Bidirectional Relationship Between Gastroparesis and Malnutrition

Winter TA, O’Keefe SJ, Callanan M, Marks T. Impaired gastric acid and pancreatic enzyme secretion in patients with Crohn’s disease may be a consequence of a poor nutritional state. Inflam Bowel Disease 2004;10:618–625. https://doi.org/10.1097/00054725-200409000-00018.

Article  CAS  Google Scholar 

Massironi S, Viganò C, Palermo A et al. Inflammation and malnutrition in inflammatory bowel disease. Lancet Gastroenterol Hepatol 2023;8:579–590. https://doi.org/10.1016/S2468-1253(23)00011-0.

Article  CAS  PubMed  Google Scholar 

Bannert K, Sautter LF, Wiese ML et al. Analysis of ESPEN and GLIM algorithms reveals specific drivers for the diagnosis of malnutrition in patients with chronic gastrointestinal diseases. Nutrition 2023;106:111887. https://doi.org/10.1016/j.nut.2022.111887.

Article  CAS  PubMed  Google Scholar 

Amjad W, Qureshi W, Singh RU, Richter S. Nutritional deficiencies and predictors of mortality in diabetic and nondiabetic gastroparesis. Ann Gastroenterol 2021;34:788–795. https://doi.org/10.20524/aog.2021.0660.

Article  PubMed  PubMed Central  Google Scholar 

Patel J, Bains K, Kalra S et al. The effects of malnutrition on inpatient outcomes in patients with gastroparesis: A nationwide analysis. Cureus 2023;15:e47082. https://doi.org/10.7759/cureus.47082.

Article  PubMed  PubMed Central  Google Scholar 

White JV, Guenter P, Jensen G, et al; Academy Malnutrition Work Group; A.S.P.E.N. Malnutrition Task Force; A.S.P.E.N. Board of Directors. Consensus statement: Academy of Nutrition and Dietetics and American Society for Parenteral and Enteral Nutrition: characteristics recommended for the identification and documentation of adult malnutrition (undernutrition). J Parenter Enteral Nutr, 36:275–83, 2012. https://doi.org/10.1177/0148607112440285.

Parkman HP, Van Natta M, Yamada G et al. Body weight in patients with idiopathic gastroparesis. Neurogastroenterol Motil 2021;33:e13974. https://doi.org/10.1111/nmo.13974.

Article  CAS  PubMed  Google Scholar 

Steinhauser ML, Olenchock BA, O’Keefe J et al. The circulating metabolome of human starvation. JCI Insight 2018;3:e121434. https://doi.org/10.1172/jci.insight.121434.

Article  PubMed  PubMed Central  Google Scholar 

Smith RL, Soeters MR, Wüst RCI, Houtkooper RH. Metabolic flexibility as an adaptation to energy resources and requirements in health and disease. Endocr Rev 2018;39:489–517. https://doi.org/10.1210/er.2017-0211.

Article  PubMed  PubMed Central  Google Scholar 

Bonora BM, Avogaro A, Fadini GP. Euglycemic ketoacidosis. Curr Diab Rep 2020;20:25. https://doi.org/10.1007/s11892-020-01307-x.

Article  CAS  PubMed  Google Scholar 

Gross AS, Graef MJ. Mechanisms of autophagy in metabolic stress response. Mol Biol 2020;432:28–52. https://doi.org/10.1016/j.jmb.2019.09.005.

Article  CAS  Google Scholar 

Lim SL, Ong KC, Chan YH et al. Malnutrition and its impact on cost of hospitalization, length of stay, readmission and 3-year mortality. Clin Nutr 2012;31:345–350. https://doi.org/10.1016/j.clnu.2011.11.001.

Article  PubMed  Google Scholar 

Ceniccola GD, Okamura AB, Sepúlveda Neta JDS, et al. Association between AND-ASPEN malnutrition criteria and hospital mortality in critically ill truama patients:A prospective cohort study.J Parenter Enteral Nutr. 44:1347–1354, 2020. https://doi.org/10.1002/jpen.1795.

Gilbert RJ, Siamwala JH, Kumar V et al. Reconsideration of the gastroparetic syndrome. Current Gastroenterology Reports 2023;25:75–90. https://doi.org/10.1007/s11894-023-00865-w.

