Recent developments in the study of cellular inflammation in the papillae of stone formers

Khan SR (2014) Reactive oxygen species, inflammation and calcium oxalate nephrolithiasis. Transl Androl Urol 3:256–276

PubMed  PubMed Central  Google Scholar 

Khan SR, Canales BK, Dominguez-Gutierrez PR (2021) Randall’s plaque and calcium oxalate stone formation: role for immunity and inflammation. Nat Rev Nephrol 17:417–433

Article  CAS  PubMed  Google Scholar 

Dejban P, Wilson E, Jayachandran M, Herrera Hernandez L, Haskic Z, Wellik L, Sinha S, Rule A, Denic A, Koo K, Potretzke A, Lieske J (2022) Inflammatory cells in Nephrectomy tissue from patients without and with a history of urinary Stone Disease. Clin J Am Soc Nephrol 17:414–422

Article  CAS  PubMed  PubMed Central  Google Scholar 

Capolongo G, Ferraro M, Unwin R (2023) Inflammation and kidney stones: cause and effect? Curr Opin Urol 33:129–135

Article  PubMed  Google Scholar 

Pepys MB, Hirschfield GM (2003) C-reactive protein: a critical update. J Clin Invest 111:1805–1812

Article  CAS  PubMed  PubMed Central  Google Scholar 

Shoag J, Eisner BH (2014) Relationship between C-reactive protein and kidney stone prevalence. J Urol 191:372–375

Article  CAS  PubMed  Google Scholar 

Oda E (2014) Overweight and high-sensitivity C-reactive protein are weakly associated with kidney stone formation in Japanese men. Int J Urol 21:1005–1011

Article  CAS  PubMed  Google Scholar 

Hasna A, Meiyappan K, Periyasam SG, Kalyaperumal M, Bobby Z, Subramaniam AV (2015) Is urolithiasis associated with increased levels of high sensitivity C-reactive protein and interleukin-6 in diabetic patients? J Clin Diagn Res 9:Bc01–03

PubMed  PubMed Central  Google Scholar 

Lovegrove CE, Bešević J, Wiberg A, Lacey B, Littlejohns TJ, Allen NE, Goldsworthy M, Kim J, Hannan FM, Curhan GC, Turney BW, McCarthy MI, Mahajan A, Thakker RV, Holmes MV, Furniss D, Howles SA (2023) Central Adiposity increases risk of kidney Stone Disease through effects on serum calcium concentrations. J Am Soc Nephrol 34:1991–2011

Article  PubMed  PubMed Central  Google Scholar 

Taguchi K, Okada A, Hamamoto S, Unno R, Moritoki Y, Ando R, Mizuno K, Tozawa K, Kohri K, Yasui T (2016) M1/M2-macrophage phenotypes regulate renal calcium oxalate crystal development. Sci Rep 6:35167

Article  CAS  PubMed  PubMed Central  Google Scholar 

Taguchi K, Hamamoto S, Okada A, Unno R, Kamisawa H, Naiki T, Ando R, Mizuno K, Kawai N, Tozawa K, Kohri K, Yasui T (2017) Genome-wide gene expression profiling of Randall’s plaques in Calcium Oxalate Stone formers. J Am Soc Nephrol 28:333–347

Article  CAS  PubMed  Google Scholar 

Williams J, Holmes RP, Assimos DG, Mitchell T (2016) Monocyte mitochondrial function in Calcium Oxalate Stone formers. Urology 93:224e221–224e226

Article  Google Scholar 

Makki MS, Winfree S, Lingeman JE, Witzmann FA, Worcester EM, Krambeck AE, Coe FL, Evan AP, Bledsoe S, Bergsland KJ, Khochare S, Barwinska D, Williams JC Jr., El-Achkar TM (2020) A precision medicine approach uncovers a unique signature of neutrophils in patients with brushite kidney stones. Kidney Int Rep 5:663–677

Article  PubMed  PubMed Central  Google Scholar 

Canela VH, Bowen WS, Ferreira RM, Lingeman JE, Sabo AR, Barwinska D, Winfree S, Lake B, Cheng Y-H, LaFavers KA, Zhang K, Coe FL, Worcester E, Jain S, Eadon MT, James C, Williams J, El-Achkar TM (2023) A spatially anchored transcriptomic atlas of the human kidney papilla identifies significant immune injury and matrix remodeling in patients with stone disease. Nat Commun 14:4140

Article  CAS  PubMed  PubMed Central  Google Scholar 

Coe FL, Evan AP, Lingeman JE, Worcester EM (2010) Plaque and deposits in nine human stone diseases. Urol Res 38:239–247

Article  PubMed  PubMed Central  Google Scholar 

Randall A (1937) The origin and growth of renal calculi. Ann Surg 105:1009–1027

Article  CAS  PubMed  PubMed Central  Google Scholar 

Randall A (1940) Papillary pathology as a precursor of primary renal calculus. J Urol 44:580–589

