TNF-α Inhibition Modulates CX3CR1, Pyroptosis-related Genes, and BDNF to Alleviate Anxiety-like Behavior in Type 2 Diabetic Rats

Alamri HS, Mufti R, Sabir DK, Abuderman AA, Dawood AF, ShamsEldeen AM, Haidara MA, Isenovic ER, El-Bidawy MH (2023) Forced swimming-induced depressive-like behavior and anxiety are reduced by Chlorpheniramine via suppression of oxidative and inflammatory mediators and activating the Nrf2-BDNF signaling pathway. Curr Issues Mol Biol 45(8):6449–6465. https://doi.org/10.3390/cimb45080407

Article  PubMed  PubMed Central  CAS  Google Scholar 

Babaei A, Nourshahi M, Fani M, Entezari Z, Jameie SB, Haghparast A (2021) The effectiveness of continuous and interval exercise preconditioning against chronic unpredictable stress: involvement of hippocampal PGC-1α/FNDC5/BDNF pathway. J Psychiatr Res 136:173–183. https://doi.org/10.1016/j.jpsychires.2021.02.006

Article  PubMed  Google Scholar 

Bhaskar K, Konerth M, Kokiko-Cochran ON, Cardona A, Ransohoff RM, Lamb BT (2010) Regulation of tau pathology by the microglial fractalkine receptor. Neuron 68:19–31. https://doi.org/10.1016/j.neuron.2010.08.023

Article  PubMed  PubMed Central  CAS  Google Scholar 

Bolós M, Llorens-Martín M, Perea JR, Jurado-Arjona J, Rábano A, Hernández F, Avila J (2017) Absence of CX3CR1 impairs the internalization of Tau by microglia. Mol Neurodegener 12:59. https://doi.org/10.1186/s13024-017-0200-1

Article  PubMed  PubMed Central  CAS  Google Scholar 

Brás JP, Bravo J, Freitas J, Barbosa MA, Santos SG, Summavielle T, Almeida MI (2020) TNF-alpha-induced microglia activation requires miR-342: impact on NF-kB signaling and neurotoxicity. Cell Death Dis 11:415. https://doi.org/10.1038/s41419-020-2626-6

Article  PubMed  PubMed Central  CAS  Google Scholar 

Campanati A, Diotallevi F, Martina E, Paolinelli M, Radi G, Offidani A (2020) Safety update of etanercept treatment for moderate to severe plaque psoriasis. Expert Opin Drug Saf 19:439–448. https://doi.org/10.1080/14740338.2020.1740204

Article  PubMed  CAS  Google Scholar 

Carrier M, Hui CW, Watters V, Šimončičová E, Picard K, González Ibáñez F, Vernoux N, Droit A, Desjardins M, Tremblay MÈ (2024) Behavioral as well as hippocampal transcriptomic and microglial responses differ across sexes in adult mouse offspring exposed to a dual genetic and environmental challenge. Brain Behav Immun 116:126–139. https://doi.org/10.1016/j.bbi.2023.11.025

Article  PubMed  CAS  Google Scholar 

Cassano V, Tallarico M, Armentaro G, De Sarro C, Iannone M, Leo A, Citraro R, Russo E, De Sarro G, Hribal ML, Sciacqua A (2022) Ranolazine attenuates brain inflammation in a rat model of type 2 diabetes. Int J Mol Sci 23(24):16160. https://doi.org/10.3390/ijms232416160

Article  PubMed  PubMed Central  CAS  Google Scholar 

Chakrabarty P, Herring A, Ceballos-Diaz C, Das P, Golde TE (2011) Hippocampal expression of murine TNFα results in attenuation of amyloid deposition in vivo. Mol Neurodegener 6:16. https://doi.org/10.1186/1750-1326-6-16

Article  PubMed  PubMed Central  CAS  Google Scholar 

Chandrasekaran K, Choi J, Arvas MI, Salimian M, Singh S, Xu S, Gullapalli RP, Kristian T, Russell JW (2020) Nicotinamide mononucleotide administration prevents experimental diabetes-induced cognitive impairment and loss of hippocampal neurons. Int J Mol Sci 21:3756. https://doi.org/10.3390/ijms21113756

Article  PubMed  PubMed Central  CAS  Google Scholar 

Chen YM, Tu CJ, Hung KY, Wu KD, Tsai TJ, Hsieh BS (2003) Inhibition by pentoxifylline of TNF-alpha-stimulated fractalkine production in vascular smooth muscle cells: evidence for mediation by NF-kappa B down-regulation. Br J Pharmacol 138:950–958

Article  PubMed  PubMed Central  CAS  Google Scholar 

Chen M, Peng D, Zhang Z, Zuo G, Zhao G (2016) Efficacy of etanercept for treating the active rheumatoid arthritis: an updated meta-analysis. Int J Rheum Dis 19:1132–1142. https://doi.org/10.1111/1756-185X.12724

