Bagdonas E, Raudoniute J, Bruzauskaite I, Aldonyte R. Novel aspects of pathogenesis and regeneration mechanisms in COPD. Int J Chron Obstruct Pulmon Dis. 2015;10:995–1013.

PubMed  PubMed Central  Google Scholar 

Lin CH, Cheng SL, Chen CZ, Chen CH, Lin SH, Wang HC. Current progress of COPD early detection: key points and novel strategies. Int J Chron Obstruct Pulmon Dis. 2023;18:1511–24.

Article  PubMed  PubMed Central  Google Scholar 

Christenson SA, Smith BM, Bafadhel M, Putcha N. Chronic obstructive pulmonary disease. Lancet. 2022;399(10342):2227–42.

Article  PubMed  Google Scholar 

Kaur M, Chandel J, Malik J, Naura AS. Particulate matter in COPD pathogenesis: an overview. Inflamm Res. 2022;71(7–8):797–815.

Article  CAS  PubMed  Google Scholar 

Ghonim MA, Boyd DF, Flerlage T, Thomas PG. Pulmonary inflammation and fibroblast immunoregulation: from bench to bedside. J Clin Invest. 2023;133(17):e170499.

Article  CAS  PubMed  PubMed Central  Google Scholar 

D’Anna C, Cigna D, Costanzo G, Ferraro M, Siena L, Vitulo P, et al. Cigarette smoke alters cell cycle and induces inflammation in lung fibroblasts. Life Sci. 2015;126:10–8.

Article  CAS  PubMed  Google Scholar 

Woldhuis RR, de Vries M, Timens W, van den Berge M, Demaria M, Oliver BGG, et al. Link between increased cellular senescence and extracellular matrix changes in COPD. Am J Physiol Lung Cell Mol Physiol. 2020;319(1):L48–60.

Article  CAS  PubMed  Google Scholar 

Zeng XX, Gao DD, Zhang F. Cortex Mori Radicis[Morus alba L. (Moraceae)] extract alleviates senescence via PI3k/Akt signaling in COPD fibroblasts. Phytomedicine. 2024;135:156004.

Article  CAS  PubMed  Google Scholar 

Guan R, Yuan L, Li J, Wang J, Li Z, Cai Z, et al. Bone morphogenetic protein 4 inhibits pulmonary fibrosis by modulating cellular senescence and mitophagy in lung fibroblasts. Eur Respir J. 2022;60(6):2102307.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Martins R, Lithgow GJ, Link W. Long live FOXO: unraveling the role of foxo proteins in aging and longevity. Aging Cell. 2016;15(2):196–207.

Article  CAS  PubMed  Google Scholar 

Yang W, Kim DM, Jiang W, Ai W, Pan Q, Rahman S, et al. Suppression of FOXO1 attenuates inflamm-aging and improves liver function during aging. Aging Cell. 2023;22(10):e13968.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Jiang H, Xu Y, Jiang Y, Li Y. Foxo3 activation prevents cellular senescence in emphysema induced by cigarette smoke. COPD. 2023;20(1):80–91.

Article  CAS  PubMed  Google Scholar 

Bagam P, Kaur G, Singh DP, Batra S. In vitro study of the role of foxo transcription factors in regulating cigarette smoke extract-induced autophagy. Cell Biol Toxicol. 2021;37(4):531–53.

Article  CAS  PubMed  Google Scholar 

Yamaguchi Y, Madhyastha H, Madhyastha R, Choijookhuu N, Hishikawa Y, Pengjam Y, et al. Arsenic acid inhibits proliferation of skin fibroblasts, and increases cellular senescence through ROS mediated MST1-FOXO signaling pathway. J Toxicol Sci. 2016;41(1):105–13.

