Chen J, Zhao Y, Wang X, Zang L, Yin D, Tan S (2024) Hyperoside inhibits RNF8-mediated nuclear translocation of β-catenin to repress PD-L1 expression and prostate Cancer. Anticancer Agents Med Chem 24:464–476. https://doi.org/10.2174/0118715206289246240110044931
Article CAS PubMed Google Scholar
Dabrowska S, Andrzejewska A, Strzemecki D, Muraca M, Janowski M, Lukomska B (2019) Human bone marrow mesenchymal stem cell-derived extracellular vesicles attenuate neuroinflammation evoked by focal brain injury in rats. J Neuroinflammation 16:216. https://doi.org/10.1186/s12974-019-1602-5
Article CAS PubMed PubMed Central Google Scholar
Deng Y, Chen D, Gao F et al. (2019) Exosomes derived from microRNA-138-5p-overexpressing bone marrow-derived mesenchymal stem cells confer neuroprotection to astrocytes following ischemic stroke via Inhibition of LCN2. J Biol Eng 13:71. https://doi.org/10.1186/s13036-019-0193-0
Article CAS PubMed PubMed Central Google Scholar
Gao Y, Xiao X, Luo J et al. (2022) E3 ubiquitin ligase FBXO3 drives neuroinflammation to aggravate cerebral ischemia/reperfusion injury. Int J Mol Sci 23:13648. https://doi.org/10.3390/ijms232113648
Guo Y, Wu Y, Li N, Wang Z (2021) Up-regulation of miRNA-151-3p enhanced the neuroprotective effect of Dexmedetomidine against β-amyloid by targeting DAPK-1 and TP53. Exp Mol Pathol 118:104587. https://doi.org/10.1016/j.yexmp.2020.104587
Article CAS PubMed Google Scholar
Li T, Qin JJ, Yang X et al. (2017) The ubiquitin E3 ligase TRAF6 exacerbates ischemic stroke by ubiquitinating and activating Rac1. J Neurosci 37:12123–12140. https://doi.org/10.1523/jneurosci.1751-17.2017
Article CAS PubMed PubMed Central Google Scholar
Li X, Zhang Y, Wang Y et al. (2020) Exosomes derived from CXCR4-Overexpressing BMSC promoted activation of microvascular endothelial cells in cerebral ischemia/reperfusion injury. Neural Plast 2020:8814239. https://doi.org/10.1155/2020/8814239
Article CAS PubMed PubMed Central Google Scholar
Li X, Bi T, Yang S (2022a) Exosomal microRNA-150-5p from bone marrow mesenchymal stromal cells mitigates cerebral ischemia/reperfusion injury via targeting toll-like receptor 5. Bioengineered 13:3030–3043. https://doi.org/10.1080/21655979.2021.2012402
Article CAS PubMed Google Scholar
Li Y, Li S, Wu H (2022b) Ubiquitination-Proteasome system (UPS) and autophagy two main protein degradation machineries in response to cell stress. Cells 11:851. https://doi.org/10.3390/cells11050851
Article CAS PubMed PubMed Central Google Scholar
Liu X, Ye Q, Huang Z et al. (2023) BAG3 overexpression attenuates ischemic stroke injury by activating autophagy and inhibiting apoptosis. Stroke 54:2114–2125. https://doi.org/10.1161/strokeaha.123.041783
Article CAS PubMed Google Scholar
Noori T, Shirooie S, Sureda A, Sobarzo-Sanchez E, Dehpour AR, Saldías M, Akkol EK (2022) Regulation of DAPK1 by natural products: an important target in treatment of stroke. Neurochem Res 47:2142–2157. https://doi.org/10.1007/s11064-022-03628-7
Article CAS PubMed Google Scholar
Ouyang S, Song Y, Tian Y, Chen Y, Yu X, Wang D (2015) RNF8 deficiency results in neurodegeneration in mice. Neurobiol Aging 36:2850–2860. https://doi.org/10.1016/j.neurobiolaging.2015.07.010
Article CAS PubMed PubMed Central Google Scholar
Shi Y, Tian T, Cai EL, Yang C, Yang X (2021) miR-214 alleviates ischemic Stroke-Induced neuronal death by targeting DAPK1 in mice. Front Neurosci 15:649982. https://doi.org/10.3389/fnins.2021.649982
Article PubMed PubMed Central Google Scholar
Shi Y, Cui W, Wang Q et al (2022) MicroRNA-124/Death-Associated protein kinase 1 signaling regulates neuronal apoptosis in traumatic brain injury via phosphorylating NR2B. Front Cell Neurosci 16:892197. https://doi.org/10.3389/fncel.2022.892197
