Sirt1 overexpression inhibits chondrocyte ferroptosis via Ftl deacetylation to suppress the development of osteoarthritis

Martel-Pelletier J, Barr AJ, Cicuttini FM, Conaghan PG, Cooper C, Goldring MB, Goldring SR, Jones G, Teichtahl AJ, Pelletier JP (2016) Osteoarthr. Nat Rev Dis Prim 2:16072

Article  PubMed  Google Scholar 

Quicke JG, Conaghan PG, Corp N, Peat G (2022) Osteoarthritis year in review 2021: epidemiology & therapy. Osteoarthr Cartil 30:196–206

Article  CAS  Google Scholar 

Decker RS, Koyama E, Pacifici M (2015) Articular cartilage: structural and developmental intricacies and questions. Curr Osteoporos Rep 13:407–414

Article  PubMed  PubMed Central  Google Scholar 

Bačenková D, Trebuňová M, Demeterová J, Živčák J (2023) Human chondrocytes, metabolism of articular cartilage, and strategies for application to tissue engineering. Int J Mol Sci 24:17096

Article  PubMed  PubMed Central  Google Scholar 

Coryell PR, Diekman BO, Loeser RF (2021) Mechanisms and therapeutic implications of cellular senescence in osteoarthritis. Nat Rev Rheumatol 17:47–57

Article  PubMed  Google Scholar 

Jang S, Lee K, Ju JH (2021) Recent updates of diagnosis, pathophysiology, and treatment on osteoarthritis of the knee. Int J Mol Sci 22:2619

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zheng L, Zhang Z, Sheng P, Mobasheri A (2021) The role of metabolism in chondrocyte dysfunction and the progression of osteoarthritis. Age Res Rev 66:101249

Article  CAS  Google Scholar 

Ferrao BM, Domenech GH, Legeai-Mallet L, van Osch G (2021) Tyrosine kinases regulate chondrocyte hypertrophy: promising drug targets for osteoarthritis. Osteoarthr Cartil 29:1389–1398

Article  Google Scholar 

Liu L, Zhang W, Liu T, Tan Y, Chen C, Zhao J, Geng H, Ma C (2023) The physiological metabolite alpha-ketoglutarate ameliorates osteoarthritis by regulating mitophagy and oxidative stress. Redox Biol 62:102663

Article  CAS  PubMed  PubMed Central  Google Scholar 

Jiang X, Stockwell BR, Conrad M (2021) Ferroptosis: mechanisms, biology and role in disease. Nat Rev Mol Cell Biol 22:266–282

Article  PubMed  PubMed Central  Google Scholar 

Sun Z, Wu J, Bi Q, Wang W (2022) Exosomal lncRNA TUG1 derived from human urine-derived stem cells attenuates renal ischemia/reperfusion injury by interacting with SRSF1 to regulate ASCL4-mediated ferroptosis. Stem Cell Res Ther 13:297

Article  PubMed  PubMed Central  Google Scholar 

ZubavlenkoRcapital AC, Belova SV, Gladkova Capital IEC, Matveeva OV, Ulyanov VY (2021) Morphological changes in articular cartilage and free-radical lipid peroxidation in rats with posttraumatic osteoarthrosis. Bull Exp Biol Med 172:214–217

Article  Google Scholar 

D’Amico D, Olmer M, Fouassier AM, Valdes P, Andreux PA, Rinsch C, Lotz M (2022) Urolithin A improves mitochondrial health, reduces cartilage degeneration, and alleviates pain in osteoarthritis. Aging Cell 21:e13662

Article  CAS  PubMed  PubMed Central  Google Scholar 

Yao X, Sun K, Yu S, Luo J, Guo J, Lin J, Wang G, Guo Z, Ye Y, Guo F (2021) Chondrocyte ferroptosis contribute to the progression of osteoarthritis. J Orthop Translat 27:33–43

Article  PubMed  Google Scholar 

Zhou X, Zheng Y, Sun W, Zhang Z, Liu J, Yang W, Yuan W, Yi Y, Wang J, Liu J (2021) D-mannose alleviates osteoarthritis progression by inhibiting chondrocyte ferroptosis in a HIF-2α-dependent manner. Cell Prolif 54:e13134

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chang HC, Guarente L (2014) SIRT1 and other sirtuins in metabolism. Trend Endocrinol Metab 25:138–145

