Al-Qazzaz NK, Ali SH, Ahmad SA, Islam S, Mohamad K (2014) Cognitive impairment and memory dysfunction after a stroke diagnosis: A post-stroke memory assessment. Neuropsychiatr Dis Treat 10. https://doi.org/10.2147/NDT.S67184
Albert-Gascó H, Ros-Bernal F, Castillo-Gómez E, Olucha-Bordonau FE (2020) Map/erk signaling in developing cognitive and emotional function and its effect on pathological and neurodegenerative processes. Int J Mol Sci. https://doi.org/10.3390/ijms21124471
Article PubMed PubMed Central Google Scholar
Campbell BCV, De Silva DA, Macleod MR, Coutts SB, Schwamm LH, Davis SM et al (2019) Ischaemic stroke. Nat Rev Dis Primers. https://doi.org/10.1038/s41572-019-0118-8
Cheon SY, Cho KJ (2019) Pathological role of apoptosis signal-regulating kinase 1 in human diseases and its potential as a therapeutic target for cognitive disorders. J Mol Med. https://doi.org/10.1007/s00109-018-01739-9
Childs BG, Durik M, Baker DJ, Van Deursen JM (2015) Cellular senescence in aging and age-related disease: from mechanisms to therapy. Nat Med. https://doi.org/10.1038/nm.4000
Article PubMed PubMed Central Google Scholar
Clarkson AN, López-Valdés HE, Overman JJ, Charles AC, Brennan KC, Thomas Carmichael S (2013) Multimodal examination of structural and functional remapping in the mouse photothrombotic stroke model. J Cereb Blood Flow Metab. https://doi.org/10.1038/jcbfm.2013.7
Article PubMed PubMed Central Google Scholar
Correa-Paz C, Pérez-Mato M, Bellemain-Sagnard M, González-Domínguez M, Marie P, Pérez-Gayol L et al (2024) Pharmacological preclinical comparison of tenecteplase and alteplase for the treatment of acute stroke. J Cereb Blood Flow Metab. https://doi.org/10.1177/0271678X241237427
Article PubMed PubMed Central Google Scholar
Cramer SC (2008) Repairing the human brain after stroke: I. mechanisms of spontaneous recovery. Ann Neurol. https://doi.org/10.1002/ana.21393
Cunningham KS, Gotlieb AI (2005) The role of shear stress in the pathogenesis of atherosclerosis. Lab Invest. https://doi.org/10.1038/labinvest.3700215
Dobolyi A, Vincze C, Pál G, Lovas G (2012) The neuroprotective functions of transforming growth factor beta proteins. Int J Mol Sci. https://doi.org/10.3390/ijms13078219
Article PubMed PubMed Central Google Scholar
Dong Z, Han H, Li H, Bai Y, Wang W, Tu M et al (2015) Long-term potentiation decay and memory loss are mediated by AMPAR endocytosis. J Clin Invest. https://doi.org/10.1172/JCI77888
Article PubMed PubMed Central Google Scholar
Duronio RJ, Xiong Y (2013) Signaling pathways that control cell proliferation. Cold Spring Harb Perspect Biol. https://doi.org/10.1101/cshperspect.a008904
Article PubMed PubMed Central Google Scholar
Garcia S, Saldana-Caboverde A, Anwar M, Raval AP, Nissanka N, Pinto M et al (2022) Enhanced glycolysis and GSK3 inactivation promote brain metabolic adaptations following neuronal mitochondrial stress. Hum Mol Genet. https://doi.org/10.1093/hmg/ddab282
Article PubMed PubMed Central Google Scholar
Gee MS, Son SH, Jeon SH, Do J, Kim N, Ju YJ et al (2020) A selective p38α/β MAPK inhibitor alleviates neuropathology and cognitive impairment, and modulates microglia function in 5XFAD mouse. Alzheimers Res Ther. https://doi.org/10.1186/s13195-020-00617-2
Article PubMed PubMed Central Google Scholar
WHO (2019) Global health estimates: leading causes of death. World Health Organisation
World Stroke Organization (2022) Global stroke fact sheet 2022, vol 13. World Stroke Organization (WSO)
Gottesman RF, Hillis AE (2010) Predictors and assessment of cognitive dysfunction resulting from ischaemic stroke. Lancet Neurol. https://doi.org/10.1016/S1474-4422(10)70164-2
Article PubMed PubMed Central Google Scholar
