Empagliflozin Mitigates PTZ-Induced Seizures in Rats: Modulating Npas4 and CREB-BDNF Signaling Pathway

Abdel-latif RG, Rifaai RA, Amin EF (2020) Empagliflozin alleviates neuronal apoptosis induced by cerebral ischemia/reperfusion injury through HIF-1α/VEGF signaling pathway. Arch Pharm Res 43(5):514–525

Article  PubMed  CAS  Google Scholar 

Abdelhamid AM, Elsheakh AR, Abdelaziz RR, Suddek GM (2020) Empagliflozin ameliorates ethanol-induced liver injury by modulating NF-κB/Nrf-2/PPAR-γ interplay in mice. Life Sci 256:117908

Article  PubMed  CAS  Google Scholar 

Aguiar CC, Almeida AB, Araújo PV, de Abreu RN, Chaves EM, Vale OC, Macêdo DS, Woods DJ, Fonteles MM, Vasconcelos SM (2012) Oxidative stress and epilepsy: literature review. Oxid Med Cell Longev 2012: 795259

Ahmed MM, Arif M, Chikuma T, Kato T (2005) Pentylenetetrazol-induced seizures affect the levels of prolyl oligopeptidase, thimet oligopeptidase and glial proteins in rat brain regions, and attenuation by MK-801 pretreatment. Neurochem Int 47(4):248–259

Article  PubMed  CAS  Google Scholar 

Ahmed S, El-Sayed MM, Kandeil MA, Khalaf MM (2022) Empagliflozin attenuates neurodegeneration through antioxidant, anti-inflammatory, and modulation of α-synuclein and Parkin levels in rotenone-induced Parkinson’s disease in rats. Saudi Pharm J 30(6):863–873

Article  PubMed  PubMed Central  CAS  Google Scholar 

Alberini CM (2009) Transcription factors in long-term. Memory Synaptic Plast 89(1):121–145

CAS  Google Scholar 

Amin EF, Rifaai RA, Abdel-Latif RG (2020a) Empagliflozin attenuates transient cerebral ischemia/reperfusion injury in hyperglycemic rats via repressing oxidative-inflammatory-apoptotic pathway. Fundam Clin Pharmacol 34(5):548–558

Article  PubMed  CAS  Google Scholar 

Amin SN, Hassan SS, Khashaba AS, Youakim MF, Latif NSA, Rashed LA, Yassa HD (2020b) Hippocampal and cerebellar changes in Acute Restraint stress and the impact of pretreatment with Ceftriaxone. Brain Sci 10(4)

Attia GM, Elmansy RA, Elsaed WM (2019) Neuroprotective effect of nilotinib on pentylenetetrazol-induced epilepsy in adult rat hippocampus: involvement of oxidative stress, autophagy, inflammation, and apoptosis. Folia Neuropathol 57(2):146–160

Article  PubMed  Google Scholar 

Bezzi P, Domercq M, Brambilla L, Galli R, Schols D, De Clercq E, Vescovi A, Bagetta G, Kollias G, Meldolesi J, Volterra A (2001) CXCR4-activated astrocyte glutamate release via TNFα: amplification by microglia triggers neurotoxicity. Nat Neurosci 4(7):702–710

Article  PubMed  CAS  Google Scholar 

Bibi F, Ullah I, Kim MO, Naseer MI (2017) Metformin attenuate PTZ-induced apoptotic neurodegeneration in human cortical neuronal cells. Pak J Med Sci 33(3):581–585

Article  PubMed  PubMed Central  Google Scholar 

Borowicz-Reutt KK, Czuczwar SJ (2020) Role of oxidative stress in epileptogenesis and potential implications for therapy. Pharmacol Rep 72(5):1218–1226

Article  PubMed  PubMed Central  Google Scholar 

Campos MSA, Ayres LR, Morelo MRS, Carizio FAM, Pereira LRL (2018) Comparative efficacy of antiepileptic drugs for patients with generalized epileptic seizures: systematic review and network meta-analyses. Int J Clin Pharm 40(3):589–598

