Schenkel, J. M. & Masopust, D. Tissue-resident memory T cells. Immunity 41, 886–897 (2014).

CAS  PubMed  PubMed Central  Google Scholar 

Park, C. O. & Kupper, T. S. The emerging role of resident memory T cells in protective immunity and inflammatory disease. Nat. Med. 21, 688–697 (2015).

CAS  PubMed  PubMed Central  Google Scholar 

Mueller, S. N. & Mackay, L. K. Tissue-resident memory T cells: local specialists in immune defence. Nat. Rev. Immunol. 16, 79–89 (2016).

CAS  PubMed  Google Scholar 

van Gisbergen, K., Zens, K. D. & Munz, C. T-cell memory in tissues. Eur. J. Immunol. 51, 1310–1324 (2021).

PubMed  Google Scholar 

Clark, R. A. Resident memory T cells in human health and disease. Sci. Transl. Med. 7, 269rv261 (2015).

Google Scholar 

Weisberg, S. P., Ural, B. B. & Farber, D. L. Tissue-specific immunity for a changing world. Cell 184, 1517–1529 (2021).

CAS  PubMed  PubMed Central  Google Scholar 

Buggert, M., Price, D. A., Mackay, L. K. & Betts, M. R. Human circulating and tissue-resident memory CD8(+) T cells. Nat. Immunol. 24, 1076–1086 (2023).

CAS  PubMed  Google Scholar 

Masopust, D. & Soerens, A. G. Tissue-resident T cells and other resident leukocytes. Annu. Rev. Immunol. 37, 521–546 (2019).

CAS  PubMed  PubMed Central  Google Scholar 

Lam, N., Lee, Y. & Farber, D. L. A guide to adaptive immune memory. Nat. Rev. Immunol. 24, 810–829 (2024).

CAS  PubMed  Google Scholar 

Hondowicz, B. D. et al. Interleukin-2-dependent allergen-specific tissue-resident memory cells drive asthma. Immunity 44, 155–166 (2016).

CAS  PubMed  Google Scholar 

Christo, S. N., Park, S. L., Mueller, S. N. & Mackay, L. K. The multifaceted role of tissue-resident memory T cells. Annu. Rev. Immunol. 42, 317–345 (2024).

CAS  PubMed  Google Scholar 

Buquicchio, F. A. et al. Distinct epigenomic landscapes underlie tissue-specific memory T cell differentiation. Immunity 57, 2202–2215 e2206 (2024).

CAS  PubMed  Google Scholar 

Mackay, L. K. & Kallies, A. Transcriptional regulation of tissue-resident lymphocytes. Trends Immunol. 38, 94–103 (2017).

CAS  PubMed  Google Scholar 

Beura, L. K. et al. CD4(+) resident memory T cells dominate immunosurveillance and orchestrate local recall responses. J. Exp. Med. 216, 1214–1229 (2019).

CAS  PubMed  PubMed Central  Google Scholar 

Carbone, F. R. & Gebhardt, T. Should I stay or should I go-Reconciling clashing perspectives on CD4(+) tissue-resident memory T cells. Sci. Immunol. 4, eaax5595 (2019).

Klicznik, M. M. et al. Human CD4(+)CD103(+) cutaneous resident memory T cells are found in the circulation of healthy individuals. Sci. Immunol. 4, eaav8995 (2019).

Fonseca, R. et al. Developmental plasticity allows outside-in immune responses by resident memory T cells. Nat. Immunol. 21, 412–421 (2020).

CAS  PubMed  PubMed Central  Google Scholar 

Bromley, S. K., Yan, S., Tomura, M., Kanagawa, O. & Luster, A. D. Recirculating memory T cells are a unique subset of CD4+ T cells with a distinct phenotype and migratory pattern. J. Immunol. 190, 970–976 (2013).

CAS  PubMed  Google Scholar 

Turner, D. L. & Farber, D. L. Mucosal resident memory CD4 T cells in protection and immunopathology. Front. Immunol. 5, 331 (2014).

PubMed  PubMed Central  Google Scholar 

Schenkel, J. M., Fraser, K. A., Vezys, V. & Masopust, D. Sensing and alarm function of resident memory CD8(+) T cells. Nat. Immunol. 14, 509–513 (2013).

CAS  PubMed  PubMed Central  Google Scholar 

Ariotti, S. et al. T cell memory. Skin-resident memory CD8⁺ T cells trigger a state of tissue-wide pathogen alert. Science 346, 101–105 (2014).

CAS  PubMed  Google Scholar 

Teijaro, J. R. et al. Cutting edge: Tissue-retentive lung memory CD4 T cells mediate optimal protection to respiratory virus infection. J. Immunol. 187, 5510–5514 (2011).