Article  CAS  Google Scholar 

Wang AJ, Tang Y, Zhang J, Wang BJ, Xiao M, Lu G, Li J, Liu Q, Guo Y, Gu J (2022) Cardiac SIRT1 ameliorates doxorubicin-induced cardiotoxicity by targeting sestrin 2. Redox Biol 52:102310

Article  CAS  Google Scholar 

Matsuzaki T, Matsushita T, Takayama K, Matsumoto T, Nishida K, Kuroda R, Kurosaka M (2014) Disruption of Sirt1 in chondrocytes causes accelerated progression of osteoarthritis under mechanical stress and during ageing in mice. Ann Rheum Dis 73:1397–1404

Article  CAS  PubMed  Google Scholar 

Gabay O, Oppenhiemer H, Meir H, Zaal K, Sanchez C, Dvir-Ginzberg M (2012) Increased apoptotic chondrocytes in articular cartilage from adult heterozygous SirT1 mice. Ann Rheum Dis 71:613–616

Article  CAS  PubMed  Google Scholar 

An S, Hu H, Li Y, Hu Y (2020) Pyroptosis plays a role in osteoarthritis. Aging Dis 11:1146–1157

Article  PubMed  PubMed Central  Google Scholar 

Zhang C, Lin S, Li T, Jiang Y, Huang Z, Wen J, Cheng W, Li H (2017) Mechanical force-mediated pathological cartilage thinning is regulated by necroptosis and apoptosis. Osteoarthr Cartil 25:1324–1334

Article  CAS  Google Scholar 

Miao Y, Chen Y, Xue F, Liu K, Zhu B, Gao J, Yin J, Zhang C, Li G (2022) Contribution of ferroptosis and GPX4’s dual functions to osteoarthritis progression. EBioMedicine 76:103847

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chen R, Ying C, Zou Y, Lin C, Fu Q, Xiang Z, Bao J, Chen W (2023) Sarsasapogenin inhibits YAP1-dependent chondrocyte ferroptosis to alleviate osteoarthritis. Biomed Pharmacother 168:115772

Article  CAS  PubMed  Google Scholar 

Xiao J, Luo C, Li A, Cai F, Wang Y, Pan X, Xu L, Wang Z, Xing Z, Yu L, Chen Y, Tian M (2024) Icariin inhibits chondrocyte ferroptosis and alleviates osteoarthritis by enhancing the SLC7A11/GPX4 signaling. Int Immunopharmacol 133:112010

Article  CAS  PubMed  Google Scholar 

Chen J, Zhang J, Li J, Qin R, Lu N, Goltzman D, Miao D, Yang R (2023) 1,25-dihydroxyvitamin D deficiency accelerates aging-related osteoarthritis via downregulation of Sirt1 in mice. Int J Biol Sci 19:610–624

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bar Oz M, Kumar A, Elayyan J, Reich E, Binyamin M, Kandel L, Liebergall M, Steinmeyer J, Lefebvre V, Dvir Ginzberg M (2016) Acetylation reduces SOX9 nuclear entry and ACAN gene transactivation in human chondrocytes. Aging Cell 15:499–508

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lu Q, Liu P, Miao Z, Luo D, Li S, Lu M (2022) SIRT1 restoration enhances chondrocyte autophagy in osteoarthritis through PTEN-mediated EGFR ubiquitination. Cell Death Discov 8:203

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chen M, Huang L, Lv Y, Li L, Dong Q (2021) Sulforaphane protects against oxidative stress-induced apoptosis via activating SIRT1 in mouse osteoarthritis. Mol Med Rep. https://doi.org/10.3892/mmr.2021.12251

Article  PubMed  PubMed Central  Google Scholar 

Ruan Q, Wang C, Zhang Y, Sun J (2023) Brevilin A attenuates cartilage destruction in osteoarthritis mouse model by inhibiting inflammation and ferroptosis via SIRT1/Nrf2/GPX4 signaling pathway. Int Immunopharmacol 124:110924

Article  CAS  PubMed  Google Scholar 

Sun J, Zhang Y, Wang C, Ruan Q (2023) Kukoamine A protects mice against osteoarthritis by inhibiting chondrocyte inflammation and ferroptosis via SIRT1/GPX4 signaling pathway. Life Sci 332:122117

Article  CAS  PubMed  Google Scholar 

Liu J, Gao L, Zhan N, Xu P, Yang J, Yuan F, Xu Y, Cai Q, Geng R, Chen Q (2020) Hypoxia induced ferritin light chain (FTL) promoted epithelia mesenchymal transition and chemoresistance of glioma. J Exp Clin Cancer Res 39:137

Article  CAS  PubMed 

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