Ndumele CE, Rangaswami J, Chow SL, Neeland IJ, Tuttle KR, Khan SS, et al. Cardiovascular-Kidney-Metabolic health: a presidential advisory from the American heart association. Circulation. 2023;148:1606–35.
Baker-Smith CM, Gauen AM, Petito LC, Khan SS, Allen NB. Prevalence of cardiovascular-kidney-metabolic stages in US adolescents and relationship to social determinants of health. J Am Heart Assoc. 2025;14:e040269.
PubMed PubMed Central Google Scholar
Cao Y, Wang W, Xie S, Xu Y, Lin Z. Joint association of the inflammatory marker and cardiovascular-kidney-metabolic syndrome stages with all-cause and cardiovascular disease mortality: a National prospective study. BMC Public Health. 2025;25:10.
PubMed PubMed Central Google Scholar
Li W, Shen C, Kong W, Zhou X, Fan H, Zhang Y, et al. Association between the triglyceride glucose-body mass index and future cardiovascular disease risk in a population with cardiovascular-kidney-metabolic syndrome stage 0–3: a nationwide prospective cohort study. Cardiovasc Diabetol. 2024;23:292.
PubMed PubMed Central Google Scholar
Kanbay M, Guldan M, Ozbek L, Copur S, Covic AS, Covic A. Exploring the nexus: the place of kidney diseases within the cardiovascular-kidney-metabolic syndrome spectrum. Eur J Intern Med. 2024;127:1–14.
Zhang C, Hao C, Liang W, Hu K, Guo T, Chen Y, et al. Abdominal obesity and frailty progression in population across different cardiovascular-kidney-metabolic syndrome stages: a nationwide longitudinal study. Diabetol Metab Syndr. 2025;17:75.
CAS PubMed PubMed Central Google Scholar
Masenga SK, Kabwe LS, Chakulya M, Kirabo A. Mechanisms of oxidative stress in metabolic syndrome. Int J Mol Sci. 2023;24:7898.
CAS PubMed PubMed Central Google Scholar
Pandey S. Metabolomics for the identification of biomarkers in kidney diseases. Nanotheranostics. 2025;9:110–20.
PubMed PubMed Central Google Scholar
Claudel SE, Schmidt IM, Waikar SS, Verma A. Cumulative incidence of mortality associated with cardiovascular-kidney-metabolic (CKM) syndrome. J Am Soc Nephrol [Internet]. 2025; Available from: https://doi.org/10.1681/ASN.0000000637
Aggarwal R, Ostrominski JW, Vaduganathan M. Prevalence of cardiovascular-kidney-metabolic syndrome stages in US adults, 2011–2020. JAMA. 2024;331:1858.
CAS PubMed PubMed Central Google Scholar
Sebastian SA, Padda I, Johal G. Cardiovascular-kidney-metabolic (CKM) syndrome: a state-of-the-art review. Curr Probl Cardiol. 2024;49:102344.
Sen P, Hamers J, Sittig T, Shashikadze B, d’Ambrosio L, Stöckl JB, et al. Oxidative stress initiates hemodynamic change in CKD-induced heart disease. Basic Res Cardiol. 2024;119:957–71.
CAS PubMed PubMed Central Google Scholar
Chen X, Xie N, Feng L, Huang Y, Wu Y, Zhu H, et al. Oxidative stress in diabetes mellitus and its complications: from pathophysiology to therapeutic strategies. Chin Med J (Engl). 2024;138:15–27.
Schulze MB, Martínez-González MA, Fung TT, Lichtenstein AH, Forouhi NG. Food based dietary patterns and chronic disease prevention. Br Med J. 2018;361:k2396.
Karimi E, Gholizadeh M, Abdolahi M, Sedighiyan M, Salehinia F, Siri G, et al. Effect of vitamin B1 supplementation on blood creatinine and lactate levels and clinical outcomes in patients in intensive care units: a systematic review and meta-analysis of randomized controlled trials. Nutr Rev. 2023;82:804–14.
Abdollahi H, Salehinia F, Badeli M, Karimi E, Gandomkar H, Asadollahi A, et al. The biochemical parameters and vitamin D levels in ICU patients with covid-19: a cross-sectional study. Endocr Metab Immune Disord Drug Targets. 2021;21:2191–202.
Puertollano MA, Puertollano E, de Cienfuegos GÁ, de Pablo MA. Dietary antioxidants: immunity and host defense. Curr Top Med Chem. 2011;11:1752–66.
Lee GY, Han SN. The role of vitamin E in immunity. Nutrients. 2018;10:1614.
PubMed PubMed Central Google Scholar
Yin B, Tang S, Sun J, Zhang X, Xu J, Di L, et al. Vitamin C and sodium bicarbonate enhance the antioxidant ability of H9C2 cells and induce HSPs to relieve heat stress. Cell Stress Chaperones. 2018;23:735–48.
CAS PubMed PubMed Central Google Scholar
El-Senousey HK, Chen B, Wang JY, Atta AM, Mohamed FR, Nie QH. Effects of dietary vitamin C, vitamin E, and alpha-lipoic acid supplementation on the antioxidant defense system and immune-related gene expression in broilers exposed to oxidative stress by dexamethasone. Poult Sci. 2018;97:30–8.