Goyal A, Agrawal A, Verma A, Dubey N (2022) The PI3K-AKT pathway: A plausible therapeutic target in parkinson’s disease. Exp Mol Pathol 129. https://doi.org/10.1016/j.yexmp.2022.104846
Gravandi MM, Abdian S, Tahvilian M, Iranpanah A, Moradi SZ, Fakhri S et al (2023) Therapeutic targeting of Ras/Raf/MAPK pathway by natural products: a systematic and mechanistic approach for neurodegeneration. Phytomedicine. https://doi.org/10.1016/j.phymed.2023.154821
Gu C, Zhang Q, Li Y, Li R, Feng J, Chen W et al (2022) The PI3K/AKT pathway—the potential key mechanisms of traditional Chinese medicine for stroke. Front Med Lausanne. https://doi.org/10.3389/fmed.2022.900809
Article PubMed PubMed Central Google Scholar
Gutierrez J (2020) Heterogeneity of the circle of Willis and its implication in hippocampal perfusion. Brain. https://doi.org/10.1093/brain/awaa169
Article PubMed PubMed Central Google Scholar
Higashi Y, Aratake T, Shimizu T, Shimizu S, Saito M (2021) Protective role of glutathione in the hippocampus after brain ischemia. Int J Mol Sci. https://doi.org/10.3390/ijms22157765
Article PubMed PubMed Central Google Scholar
Hou K, Xiao ZC, Dai HL (2022) P38 MAPK endogenous inhibition improves neurological deficits in global cerebral ischemia/reperfusion mice. Neural Plast. https://doi.org/10.1155/2022/3300327
Article PubMed PubMed Central Google Scholar
Hull M, Lieb K, Fiebich B (2012) Pathways of inflammatory activation in alzheimers disease: potential targets for disease modifying drugs. Curr Med Chem 9. https://doi.org/10.2174/0929867023371292
Imbrosci B, Mittmann T (2011) Functional consequences of the disturbances in the GABA-mediated inhibition induced by injuriesin the cerebral cortex. Neural Plast. https://doi.org/10.1155/2011/614329
Article PubMed PubMed Central Google Scholar
Jehle A, Garaschuk O (2022) The interplay between cGMP and calcium signaling in Alzheimer’s disease. Int J Mol Sci. https://doi.org/10.3390/ijms23137048
Article PubMed PubMed Central Google Scholar
Jiang LH, Roger S (2020) Targeting the P2X7 receptor in microglial cells to prevent brain inflammation. Neural Regen Res. https://doi.org/10.4103/1673-5374.272575
Article PubMed PubMed Central Google Scholar
Johnson AC (2023) Hippocampal vascular supply and its role in vascular cognitive impairment. Stroke. https://doi.org/10.1161/STROKEAHA.122.038263
Article PubMed PubMed Central Google Scholar
Kaminska B, Gozdz A, Zawadzka M, Ellert-Miklaszewska A, Lipko M (2009) Mapk signal transduction underlying brain inflammation and gliosis as therapeutic target. Anat Rec. https://doi.org/10.1002/ar.21047
Khoshnam SE, Sarkaki A, Khorsandi L, Winlow W, Badavi M, Moghaddam HF et al (2017) Vanillic acid attenuates effects of transient bilateral common carotid occlusion and reperfusion in rats. Biomed Pharmacother. https://doi.org/10.1016/j.biopha.2017.10.052
Kim D, Pertea G, Trapnell C, Pimentel H, Kelley R, Salzberg SL (2013) Tophat2: accurate alignment of transcriptomes in the presence of insertions, deletions and gene fusions. Genome Biol. https://doi.org/10.1186/gb-2013-14-4-r36
Article PubMed PubMed Central Google Scholar
Koukalova L, Chmelova M, Amlerova Z, Vargova L (2024) Out of the core: the impact of focal ischemia in regions beyond the penumbra. Front Cell Neurosci. https://doi.org/10.3389/fncel.2024.1336886
Article PubMed PubMed Central Google Scholar
Kumar Verma A, Farswan Singh M, Awasthi A (2021) Role of p38 MAP kinase inhibitor (SB239063) and vitamin B12 against neuroinflammation. Int J Pharm Investig. https://doi.org/10.5530/ijpi.2021.1.17
Lai TW, Zhang S, Wang YT (2014) Excitotoxicity and stroke: identifying novel targets for neuroprotection. Prog Neurobiol. https://doi.org/10.1016/j.pneurobio.2013.11.006
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