Article CAS PubMed PubMed Central Google Scholar
Tu W, Xu X, Peng L et al. (2010) DAPK1 interaction with NMDA receptor NR2B subunits mediates brain damage in stroke. Cell 140:222–234. https://doi.org/10.1016/j.cell.2009.12.055
Article CAS PubMed PubMed Central Google Scholar
Wang H, Chen F, Li J et al. (2020a) Vaspin antagonizes high fat-induced bone loss in rats and promotes osteoblastic differentiation in primary rat osteoblasts through Smad-Runx2 signaling pathway. Nutr Metab (Lond) 17:9. https://doi.org/10.1186/s12986-020-0429-5
Article CAS PubMed Google Scholar
Wang S, Chen K, Yu J et al. (2020b) Presynaptic Caytaxin prevents apoptosis via deactivating DAPK1 in the acute phase of cerebral ischemic stroke. Exp Neurol 329:113303. https://doi.org/10.1016/j.expneurol.2020.113303
Article CAS PubMed Google Scholar
Wang Y, Shi M, Hong Z, Kang J, Pan H, Yan C (2021) MiR-130a-3p has protective effects in alzheimer’s disease via targeting DAPK1. Am J Alzheimers Dis Other Demen 36:15333175211020572. https://doi.org/10.1177/15333175211020572
Article PubMed PubMed Central Google Scholar
Wang QS, Xiao RJ, Peng J, Yu ZT, Fu JQ, Xia Y (2023a) Bone marrow mesenchymal stem Cell-Derived Exosomal KLF4 alleviated ischemic stroke through inhibiting N6-Methyladenosine modification level of Drp1 by targeting lncRNA-ZFAS1. Mol Neurobiol 60:3945–3962. https://doi.org/10.1007/s12035-023-03301-2
Article CAS PubMed Google Scholar
Wang Y, Chen H, Fan X et al. (2023b) Bone marrow mesenchymal stem cell-derived Exosomal miR-193b-5p reduces pyroptosis after ischemic stroke by targeting AIM2. J Stroke Cerebrovasc Dis 32:107235. https://doi.org/10.1016/j.jstrokecerebrovasdis.2023.107235
Xia Q, Zhan G, Mao M, Zhao Y, Li X (2022) TRIM45 causes neuronal damage by aggravating microglia-mediated neuroinflammation upon cerebral ischemia and reperfusion injury. Exp Mol Med 54:180–193. https://doi.org/10.1038/s12276-022-00734-y
Article CAS PubMed PubMed Central Google Scholar
Xiao R, Wang Q, Peng J, Yu Z, Zhang J, Xia Y (2023) BMSC-Derived Exosomal Egr2 ameliorates ischemic stroke by directly upregulating SIRT6 to suppress Notch signaling. Mol Neurobiol 60:1–17. https://doi.org/10.1007/s12035-022-03037-5
Article CAS PubMed Google Scholar
Xiong WP, Yao WQ, Wang B, Liu K (2021) BMSCs-exosomes containing GDF-15 alleviated SH-SY5Y cell injury model of alzheimer’s disease via AKT/GSK-3β/β-catenin. Brain Res Bull 177:92–102. https://doi.org/10.1016/j.brainresbull.2021.09.008
Article CAS PubMed Google Scholar
Xu Y, Hu Y, Xu T et al. (2021) RNF8-mediated regulation of Akt promotes lung cancer cell survival and resistance to DNA damage. Cell Rep 37:109854. https://doi.org/10.1016/j.celrep.2021.109854
Article CAS PubMed Google Scholar
Yang H, Chen J (2022) Bone marrow mesenchymal stem cell-derived exosomes carrying long noncoding RNA ZFAS1 alleviate oxidative stress and inflammation in ischemic stroke by inhibiting microRNA-15a-5p. Metab Brain Dis 37:2545–2557. https://doi.org/10.1007/s11011-022-00997-4
Article CAS PubMed Google Scholar
Yang X, Xu J, Lan S, Tong Z, Chen K, Liu Z, Xu S (2023) Exosomal miR-133a-3p derived from BMSCs alleviates cerebral Ischemia-Reperfusion injury via targeting DAPK2. Int J Nanomed 18:65–78. https://doi.org/10.2147/ijn.S385395
Zhang S, Wang D, Li L (2023) Recombinant tissue-type plasminogen activator (rt-PA) effectively restores neurological function and improves prognosis in acute ischemic stroke. Am J Transl Res 15:3460–3467
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