The Metazoan SpoT Homolog 1 promotes ferroptosis by regulating the intracellular redox cycle and iron levels in hepatocellular carcinoma

Shi Y, Wu Z, Liu S et al (2024) Targeting PRMT3 impairs methylation and oligomerization of HSP60 to boost anti-tumor immunity by activating cGAS/STING signaling. Nat Commun 15(1):7930

CAS  PubMed  PubMed Central  Google Scholar 

Dixon SJ, Lemberg KM, Lamprecht MR et al (2012) Ferroptosis: an iron-dependent form of nonapoptotic cell death. Cell 149(5):1060–1072

CAS  PubMed  PubMed Central  Google Scholar 

Stockwell BR, Friedmann Angeli JP, Bayir H et al (2017) Ferroptosis: a regulated cell death nexus linking metabolism, redox biology, and disease. Cell 171(2):273–285

CAS  PubMed  PubMed Central  Google Scholar 

Ni L, Yuan C, Wu X (2022) Targeting ferroptosis in acute kidney injury. Cell Death Dis 13(2):182

CAS  PubMed  PubMed Central  Google Scholar 

Koppula P, Zhang Y, Zhuang L et al (2018) Amino acid transporter SLC7A11/xCT at the crossroads of regulating redox homeostasis and nutrient dependency of cancer. Cancer Commun 38(1):1–13

Google Scholar 

Ding Z, Pan Y, Shang T et al (2023) URI alleviates tyrosine kinase inhibitors-induced ferroptosis by reprogramming lipid metabolism in p53 wild-type liver cancers. Nat Commun 14(1):6269

CAS  PubMed  PubMed Central  Google Scholar 

Ryan SK, Zelic M, Han Y et al (2023) Microglia ferroptosis is regulated by SEC24B and contributes to neurodegeneration. Nat Neurosci 26(1):12–26

CAS  PubMed  Google Scholar 

Fang X, Wang H, Han D et al (2019) Ferroptosis as a target for protection against cardiomyopathy. Proc Natl Acad Sci USA 116(7):2672–2680

CAS  PubMed  PubMed Central  Google Scholar 

Potrykus K, Cashel M (2008) (p)ppGpp: still magical? Annu Rev Microbiol 62(1):35–51

CAS  PubMed  Google Scholar 

Sun D, Lee G, Lee JH et al (2010) A metazoan ortholog of SpoT hydrolyzes ppGpp and functions in starvation responses. Nat Struct Mol Biol 17(10):1188–1194

CAS  PubMed  Google Scholar 

Ding CKC, Rose J, Sun T et al (2020) MESH1 is a cytosolic NADPH phosphatase that regulates ferroptosis. Nat Metab 2(3):270–277

CAS  PubMed  PubMed Central  Google Scholar 

Itoh S, Shirabe K, Taketomi A et al (2012) Zero mortality in more than 300 hepatic resections: validity of preoperative volumetric analysis. Surg Today 42(5):435–440

PubMed  Google Scholar 

Chandrashekar DS, Karthikeyan SK, Korla PK et al (2022) UALCAN: An update to the integrated cancer data analysis platform. Neoplasia 25:18–27

CAS  PubMed  PubMed Central  Google Scholar 

Lánczky A, Győrffy B (2021) Web-based survival analysis tool tailored for medical research (KMplot): development and implementation. J Med Internet Res 23(7):e27633

PubMed  PubMed Central  Google Scholar 

Iseda N, Itoh S, Toshida K et al (2022) Ferroptosis is induced by lenvatinib through fibroblast growth factor receptor-4 inhibition in hepatocellular carcinoma. Cancer Sci 113(7):2272–2287

CAS  PubMed  PubMed Central  Google Scholar 

Lin W, Tsai W, Shao R et al (2010) Hepatitis C virus regulates transforming growth factor β1 production through the generation of reactive oxygen species in a nuclear factor κB–dependent manner. Gastroenterology 138(7):2509-2518.e1

CAS  PubMed  Google Scholar 

Hiromatsu M, Toshida K, Itoh S et al (2023) Transferrin receptor is associated with sensitivity to ferroptosis inducers in hepatocellular carcinoma. Ann Surg Oncol 30(13):8675–8689

PubMed  Google Scholar 

Mestre AA, Zhou P, Chi JT (2022) Metazoan stringent-like response mediated by MESH1 phenotypic conservation via distinct mechanisms. Comput Struct Biotechnol J 6(20):2680–2684

Google Scholar 

Lin CC, Ding CKC, Sun T et al (2021) The regulation of ferroptosis by MESH1 through the activation of the integrative stress response. Cell Death Dis 12(8):727

CAS  PubMed  PubMed Central  Google Scholar 

Chen X, Li J, Kang R et al (2021) Ferroptosis: machinery and regulation. Autophagy 17(9):2054–2081

CAS  PubMed  Google Scholar 

Koppula P, Zhuang L, Gan B (2021) Cystine transporter SLC7A11/xCT in cancer: ferroptosis, nutrient dependency, and cancer therapy. Protein Cell 12(8):599–620

CAS  PubMed  Google Scholar 

Bersuker K, Hendricks JM, Li Z et al (2019) The CoQ oxidoreductase FSP1 acts parallel to GPX4 to inhibit ferroptosis. Nature 575(7784):688–692

CAS  PubMed  PubMed Central  Google Scholar 

Ajoolabady A, Tang D, Kroemer G et al (2022) Ferroptosis in hepatocellular carcinoma: mechanisms and targeted therapy. Br J Cancer 13:1–16

Google Scholar 

Kerins MJ, Ooi A (2018) The roles of NRF2 in modulating cellular iron homeostasis. Antioxid Redox Signal 29(17):1756–1773

CAS  PubMed  PubMed Central  Google Scholar 

Sun X, Ou Z, Chen R et al (2016) Activation of the p62-Keap1-NRF2 pathway protects against ferroptosis in hepatocellular carcinoma cells. Hepatology 63(1):173–184

CAS  PubMed  Google Scholar 

Rydz L, Wróbel M, Jurkowska H (2021) Sulfur administration in Fe–S cluster homeostasis. Antioxidants 10(11):1738

CAS  PubMed  PubMed Central  Google Scholar 

Iseda N, Itoh S, Toshima T et al (2024) Outcome of hepatectomy after systemic therapy for hepatocellular carcinoma: a Japanese multicenter study. Surg Today. https://doi.org/10.1007/s00595-024-02930-x

Article  PubMed  Google Scholar 

Zhao FY, Wang DY, Qian NS (2024) Unresectable hepatocellular carcinoma: transarterial chemoembolization combined with lenvatinib in combination with programmed death-1 inhibition is a possible approach. World J Gastrointest Oncol 16(10):4042–4044

PubMed  PubMed Central  Google Scholar 

Qin Y, Han S, Yu Y et al (2024) Lenvatinib in hepatocellular carcinoma: Resistance mechanisms and strategies for improved efficacy. Liver Int 44(8):1808–1831

CAS  PubMed  Google Scholar 

Comments (0)

No login
gif