Jankovic J. Parkinson’s disease: clinical features and diagnosis. J Neurol Neurosurg Psychiatry. 2008;79(4):368–76.
Article CAS PubMed Google Scholar
Rodriguez-Oroz MC, Jahanshahi M, Krack P, Litvan I, Macias R, Bezard E, Obeso JA. Initial clinical manifestations of Parkinson’s disease: features and pathophysiological mechanisms. Lancet Neurol. 2009;8(12):1128–39.
Article CAS PubMed Google Scholar
Samii A, Nutt JG, Ransom BR. Parkinson’s disease. Lancet. 2004;363(9423):1783–93.
Article CAS PubMed Google Scholar
Comi C, Magistrelli L, Oggioni GD, Carecchio M, Fleetwood T, Cantello R, Mancini F, Antonini A. Peripheral nervous system involvement in Parkinson’s disease: evidence and controversies. Parkinsonism Relat Disord. 2014;20(12):1329–34.
Article CAS PubMed Google Scholar
Ma C, Zhang W, Cao M. Role of the peripheral nervous system in PD pathology, diagnosis, and treatment. Front Neurosci. 2021;15:598457. https://doi.org/10.3389/fnins.2021.598457.
Article PubMed PubMed Central Google Scholar
Del Tredici K, Rub U, De Vos RA, Bohl JRE, Braak H. Where does Parkinson disease pathology begin in the brain? J Neuropathol Exp Neurol. 2002;61(5):413–26.
Jellinger KA. Neuropathological spectrum of synucleinopathies. Mov Disord. 2003;18(Suppl 6):2–12.
Braak H, Ghebremedhin E, Rub U, Bratzke H, Del Tredici K. Stages in the development of Parkinson’s disease-related pathology. Cell Tissue Res. 2004;318(1):121–34.
Braak H, Del Tredici K. Invited article: nervous system pathology in sporadic Parkinson disease. Neurology. 2008;70(20):1916–25.
Beach TG, Adler CH, Sue LI, Vedders L, Lue L, White CL 3rd, et al. Multi-organ distribution of phosphorylated alpha-synuclein histopathology in subjects with Lewy body disorders. Acta Neuropathol. 2010;119(6):689–702.
Article CAS PubMed PubMed Central Google Scholar
Beach TG, Adler CH, Sue LI, Shill HA, Driver-Dunckley E, Mehta SH, et al. Vagus nerve and stomach synucleinopathy in Parkinson’s disease, incidental Lewy body disease, and normal elderly subjects: evidence against the “body-first” hypothesis. J Parkinsons Dis. 2021;11(4):1833–43.
Article CAS PubMed PubMed Central Google Scholar
Beach TG, Corbillé AG, Letournel F, Kordower JH, Kremer T, Munoz DG, et al. Multicenter assessment of immunohistochemical methods for pathological alpha-synuclein in sigmoid colon of autopsied Parkinson’s disease and control subjects. J Parkinsons Dis. 2016;6(4):761–70.
Article CAS PubMed PubMed Central Google Scholar
Beach TG, Adler CH, Dugger BN, Serrano G, Hidalgo J, Henry-Watson J, et al. Submandibular gland biopsy for the diagnosis of Parkinson disease. J Neuropathol Exp Neurol. 2013;72(2):130–6.
Article CAS PubMed Google Scholar
Beach TG, Adler CH, Serrano G, Sue L, Walker DG, Dugger BN, et al. Prevalence of submandibular gland synucleinopathy in Parkinson’s disease, dementia with Lewy bodies and other Lewy body disorders. J Parkinsons Dis. 2016;6(1):153–63.
Article CAS PubMed PubMed Central Google Scholar
Beach TG, Carew J, Serrano G, Adler CH, Shill HA, Sue LI, et al. Phosphorylated α-synuclein-immunoreactive retinal neuronal elements in Parkinson’s disease subjects. Neurosci Lett. 2014;571:34–8.
Article CAS PubMed PubMed Central Google Scholar
Chahine LM, Beach TG, Brumm MC, Adler CH, Coffey CS, Mosovsky S, et al. In vivo distribution of α-synuclein in multiple tissues and biofluids in Parkinson disease. Neurology. 2020;95(9):e1267–e84.
