Guizhen Z, Guanchang J, Liwen L, Huifen W, Zhigang R, Ranran S et al. The tumor microenvironment of hepatocellular carcinoma and its targeting strategy by CAR-T cell immunotherapy. Front Endocrinol (Lausanne). 2022;13:918869.
Article PubMed PubMed Central Google Scholar
Choo SP, Tan WL, Goh BKP, Tai WM, Zhu AX. Comparison of hepatocellular carcinoma in Eastern versus Western populations. Cancer. 2016;122:3430–3446.
McGlynn KA, Petrick JL, El-Serag HB. Epidemiology of hepatocellular carcinoma. Hepatology. 2021;731 Suppl 1:4–13.
Mohamed EA, Giama NH, Abdalla AO, Shaleh HM, Oseini AM, Ali HA et al. High prevalence of chronic viral hepatitis B and C in Minnesota Somalis contributes to rising hepatocellular carcinoma incidence. World J Gastroenterol. 2022;28:5217–5229.
Article PubMed PubMed Central Google Scholar
Llovet JM, Kelley RK, Villanueva A, Singal AG, Pikarsky E, Roayaie S et al. Hepatocellular carcinoma. Nat Rev Dis Primers. 2021;7:6.
Sondergaard JN, Sommerauer C, Atanasoai I, Hinte LC, Geng K, Guiducci G et al. CCT3-LINC00326 axis regulates hepatocarcinogenic lipid metabolism. Gut. 2022;71:2081–2092.
Article CAS PubMed Google Scholar
Li S, Yao J, Xie M, Liu Y, Zheng M. Exosomal miRNAs in hepatocellular carcinoma development and clinical responses. J Hematol Oncol. 2018;11:54.
Article PubMed PubMed Central Google Scholar
Wang Y, Deng B. Hepatocellular carcinoma: molecular mechanism, targeted therapy, and biomarkers. Cancer Metastasis Rev. 2023;42:629–652.
Finn RS. Current and future treatment strategies for patients with advanced hepatocellular carcinoma: role of mTOR inhibition. Liver Cancer. 2012;1:247–256.
Article CAS PubMed PubMed Central Google Scholar
Wang Y, Chen Y, Zhang J, Yang Y, Fleishman JS, Wang Y et al. Cuproptosis: a novel therapeutic target for overcoming cancer drug resistance. Drug Resist Updat. 2024;72:101018.
Article CAS PubMed Google Scholar
Liu WQ, Lin WR, Yan L, Xu WH, Yang J. Copper homeostasis and cuproptosis in cancer immunity and therapy. Immunol Rev. 2024;321:211–227.
Article CAS PubMed Google Scholar
Tsvetkov P, Coy S, Petrova B, Dreishpoon M, Verma A, Abdusamad M et al. Copper induces cell death by targeting lipoylated TCA cycle proteins. Science. 2022;375:1254–1261.
Article CAS PubMed PubMed Central Google Scholar
Dong H, Strome SE, Salomao DR, Tamura H, Hirano F, Flies DB et al. Tumor-associated B7–H1 promotes T-cell apoptosis: a potential mechanism of immune evasion. Nat Med. 2002;8:793–800.
Article CAS PubMed Google Scholar
El-Khoueiry AB, Sangro B, Yau T, Crocenzi TS, Kudo M, Hsu C et al. Nivolumab in patients with advanced hepatocellular carcinoma (CheckMate 040): an open-label, non-comparative, phase 1/2 dose escalation and expansion trial. Lancet. 2017;389:2492–2502.
Article CAS PubMed PubMed Central Google Scholar
Patel MS, Nemeria NS, Furey W, Jordan F. The pyruvate dehydrogenase complexes: structure-based function and regulation. J Biol Chem. 2014;289:16615–16623.
Article CAS PubMed PubMed Central Google Scholar
Kolobova E, Tuganova A, Boulatnikov I, Popov KM. Regulation of pyruvate dehydrogenase activity through phosphorylation at multiple sites. Biochem J. 2001;358:69–77.
