Clark T, Maximin S, Meier J, Pokharel S, Bhargava P. Hepatocellular Carcinoma: Review of Epidemiology, Screening, Imaging Diagnosis, Response Assessment, and Treatment. Curr Probl Diagn Radiol. 2015;44:479–486.

Article  PubMed  Google Scholar 

Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A et al. Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries. CA Cancer J Clin. 2021;71:209–249.

Article  PubMed  Google Scholar 

Serper M, Taddei TH, Mehta R, D’Addeo K, Dai F, Aytaman A et al. Association of Provider Specialty and Multidisciplinary Care With Hepatocellular Carcinoma Treatment and Mortality. Gastroenterology. 2017;152:1954–1964.

Article  PubMed  Google Scholar 

Berzigotti A, Reig M, Abraldes JG, Bosch J, Bruix J. Portal hypertension and the outcome of surgery for hepatocellular carcinoma in compensated cirrhosis: a systematic review and meta-analysis. Hepatology. 2015;61:526–536.

Article  PubMed  Google Scholar 

Siegel RL, Miller KD, Jemal A. Cancer statistics, 2019. CA Cancer J Clin. 2019;69:7–34.

Article  PubMed  Google Scholar 

Corfield A. Eukaryotic protein glycosylation: a primer for histochemists and cell biologists. Histochem Cell Biol. 2017;147:119–147.

Article  CAS  PubMed  Google Scholar 

Andrianifahanana M, Moniaux N, Batra SK. Regulation of mucin expression: mechanistic aspects and implications for cancer and inflammatory diseases. Biochim Biophys Acta. 2006;1765:189–222.

CAS  PubMed  Google Scholar 

Zhan XX, Zhao B, Diao C, Cao Y, Cheng RC. Expression of MUC1 and CD176 (Thomsen-Friedenreich antigen) in papillary thyroid carcinomas. Endocr Pathol. 2015;26:21–26.

Article  CAS  PubMed  Google Scholar 

Jing X, Liang H, Hao C, Yang X, Cui X. Overexpression of MUC1 predicts poor prognosis in patients with breast cancer. Oncol Rep. 2019;41:801–810.

CAS  PubMed  Google Scholar 

Chen FY, Zhou C, Zhang XY, Zhou KQ, Peng YF, Yu L et al. Integrated Bioinformatics analysis and clinical validation reveals that high expression of mucin 1 in intrahepatic cholangiocarcinoma predicts recurrence after curative resection. Exp Ther Med. 2020;20:50.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wang X, Zhou X, Zeng F, Wu X, Li H. miR-485-5p inhibits the progression of breast cancer cells by negatively regulating MUC1. Breast Cancer. 2020;27:765–775.

Article  PubMed  Google Scholar 

Xie Q, Zhao S, Liu W, Cui Y, Li F, Li Z et al. YBX1 Enhances Metastasis and Stemness by Transcriptionally Regulating MUC1 in Lung Adenocarcinoma. Front Oncol. 2021;11:702491.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lan Y, Ni W, Tai G. Expression of MUC1 in different tumours and its clinical significance (Review). Mol Clin Oncol. 2022;17:161.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Li Q, Wang F, Liu G, Yuan H, Chen T, Wang J et al. Impact of Mucin1 knockdown on the phenotypic characteristics of the human hepatocellular carcinoma cell line SMMC-7721. Oncol Rep. 2014;31:2811–2819.

Article  CAS  PubMed  Google Scholar 

Zhu T, Zheng J, Zhuo W, Pan P, Li M, Zhang W et al. ETV4 promotes breast cancer cell stemness by activating glycolysis and CXCR4-mediated sonic Hedgehog signaling. Cell Death Discov. 2021;7:126.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Rao CV, Mohammed A. New insights into pancreatic cancer stem cells. World J Stem Cells. 2015;7:547–555.

Article  PubMed  PubMed Central  Google Scholar 

O’Connor ML, Xiang D, Shigdar S, Macdonald J, Li Y, Wang T et al. Cancer stem cells: A contentious hypothesis now moving forward. Cancer Lett. 2014;344:180–187.