Article  CAS  Google Scholar 

Letavernier E, Vandermeersch S, Traxer O, Tligui M, Baud L, Ronco P, Haymann JP, Daudon M (2015) Demographics and characterization of 10,282 Randall plaque-related kidney stones: a new epidemic? Med (Baltim) 94:e566

Article  Google Scholar 

Williams JC, Al-Awadi H, Muthenini M, Bledsoe SB, El-Achkar T, Evan AP, Coe F, Lingeman JE, Worcester EM (2022) Stone morphology distinguishes two pathways of idiopathic calcium oxalate stone pathogenesis. J Endourol 36:694–702

Article  PubMed  PubMed Central  Google Scholar 

Williams JC Jr., Bowen WS, Lingeman JE, Rivera M, Worcester EM, El-Achkar TM (2024) Two distinct phenotypes of calcium oxalate stone formers could imply different long-term risks for renal function. Urolithiasis 52:133

Article  PubMed  Google Scholar 

Borofsky MS, Paonessa JE, Evan AP, Williams JC Jr., Coe FL, Worcester EM, Lingeman JE (2016) A proposed Grading System to standardize the description of renal papillary appearance at the Time of Endoscopy in patients with Nephrolithiasis. J Endourol 30:122–127

Article  PubMed  PubMed Central  Google Scholar 

Borofsky MS, Williams JC Jr., Dauw CA, Cohen A, Evan AP, Coe FL, Worcester E, Lingeman JE (2019) Association between Randall’s Plaque Stone anchors and renal papillary pits. J Endourol 33:337–342

Article  PubMed  PubMed Central  Google Scholar 

Evan AP, Lingeman JE, Coe FL, Shao Y, Parks JH, Bledsoe SB, Phillips CL, Bonsib S, Worcester EM, Sommer AJ, Kim SC, Tinmouth WW, Grynpas M (2005) Crystal-associated nephropathy in patients with brushite nephrolithiasis. Kidney Int 67:576–591

Article  CAS  PubMed  Google Scholar 

Iványi B, Olsen S (1995) Tubulitis in Renal Disease. In: Dodd SM (ed) Tubulointerstitial and cystic disease of the kidney. Springer Berlin Heidelberg, Berlin, Heidelberg, pp 117–143

Chapter  Google Scholar 

Borofsky MS, Handa RK, Evan AP, Williams JC Jr., Bledsoe S, Coe FL, Worcester EM, Lingeman JE (2020) In vivo renal tubule pH in stone-forming human kidneys. J Endourol 34:203–208

Article  PubMed  PubMed Central  Google Scholar 

Evan AP, Lingeman JE, Worcester EM, Sommer AJ, Phillips CL, Williams JC Jr., Coe FL (2014) Contrasting histopathology and crystal deposits in kidneys of idiopathic stone formers who produce hydroxyapatite, brushite, or calcium oxalate stones. Anat Rec 297:731–748

Article  CAS  Google Scholar 

Worcester EM, Evan AP, Coe FL, Lingeman JE, Krambeck A, Sommers A, Phillips CL, Milliner D (2013) A test of the hypothesis that oxalate secretion produces proximal tubule crystallization in primary hyperoxaluria type I. Am J Physiol - Ren Physiol 305:F1574–F1584

Article  CAS  Google Scholar 

Thamilselvan S, Khan SR (1998) Oxalate and calcium oxalate crystals are injurious to renal epithelial cells: results of in vivo and in vitro studies. J Nephrol 11(Suppl 1):66–69

PubMed  Google Scholar 

Sun XY, Gan QZ, Ouyang JM (2015) Calcium oxalate toxicity in renal epithelial cells: the mediation of crystal size on cell death mode. Cell Death Discovery 1:15055

Article  CAS  PubMed  PubMed Central  Google Scholar 

Letavernier E, Kauffenstein G, Huguet L, Navasiolava N, Bouderlique E, Tang E, Delaitre L, Bazin D, de Frutos M, Gay C, Perez J, Verpont M-C, Haymann J-P, Pomozi V, Zoll J, Le Saux O, Daudon M, Leftheriotis G, Martin L (2018) ABCC6 Deficiency Promotes Development of Randall Plaque. J Am Soc Nephrol 29:2337–2347

Article  CAS  PubMed  PubMed Central  Google Scholar 

Curry JN, Saurette M, Askari M, Pei L, Filla MB, Beggs MR, Rowe PSN, Fields T, Sommer AJ, Tanikawa C, Kamatani Y, Evan AP, Totonchi M, Alexander RT, Matsuda K, Yu ASL (2020) Claudin-2 deficiency associates with hypercalciuria in mice and human kidney stone disease. J Clin Investig 130

Klahr S, Morrissey J (2002) Obstructive nephropathy and renal fibrosis. Am J Physiol Ren Physiol 283:F861–875

Article  Google Scholar 

Comments (0)

No login
gif