Emerging Role of Oligodendrocytes Malfunction in the Progression of Alzheimer's Disease

Abbott NJ, Rönnbäck L, Hansson E (2006) Astrocyte-endothelial interactions at the blood-brain barrier. Nat Rev Neurosci. https://doi.org/10.1038/nrn1824

Article  PubMed  Google Scholar 

Abdelnour C, Agosta F, Bozzali M, Fougère B, Iwata A, Nilforooshan R et al (2022) Perspectives and challenges in patient stratification in Alzheimer’s disease. Alzheimers Res Ther. BioMed Central Ltd

Aggarwal S, Snaidero N, Pähler G, Frey S, Sánchez P, Zweckstetter M et al (2013) Myelin membrane assembly is driven by a phase transition of myelin basic proteins into a cohesive protein meshwork. PLoS Biol. https://doi.org/10.1371/journal.pbio.1001577

Article  PubMed  PubMed Central  Google Scholar 

Ahmed H, Wang Y, Griffiths WJ, Levey AI, Pikuleva I, Liang SH et al (2024) Brain cholesterol and Alzheimer’s disease: challenges and opportunities in probe and drug development. Brain 147:1622–1635

Article  PubMed  PubMed Central  Google Scholar 

Akay LA, Effenberger AH, Tsai L-H (2021) Cell of all trades: oligodendrocyte precursor cells in synaptic, vascular, and immune function. Available from: http://www.genesdev.org/cgi/doi/10.1101/gad.344218

Arjunan A, Sah DK, Woo M, Song J (2023) Identification of the molecular mechanism of insulin-like growth factor-1 (IGF-1): a promising therapeutic target for neurodegenerative diseases associated with metabolic syndrome. Cell Biosci. BioMed Central Ltd

Baaklini CS, Ho MFS, Lange T, Hammond BP, Panda SP, Zirngibl M et al (2023) Microglia promote remyelination independent of their role in clearing myelin debris. Cell Rep. https://doi.org/10.1016/j.celrep.2023.113574

Article  PubMed  Google Scholar 

Bai R, Guo J, Ye X-Y, Xie Y, Xie T (2022) Oxidative stress: the core pathogenesis and mechanism of Alzheimer’s disease. Ageing Res Rev 77:101619

Article  PubMed  CAS  Google Scholar 

Bauer NM, Moos C, van Horssen J, Witte M, van der Valk P, Altenhein B et al (2012) Myelin basic protein synthesis is regulated by small non-coding RNA 715. EMBO Rep 13:827–834

Article  PubMed  PubMed Central  CAS  Google Scholar 

Bechler ME, Byrne L, ffrench-Constant C (2015) CNS myelin sheath lengths are an intrinsic property of oligodendrocytes. Curr Biol 25:2411–2416

Article  PubMed  PubMed Central  CAS  Google Scholar 

Beiter RM, Raghavan TP, Suchocki O, Ennerfelt HE, Rivet-Noor CR, Merchak AR et al (2024) Oligomeric amyloid beta prevents myelination in a clusterin-dependent manner [Internet]. Available from: https://www.researchsquare.com/article/rs-4415143/v1

Bennett J, Basivireddy J, Kollar A, Biron KE, Reickmann P, Jefferies WA et al (2010) Blood–brain barrier disruption and enhanced vascular permeability in the multiple sclerosis model EAE. J Neuroimmunol 229:180–191

Article  PubMed  CAS  Google Scholar 

Benoit MR, Darboe M, Das B, Ge Y, Zhou J, Yao A et al (2023) Postnatal neuronal Bace1 deletion impairs neuroblast and oligodendrocyte maturation. Hum Mol Genet 32(7):1193–1207

Article  PubMed  CAS  Google Scholar 

Blanchard JW, Akay LA, Davila-Velderrain J, von Maydell D, Mathys H, Davidson SM et al (2022) APOE4 impairs myelination via cholesterol dysregulation in oligodendrocytes. Nature 611:769–779

Article  PubMed  PubMed Central  CAS  Google Scholar 

Boisvert MM, Erikson GA, Shokhirev MN, Allen NJ (2018) The aging astrocyte transcriptome from multiple regions of the mouse brain. Cell Rep 22:269–285

Article  PubMed  PubMed Central  CAS  Google Scholar 

Bolós M, Llorens-Martín M, Jurado-Arjona J, Hernández F, Rábano A, Avila J (2016) Direct evidence of internalization of tau by microglia in vitro and in vivo. J Alzheimers Dis 50:77–87

Article  PubMed  Google Scholar 

Braak H, Braak E (1996) Development of Alzheimer-related neurofibrillary changes in the neocortex inversely recapitulates cortical myelogenesis. Acta Neuropathol 92:197–201

Article  PubMed  CAS  Google Scholar 

Castillo E, Leon J, Mazzei G, Abolhassani N, Haruyama N, Saito T et al (2017) Comparative profiling of cortical gene expression in Alzheimer’s disease patients and mouse models demonstrates a link between amyloidosis and neuroinflammation. Sci Rep. https://doi.org/10.1038/s41598-017-17999-3