Apak R, Güçlü K, Ozyürek M, Karademir SE. Novel total antioxidant capacity index for dietary polyphenols and vitamins C and E, using their cupric ion reducing capability in the presence of neocuproine: CUPRAC method. J Agric Food Chem. 2004;52:7970–81.
Wright ME, Mayne ST, Stolzenberg-Solomon RZ, Li Z, Pietinen P, Taylor PR, et al. Development of a comprehensive dietary antioxidant index and application to lung cancer risk in a cohort of male smokers. Am J Epidemiol. 2004;160:68–76.
Kim Y, Je Y. Flavonoid intake and mortality from cardiovascular disease and all causes: a meta-analysis of prospective cohort studies. Clin Nutr ESPEN. 2017;20:68–77.
Kang JH, Cook NR, Manson JE, Buring JE, Albert CM, Grodstein F. Vitamin E, vitamin C, beta carotene, and cognitive function among women with or at risk of cardiovascular disease: the women’s antioxidant and cardiovascular study. Circulation. 2009;119:2772–80.
CAS PubMed PubMed Central Google Scholar
Al-Daghri NM, Khan N, Alkharfy KM, Al-Attas OS, Alokail MS, Alfawaz HA, et al. Selected dietary nutrients and the prevalence of metabolic syndrome in adult males and females in Saudi arabia: a pilot study. Nutrients. 2013;5:4587–604.
PubMed PubMed Central Google Scholar
Liu W, Xu Y, Xiao L, Li K, Liu Q. Composite dietary antioxidant index is associated with the prevalence of metabolic syndrome in females: results from NHANES 2011–2016. Front Nutr. 2025;12:1529332.
PubMed PubMed Central Google Scholar
Wu M, Si J, Liu Y, Kang L, Xu B. Association between composite dietary antioxidant index and hypertension: insights from NHANES. Clin Exp Hypertens. 2023;45:2233712.
Liu C, Lai W, Zhao M, Zhang Y, Hu Y. Association between the composite dietary antioxidant index and atherosclerotic cardiovascular disease in postmenopausal women: a cross-sectional study of NHANES data, 2013–2018. Antioxidants (Basel). 2023;12:1740.
Tan Z, Meng Y, Li L, Wu Y, Liu C, Dong W, et al. Association of dietary fiber, composite dietary antioxidant index and risk of death in tumor survivors: National health and nutrition examination survey 2001–2018. Nutrients. 2023;15:2968.
PubMed PubMed Central Google Scholar
Li W, Bai J, Ge Y, Fan Y, Huang Q, Deng Z. Association between compound dietary antioxidant index and all-cause and cancer mortality in patients with chronic obstructive pulmonary disease: results from NHANES 1999–2018. Front Med. 2025;12:1544841.
Carrier A. Metabolic syndrome and oxidative stress: a complex relationship. Antioxid Redox Signal. 2017;26:429–31.
Whaley-Connell A, Sowers JR. Oxidative stress in the cardiorenal metabolic syndrome. Curr Hypertens Rep. 2012;14:360–5.
CAS PubMed PubMed Central Google Scholar
Otani H. Oxidative stress as pathogenesis of cardiovascular risk associated with metabolic syndrome. Antioxid Redox Signal. 2011;15:1911–26.
Whaley-Connell A, McCullough PA, Sowers JR. The role of oxidative stress in the metabolic syndrome. Rev Cardiovasc Med. 2011;12:21–9.
Koumallos N, Sigala E, Milas T, Baikoussis NG, Aragiannis D, Sideris S, et al. Angiotensin regulation of vascular homeostasis: exploring the role of ROS and RAS blockers. Int J Mol Sci. 2023;24:12111.
CAS PubMed PubMed Central Google Scholar
Chen S-J, Yen C-H, Huang Y-C, Lee B-J, Hsia S, Lin P-T. Relationships between inflammation, adiponectin, and oxidative stress in metabolic syndrome. PLoS ONE. 2012;7:e45693.
CAS PubMed PubMed Central Google Scholar
Henriksen EJ, Diamond-Stanic MK, Marchionne EM. Oxidative stress and the etiology of insulin resistance and type 2 diabetes. Free Radical Biol Med. 2011;51:993–9.
de Lima EP, Moretti RC, Torres Pomini K, Laurindo LF, Sloan KP, Sloan LA, et al. Glycolipid metabolic disorders, metainflammation, oxidative stress, and cardiovascular diseases: unraveling pathways. Biology (Basel). 2024;13:519.
Kishi S, Nagasu H, Kidokoro K, Kashihara N. Oxidative stress and the role of redox signalling in chronic kidney disease. Nat Rev Nephrol. 2023;20:101–19.
Ravarotto V, Simioni F, Pagnin E, Davis PA, Calò LA. Oxidative stress - chronic kidney disease - cardiovascular disease: a vicious circle. Life Sci. 2018;210:125–31.
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