Article  CAS  PubMed  Google Scholar 

Takebe N, Miele L, Harris PJ, Jeong W, Bando H, Kahn M et al. Targeting Notch, Hedgehog, and Wnt pathways in cancer stem cells: clinical update. Nat Rev Clin Oncol. 2015;12:445–464.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Meng X, Liu K, Xiang Z, Yu X, Wang P, Ma Q. MiR-125b-2-3p associates with prognosis of ccRCC through promoting tumor metastasis via targeting EGR1. American journal of translational research. 2020;12:5575–5585.

CAS  PubMed  PubMed Central  Google Scholar 

Sikandar SS, Pate KT, Anderson S, Dizon D, Edwards RA, Waterman ML et al. NOTCH signaling is required for formation and self-renewal of tumor-initiating cells and for repression of secretory cell differentiation in colon cancer. Cancer Res. 2010;70:1469–1478.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zhou B, Lin W, Long Y, Yang Y, Zhang H, Wu K et al. Notch signaling pathway: architecture, disease, and therapeutics. Signal transduction and targeted therapy. 2022;7:95.

Article  PubMed  PubMed Central  Google Scholar 

Jiang N, Zou C, Zhu Y, Luo Y, Chen L, Lei Y et al. HIF-1a-regulated miR-1275 maintains stem cell-like phenotypes and promotes the progression of LUAD by simultaneously activating Wnt/beta-catenin and Notch signaling. Theranostics. 2020;10:2553–2570.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Yi L, Zhou X, Li T, Liu P, Hai L, Tong L et al. Notch1 signaling pathway promotes invasion, self-renewal and growth of glioma initiating cells via modulating chemokine system CXCL12/CXCR4. J Exp Clin Cancer Res. 2019;38:339.

Article  PubMed  PubMed Central  Google Scholar 

Bai S, Chen W, Zheng M, Wang X, Peng W, Zhao Y et al. Spindle and kinetochore-associated complex subunit 3 (SKA3) promotes stem cell-like properties of hepatocellular carcinoma cells through activating Notch signaling pathway. Ann Transl Med. 2021;9:1361.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wang R, Li Y, Tsung A, Huang H, Du Q, Yang M et al. iNOS promotes CD24(+)CD133(+) liver cancer stem cell phenotype through a TACE/ADAM17-dependent Notch signaling pathway. Proc Natl Acad Sci USA. 2018;115:E10127–E10136.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Song F, Chen FY, Wu SY, Hu B, Liang XL, Yang HQ et al. Mucin 1 promotes tumor progression through activating WNT/beta-catenin signaling pathway in intrahepatic cholangiocarcinoma. J Cancer. 2021;12:6937–6947.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Jiang QL, Feng SJ, Yang ZY, Xu Q, Wang SZ. CircHECTD1 up-regulates mucin 1 expression to accelerate hepatocellular carcinoma development by targeting microRNA-485-5p via a competing endogenous RNA mechanism. Chin Med J (Engl). 2020;133:1774–1785.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Luan Z, Morimoto Y, Fushimi A, Yamashita N, Suo W, Bhattacharya A et al. MUC1-C dictates neuroendocrine lineage specification in pancreatic ductal adenocarcinomas. Carcinogenesis. 2022;43:67–76.

Article  CAS  PubMed  Google Scholar 

Li W, Zhang N, Jin C, Long MD, Rajabi H, Yasumizu Y et al. MUC1-C drives stemness in progression of colitis to colorectal cancer. JCI Insight. 2020. https://doi.org/10.1172/jci.insight.137112.

Article  PubMed  PubMed Central  Google Scholar 

Rawla P, Sunkara T, Muralidharan P, Raj JP. Update in global trends and aetiology of hepatocellular carcinoma. Contemp Oncol (Pozn). 2018;22:141–150.

CAS  PubMed  PubMed Central