Scheltens P, Strooper BD, Kivipelto M, Holstege H, Chételat G, Teunissen CE, et al. Alzheimer’s disease. Lancet. 2021;397(10284):1577–90. https://doi.org/10.1016/s0140-6736(20)32205-4.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Boxer AL, Sperling R. Accelerating alzheimer’s therapeutic development: the past and future of clinical trials. Cell. 2023;186(22):4757–72. https://doi.org/10.1016/j.cell.2023.09.023.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ferrari C, Sorbi S. The complexity of alzheimer’s disease: an evolving puzzle. Physiol Rev. 2021;101(3):1047–81. https://doi.org/10.1152/physrev.00015.2020.

Article  CAS  PubMed  Google Scholar 

Mangialasche F, Solomon A, Winblad B, Mecocci P, Kivipelto M. Alzheimer’s disease: clinical trials and drug development. Lancet Neurol. 2010;9(7):702–16. https://doi.org/10.1016/s1474-4422(10)70119-8.

Article  CAS  PubMed  Google Scholar 

Cunnane SC, Trushina E, Morland C, Prigione A, Casadesus G, Andrews ZB, et al. Brain energy rescue: an emerging therapeutic concept for neurodegenerative disorders of ageing. Nat Rev Drug Discov. 2020;19(9):609–33. https://doi.org/10.1038/s41573-020-0072-x.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Batra R, Arnold M, Wörheide MA, Allen M, Wang X, Blach C, et al. The landscape of metabolic brain alterations in alzheimer’s disease. Alzheimers Dement. 2022;19(3):980–98. https://doi.org/10.1002/alz.12714.

Article  PubMed  Google Scholar 

Harerimana NV, Paliwali D, Romero-Molina C, Bennett DA, Pa J, Goate A, et al. The role of mitochondrial genome abundance in alzheimer’s disease. Alzheimers Dement. 2022;19(5):2069–83. https://doi.org/10.1002/alz.12812.

Article  CAS  PubMed  Google Scholar 

Ashleigh T, Swerdlow RH, Beal MF. The role of mitochondrial dysfunction in alzheimer’s disease pathogenesis. Alzheimers Dement. 2022;19(1):333–42. https://doi.org/10.1002/alz.12683.

Article  CAS  PubMed  Google Scholar 

Stocker H, Gentiluomo M, Trares K, Beyer L, Stevenson-Hoare J, Rujescu D, et al. Mitochondrial DNA abundance in blood is associated with alzheimer’s disease- and dementia-risk. Mol Psychiatry. 2024. https://doi.org/10.1038/s41380-024-02670-x.

Article  PubMed  Google Scholar 

Therriault J, Schindler SE, Salvadó G, Pascoal TA, Benedet AL, Ashton NJ, et al. Biomarker-based staging of alzheimer disease: rationale and clinical applications. Nat Rev Neurol. 2024;20(4):232–44. https://doi.org/10.1038/s41582-024-00942-2.

Article  PubMed  Google Scholar 

Ossenkoppele R, van der Kant R, Hansson O. Tau biomarkers in alzheimer’s disease: towards implementation in clinical practice and trials. Lancet Neurol. 2022;21(8):726–34. https://doi.org/10.1016/S1474-4422(22)00168-5.

Article  CAS  PubMed  Google Scholar 

Dienel GA. Brain glucose metabolism: integration of energetics with function. Physiol Rev. 2019;99(1):949–1045. https://doi.org/10.1152/physrev.00062.2017.

Article  CAS  PubMed  Google Scholar 

Demetrius LA, Eckert A, Grimm A. Sex differences in alzheimer’s disease: metabolic reprogramming and therapeutic intervention. Trends Endocrinol Metab. 2021;32(12):963–doi979. https://doi.org/10.1016/j.tem.2021.09.004.

Article  CAS  PubMed  Google Scholar 

Jimenez-Blasco D, Agulla J, Lapresa R, Garcia-Macia M, Bobo-Jimenez V, Garcia-Rodriguez D, et al. Weak neuronal Glycolysis sustains cognition and organismal fitness. Nat Metab. 2024;6(7):1253–67. https://doi.org/10.1038/s42255-024-01049-0.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kawano I, Bazila B, Ježek P, Dlasková A. Mitochondrial dynamics and Cristae shape changes during metabolic reprogramming. Antioxid Redox Signal. 2023;39(10–12):684–707. https://doi.org/10.1089/ars.2023.0268.

Article  CAS  PubMed  Google Scholar 

Tábara LC, Burr SP, Frison M, Chowdhury SR, Paupe V, Nie Y, et al. MTFP1 controls mitochondrial fusion to regulate inner membrane quality control and maintain MtDNA levels. Cell. 2024;187(14):3619–e36373627. https://doi.org/10.1016/j.cell.2024.05.017.