Article  PubMed  Google Scholar 

Püschel F, Favaro F, Redondo-Pedraza J et al. Starvation and antimetabolic therapy promote cytokine release and recruitment by immune cells. Proc Natl Acad Sci USA 2020;117:9932–9941. https://doi.org/10.1073/pnas.1913707117.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bourke CD, Jones KDJ, Prendergast AJ. Current understanding of innate immune call dysfunction in childhood undernutrition. Front Immunol 2019;10:1728. https://doi.org/10.3389/fimmu.2019.01728.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Campbell DI, Murch SH, Elia M et al. Chronic T cell-mediated enteropathy in rural west African children: relationship with nutritional status and small bowel function. Pediatric Res 2003;54:306–311. https://doi.org/10.1203/01.PDR.0000076666.16021.5E.

Article  Google Scholar 

Liu J, Bolick DT, Kolling GL et al. Protein malnutrition impairs intestinal epithelial cell turnover, a potential mechanism of increased cryptosporidiosis in a murine model. Infection Immunity. 2016;84:3542–3549. https://doi.org/10.1128/IAI.00705-16.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Vlasova AN, Paim FC, Kandasamy S, et al. Protein malnutrition modifies innate immunity and gene expression by intestinal epithelial cells and human rotavirus infection in neonatal gnotobiotic pigs. mSphere. 2:e00046–17, 2017. https://doi.org/10.1128/mSphere.00046-17.

Brown EM, Wlodarska M, Willing BP et al. Diet and specific microbial exposure trigger features of environmental enteropathy in a novel murine model. Nat Commun 2015;6:7806. https://doi.org/10.1038/ncomms8806.

Article  CAS  PubMed  Google Scholar 

Becker L, Nguyen L, Gill J, et al. A. Age-dependent shift in macrophage polarization causes inflammation-mediated degeneration of enteric nervous system. Gut, 67: 827–836, 2018. https://doi.org/10.1136/gutjnl-2016-312940.

Chikkamenahalli LL, Jessen E, Bernard CE, et al; NIDDK Gastroparesis Clinical Research Consortium (GpCRC). Single cell atlas of human gastric muscle immune cells and macrophage-driven changes in idiopathic gastroparesis. iScience. 2024 Jan 23;27:108991, 2024. https://doi.org/10.1016/j.isci.2024.108991

Saxton RA, Sabatini DM. mTOR signaling in growth, metabolism, and disease. Cell 2017;168:960–976. https://doi.org/10.1016/j.cell.2017.02.004.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wang X, Proud CG. The mTOR pathway in the control of protein synthesis. Physiology (Bethesda) 2006;21:362–369. https://doi.org/10.1152/physiol.00024.2006.

Article  CAS  PubMed  Google Scholar 

Wyant GA, Abu-Remaileh M, Frenkel EM et al. NUFIP1 is a ribosome receptor for starvation-induced ribophagy. Science 2018;360:751–758. https://doi.org/10.1126/science.aar2663.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Konieczny P, Xing Y, Sidhu I, et al. Interleukin-17 governs hypoxic adaptation of injured epithelium. Science, 377, 2022. https://doi.org/10.1126/science.abg9302.

Bar-Peled L, Chantranupong L, Cherniack AD et al. A tumor suppressor complex with GAP activity for the Rag GTPases that signal amino acid sufficiency to mTORC1. Science 2013;340:1100–1106. https://doi.org/10.1126/science.1232044.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Szwed A, Kim E, Jacinto E. Regulation and metabolic functions of mTORC1 and mTORC2. Physiol Rev 2021;101:1371–1426. https://doi.org/10.1152/physrev.00026.2020.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Fu W, Hall MN. Regulation of mTORC2 Signaling. Genes (Basel) 2020;11:1045. https://doi.org/10.3390/genes11091045.

Article  CAS  PubMed  Google Scholar 

Panwar V, Singh A, Bhatt M, et al. Multifaceted role of mTOR (mammalian target of rapamycin) signaling pathway in human health and disease. Signal Transduct Target Ther 2023;8:375. https://doi.org/10.1038/s41392-023-01608-z.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ebner M, Puchkov D, López-Ortega O, et al. Nutrient-regulated control of lysosome function by signaling lipid conversion. Cell 2023;186:5328-5346.e26. https://doi.org/10.1016/j.cell.2023.09.027.

Article  CAS  PubMed  Google Scholar 

Sahin HH, Cumbul A, Uslu U et al. The effect of 1,25 dihydroxyvitamin D3 on HCl/Ethanol-induced gastric injury in rats. Tissue Cell. 2018;51:2018. https://doi.org/10.1016/j.tice.2018.03.003.

Article  CAS  Google Scholar 

El-Sayed SF, Mahmoud SM, Samy W et al. Vitamin D3 mitigates aspirin-induced gastric injury by modulating gastrokines, E-cadherin, and inhibiting NLRP3 and NF-kappa B/MMP-9 signaling pathway. Tissue Cell 2025;93:102724. https://doi.org/10.1016/j.tice.2025.102724.

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