Density of ectopic fat depots predict distinct biomarkers of glycemic and insulinemic status in persons with HIV

Trickey A, Sabin CA, Burkholder G, Crane H, Monforte AA, Egger M, et al. Life expectancy after 2015 of adults with HIV on long-term antiretroviral therapy in Europe and North America: a collaborative analysis of cohort studies. Lancet HIV. 2023;10:e295–307.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hernandez-Romieu AC, Garg S, Rosenberg ES, Thompson-Paul AM, Skarbinski J. Is diabetes prevalence higher among HIV-infected individuals compared with the general population? Evidence from MMP and NHANES 2009-2010. BMJ Open Diabetes Res Care. 2017;5:e000304.

Article  PubMed  PubMed Central  Google Scholar 

Spieler G, Westfall AO, Long DM, Cherrington A, Burkholder GA, Funderburg N, et al. Trends in diabetes incidence and associated risk factors among people with HIV in the current treatment era. AIDS. 2022;36:1811–8.

Article  CAS  PubMed  Google Scholar 

O’Halloran JA, Sahrmann J, Parra-Rodriguez L, Vo DT, Butler AM, Olsen MA, et al. Integrase strand transfer inhibitors are associated with incident diabetes mellitus in people with human immunodeficiency virus. Clin Infect Dis. 2022;75:2060–5.

Article  PubMed  PubMed Central  Google Scholar 

Bailin SS, Koethe JR. Diabetes in HIV: the link to weight gain. Curr HIV/AIDS Rep. 2023;20:9–18.

Article  PubMed  Google Scholar 

Herrin M, Tate JP, Akgün KM, Butt AA, Crothers K, Freiberg MS, et al. Weight gain and incident diabetes among HIV-infected veterans initiating antiretroviral therapy compared with uninfected individuals. J Acquir Immune Defic Syndr. 2016;73:228–36.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hyatt AN, Lake JE. Ectopic fat and cardiac health in people with HIV: serious as a heart attack. Curr HIV/AIDS Rep. 2022;19:415–24.

Godfrey C, Bremer A, Alba D, Apovian C, Koethe JR, Koliwad S, et al. Obesity and fat metabolism in human immunodeficiency virus-infected individuals: immunopathogenic mechanisms and clinical implications. J Infect Dis. 2019;220:420–31.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Debroy P, Feng H, Miao H, Milic J, Ligabue G, Draisci S, et al. Changes in central adipose tissue after switching to integrase inhibitors. HIV Res Clin Pract. 2020;21:168–73.

Article  CAS  PubMed  Google Scholar 

Conley LJ, Bush TJ, Rupert AW, Sereti I, Patel P, Brooks JT, et al. Obesity is associated with greater inflammation and monocyte activation among HIV-infected adults receiving antiretroviral therapy. AIDS. 2015;29:2201–7.

Article  CAS  PubMed  Google Scholar 

Winder C, Clark M, Frood R, Smith L, Bulpitt A, Cook G, et al. Automated extraction of body composition metrics from abdominal CT or MR imaging: a scoping review. Eur J Radio. 2024;181:111764.

Article  Google Scholar 

Adrian S, Miao H, Feng H, Scherzinger A, Nardini G, Beghetto B, et al. Effects of atazanavir, darunavir, and raltegravir on fat and muscle among persons living with HIV. HIV Res Clin Pract. 2020;21:91–8.

Article  CAS  PubMed  Google Scholar 

Ladeiras-Lopes R, Sampaio F, Bettencourt N, Fontes-Carvalho R, Ferreira N, Leite-Moreira A, et al. The ratio between visceral and subcutaneous abdominal fat assessed by computed tomography is an independent predictor of mortality and cardiac events. Rev Esp Cardiol. 2017;70:331–7.

Article  PubMed  Google Scholar 

Debroy P, Lake JE, Moser C, Olefsky M, Erlandson KM, Scherzinger A, et al. Antiretroviral therapy initiation is associated with decreased visceral and subcutaneous adipose tissue density in people living with human immunodeficiency virus. Clin Infect Dis. 2021;72:979–86.

Article  CAS  PubMed  Google Scholar 

Oliveira VHF, Borsari AL, Webel AR, Erlandson KM, Deminice R. Sarcopenia in people living with the human immunodeficiency virus: a systematic review and meta-analysis. Eur J Clin Nutr. 2020;74:1009–21.

Article  PubMed  Google Scholar 

Medici F, Rizzo S, Buwenge M, Arcelli A, Ferioli M, Macchia G, et al. Everything you always wanted to know about sarcopenia but were afraid to ask: a quick guide for radiation oncologists (impact of sarcopenia in radiotherapy: the AFRAID project). Curr Oncol. 2022;29:8513–28.

