Kato GJ, Steinberg MH, Gladwin MT. Intravascular hemolysis and the pathophysiology of sickle cell disease. J Clin Invest. 2017;127(3):750–60. https://doi.org/10.1172/JCI89741.

Article  PubMed  PubMed Central  Google Scholar 

Theocharidou E, Suddle AR. The liver in sickle cell disease. Clin Liver Dis. 2019;23(2):177–89. https://doi.org/10.1016/j.cld.2018.12.002.

Article  PubMed  Google Scholar 

Manganas K, Delicou S, Xydaki A, Kourakli A, Evliati L, Vlachaki E, et al. Predisposing factors for advanced liver fibrosis in patients with sickle cell disease. Br J Haematol. 2023;202(6):1192–8. https://doi.org/10.1111/bjh.18970.

Article  PubMed  Google Scholar 

Breit SN, Johnen H, Cook AD, Tsai VW, Mohammad MG, Kuffner T, et al. The TGF-β superfamily cytokine, MIC-1/GDF15: a pleotrophic cytokine with roles in inflammation, cancer and metabolism. Growth Factors. 2011;29(5):187–95. https://doi.org/10.3109/08977194.2011.607137.

Article  CAS  PubMed  Google Scholar 

Radwanska A, Cottage CT, Piras A, Overed-Sayer C, Sihlbom C, Budida R, et al. Increased expression and accumulation of GDF15 in IPF extracellular matrix contribute to fibrosis. JCI Insight. 2022;7(16): e153058. https://doi.org/10.1172/jci.insight.153058.

Article  PubMed  PubMed Central  Google Scholar 

Zhang CY, Yuan WG, He P, Lei JH, Wang CX. Liver fibrosis and hepatic stellate cells: etiology, pathological hallmarks and therapeutic targets. World J Gastroenterol. 2016;22(48):10512–22. https://doi.org/10.3748/wjg.v22.i48.10512.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Qi P, Ma MZ, Kuai JH. Identification of growth differentiation factor 15 as a pro-fibrotic factor in mouse liver fibrosis progression. Int J Exp Pathol. 2021;102(3):148–56. https://doi.org/10.1111/iep.12398.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Li X, Huai Q, Zhu C, Zhang X, Xu W, Dai H, et al. GDF15 ameliorates liver fibrosis by metabolic reprogramming of macrophages to acquire anti-inflammatory properties. Cell Mol Gastroenterol Hepatol. 2023;16(5):711–34. https://doi.org/10.1016/j.jcmgh.2023.07.009.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Tanno T, Bhanu NV, Oneal PA, Goh SH, Staker P, Lee YT, et al. High levels of GDF15 in thalassemia suppress expression of the iron regulatory protein hepcidin. Nat Med. 2007;13(9):1096–101. https://doi.org/10.1038/nm1629.

Article  CAS  PubMed  Google Scholar 

Foucher J, Chanteloup E, Vergniol J, Castéra L, Le Bail B, Adhoute X, et al. Diagnosis of cirrhosis by transient elastography (FibroScan): a prospective study. Gut. 2006;55(3):403–8. https://doi.org/10.1136/gut.2005.069153.

Article  CAS  PubMed  PubMed Central  Google Scholar 

de Oliveira AC, El-Bacha I, Vianna MV, Parise ER. Utility and limitations of APRI and FIB4 to predict staging in a cohort of nonselected outpatients with hepatitis C. Ann Hepatol. 2016;15(3):326–32. https://doi.org/10.5604/16652681.1198801.

Article  PubMed  Google Scholar 

Kumazaki S, Hikita H, Tahata Y, Sung JH, Fukumoto K, Myojin Y, et al. Serum growth differentiation factor 15 is a novel biomarker with high predictive capability for liver cancer occurrence in patients with MASLD regardless of liver fibrosis. Aliment Pharmacol Ther. 2024;60(3):327–39. https://doi.org/10.1111/apt.18063.

