Samsu N (2021) Diabetic nephropathy: challenges in pathogenesis, diagnosis, and treatment. Biomed Res Int 2021:1497449. https://doi.org/10.1155/2021/1497449
Article CAS PubMed PubMed Central Google Scholar
Faselis C, Katsimardou A, Imprialos K, Deligkaris P, Kallistratos M, Dimitriadis K (2020) Microvascular complications of type 2 diabetes mellitus. Curr Vasc Pharmacol 18(2):117–124. https://doi.org/10.2174/1570161117666190502103733
Article CAS PubMed Google Scholar
Sladek R, Bader JA, Giguère V (1997) The orphan nuclear receptor estrogen-related receptor alpha is a transcriptional regulator of the human medium-chain acyl coenzyme A dehydrogenase gene. Mol Cell Biol 17(9):5400–5409. https://doi.org/10.1128/MCB.17.9.5400
Article CAS PubMed PubMed Central Google Scholar
Mason E, Hindmarch CCT, Dunham-Snary KJ (2023) Medium-chain Acyl-COA dehydrogenase deficiency: pathogenesis, diagnosis, and treatment. Endocrinol Diabetes Metab 6(1):e385. https://doi.org/10.1002/edm2.385
Article CAS PubMed Google Scholar
Tolwani RJ, Hamm DA, Tian L, Sharer JD, Vockley J, Rinaldo P, Matern D, Schoeb TR, Wood PA (2005) Medium-chain acyl-CoA dehydrogenase deficiency in gene-targeted mice. PLoS Genet 1(2):e23. https://doi.org/10.1371/journal.pgen.0010023
Article CAS PubMed PubMed Central Google Scholar
Afreh-Mensah D, Agwu JC (2021) Coexistence of medium chain acyl-CoA dehydrogenase deficiency (MCADD) and type 1 diabetes (T1D): a management challenge. BMJ Case Rep 14(3):e239325. https://doi.org/10.1136/bcr-2020-239325
Article PubMed PubMed Central Google Scholar
Djouadi F, Bastin J, Kelly DP, Merlet-Benichou C (1996) Transcriptional regulation by glucocorticoids of mitochondrial oxidative enzyme genes in the developing rat kidney. Biochem J 315 (Pt 2)(Pt 2):555– 62. https://doi.org/10.1042/bj3150555
Li S, Wu P, Yarlagadda P, Vadjunec NM, Proia AD, Harris RA, Portilla D (2004) PPAR alpha ligand protects during cisplatin-induced acute renal failure by preventing Inhibition of renal FAO and PDC activity. Am J Physiol Ren Physiol 286(3):F572–F580. https://doi.org/10.1152/ajprenal.00190.2003
Li S, Nagothu KK, Desai V, Lee T, Branham W, Moland C, Megyesi JK, Crew MD, Portilla D (2009) Transgenic expression of proximal tubule peroxisome proliferator-activated receptor-alpha in mice confers protection during acute kidney injury. Kidney Int 76(10):1049–1062. https://doi.org/10.1038/ki.2009.330
Article CAS PubMed PubMed Central Google Scholar
Zhou Y, Lin S, Zhang L, Li Y (2016) Resveratrol prevents renal lipotoxicity in high-fat diet-treated mouse model through regulating PPAR-α pathway. Mol Cell Biochem 411(1–2):143–150. https://doi.org/10.1007/s11010-015-2576-y
Article CAS PubMed Google Scholar
Muroya Y, Ito O (2016) Effect of Clofibrate on fatty acid metabolism in the kidney of puromycin-induced nephrotic rats. Clin Exp Nephrol 20(6):862–870. https://doi.org/10.1007/s10157-016-1253-0
Article CAS PubMed Google Scholar
Tang C, Deng X, Qu J, Miao Y, Tian L, Zhang M, Li X, Sun B, Chen L (2023) Fenofibrate attenuates renal tubular cell apoptosis by Up-Regulating MCAD in diabetic kidney disease. Drug Des Devel Ther 17:1503–1514. https://doi.org/10.2147/DDDT.S405266
Article CAS PubMed PubMed Central Google Scholar
Bowden J, Holmes MV (2019) Meta-analysis and Mendelian randomization: A review. Res Synth Methods 10(4):486–496. https://doi.org/10.1002/jrsm.1346
Article PubMed PubMed Central Google Scholar
Verbanck M, Chen CY, Neale B, Do R (2018) Detection of widespread horizontal Pleiotropy in causal relationships inferred from Mendelian randomization between complex traits and diseases. Nat Genet 50(5):693–698. https://doi.org/10.1038/s41588-018-0099-7