Article CAS PubMed PubMed Central Google Scholar
Golias T, Papandreou I, Sun R, Kumar B, Brown NV, Swanson BJ et al. Hypoxic repression of pyruvate dehydrogenase activity is necessary for metabolic reprogramming and growth of model tumours. Sci Rep. 2016;6:31146.
Article CAS PubMed PubMed Central Google Scholar
Liu Z, Yu M, Fei B, Fang X, Ma T, Wang D. miR-21-5p targets PDHA1 to regulate glycolysis and cancer progression in gastric cancer. Oncol Rep. 2018;40:2955–2963.
Li Y, Li X, Li X, Zhong Y, Ji Y, Yu D et al. PDHA1 gene knockout in prostate cancer cells results in metabolic reprogramming towards greater glutamine dependence. Oncotarget. 2016;7:53837–53852.
Article PubMed PubMed Central Google Scholar
Zhong C, Long Z, Yang T, Wang S, Zhong W, Hu F et al. M6A-modified circRBM33 promotes prostate cancer progression via PDHA1-mediated mitochondrial respiration regulation and presents a potential target for ARSI therapy. Int J Biol Sci. 2023;19:1543–1563.
Article CAS PubMed PubMed Central Google Scholar
Chen KY, Liu Z, Yi J, Hui YP, Song YN, Lu JH et al. PDHA1 alleviates myocardial ischemia-reperfusion injury by improving myocardial insulin resistance during cardiopulmonary bypass surgery in rats. Cardiovasc Drugs Ther. 2023;39:17–31.
Cobine PA, Brady DC. Cuproptosis: cellular and molecular mechanisms underlying copper-induced cell death. Mol Cell. 2022;82:1786–1787.
Article CAS PubMed Google Scholar
Chen J, Li ZY, Zheng G, Cao L, Guo YM, Lian Q et al. RNF4 mediated degradation of PDHA1 promotes colorectal cancer metabolism and metastasis. NPJ Precis Oncol. 2024;8:258.
Article CAS PubMed PubMed Central Google Scholar
Zhao L, Geng R, Huang Y, Zhang J, Cheng H, Zhou C et al. AP2alpha negatively regulates PDHA1 in cervical cancer cells to promote aggressive features and aerobic glycolysis in vitro and in vivo. J Gynecol Oncol. 2023;34:e59.
Article PubMed PubMed Central Google Scholar
Olou AA, Ambrose J, Jack JL, Walsh M, Ruckert MT, Eades AE et al. SHP2 regulates adipose maintenance and adipocyte-pancreatic cancer cell crosstalk via PDHA1. J Cell Commun Signal. 2023;17:575–590.
Article CAS PubMed Google Scholar
Liu X, Luo B, Wu X, Tang Z. Cuproptosis and cuproptosis-related genes: Emerging potential therapeutic targets in breast cancer. Biochim Biophys Acta Rev Cancer. 2023;1878:189013.
Article CAS PubMed Google Scholar
Yang L, Yang P, Lip GYH, Ren J. Copper homeostasis and cuproptosis in cardiovascular disease therapeutics. Trends Pharmacol Sci. 2023;44:573–585.
Article CAS PubMed Google Scholar
Ladd AD, Duarte S, Sahin I, Zarrinpar A. Mechanisms of drug resistance in HCC. Hepatology. 2024;79:926–940.
Chen C, Wang Z, Ding Y, Qin Y. Tumor microenvironment-mediated immune evasion in hepatocellular carcinoma. Front Immunol. 2023;14:1133308.
Article CAS PubMed PubMed Central Google Scholar
Peiseler M, Schwabe R, Hampe J, Kubes P, Heikenwalder M, Tacke F. Immune mechanisms linking metabolic injury to inflammation and fibrosis in fatty liver disease—novel insights into cellular communication circuits. J Hepatol. 2022;77:1136–1160.
Article CAS PubMed Google Scholar
Li Q, Han J, Yang Y, Chen Y. PD-1/PD-L1 checkpoint inhibitors in advanced hepatocellular carcinoma immunotherapy. Front Immunol. 2022;13:1070961.
Comments (0)