Article  CAS  PubMed  Google Scholar 

Arinaga-Hino T, Ide T, Akiba J, Suzuki H, Kuwahara R, Amano K, et al. Growth differentiation factor 15 as a novel diagnostic and therapeutic marker for autoimmune hepatitis. Sci Rep. 2022;12(1):8759. https://doi.org/10.1038/s41598-022-12762-9.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wang Y, Chen C, Chen J, Sang T, Peng H, Lin X, et al. Overexpression of NAG-1/GDF15 prevents hepatic steatosis through inhibiting oxidative stress-mediated dsDNA release and AIM2 inflammasome activation. Redox Biol. 2022;52: 102322. https://doi.org/10.1016/j.redox.2022.102322.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kim KH, Kim SH, Han DH, Jo YS, Lee YH, Lee MS. Growth differentiation factor 15 ameliorates nonalcoholic steatohepatitis and related metabolic disorders in mice. Sci Rep. 2018;8(1):6789. https://doi.org/10.1038/s41598-018-25098-0.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Abou Zaghla HMA, El Sebai AA, Ahmed OA, Ahmed AF, Saab AAR. Growth differentiation factor 15: an emerging diagnostic biomarker of liver fibrosis in chronic hepatitis C patients. Egypt Liver J. 2021;11(1):6. https://doi.org/10.1186/s43066-021-00075-x.

Article  PubMed  PubMed Central  Google Scholar 

Zhang Y, Tian XL, Li JQ, Wu DS, Li Q, Chen B. Mitochondrial dysfunction affects hepatic immune and metabolic remodeling in patients with hepatitis B virus-related acute-on-chronic liver failure. World J Gastroenterol. 2024;30(8):881–900. https://doi.org/10.3748/wjg.v30.i8.881.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Li Y, Zhang J, Chen S, Ke Y, Li Y, Chen Y. Growth differentiation factor 15: emerging role in liver diseases. Cytokine. 2024;182: 156727. https://doi.org/10.1016/j.cyto.2024.156727.

Article  CAS  PubMed  Google Scholar 

Wang XL, Yang M, Wang Y. Roles of transforming growth factor-β signaling in liver disease. World J Hepatol. 2024;16(7):973–9. https://doi.org/10.4254/wjh.v16.i7.973.

Article  PubMed  PubMed Central  Google Scholar 

Zhang Z, Xu X, Tian W, Jiang R, Lu Y, Sun Q, et al. ARRB1 inhibits non-alcoholic steatohepatitis progression by promoting GDF15 maturation. J Hepatol. 2020;72(5):976–89. https://doi.org/10.1016/j.jhep.2019.12.004.

Article  CAS  PubMed  Google Scholar 

Koo BK, Um SH, Seo DS, Joo SK, Bae JM, Park JH, et al. Growth differentiation factor 15 predicts advanced fibrosis in biopsy-proven non-alcoholic fatty liver disease. Liver Int. 2018;38(4):695–705. https://doi.org/10.1111/liv.13587.

Article  CAS  PubMed  Google Scholar 

Lee ES, Kim SH, Kim HJ, Kim KH, Lee BS, Ku BJ. Growth differentiation factor 15 predicts chronic liver disease severity. Gut Liver. 2017;11(2):276–82. https://doi.org/10.5009/gnl16049.

Article  CAS  PubMed  Google Scholar 

Bilson J, Scorletti E, Bindels LB, Afolabi PR, Targher G, Calder PC, et al. Growth differentiation factor-15 and the association between type 2 diabetes and liver fibrosis in NAFLD. Nutr Diabetes. 2021;11(1):32. https://doi.org/10.1038/s41387-021-00170-3.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Duvoux C, Blaise L, Matimbo JJ, Mubenga F, Ngongang N, Hurtova M, et al. The liver in sickle cell disease. Presse Med. 2023;52(4): 104212. https://doi.org/10.1016/j.lpm.2023.104212.

Article  PubMed  Google Scholar 

Tantawy AA, Adly AA, Ismail EA, Darwish YW, Ali ZM. Growth differentiation factor-15 in young sickle cell disease patients: relation to hemolysis, iron overload and vascular complications. Blood Cells Mol Dis. 2014;53(4):189–93. https://doi.org/10.1016/j.bcmd.2014.07.003.

Article  CAS  PubMed  Google Scholar 

Porter JB. Pathophysiology of transfusional iron overload: contrasting patterns in thalassemia major and sickle cell disease. Hemoglobin. 2009;33(1):37–45. https://doi.org/10.3109/03630260903346627.

Article  CAS  Google Scholar 

Raghupathy R, Manwani D, Little JA. Iron overload in sickle cell disease. Adv Hematol. 2010;2010: 272940. https://doi.org/10.1155/2010/272940.

Article  CAS  PubMed