Humoral immunity after hematopoietic stem cell transplantation: evaluation by B-cell receptor repertoire analysis

Copelan EA. Hematopoietic stem-cell transplantation. N Engl J Med. 2006;354:1813–26.

CAS  PubMed  Google Scholar 

Niederwieser D, Baldomero H, Bazuaye N, Bupp C, Chaudhri N, Corbacioglu S, et al. One and a half million hematopoietic stem cell transplants: continuous and differential improvement in worldwide access with the use of non-identical family donors. Haematologica. 2022;107:1045–53.

PubMed  Google Scholar 

Ogonek J, Kralj Juric M, Ghimire S, Varanasi PR, Holler E, Greinix H, et al. Immune reconstitution after allogeneic hematopoietic stem cell transplantation. Front Immunol. 2016;7: 507.

PubMed  PubMed Central  Google Scholar 

Chaudhry MS, Velardi E, Malard F, van den Brink MR. Immune reconstitution after allogeneic hematopoietic stem cell transplantation: time to T up the thymus. J Immunol. 2017;198:40–6.

CAS  PubMed  Google Scholar 

Kamboj M, Bohlke K, Baptiste DM, Dunleavy K, Fueger A, Jones L, et al. Vaccination of adults with cancer: ASCO guideline. J Clin Oncol. 2024. https://doi.org/10.1200/JCO.24.00032.

Article  PubMed  Google Scholar 

Cordonnier C, Einarsdottir S, Cesaro S, Di Blasi R, Mikulska M, Rieger C, et al. Vaccination of haemopoietic stem cell transplant recipients: guidelines of the 2017 European Conference on Infections in Leukaemia (ECIL 7). Lancet Infect Dis. 2019;19:e200–12.

PubMed  Google Scholar 

Watanabe M, Yakushijin K, Funakoshi Y, Ohji G, Ichikawa H, Sakai H, et al. A third dose COVID-19 vaccination in allogeneic hematopoietic stem cell transplantation patients. Vaccines (Basel). 2022. https://doi.org/10.3390/vaccines10111830.

Article  PubMed  Google Scholar 

Watanabe M, Yakushijin K, Funakoshi Y, Ohji G, Hojo W, Sakai H, et al. The safety and immunogenicity of the BNT162b2 mRNA COVID-19 vaccine in Japanese patients after allogeneic stem cell transplantation. Vaccines. 2022. https://doi.org/10.3390/vaccines10020158.

Article  PubMed  PubMed Central  Google Scholar 

Park BG, Park CJ, Jang S, Chi HS, Kim DY, Lee JH, et al. Reconstitution of lymphocyte subpopulations after hematopoietic stem cell transplantation: comparison of hematologic malignancies and donor types in event-free patients. Leuk Res. 2015;39:1334–41.

PubMed  Google Scholar 

Marie-Cardine A, Divay F, Dutot I, Green A, Perdrix A, Boyer O, et al. Transitional B cells in humans: characterization and insight from B lymphocyte reconstitution after hematopoietic stem cell transplantation. Clin Immunol. 2008;127:14–25.

CAS  PubMed  Google Scholar 

Suryani S, Fulcher DA, Santner-Nanan B, Nanan R, Wong M, Shaw PJ, et al. Differential expression of CD21 identifies developmentally and functionally distinct subsets of human transitional B cells. Blood. 2010;115:519–29.

CAS  PubMed  Google Scholar 

Funakoshi Y, Yakushijin K, Ohji G, Matsutani T, Hojo W, Sakai H, et al. Response to mRNA SARS-CoV-2 vaccination evaluated by B-cell receptor repertoire after tixagevimab/cilgavimab administration. Br J Haematol. 2023;202:504–16.

CAS  PubMed  Google Scholar 

Funakoshi Y, Yakushijin K, Ohji G, Matsutani T, Doi K, Sakai H, et al. Analysis of B-cell receptor repertoire to evaluate immunogenicity of monovalent Omicron XBB.1.5 mRNA vaccines. EJHaem. 2024;5:661–8.