Article  CAS  PubMed  Google Scholar 

Zhang Y, Liu X, Wiggins KL, Kurniansyah N, Guo X, Rodrigue AL, et al. Association of mitochondrial DNA copy number with brain MRI markers and cognitive function: A Meta-analysis of Community-Based cohorts. Neurology. 2023;100(18). https://doi.org/10.1212/wnl.0000000000207157.

Klein H-U, Trumpff C, Yang H-S, Lee AJ, Picard M, Bennett DA, et al. Characterization of mitochondrial DNA quantity and quality in the human aged and alzheimer’s disease brain. Mol Psychiatry. 2021;16(1). https://doi.org/10.1186/s13024-021-00495-8.

Horgusluoglu E, Neff R, Song WM, Wang M, Wang Q, Arnold M, et al. Integrative metabolomics-genomics approach reveals key metabolic pathways and regulators of alzheimer’s disease. Alzheimers Dement. 2021;18(6):1260–78. https://doi.org/10.1002/alz.12468.

Article  CAS  PubMed  Google Scholar 

Xiao Y-L, Gong Y, Qi Y-J, Shao Z-M, Jiang Y-Z. Effects of dietary intervention on human diseases: molecular mechanisms and therapeutic potential. Signal Transduct Target Ther. 2024;9(1). https://doi.org/10.1038/s41392-024-01771-x.

Haynes PR, Pyfrom ES, Li Y, Stein C, Cuddapah VA, Jacobs JA, et al. A neuron–glia lipid metabolic cycle couples daily sleep to mitochondrial homeostasis. Nat Neurosci. 2024;27(4):666–78. https://doi.org/10.1038/s41593-023-01568-1.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Liu S, Zhong H, Zhu J, Wu L. Identification of blood metabolites associated with risk of alzheimer’s disease by integrating genomics and metabolomics data. Mol Psychiatry. 2024;29(4):1153–62. https://doi.org/10.1038/s41380-023-02400-9.

Article  PubMed  PubMed Central  Google Scholar 

van der Lee SJ, Teunissen CE, Pool R, Shipley MJ, Teumer A, Chouraki V, et al. Circulating metabolites and general cognitive ability and dementia: evidence from 11 cohort studies. Alzheimers Dement. 2018;14(6):707–22. https://doi.org/10.1016/j.jalz.2017.11.012.

Article  PubMed  Google Scholar 

Elsworth B, Lyon M, Alexander T, Liu Y, Matthews P, Hallett J et al. The MRC IEU OpenGWAS data infrastructure. BioRxiv. 2020.08.10.244293v1. https://doi.org/10.1101/2020.08.10.244293.

Chong M, Mohammadi-Shemirani P, Perrot N, Nelson W, Morton R, Narula S, et al. GWAS and ExWAS of blood mitochondrial DNA copy number identifies 71 loci and highlights a potential causal role in dementia. Elife. 2022;11. https://doi.org/10.7554/eLife.70382.

Kettunen J, Demirkan A, Würtz P, Draisma HHM, Haller T, Rawal R, et al. Genome-wide study for Circulating metabolites identifies 62 loci and reveals novel systemic effects of LPA. Nat Commun. 2016;7(1). https://doi.org/10.1038/ncomms11122.

Shin S-Y, Fauman EB, Petersen A-K, Krumsiek J, Santos R, Huang J, et al. An atlas of genetic influences on human blood metabolites. Nat Genet. 2014;46(6):543–50. https://doi.org/10.1038/ng.2982.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Suhre K, Arnold M, Bhagwat AM, Cotton RJ, Engelke R, Raffler J, et al. Connecting genetic risk to disease end points through the human blood plasma proteome. Nat Commun. 2017;8(1). https://doi.org/10.1038/ncomms14357.

Ardissino M, Morley AP, Slob EAW, Schuermans A, Rayes B, Raisi-Estabragh Z, et al. Birth weight influences cardiac structure, function, and disease risk: evidence of a causal association. Eur Heart J. 2024;45(6):443–54. https://doi.org/10.1093/eurheartj/ehad631.

Article  PubMed  Google Scholar 

Slatkin M. Linkage disequilibrium-understanding the evolutionary past and mapping the medical future. Nat Rev Genet. 2008;9(6):477–85. https://doi.org/10.1038/nrg2361.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bull CJ, Bell JA, Murphy N, Sanderson E, Davey Smith G, Timpson NJ, et al. Adiposity, metabolites, and colorectal cancer risk: Mendelian randomization study. BMC Med. 2020;18(1). https://doi.org/10.1186/s12916-020-01855-9.

Kamat MA, Blackshaw JA, Young R, Surendran P, Burgess S, Danesh J, et al. PhenoScanner V2: an expanded tool for searching human genotype-phenotype associations. Bioinformatics. 2019;35(22):4851–3. https://doi.org/10.1093/bioinformatics/btz469.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lin S-H, Brown DW, Machiela MJ. LDtrait: an online tool for identifying published phenotype associations in linkage disequilibrium. Cancer Res. 2020;80(16):3443–6. https://doi.org/10.1158/0008-5472.Can-20-0985.

Article  CAS  PubMed