CAS  PubMed  Google Scholar 

Rotrosen, E. & Kupper, T. S. Assessing the generation of tissue resident memory T cells by vaccines. Nat. Rev. Immunol. 23, 655–665 (2023).

Gray, J. I., Westerhof, L. M. & MacLeod, M. K. L. The roles of resident, central and effector memory CD4 T-cells in protective immunity following infection or vaccination. Immunology 154, 574–581 (2018).

CAS  PubMed  PubMed Central  Google Scholar 

Wilk, M. M. & Mills, K. H. G. CD4 T(RM) Cells Following Infection and Immunization: implications for More Effective Vaccine Design. Front. Immunol. 9, 1860 (2018).

PubMed  PubMed Central  Google Scholar 

Hassert, M. & Harty, J. T. Tissue resident memory T cells- A new benchmark for the induction of vaccine-induced mucosal immunity. Front. Immunol. 13, 1039194 (2022).

CAS  PubMed  PubMed Central  Google Scholar 

Jiang, X. et al. Skin infection generates non-migratory memory CD8+ T(RM) cells providing global skin immunity. Nature 483, 227–231 (2012).

CAS  PubMed  PubMed Central  Google Scholar 

Murata, A. & Hayashi, S. I. CD4(+) resident memory T cells mediate long-term local skin immune memory of contact hypersensitivity in BALB/c Mice. Front. Immunol. 11, 775 (2020).

CAS  PubMed  PubMed Central  Google Scholar 

Glennie, N. D., Volk, S. W. & Scott, P. Skin-resident CD4+ T cells protect against Leishmania major by recruiting and activating inflammatory monocytes. PLoS Pathog. 13, e1006349 (2017).

PubMed  PubMed Central  Google Scholar 

Shah, P. N. et al. Systemic and skin-limited delayed-type drug hypersensitivity reactions associate with distinct resident and recruited T cell subsets. J. Clin. Invest. 134, e178253 (2024).

Trubiano, J. A. et al. Analysis of skin-resident memory T cells following drug hypersensitivity reactions. J. Invest. Dermatol. 140, 1442–1445 e1444 (2020).

CAS  PubMed  Google Scholar 

Clark, R. A. et al. The vast majority of CLA+ T cells are resident in normal skin. J. Immunol. 176, 4431–4439 (2006).

CAS  PubMed  Google Scholar 

Szabo, P. A., Miron, M., Farber, D. L. Location, location, location: tissue resident memory T cells in mice and humans. Sci. Immunol. 4, eaas9673 (2019).

Beura, L. K. et al. Normalizing the environment recapitulates adult human immune traits in laboratory mice. Nature 532, 512–516 (2016).

CAS  PubMed  PubMed Central  Google Scholar 

Jirmanus, L. et al. Epidemiological and clinical changes in American tegumentary leishmaniasis in an area of Leishmania (Viannia) braziliensis transmission over a 20-year period. Am. J. Trop. Med. Hyg. 86, 426–433 (2012).

PubMed  PubMed Central  Google Scholar 

Scorza, B. M., Carvalho, E. M. & Wilson, M. E. Cutaneous manifestations of human and murine leishmaniasis. Int. J. Mol. Sci. 18, 1296 (2017).

Wells, T. J., Esposito, T., Henderson, I. R. & Labzin, L. I. Mechanisms of antibody-dependent enhancement of infectious disease. Nat. Rev. Immunol. 25, 6–21 (2025).

CAS  PubMed  Google Scholar 

Buxbaum, L. U. & Scott, P. Interleukin 10- and Fcgamma receptor-deficient mice resolve Leishmania mexicana lesions. Infect. Immun. 73, 2101–2108 (2005).

CAS  PubMed  PubMed Central  Google Scholar 

Scott, P. & Novais, F. O. Cutaneous leishmaniasis: immune responses in protection and pathogenesis. Nat. Rev. Immunol. 16, 581–592 (2016).

CAS  PubMed  Google Scholar 

Glennie, N. D. et al. Skin-resident memory CD4+ T cells enhance protection against Leishmania major infection. J. Exp. Med 212, 1405–1414 (2015).

CAS  PubMed  PubMed Central  Google Scholar 

Glennie, N. D. & Scott, P. Memory T cells in cutaneous leishmaniasis. Cell. Immunol. 309, 50–54 (2016).

CAS  PubMed  PubMed Central  Google Scholar 

Laczkó, D. et al. A single immunization with nucleoside-modified mRNA vaccines elicits strong cellular and humoral immune responses against SARS-CoV-2 in mice. Immunity 53, 724–732.e727 (2020).

PubMed  PubMed Central  Google Scholar