Article  PubMed  PubMed Central  Google Scholar 

Chacon-De-La-Rocha I, Fryatt G, Rivera AD, Verkhratsky A, Raineteau O, Gomez-Nicola D et al (2020) Accelerated dystrophy and decay of oligodendrocyte precursor cells in the APP/PS1 model of Alzheimer’s-like pathology. Front Cell Neurosci. https://doi.org/10.3389/fncel.2020.575082

Article  PubMed  PubMed Central  Google Scholar 

Chen JF, Liu K, Hu B, Li RR, Xin W, Chen H et al (2021) Enhancing myelin renewal reverses cognitive dysfunction in a murine model of Alzheimer’s disease. Neuron 109:2292-2307.e5

Article  PubMed  PubMed Central  CAS  Google Scholar 

Chen J, Wang F, Huang N, Xiao L, Mei F (2022) Oligodendrocytes and myelin: Active players in neurodegenerative brains? Dev Neurobiol 82:160–174

Article  PubMed  Google Scholar 

Chen P, Guo ZL, Zhou B (2023) Disease-Associated Oligodendrocyte: New Player in Alzheimer’s Disease and CNS Pathologies. J Integr Neurosci. IMR Press Limited

Cheng GWY, Mok KKS, Yeung SHS, Kofler J, Herrup K, Tse KH (2022) Apolipoprotein E ε4 mediates myelin breakdown by targeting oligodendrocytes in sporadic Alzheimer disease. J Neuropathol Exp Neurol 81:717–730

Article  PubMed  PubMed Central  CAS  Google Scholar 

Cignarella F, Filipello F, Bollman B, Cantoni C, Locca A, Mikesell R et al (2020) TREM2 activation on microglia promotes myelin debris clearance and remyelination in a model of multiple sclerosis. Acta Neuropathol 140:513–534

Article  PubMed  PubMed Central  CAS  Google Scholar 

Couttas TA, Kain N, Suchowerska AK, Quek L-E, Turner N, Fath T et al (2016) Loss of ceramide synthase 2 activity, necessary for myelin biosynthesis, precedes tau pathology in the cortical pathogenesis of Alzheimer’s disease. Neurobiol Aging 43:89–100

Article  PubMed  CAS  Google Scholar 

de la Fuente AG, Queiroz RML, Ghosh T, McMurran CE, Cubillos JF, Bergles DE et al (2020) Changes in the oligodendrocyte progenitor cell proteome with ageing. Mol Cell Proteomics 19:1281–1302

Article  PubMed  PubMed Central  Google Scholar 

de Laat R, Meabon JS, Wiley JC, Hudson MP, Montine TJ, Bothwell M (2015) LINGO-1 promotes lysosomal degradation of amyloid-β protein precursor. Pathobiol Aging Age-Related Diseases 5:25796

Article  Google Scholar 

DeFlitch L, Gonzalez-Fernandez E, Crawley I, Kang SH (2022) Age and Alzheimer’s disease-related oligodendrocyte changes in hippocampal subregions. Front Cell Neurosci. https://doi.org/10.3389/fncel.2022.847097

Article  PubMed  PubMed Central  Google Scholar 

Depp C, Sun T, Sasmita AO, Spieth L, Berghoff SA, Steixner-Kumar AA et al (2021) Ageing-associated myelin dysfunction drives amyloid deposition in mouse models of Alzheimer’s disease [Internet]. Available from: http://biorxiv.org/lookup/doi/10.1101/2021.07.31.454562

Desai MK, Sudol KL, Janelsins MC, Mastrangelo MA, Frazer ME, Bowers WJ (2009) Triple-transgenic Alzheimer’s disease mice exhibit region-specific abnormalities in brain myelination patterns prior to appearance of amyloid and tau pathology. Glia 57:54–65

Article  PubMed  PubMed Central  Google Scholar 

Desai MK, Mastrangelo MA, Ryan DA, Sudol KL, Narrow WC, Bowers WJ (2010) Early oligodendrocyte/myelin pathology in Alzheimer’s disease mice constitutes a novel therapeutic target. Am J Pathol 177:1422–1435

Article  PubMed  PubMed Central  CAS  Google Scholar 

Desai MK, Guercio BJ, Narrow WC, Bowers WJ (2011) An Alzheimer’s disease-relevant presenilin-1 mutation augments amyloid-beta-induced oligodendrocyte dysfunction. Glia 59:627–640

Article  PubMed  PubMed Central  Google Scholar 

De Sousa RAL (2022) Reactive gliosis in Alzheimer’s disease: a crucial role for cognitive impairment and memory loss. Metab Brain Dis. Springer p 851–7

Dong YX, Zhang HY, Li HY, Liu PH, Sui Y, Sun XH (2018) Association between Alzheimer’s disease pathogenesis and early demyelination and oligodendrocyte dysfunction. Neural Regen Res 13:908–914

Article  PubMed  PubMed Central  CAS  Google Scholar 

Duncan ID, Radcliff AB, Heidari M, Kidd G, August BK, Wierenga LA (2018) The adult oligodendrocyte can participate in remyelination. Proceedings of the National Academy of Sciences. 115

Fawcett JW, Asher RA (1999) The glial scar and central nervous system repair. Brain Res ull 49:377–391

Article  CAS 

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