenterol 2016;9:199–212.

Article  CAS  Google Scholar 

Lacy BE, Pimentel M, Brenner DM et al. ACG clinical guideline: management of irritable bowel syndrome. Am J Gastroenterol 2020;116:17–44.

Article  Google Scholar 

Vasant DH, Paine PA, Black CJ et al. British Society of Gastroenterology guidelines on the management of irritable bowel syndrome. Gut 2021;70:1–27.

Article  Google Scholar 

Le Zhan Y, An Zhan Y, Xue Dai S. Is a low FODMAP diet beneficial for patients with inflammatory bowel disease? A meta-analysis and systematic review. Clin Nutr 2018;37:123–129.

Article  PubMed  Google Scholar 

Pedersen N, Ankersen DV, Felding M et al. Low-FODMAP diet reduces irritable bowel symptoms in patients with inflammatory bowel disease. World J Gastroenterol 2017;23:3356–3366.

Article  PubMed  PubMed Central  Google Scholar 

Grammatikopoulou MG, Goulis DG, Gkiouras K et al. Low FODMAP diet for functional gastrointestinal symptoms in quiescent inflammatory bowel disease: a systematic review of randomized controlled trials. Nutrients 2020;12:1–22.

Article  Google Scholar 

Melgaard D, Sørensen J, Riis J et al. Efficacy of FODMAP elimination and subsequent blinded placebo-controlled provocations in a randomised controlled study in patients with ulcerative colitis in remission and symptoms of irritable bowel syndrome: a feasibility study. Nutrients 2022;14:4–7.

Article  Google Scholar 

Gu B, Yu Z, Shi C, Yan C, Chen B, Zhou J. Effects of low-FODMAP diet on irritable bowel symptoms in patients with quiescent inflammatory bowel disease. Medicine (United States) 2022;101:4–7.

Google Scholar 

Lewis JD, Sandler RS, Brotherton C et al. A randomized trial comparing the specific carbohydrate diet to a Mediterranean diet in adults with Crohn’s disease. Gastroenterology 2021;161:837-852.e9.

Article  CAS  PubMed  Google Scholar 

Kuang R, Levinthal DJ, Ghaffari AA, del Aguila de Rivers CR, Tansel A, Binion DG. Nightshade vegetables: a dietary trigger for worsening inflammatory bowel disease and irritable bowel syndrome? Dig Dis Sci 2023;68:2853–2860. https://doi.org/10.1007/s10620-023-07955-9.

Article  CAS  PubMed  Google Scholar 

Robelin K, Senada P, Ghoz H et al. Prevalence and clinician recognition of avoidant/restrictive food intake disorder in patients with inflammatory bowel disease. Gastroenterol Hepatol 2021;17:510–514.

Google Scholar 

Yelencich E, Truong E, Widaman AM et al. Avoidant restrictive food intake disorder prevalent among patients with inflammatory bowel disease. Clin Gastroenterol Hepatol 2022;20:1282-1289.e1.

Article  CAS  PubMed  Google Scholar 

Bianco A, Russo F, Franco I et al. Enhanced physical capacity and gastrointestinal symptom improvement in southern Italian IBS patients following three months of moderate aerobic exercise. J Clin Med 2023;12:6786.

Article  PubMed  PubMed Central  Google Scholar 

Zhou C, Zhao E, Li Y, Jia Y, Li F. Exercise therapy of patients with irritable bowel syndrome: a systematic review of randomized controlled trials. Neurogastroenterol Motil 2019;31:1–10.

Article  Google Scholar 

D’Silva A, Islam Z, Marshall DA et al. Experiences of irritable bowel syndrome patients in a virtual yoga program: qualitative findings from a clinical trial. Dig Dis Sci 2024;69:169–179. https://doi.org/10.1007/s10620-023-08125-7.

Article  PubMed 

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