Kwon NY, Sung Sung H, Ferlay J, Siegel RL, et al. Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2021;71(3):209–49.
Zugazagoitia J, Guedes C, Ponce S, Ferrer I, Molina-Pinelo S, Paz-Ares L. Current challenges in cancer treatment. Clin Ther. 2016;38(7):1551–66.
Avci FG, Akbulut BS, Ozkirimli E. Membrane active peptides and their biophysical characterization. Biomolecules. 2018;8(3):77.
Article PubMed Central PubMed Google Scholar
Zhou J, Wan C, Cheng J, et al. Delivery strategies for melittin-based cancer therapy. ACS Appl Mater Interfaces. 2021;13(15):17158–73.
Article CAS PubMed Google Scholar
Kwon NY, Sung SH, Sung HK, Park JK. Anticancer activity of bee venom components against breast cancer. Toxins. 2022;14(7):460.
Article CAS PubMed Central PubMed Google Scholar
Zhou Y, Zhang S, Chen Z, et al. Targeted delivery of secretory promelittin via novel Poly(lactone-co-β-amino ester) nanoparticles for treatment of breast cancer brain metastases. Adv Sci. 2020;7(5):1901866.
Zhou Y, Ye T, Ye C, et al. Secretions from hypochlorous acid-treated tumor cells delivered in a melittin hydrogel potentiate cancer immunotherapy. Bioact Mater. 2021;9:541–53.
PubMed Central PubMed Google Scholar
Han E, Kim D, Cho Y, Lee S, Kim J, Kim H. Development of polymersomes co-delivering doxorubicin and melittin to overcome multidrug resistance. Molecules. 2023;28(3):1087.
Article CAS PubMed Central PubMed Google Scholar
Guo Y, Zhang X, Wang SZ, Feng HH, Wu SY, Wu FG. Metal-phenolic network-facilitated “foe-to-friend” conversion of melittin for cancer immunotherapy with boosted abscopal effect. Research. 2023;6:0052.
Article CAS PubMed Central PubMed Google Scholar
Mohammed ER, Elmasry GF. Development of newly synthesised quinazolinone-based CDK2 inhibitors with potent efficacy against melanoma. J Enzyme Inhib Med Chem. 2022;37(1):686–700.
Article CAS PubMed Central PubMed Google Scholar
Jirawatnotai S, Hu Y, Michowski W, et al. A function for cyclin D1 in DNA repair uncovered by protein interactome analyses in human cancers. Nature. 2011;474(7350):230–4.
Article CAS PubMed Central PubMed Google Scholar
Mansour GH, El-Magd MA, Mahfouz DH, et al. Bee venom and its active component Melittin synergistically potentiate the anticancer effect of sorafenib against HepG2 cells. Bioorg Chem. 2021;116:105329.
Article CAS PubMed Google Scholar
Tipgomut C, Wongprommoon A, Takeo E, Ittiudomrak T, Puthong S, Chanchao C. Melittin induced G1 cell cycle arrest and apoptosis in chago-K1 human bronchogenic carcinoma cells and inhibited the differentiation of THP-1 cells into tumour- associated macrophages. Asian Pac J Cancer Prev. 2018;19(12):3427–34.
Article CAS PubMed Central PubMed Google Scholar
Sun M, Wu Y, Zhou Z, Liu S, Mao S, Li G. Co-delivery of EGCG and melittin with self-assembled fluoro-nanoparticles for enhanced cancer therapy. Aging. 2023;15(11):4875–88.
PubMed Central PubMed Google Scholar
Fahmy UA, Badr-Eldin SM, Aldawsari HM, et al. Potentiality of raloxifene loaded melittin functionalized lipidic nanovesicles against pancreatic cancer cells. Drug Deliv. 2022;29(1):1863–77.
Article CAS PubMed Central PubMed Google Scholar
Shi P, Xie S, Yang J, et al. Pharmacological effects and mechanisms of bee venom and its main components: recent progress and perspective. Front Pharmacol. 2022;13:1001553.
Article CAS PubMed Central PubMed Google Scholar
Obeidat M, Al-Khraisat IF, Jaradat DMM, et al. Mellitin peptide quantification in seasonally collected crude bee venom and its anticancer effects on myelogenous K562 human leukaemia cell line. BMC Complement Med Ther. 2023;23(1):132.
Article CAS PubMed Central PubMed Google Scholar
Rady I, Siddiqui IA, Rady M, Mukhtar H. Melittin, a major peptide component of bee venom, and its conjugates in cancer therapy. Cancer Lett. 2017;402:16–31.