Article  PubMed  CAS  Google Scholar 

Carmody S, Brennan L (2010) Effects of pentylenetetrazole-induced seizures on metabolomic profiles of rat brain. Neurochem Int 56(2):340–344

Article  PubMed  CAS  Google Scholar 

Cherubini E, Miles R (2015) The CA3 region of the hippocampus: how is it? What is it for? How does it do it? Front Cell Neurosci 9:19

Article  PubMed  PubMed Central  Google Scholar 

Cifelli P, Palma E, Roseti C, Verlengia G, Simonato M (2013) Changes in the sensitivity of GABAA current rundown to drug treatments in a model of temporal lobe epilepsy. 7

Civita P, Valerio O, Naccarato AG, Gumbleton M, Pilkington GJ (2020) Satellitosis, a crosstalk between neurons, vascular structures and neoplastic cells in Brain tumours; early Manifestation of Invasive Behaviour. Cancers (Basel) 12(12)

Colucci-D’Amato L, Speranza L, Volpicelli F (2020) Neurotrophic Factor BDNF, Physiological Functions and Therapeutic Potential in Depression, Neurodegeneration and Brain Cancer. Int J Mol Sci 21(20)

Corda MG, Giorgi O, Longoni B, Orlandi M, Biggio G (1990) Decrease in the function of the γ-Aminobutyric acid-coupled Chloride Channel produced by the Repeated Administration of Pentylenetetrazol to rats. J Neurochem 55(4):1216–1221

Article  PubMed  CAS  Google Scholar 

Coulter DA, Steinhäuser C (2015) Role of astrocytes in epilepsy. Cold Spring Harb Perspect Med 5(3):a022434

Article  PubMed  PubMed Central  Google Scholar 

Davoudi M, Shojaei A, Palizvan MR, Javan M, Mirnajafi-Zadeh J (2013) Comparison between standard protocol and a novel window protocol for induction of pentylenetetrazol kindled seizures in the rat. Epilepsy Res 106(1–2):54–63

Article  PubMed  CAS  Google Scholar 

de Souza AG, Chaves Filho AJM, Souza Oliveira JV, de Souza DAA, Lopes IS, de Carvalho MAJ, de Lima KA, Florenço Sousa FC, Mendes Vasconcelos SM, Macedo D (2019) and M. M. de França Fonteles Prevention of pentylenetetrazole-induced kindling and behavioral comorbidities in mice by levetiracetam combined with the GLP-1 agonist liraglutide: Involvement of brain antioxidant and BDNF upregulating properties. Biomed Pharmacother 109: 429–439

Dong M, Wen S, Zhou L (2022) The Relationship between the blood-brain-barrier and the Central effects of Glucagon-Like Peptide-1 receptor agonists and sodium-glucose Cotransporter-2 inhibitors. Diabetes Metab Syndr Obes 15:2583–2597

Article  PubMed  PubMed Central  Google Scholar 

Dorandish S, Atali S, Ray R, Al Khashali H, Coleman KL, Guthrie J, Heyl D, Evans HG (2021) Differences in the Relative Abundance of ProBDNF and Mature BDNF in A549 and H1299 Human Lung Cancer Cell Media. Int J Mol Sci 22(13)

Dyson HJ, Wright PE (2016) Role of intrinsic protein disorder in the function and interactions of the transcriptional coactivators CREB-binding protein (CBP) and p300. J Biol Chem 291(13):6714–6722

Article  PubMed  PubMed Central  CAS  Google Scholar 

El-Adli D, Gawish SA, AbdElFattah AAM, Soliman MF (2023) The effect of experimentally-induced diabetes on rat hippocampus and the potential neuroprotective effect of Cerebrolysin combined with insulin. A histological and immunohistochemical study. Egypt J Basic Appl Sci 10(1):255–273

Google Scholar 

Erdogan MA, Yusuf D, Christy J, Solmaz V, Erdogan A, Taskiran E, Erbas O (2018) Highly selective SGLT2 inhibitor dapagliflozin reduces seizure activity in pentylenetetrazol-induced murine model of epilepsy. BMC Neurol 18(1):81–81