Article CAS PubMed PubMed Central Google Scholar
Pietzner M, Wheeler E, Carrasco-Zanini J, Raffler J, Kerrison ND, Oerton E, Auyeung VPW, Luan J, Finan C, Casas JP, Ostroff R, Williams SA, Kastenmüller G, Ralser M, Gamazon ER, Wareham NJ, Hingorani AD, Langenberg C (2020) Genetic architecture of host proteins involved in SARS-CoV-2 infection. Nat Commun 11(1):6397. https://doi.org/10.1038/s41467-020-19996-z
Article CAS PubMed PubMed Central Google Scholar
Shi H, Zhao T, Geng R, Sun L, Fan H (2023) The associations between gut microbiota and chronic respiratory diseases: a Mendelian randomization study. Front Microbiol 14:1200937. https://doi.org/10.3389/fmicb.2023.1200937
Article PubMed PubMed Central Google Scholar
Feng R, Lu M, Xu J, Zhang F, Yang M, Luo P, Xu K, Xu P (2022) Pulmonary embolism and 529 human blood metabolites: genetic correlation and two-sample Mendelian randomization study. BMC Genom Data 23(1):69. https://doi.org/10.1186/s12863-022-01082-6
Article CAS PubMed PubMed Central Google Scholar
Rosoff DB, Davey Smith G, Mehta N, Clarke TK, Lohoff FW (2020) Evaluating the relationship between alcohol consumption, tobacco use, and cardiovascular disease: A multivariable Mendelian randomization study. PLoS Med 17(12):e1003410. https://doi.org/10.1371/journal.pmed.1003410
Article PubMed PubMed Central Google Scholar
Hemani G, Tilling K, Davey Smith G (2017) Orienting the causal relationship between imprecisely measured traits using GWAS summary data. PLoS Genet 13(11):e1007081. https://doi.org/10.1371/journal.pgen.1007081
Article CAS PubMed PubMed Central Google Scholar
Hemani G, Zheng J, Elsworth B, Wade KH, Haberland V, Baird D, Laurin C, Burgess S, Bowden J, Langdon R, Tan VY, Yarmolinsky J, Shihab HA, Timpson NJ, Evans DM, Relton C, Martin RM, Davey Smith G, Gaunt TR, Haycock PC (2018) The MR-Base platform supports systematic causal inference across the human phenome. Elife 7:e34408. https://doi.org/10.7554/eLife.34408
Article PubMed PubMed Central Google Scholar
Niu H, Ren X, Tan E, Wan X, Wang Y, Shi H, Hou Y, Wang L (2023) CD36 deletion ameliorates diabetic kidney disease by restoring fatty acid oxidation and improving mitochondrial function. Ren Fail 45(2):2292753. https://doi.org/10.1080/0886022X.2023.2292753
Article PubMed PubMed Central Google Scholar
Hu H, Li W, Hao Y, Peng Z, Zou Z, Liang W (2024) Baicalin ameliorates renal fibrosis by upregulating CPT1α-mediated fatty acid oxidation in diabetic kidney disease. Phytomedicine 122:155162. https://doi.org/10.1016/j.phymed.2023.155162
Article CAS PubMed Google Scholar
Houten SM, Wanders RJ (2010) A general introduction to the biochemistry of mitochondrial fatty acid β-oxidation. J Inherit Metab Dis 33(5):469–477. https://doi.org/10.1007/s10545-010-9061-2
Article CAS PubMed PubMed Central Google Scholar
Chen S, Lu Z, Jia H, Yang B, Liu C, Yang Y, Zhang S, Wang Z, Yang L, Li S, Li J, Yang C (2023) Hepatocyte-specific Mas activation enhances lipophagy and fatty acid oxidation to protect against acetaminophen-induced hepatotoxicity in mice. J Hepatol 78(3):543–557. https://doi.org/10.1016/j.jhep.2022.10.028
Article CAS PubMed Google Scholar
Fromenty B, Roden M (2023) Mitochondrial alterations in fatty liver diseases. J Hepatol 78(2):415–429. https://doi.org/10.1016/j.jhep.2022.09.020
Article CAS PubMed Google Scholar
Jiang MY, Man WR, Zhang XB, Zhang XH, Duan Y, Lin J, Zhang Y, Cao Y, Wu DX, Shu XF, Xin L, Wang H, Zhang X, Li CY, Gu XM, Zhang X, Sun DD (2023) Adipsin inhibits Irak2 mitochondrial translocation and improves fatty acid β-oxidation to alleviate diabetic cardiomyopathy. Mil Med Res 10(1):63. https://doi.org/10.1186/s40779-023-00493-5
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