Article CAS PubMed Central PubMed Google Scholar
Moghaddam FD, Mortazavi P, Hamedi S, Nabiuni M, Roodbari NH. Apoptotic effects of melittin on 4T1 breast cancer cell line is associated with Up regulation of Mfn1 and Drp1 mRNA expression. Anticancer Agents Med Chem. 2020;20(7):790–9.
Article CAS PubMed Google Scholar
Yu CL, Lee HL, Yang SF, et al. Protodioscin induces mitochondrial apoptosis of human hepatocellular carcinoma cells through eliciting ER stress-mediated IP3R targeting Mfn1/Bak expression. J Hepatocell Carcinoma. 2022;9:327–41.
Article PubMed Central PubMed Google Scholar
Peña-Blanco A, García-Sáez AJ. Bax, Bak and beyond—mitochondrial performance in apoptosis. FEBS J. 2018;285(3):416–31.
Ceremuga M, Stela M, Janik E, et al. Melittin-A natural peptide from bee venom which induces apoptosis in human leukaemia cells. Biomolecules. 2020;10(2):247.
Article CAS PubMed Central PubMed Google Scholar
Yan R, Dai W, Wu R, Huang H, Shu M. Therapeutic targeting m6A-guided miR-146a-5p signaling contributes to the melittin-induced selective suppression of bladder cancer. Cancer Lett. 2022;534:215615.
Article CAS PubMed Google Scholar
Soliman C, Eastwood S, Truong VK, Ramsland PA, Elbourne A. The membrane effects of melittin on gastric and colorectal cancer. PLoS ONE. 2019;14(10):e0224028.
Article CAS PubMed Central PubMed Google Scholar
Moreno M, Giralt E. Three valuable peptides from bee and wasp venoms for therapeutic and biotechnological use: melittin, apamin and mastoparan. Toxins. 2015;7(4):1126–50.
Article CAS PubMed Central PubMed Google Scholar
Liu M, Wang H, Liu L, Wang B, Sun G. Melittin-MIL-2 fusion protein as a candidate for cancer immunotherapy. J Transl Med. 2016;14(1):155.
Article PubMed Central PubMed Google Scholar
Xu T, Cui T, Peng L, Kong S, Zou J, Tian X. The anti-hepatocellular carcinoma activity of Mel-P15 is mediated by natural killer cells. Oncol Lett. 2017;14(6):6901–6.
PubMed Central PubMed Google Scholar
Rocha MM, Dariva I, Zornoff GC, et al. A new therapeutic approach for bone metastasis in colorectal cancer: intratumoral melittin. J Venom Anim Toxins Incl Trop Dis. 2022;28:e20210067.
CAS PubMed Central PubMed Google Scholar
Fomitcheva-Khartchenko A, Kashyap A, Geiger T, Kaigala GV. Space in cancer biology: its role and implications. Trends Cancer. 2022;8(12):1019–32.
Article CAS PubMed Google Scholar
Huh JE, Kang JW, Nam D, et al. Melittin suppresses VEGF-A-induced tumor growth by blocking VEGFR-2 and the COX-2-mediated MAPK signaling pathway. J Nat Prod. 2012;75(11):1922–9.
Article CAS PubMed Google Scholar
Shin JM, Jeong YJ, Cho HJ, et al. Melittin suppresses HIF-1α/VEGF expression through inhibition of ERK and mTOR/p70S6K pathway in human cervical carcinoma cells. PLoS ONE. 2013;8(7):e69380.
Article CAS PubMed Central PubMed Google Scholar
El Bakary NM, Alsharkawy AZ, Shouaib ZA, Barakat EMS. Role of bee venom and melittin on restraining angiogenesis and metastasis in γ-irradiated solid ehrlich carcinoma-bearing mice. Integr Cancer Ther. 2020;19:1–13.
Aufschnaiter A, Kohler V, Khalifa S, et al. Apitoxin and its components against cancer, neurodegeneration and rheumatoid arthritis: limitations and possibilities. Toxins. 2020;12(2):66.
Article CAS PubMed Central PubMed Google Scholar
Liu S, Yu M, He Y, et al. Melittin prevents liver cancer cell metastasis through inhibition of the Rac1-dependent pathway. Hepatology. 2008;47(6):1964–73.
Article CAS PubMed Google Scholar
Salimian F, Nabiuni M, Salehghamari E. Melittin prevents metastasis of epidermal growth factor-induced MDA-MB-231 cells through the inhibition of the SDF-1α/CXCR4 signaling pathway. Cell J. 2022;24(2):85–90.
PubMed Central PubMed Google Scholar
Chen M, Rong R, Xia X. Spotlight on pyroptosis: role in pathogenesis and therapeutic potential of ocular diseases. J Neuroinflamm. 2022;19(1):183.
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