Emerging Roles of Eosinophils in Bone

Lee JJ, Jacobsen EA, Ochkur SI, McGarry MP, Condjella RM, Doyle AD, et al. Human versus mouse eosinophils: that which we call an eosinophil, by any other name would stain as red. J Allergy Clin Immunol. 2012;130(3):572–84.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Lorenzo J, Choi Y, Osteoimmunology. Immunol Rev. 2005;208:5–6.

Article  PubMed  Google Scholar 

Walker-Bone K. Recognizing and treating secondary osteoporosis. Nat Rev Rheumatol. 2012;8(8):480–92.

Article  PubMed  CAS  Google Scholar 

Takayanagi H. Osteoimmunology: shared mechanisms and crosstalk between the immune and bone systems. Nat Rev Immunol. 2007;7(4):292–304.

Article  PubMed  CAS  Google Scholar 

Omata Y, Frech M, Saito T, Schett G, Zaiss MM, Tanaka S. Inflammatory arthritis and bone metabolism regulated by type 2 innate and adaptive immunity. Int J Mol Sci. 2022;23(3).

Varricchi G, Galdiero MR, Loffredo S, Lucarini V, Marone G, Mattei F, et al. Eosinophils: the unsung heroes in cancer? Oncoimmunology. 2018;7(2):e1393134.

Article  PubMed  Google Scholar 

Mack EA, Pear WS. Transcription factor and cytokine regulation of eosinophil lineage commitment. Curr Opin Hematol. 2020;27(1):27–33.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Yu C, Cantor AB, Yang H, Browne C, Wells RA, Fujiwara Y, et al. Targeted deletion of a high-affinity GATA-binding site in the GATA-1 promoter leads to selective loss of the eosinophil lineage in vivo. J Exp Med. 2002;195(11):1387–95.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Arnold IC, Munitz A. Spatial adaptation of eosinophils and their emerging roles in homeostasis, infection and disease. Nat Rev Immunol. 2024.

Lee JJ, Jacobsen EA, McGarry MP, Schleimer RP, Lee NA. Eosinophils in health and disease: the LIAR hypothesis. Clin Exp Allergy. 2010;40(4):563–75.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Mesnil C, Raulier S, Paulissen G, Xiao X, Birrell MA, Pirottin D, et al. Lung-resident eosinophils represent a distinct regulatory eosinophil subset. J Clin Invest. 2016;126(9):3279–95.

Article  PubMed  PubMed Central  Google Scholar 

Abdala-Valencia H, Coden ME, Chiarella SE, Jacobsen EA, Bochner BS, Lee JJ, et al. Shaping eosinophil identity in the tissue contexts of development, homeostasis, and disease. J Leukoc Biol. 2018;104(1):95–108.

Article  PubMed  CAS  Google Scholar 

Shah K, Ignacio A, McCoy KD, Harris NL. The emerging roles of eosinophils in mucosal homeostasis. Mucosal Immunol. 2020;13(4):574–83.

Article  PubMed  CAS  Google Scholar 

Kim HJ, Jung Y. The emerging role of eosinophils as multifunctional leukocytes in health and disease. Immune Netw. 2020;20(3):e24.

Article  PubMed  PubMed Central  Google Scholar 

Weller PF, Spencer LA. Functions of tissue-resident eosinophils. Nat Rev Immunol. 2017;17(12):746–60.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Gurtner A, Borrelli C, Gonzalez-Perez I, Bach K, Acar IE, Nunez NG, et al. Active eosinophils regulate host defence and immune responses in colitis. Nature. 2023;615(7950):151–7.

Article  PubMed  CAS  Google Scholar 

Manolagas SC, Parfitt AM. What old means to bone. Trends Endocrinol Metab. 2010;21(6):369–74.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Raggatt LJ, Partridge NC. Cellular and molecular mechanisms of bone remodeling. J Biol Chem. 2010;285(33):25103–8.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Dai XM, Ryan GR, Hapel AJ, Dominguez MG, Russell RG, Kapp S, et al. Targeted disruption of the mouse colony-stimulating factor 1 receptor gene results in osteopetrosis, mononuclear phagocyte deficiency, increased primitive progenitor cell frequencies, and reproductive defects. Blood. 2002;99(1):111–20.

Article  PubMed  CAS  Google Scholar 

Dougall WC, Glaccum M, Charrier K, Rohrbach K, Brasel K, De Smedt T, et al. RANK is essential for osteoclast and lymph node development. Genes Dev. 1999;13(18):2412–24.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Aeschlimann D, Evans BA. The vital osteoclast: how is it regulated? Cell Death Differ. 2004;11(Suppl 1):S5–7.

Article  PubMed  CAS  Google Scholar 

Arai F, Miyamoto T, Ohneda O, Inada T, Sudo T, Brasel K, et al. Commitment and differentiation of osteoclast precursor cells by the sequential expression of c-Fms and receptor activator of nuclear factor kappab (RANK) receptors. J Exp Med. 1999;190(12):1741–54.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Okamoto K, Nakashima T, Shinohara M, Negishi-Koga T, Komatsu N, Terashima A, et al. Osteoimmunology: the conceptual framework unifying the immune and skeletal systems. Physiol Rev. 2017;97(4):1295–349.

Article  PubMed  CAS  Google Scholar 

Teitelbaum SL, Ross FP. Genetic regulation of osteoclast development and function. Nat Rev Genet. 2003;4(8):638–49.

Article  PubMed  CAS  Google Scholar 

Fakhry M, Hamade E, Badran B, Buchet R, Magne D. Molecular mechanisms of mesenchymal stem cell differentiation towards osteoblasts. World J Stem Cells. 2013;5(4):136–48.

Article  PubMed  PubMed Central  Google Scholar 

Komori T, Yagi H, Nomura S, Yamaguchi A, Sasaki K, Deguchi K, et al. Targeted disruption of Cbfa1 results in a complete lack of bone formation owing to maturational arrest of osteoblasts. Cell. 1997;89(5):755–64.

Article  PubMed  CAS  Google Scholar 

Crockett JC, Rogers MJ, Coxon FP, Hocking LJ, Helfrich MH. Bone remodelling at a glance. J Cell Sci. 2011;124(Pt 7):991–8.

Article  PubMed  CAS  Google Scholar 

Feng X, McDonald JM. Disorders of bone remodeling. Annu Rev Pathol. 2011;6:121–45.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Kim JM, Lin C, Stavre Z, Greenblatt MB, Shim JH. Osteoblast-Osteoclast communication and bone homeostasis. Cells. 2020;9(9).

Capulli M, Paone R, Rucci N. Osteoblast and osteocyte: games without frontiers. Arch Biochem Biophys. 2014;561:3–12.

Article  PubMed  CAS  Google Scholar 

Florencio-Silva R, Sasso GR, Sasso-Cerri E, Simoes MJ, Cerri PS. Biology of bone tissue: structure, function, and factors that influence bone cells. Biomed Res Int. 2015;2015:421746.

Article  PubMed  PubMed Central  Google Scholar 

Nakashima K, Zhou X, Kunkel G, Zhang Z, Deng JM, Behringer RR, et al. The novel zinc finger-containing transcription factor Osterix is required for osteoblast differentiation and bone formation. Cell. 2002;108(1):17–29.

Article  PubMed  CAS  Google Scholar 

Blair HC, Larrouture QC, Li Y, Lin H, Beer-Stoltz D, Liu L, et al. Osteoblast differentiation and bone matrix formation in vivo and in vitro. Tissue Eng Part B Rev. 2017;23(3):268–80.

Article  PubMed 

Comments (0)

No login
gif