Article  PubMed  PubMed Central  Google Scholar 

Erdoğan F, Gölgeli A, Küçük A, Arman F, Karaman Y, Ersoy A (2005) Effects of pentylenetetrazole-induced status epilepticus on behavior, emotional memory and learning in immature rats. Epilepsy Behav 6(4):537–542

Article  PubMed  Google Scholar 

Esvald EE, Tuvikene J, Sirp A, Patil S, Bramham CR, Timmusk T (2020) CREB family transcription factors are major mediators of BDNF transcriptional autoregulation in cortical neurons. J Neurosci 40(7):1405–1426

Finkbeiner S, Tavazoie SF, Maloratsky A, Jacobs KM, Harris KM, Greenberg ME (1997) CREB: a major mediator of neuronal neurotrophin responses. Neuron 19(5):1031–1047

Article  PubMed  CAS  Google Scholar 

Floriano-Sánchez E, Brindis F, Ortega-Cuellar D, Ignacio-Mejía I, Moreno-Arriola E, Romero-Morelos P, Ceballos-Vasquez E, Córdova-Espinoza MG, Arregoitia-Sarabia CK, Sandoval-Pacheco R, Carmona-Aparicio L (2018) and N. Cárdenas-Rodríguez Differential Gene Expression Profile Induced by Valproic Acid (VPA) in Pediatric Epileptic Patients. Genes (Basel) 9(7)

Franceschetti S, Hamon B, Heinemann U (1986) The action of valproate on spontaneous epileptiform activity in the absence of synaptic transmission and on evoked changes in [Ca2+]o and [K+]o in the hippocampal slice. Brain Res 386(1–2):1–11

Article  PubMed  CAS  Google Scholar 

French JA, Bebin M, Dichter MA, Engel J Jr., Hartman AL, Jóźwiak S, Klein P, McNamara J Sr., Twyman R, Vespa P (2021) Antiepileptogenesis and disease modification: clinical and regulatory issues. Epilepsia Open 6(3):483–492

Article  PubMed  PubMed Central  Google Scholar 

Fu J, Guo O, Zhen Z, Zhen J (2020) Essential functions of the transcription factor Npas4 in Neural Circuit Development, plasticity, and diseases. Front Neurosci 14:603373

Article  PubMed  PubMed Central  Google Scholar 

Funahashi Y, Ariza A, Emi R, Xu Y, Shan W, Suzuki K, Kozawa S, Ahammad RU, Wu M, Takano T, Yura Y, Kuroda K, Nagai T, Amano M, Yamada K, Kaibuchi K (2019) Phosphorylation of Npas4 by MAPK regulates reward-related gene expression and behaviors. Cell Rep 29(10):3235–3252e3239

Article  PubMed  CAS  Google Scholar 

Gao B, Wu Y, Yang Y-J, Li W-Z, Dong K, Zhou J, Yin Y-Y, Huang D-K, Wu W-N (2018) Sinomenine exerts anticonvulsant profile and neuroprotective activity in pentylenetetrazole kindled rats: involvement of inhibition of NLRP1 inflammasome. J Neuroinflamm 15

Gerenu G, Martisova E, Ferrero H, Carracedo M, Rantamäki T, Ramirez MJ, Gil-Bea FJ (2017) Modulation of BDNF cleavage by plasminogen-activator inhibitor-1 contributes to Alzheimer’s neuropathology and cognitive deficits. Biochim Biophys Acta Mol Basis Dis 1863(4):991–1001

Article  PubMed  CAS  Google Scholar 

Geronzi U, Lotti F, Grosso S (2018) Oxidative stress in epilepsy. Expert Rev Neurother 18(5):427–434

Article  PubMed  CAS  Google Scholar 

Godlevsky L, Muratova T, Kresyun N, van Luijtelaar G, Coenen A (2014) Anxiolytic and antidepressive effects of electric stimulation of the paleocerebellar cortex in pentylenetetrazol kindled rats. Acta Neurobiol Exp 74:456–464

Article  Google Scholar 

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