Article  CAS  PubMed  Google Scholar 

Bae JH, Jeong HJ, Kim H, Leem YE, Ryu D, Park SC, et al. ZNF746/PARIS overexpression induces cellular senescence through FOXO1/p21 axis activation in myoblasts. Cell Death Dis. 2020;11(5):359.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Tominaga K, Suzuki HI. TGF-beta signaling in cellular senescence and aging-related pathology. Int J Mol Sci. 2019;20(20):5002.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ueda S, Tominaga T, Ochi A, Sakurai A, Nishimura K, Shibata E, et al. TGF-beta1 is involved in senescence-related pathways in glomerular endothelial cells via p16 translocation and p21 induction. Sci Rep. 2021;11(1):21643.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chen H, Chen H, Liang J, Gu X, Zhou J, Xie C, et al. Tgf-beta1/il-11/mek/erk signaling mediates senescence-associated pulmonary fibrosis in a stress-induced premature senescence model of bmi-1 deficiency. Exp Mol Med. 2020;52(1):130–51.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hameedaldeen A, Liu J, Batres A, Graves GS, Graves DT. FOXO1, TGF-beta regulation and wound healing. Int J Mol Sci. 2014;15(9):16257–69.

Article  PubMed  PubMed Central  Google Scholar 

Feng X, Liu H, Sheng Y, Li J, Guo J, Song W, et al. Yinchen gongying decoction mitigates CCl(4)-induced chronic liver injury and fibrosis in mice implicated in inhibition of the FOXO1/TGF-beta1/Smad2/3 and YAP signaling pathways. J Ethnopharmacol. 2024;327:117975.

Article  CAS  PubMed  Google Scholar 

Jiashuo Wu, Fangqing Z, Zhuangzhuang LI, Weiyi J, Yue S. Integration strategy of network pharmacology in traditional Chinese medicine: a narrative review. J Tradit Chin Med. 2022;42(3):479–86.

Sayyed K, Le Vee M, Chamieh H, Fardel O, Abdel-Razzak Z. Cigarette smoke condensate alters Saccharomyces cerevisiae efflux transporter mrna and activity and increases caffeine toxicity. Toxicology. 2018;409:129–36.

Article  CAS  PubMed  Google Scholar 

Palazzo A, Makulyte G, Goerhig D, Medard JJ, Gros V, Trottein F, et al. Benidipine calcium channel blocker promotes the death of cigarette smoke-induced senescent cells and improves lung emphysema. Aging (Albany NY). 2023;15(23):13581–92.

Article  CAS  PubMed  Google Scholar 

Barnes PJ, Baker J, Donnelly LE. Cellular senescence as a mechanism and target in chronic lung diseases. Am J Respir Crit Care Med. 2019;200(5):556–64.

Article  CAS  PubMed  Google Scholar 

Huang W, Hickson LJ, Eirin A, Kirkland JL, Lerman LO. Cellular senescence: the good, the bad and the unknown. Nat Rev Nephrol. 2022;18(10):611–27.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Weng J, Wu XF, Shao P, Liu XP, Wang CX. Medicine for chronic atrophic gastritis: a systematic review, meta- and network pharmacology analysis. Ann Med. 2023;55(2):2299352.

Article  PubMed  Google Scholar 

Regulski MJ. Cellular senescence: what, why, and how. Wounds. 2017;29(6):168–74.

PubMed  Google Scholar 

Afsar B, Afsar RE. Hypertension and cellular senescence. Biogerontology. 2023;24(4):457–78.

Article  PubMed  Google Scholar 

Melo Dos Santos LS, Trombetta-Lima M, Eggen B, Demaria M. Cellular senescence in brain aging and neurodegeneration. Ageing Res Rev. 2024;93:102141.

Article  CAS  PubMed  Google Scholar 

Palmer AK, Gustafson B, Kirkland JL, Smith U. Cellular senescence: at the nexus between ageing and diabetes. Diabetologia. 2019;62(10):1835–41.

Article  PubMed  PubMed Central  Google Scholar 

Cho SJ, Stout-Delgado HW. Aging and lung disease. Annu Rev Physiol. 2020;82:433–59.

Article  CAS  PubMed  Google Scholar 

Bulbiankova D, Diaz-Puertas R, Alvarez-Martinez FJ, Herranz-Lopez M, Barrajon-Catalan E, Micol V. Hallmarks and biomarkers of skin senescence: an updated review of skin senotherapeutics. Antioxidants (Basel). 2023;12(2):444.

Article