Article  PubMed  CAS  Google Scholar 

Chen D, Lou Q, Song XJ, Kang F, Liu A, Zheng C, Li Y, Wang D, Qun S, Zhang Z, Cao P, Jin Y (2024a) Microglia govern the extinction of acute stress-induced anxiety-like behaviors in male mice. Nat Commun 15(1):449. https://doi.org/10.1038/s41467-024-44704-6

Article  PubMed  PubMed Central  CAS  Google Scholar 

Chen L, Lu Y, Hua X, Zhang H, Sun S, Han C (2024b) Three methods of behavioural testing to measure anxiety - a review. Behav Processes 215:104997. https://doi.org/10.1016/j.beproc.2024.104997

Article  PubMed  Google Scholar 

Choi SH, Li Y, Parada LF, Sisodia SS (2009) Regulation of hippocampal progenitor cell survival, proliferation and dendritic development by BDNF. Mol Neurodegener 4:52. https://doi.org/10.1186/1750-1326-4-52

Article  PubMed  PubMed Central  CAS  Google Scholar 

Crowe AR, Yue W (2019) Semi-quantitative determination of protein expression using immunohistochemistry staining and analysis: an integrated protocol. Bio-protocol 9(24):e3465. https://doi.org/10.21769/BioProtoc.3465

Article  PubMed  PubMed Central  CAS  Google Scholar 

da Silva Dias IC, Carabelli B, Ishii DK, de Morais H, de Carvalho MC, Rizzo de Souza LE, Zanata SM, Brandão ML, Cunha TM, Ferraz AC, Cunha JM, Zanoveli JM (2016) Indoleamine-2,3-dioxygenase/kynurenine pathway as a potential pharmacological target to treat depression associated with diabetes. Mol Neurobiol 53(10):6997–7009. https://doi.org/10.1007/s12035-015-9617-0

Article  PubMed  CAS  Google Scholar 

Dworzak J, Renvoisé B, Habchi J, Yates EV, Combadière C, Knowles TP, Dobson CM, Blackstone C, Paulsen O, Murphy PM (2015) Neuronal Cx3cr1 deficiency protects against amyloid β-induced neurotoxicity. PLoS ONE 10:e0127730. https://doi.org/10.1371/journal.pone.0127730

Article  PubMed  PubMed Central  CAS  Google Scholar 

Ge Y, Wang L, Wang C, Chen J, Dai M, Yao S, Lin Y (2022) CX3CL1 inhibits NLRP3 inflammasome-induced microglial pyroptosis and improves neuronal function in mice with experimentally-induced ischemic stroke. Life Sci 300:120564. https://doi.org/10.1016/j.lfs.2022.120564

Article  PubMed  CAS  Google Scholar 

Ghasemi A, Khalifi S, Jedi S (2014) Streptozotocin-nicotinamide-induced rat model of type 2 diabetes (review). Acta Physiol Hung 101(4):408–420. https://doi.org/10.1556/APhysiol.101.2014.4.2

Article  PubMed  CAS  Google Scholar 

Haji N, Mandolesi G, Gentile A, Sacchetti L, Fresegna D, Rossi S, Musella A, Sepman H, Motta C, Studer V, De Chiara V, Bernardi G, Strata P, Centonze D (2012) TNF-α-mediated anxiety in a mouse model of multiple sclerosis. Exp Neurol 237(2):296–303. https://doi.org/10.1016/j.expneurol.2012.07.010

Article  PubMed  CAS  Google Scholar 

Hughes PM, Botham MS, Frentzel S, Mir A, Perry VH (2002) Expression of fractalkine (CX3CL1) and its receptor, CX3CR1, during acute and chronic inflammation in the rodent CNS. Glia 37(4):314–327

Article  PubMed  Google Scholar 

Jiang YL, Wang XS, Li XB, Liu A, Fan QY, Yang L, Feng B, Zhang K, Lu L, Qi JY, Yang F, Song DK, Wu YM, Zhao MG, Liu SB (2022) Tanshinone IIA improves contextual fear- and anxiety-like behaviors in mice via the creb/bdnf/trkb signaling pathway. Phytother Res 36(10):3932–3948. https://doi.org/10.1002/ptr.7540

Article  PubMed  CAS  Google Scholar 

Jimenez JC, Su K, Goldberg AR, Luna VM, Biane JS, Ordek G, Zhou P, Ong SK, Wright MA, Zweifel L, Paninski L, Hen R, Kheirbek MA (2018) Anxiety cells in a hippocampal-hypothalamic circuit. Neuron 97(3):670–683e6. https://doi.org/10.1016/j.neuron.2018.01.016

Article  PubMed  PubMed Central  CAS  Google Scholar 

Jin H, Zhu Y, Wang XD, Luo EF, Li YP, Wang BL, Chen YF (2021) BDNF corrects NLRP3 inflammasome-induced pyroptosis and glucose metabolism reprogramming through KLF2/HK1 pathway in vascular endothelial cells. Cell Signal 78:109843. https://doi.org/10.1016/j.cellsig.2020.109843

Article  PubMed  CAS  Google Scholar 

Kawamura N, Katsuura G, Yamada-Goto N, Novianti

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