CAS  PubMed  PubMed Central  Google Scholar 

Ohji G, Funakoshi Y, Yakushijin K, Matsutani T, Sasaki T, Kusakabe T, et al. Analysis of B-cell receptor repertoire to evaluate the immunogenicity of SARS-CoV-2 RBD mRNA vaccine: MAFB-7256a (DS-5670d). Front Immunol. 2024;15:1468760.

CAS  PubMed  PubMed Central  Google Scholar 

Sethna Z, Elhanati Y, Callan CG, Walczak AM, Mora T. OLGA: fast computation of generation probabilities of B- and T-cell receptor amino acid sequences and motifs. Bioinformatics. 2019;35:2974–81.

CAS  PubMed  PubMed Central  Google Scholar 

Kitaura K, Yamashita H, Ayabe H, Shini T, Matsutani T, Suzuki R. Different somatic hypermutation levels among antibody subclasses disclosed by a new next-generation sequencing-based antibody repertoire analysis. Front Immunol. 2017;8: 389.

PubMed  PubMed Central  Google Scholar 

Sammut SJ, Galson JD, Minter R, Sun B, Chin SF, De Mattos-Arruda L, et al. Predictability of B cell clonal persistence and immunosurveillance in breast cancer. Nat Immunol. 2024;25:916–24.

CAS  PubMed  PubMed Central  Google Scholar 

Tsoutsoukis M, Anthias C, Easdale S, Nicholson E. Re-vaccination against SARS-CoV-2 in allogeneic HSCT patients: repeated primary vaccine doses increase seroconversion rates. Br J Haematol. 2024;205:1720–6.

CAS  PubMed  Google Scholar 

Khawaja F, Papanicolaou G, Dadwal S, Pergam SA, Wingard JR, Boghdadly ZE, et al. Frequently asked questions on coronavirus disease 2019 vaccination for hematopoietic cell transplantation and chimeric antigen receptor T-cell recipients from the American Society for Transplantation and Cellular Therapy and the American Society of Hematology. Transplant Cell Ther. 2023;29:10–8.

CAS  PubMed  Google Scholar 

Moretta A, Maccario R, Fagioli F, Giraldi E, Busca A, Montagna D, et al. Analysis of immune reconstitution in children undergoing cord blood transplantation. Exp Hematol. 2001;29:371–9.

CAS  PubMed  Google Scholar 

Bae KW, Kim BE, Koh KN, Im HJ, Seo JJ. Factors influencing lymphocyte reconstitution after allogeneic hematopoietic stem cell transplantation in children. Korean J Hematol. 2012;47:44–52.

PubMed  PubMed Central  Google Scholar 

Nakatani K, Imai K, Shigeno M, Sato H, Tezuka M, Okawa T, et al. Cord blood transplantation is associated with rapid B-cell neogenesis compared with BM transplantation. Bone Marrow Transplant. 2014;49:1155–61.

CAS  PubMed  Google Scholar 

Abdel-Azim H, Elshoury A, Mahadeo KM, Parkman R, Kapoor N. Humoral immune reconstitution kinetics after allogeneic hematopoietic stem cell transplantation in children: a maturation block of IgM memory B cells may lead to impaired antibody immune reconstitution. Biol Blood Marrow Transplant. 2017;23:1437–46.

CAS  PubMed  Google Scholar 

Charrier E, Cordeiro P, Brito RM, Mezziani S, Herblot S, Le Deist F, et al. Reconstitution of maturating and regulatory lymphocyte subsets after cord blood and BMT in children. Bone Marrow Transplant. 2013;48:376–82.

CAS  PubMed  Google Scholar 

Yanir A, Schulz A, Lawitschka A, Nierkens S, Eyrich M. Immune reconstitution after allogeneic haematopoietic cell transplantation: from observational studies to targeted interventions. Front Pediatr. 2021;9: 786017.

PubMed  Google Scholar 

Comments (0)

No login
gif