Article CAS PubMed PubMed Central Google Scholar
Chahine LM, Beach TG, Adler CH, Hepker M, Kanthasamy A, Appel S, et al. Central and peripheral α-synuclein in Parkinson disease detected by seed amplification assay. Ann Clin Transl Neurol. 2023;10(5):696–705.
Article CAS PubMed PubMed Central Google Scholar
Adler CH, Dugger BN, Hinni ML, Lott DG, Driver-Dunckley E, Hidalgo J, et al. Submandibular gland needle biopsy for the diagnosis of Parkinson disease. Neurology. 2014;82(10):858–64.
Article CAS PubMed PubMed Central Google Scholar
Adler CH, Dugger BN, Hentz JG, Hinni ML, Lott DG, Driver-Dunckley E, et al. Peripheral synucleinopathy in early Parkinson’s disease: submandibular gland needle biopsy findings. Mov Disord. 2016;31(2):250–6.
Article CAS PubMed PubMed Central Google Scholar
Serrano GE, Shprecher D, Callan M, Cutler B, Glass M, Zhang N, et al. Cardiac sympathetic denervation and synucleinopathy in Alzheimer’s disease with brain Lewy body disease. Brain Commun. 2020;2(1):fcaa004.
Article PubMed PubMed Central Google Scholar
Manne S, Kondru N, Jin H, Serrano GE, Anantharam V, Kanthasamy A, et al. Blinded RT-QuIC analysis of α-synuclein biomarker in skin tissue from Parkinson’s disease patients. Mov Disord. 2020;35(12):2230–9.
Article CAS PubMed PubMed Central Google Scholar
Braak H, de Vos RAI, Bohl J, Del Tredici K. Gastric alpha-synuclein immunoreactive inclusions in Meissner’s and Auerbach’s plexuses in cases staged for Parkinson’s disease-related brain pathology. Neurosci Lett. 2006;396(1):67–72.
Article CAS PubMed Google Scholar
Wakabayashi K, Takahashi H, Ohama E, Ikuta F. Parkinson’s disease: an immunohistochemical study of Lewy body-containing neurons in the enteric nervous system. Acta Neuropathol. 1990;79(6):581–3.
Article CAS PubMed Google Scholar
Lebouvier T, Neunlist M, Bruley des Varannes S, Coron E, Drouard A, N’Guyen JM, et al. Colonic biopsies to assess the neuropathology of Parkinson’s disease and its relationship with symptoms. PLoS ONE. 2010;5(9):e12728.
Article PubMed PubMed Central Google Scholar
Cersosimo MG, Perandones C, Micheli FE, Raina GB, Beron AM, Nasswetter G, et al. Alpha-synuclein immunoreactivity in minor salivary gland biopsies of Parkinson’s disease patients. Mov Disord. 2011;26(1):188–90.
Amino T, Orimo S, Itoh Y, Takahashi A, Uchihara T, Mizusawa H. Profound cardiac sympathetic denervation occurs in Parkinson disease. Brain Pathol. 2005;15(1):29–34.
Orimo S, Uchihara T, Nakamura A, Mori F, Kakita A, Wakabayashi K, Takahashi H. Axonal alpha-synuclein aggregates herald centripetal degeneration of cardiac sympathetic nerve in Parkinson’s disease. Brain. 2008;131(Pt 3):642–50.
Dabby R, Djaldetti R, Shahmurov M, Treves TA, Gabai B, Melamed E, Sadeh M, Avinoach I. Skin biopsy for assessment of autonomic denervation in Parkinson’s disease. J Neural Transm (Vienna). 2006;113(9):1169–76.
Article CAS PubMed Google Scholar
Miki Y, Tomiyama M, Ueno T, Haga R, Nishijima H, Suzuki C, et al. Clinical availability of skin biopsy in the diagnosis of Parkinson’s disease. Neurosci Lett. 2010;469(3):357–9.
Article CAS PubMed Google Scholar
Lee JM, Derkinderen P, Kordower JH, Freeman R, Munoz DG, Kremer T, et al. The search for a peripheral biopsy indicator of α-synuclein pathology for Parkinson Disease. J Neuropathol Exp Neurol. 2017;76(1):2–15.
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