Article  PubMed  PubMed Central  Google Scholar 

Lake JE, Taron J, Ribaudo HJ, Leon-Cruz J, Utay NS, Swaminathan S, et al. Hepatic steatosis and nonalcoholic fatty liver disease are common and associated with cardiometabolic risk in a primary prevention cohort of people with HIV. AIDS. 2023;27:2149–59.

Article  Google Scholar 

Natsag J, Erlandson KM, Sellmeyer DE, Haberlen SA, Margolick J, Jacobson LP, et al. HIV infection is associated with increased fatty infiltration of the thigh muscle with aging independent of fat distribution. PLoS One. 2017;12:e0169184.

Article  PubMed  PubMed Central  Google Scholar 

Erlandson KM, Langan S, Lake JE, Sun J, Sharma A, Adrian S, et al. Differences in muscle quantity and quality by HIV serostatus and sex. J Frailty Aging. 2022;11:309–17.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Miljkovic I, Kuipers AL, Cvejkus R, Bunker CH, Patrick AL, Gordon CL, et al. Myosteatosis increases with aging and is associated with incident diabetes in African ancestry men. Obesity (Silver Spring). 2016;24:476–82.

Article  CAS  PubMed  Google Scholar 

Tanaka M, Okada H, Hashimoto Y, Kumagai M, Nishimura H, Fukui M. Low-attenuation muscle is a predictor of diabetes mellitus: a population-based cohort study. Nutrition. 2020;74:110752.

Article  CAS  PubMed  Google Scholar 

Lake JE, Moser C, Johnston L, Magyar C, Nelson SC, Erlandson KM, et al. CT fat density accurately reflects histologic fat quality in adults with HIV on and off antiretroviral therapy. J Clin Endocrinol Metab. 2019;104:4857.

Article  PubMed  PubMed Central  Google Scholar 

Swartz AZ, Robles ME, Park S, Esfandiari H, Bradshaw M, Koethe JR, et al. Cardiometabolic characteristics of obesity phenotypes in persons with HIV. Open Forum Infect Dis. 2024;11:376.

Article  Google Scholar 

Martin L, Birdsell L, MacDonald N, Reiman T, Clandinin MT, McCargar LJ, et al. Cancer cachexia in the age of obesity: skeletal muscle depletion is a powerful prognostic factor, independent of body mass index. J Clin Oncol. 2013;31:1539–47. https://doi.org/10.1200/JCO.2012.45.2722.

Article  PubMed  Google Scholar 

Sax PE, Erlandson KM, Lake JE, Mccomsey GA, Orkin C, Esser S, et al. Weight gain following initiation of antiretroviral therapy: risk factors in randomized comparative clinical trials. Clin Infect Dis. 2020;71:1379–89.

Article  CAS  PubMed  Google Scholar 

Wanjalla CN, McDonnell WJ, Barnett L, Simmons JD, Furch BD, Lima MC, et al. Adipose tissue in persons with HIV is enriched for CD4+ T effector memory and T effector memory RA+ cells, which show higher CD69 expression and CD57, CX3CR1, GPR56 co-expression with increasing glucose intolerance. Front Immunol. 2019;10:408.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Gorwood J, Bourgeois C, Mantecon M. Impact of HIV/simian immunodeficiency virus infection and viral proteins on adipose tissue fibrosis and adipogenesis. AIDS. 2019;33:953–64.

Article  CAS  PubMed  Google Scholar 

Gorwood J, Bourgeois C, Pourcher V, Pourcher G, Charlotte F, Mantecon M, et al. The integrase inhibitors dolutegravir and raltegravir exert proadipogenic and profibrotic effects and induce insulin resistance in human/simian adipose tissue and human adipocytes. Clin Infect Dis. 2020;71:e549–e560.

Article  CAS  PubMed  Google Scholar 

Keshavjee SH, Schwenger KJP, Yadav J, Pickel L, Ghorbani Y, Sung HK, et al. Adipose tissue and plasma markers associated with hba1c pre- and post-bariatric surgery: a cross-sectional and cohort study. Obes Surg. 2023;33:2443–51.

Article  PubMed  Google Scholar 

Suarez-Cuenca JA, Pena-Sosa G, Vega-Moreno K, Banderas-Lares DZ, Salamanca-Garcia M, Martinez-Hernandez JE, et al. Enlarged adipocytes from subcutaneous vs. visceral adipose tissue differentially contribute to metabolic dysfunction and atherogenic risk of patients with obesity. Sci Rep. 2021;11:1831.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Sachs S, Zarini S, Kahn DE, Harrison KA, Perreault L, Phang T, et al. Intermuscular adipose tissue directly modulates skeletal muscle insulin sensitivity in humans. Am J Physiol Endocrinol Metab. 2019;316:E866–E879.

Article  CA

Comments (0)

No login
gif