Circulating as a Diagnostic Biomarker of Early Endothelial Dysfunction in Young Dyslipidemic Individuals

Mordi I, Tzemos N. Is reversal of endothelial dysfunction still an attractive target in modern cardiology? World J Cardiol. 2014;6(8):824–35. https://doi.org/10.4330/wjc.v6.i8.824.

Article  PubMed  PubMed Central  Google Scholar 

Gutiérrez E, Flammer AJ, Lerman LO, Elízaga J, Lerman A, Fernández-Avilés F. Endothelial dysfunction over the course of coronary artery disease. Eur Heart J. 2013;34(41):3175–81. https://doi.org/10.1093/eurheartj/eht351.

Article  PubMed  PubMed Central  Google Scholar 

Flammer AJ, Anderson T, Celermajer DS, Creager MA, Deanfield J, Ganz P, Hamburg NM, Lüscher TF, Shechter M, Taddei S, Vita JA, Lerman A. The assessment of endothelial function: from research into clinical practice. Circulation. 2012;126(6):753–67. https://doi.org/10.1161/CIRCULATIONAHA.112.093245.

Article  PubMed  PubMed Central  Google Scholar 

Alloubani A, Nimer R, Samara R. Relationship between hyperlipidemia, cardiovascular disease and stroke: a systematic review. Curr Cardiol Rev. 2021;17(6): e051121189015. https://doi.org/10.2174/1573403X16999201210200342.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Drechsler M, Megens RTA, van Zandvoort M, Weber C, Soehnlein O. Hyperlipidemia-triggered neutrophilia promotes early atherosclerosis. Circulation. 2010;122(18):1837–45. https://doi.org/10.1161/CIRCULATIONAHA.110.961714.

Article  CAS  PubMed  Google Scholar 

Peng J, Luo F, Ruan G, Peng R, Li X. Hypertriglyceridemia and atherosclerosis. Lipids Health Dis. 2017;16:233. https://doi.org/10.1186/s12944-017-0625-0.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Mahalle N, Garg MK, Naik SS, Kulkarni MV. Study of pattern of dyslipidemia and its correlation with cardiovascular risk factors in patients with proven coronary artery disease. Indian J Endocrinol Metab. 2014;18(1):48–55. https://doi.org/10.4103/2230-8210.126532.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Yin Y, Li X, Sha X, Xi H, Li Y-F, Shao Y, Mai J, Virtue A, Lopez-Pastrana J, Meng S, Tilley DG, Monroy MA, Choi ET, Thomas CJ, Jiang X, Wang H, Yang X-F. Early hyperlipidemia promotes endothelial activation via a caspase-1-sirtuin 1 pathway. Arterioscler Thromb Vasc Biol. 2015;35(4):804–16. https://doi.org/10.1161/ATVBAHA.115.305282.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ceriello A, Taboga C, Tonutti L, Quagliaro L, Piconi L, Bais B, Da Ros R, Motz E. Evidence for an independent and cumulative effect of postprandial hypertriglyceridemia and hyperglycemia on endothelial dysfunction and oxidative stress generation. Circulation. 2002;106(10):1211–8. https://doi.org/10.1161/01.CIR.0000027569.76671.A8.

Article  PubMed  Google Scholar 

Liu L-Y, Aimaiti X, Zheng Y-Y, Zhi X-Y, Wang Z-L, Yin X, Pan Y, Wu T-T, Xie X. Epidemic trends of dyslipidemia in young adults: a real-world study including more than 20,000 samples. Lipids Health Dis. 2023;22(1): 108. https://doi.org/10.1186/s12944-023-01876-2.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zhang J. Biomarkers of endothelial activation and dysfunction in cardiovascular diseases. Rev Cardiovasc Med. 2022;23(2): 73. https://doi.org/10.31083/j.rcm2302073.

Article  PubMed  Google Scholar 

Bordeianu G, Mitu I, Stanescu RS, Ciobanu CP, Petrescu-Danila E, Marculescu AD, Dimitriu DC. Circulating biomarkers for laboratory diagnostics of atherosclerosis-literature review. Diagnostics. 2022;12(12): 3141. https://doi.org/10.3390/diagnostics12123141.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Valadi H, Ekström K, Bossios A, Sjöstrand M, Lee JJ, Lötvall JO. Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells. Nat Cell Biol. 2007;9(6):654–9. https://doi.org/10.1038/ncb1596.

Article  CAS  PubMed  Google Scholar 

Williams Z, Ben-Dov IZ, Elias R, Mihailovic A, Brown M, Rosenwaks Z, Tuschl T. Comprehensive profiling of circulating microrna via small RNA sequencing of cDNA libraries reveals biomarker potential and limitations. Proceed Nat Acad Science. 2013;110:4255–60. https://doi.org/10.1073/pnas.1214046110.

Article  Google Scholar 

Chen W, Li L, Wang J, Li Q, Zhang R, Wang S, Wu Y, Xing D. Extracellular vesicle YRNA in atherosclerosis. Clin Chim Acta. 2021;517:15–22. https://doi.org/10.1016/j.cca.2021.02.003.

Article  CAS  PubMed  Google Scholar 

Jing T, Ya-Shu K, Xue-Jun W, Han-Jing H, Yan L, Yi-An Y, Fei C, Xue-Bo L. Sirt6 mRNA-incorporated endothelial microparticles (EMPs) attenuates DM patient-derived EMP-induced endothelial dysfunction. Oncotarget. 2017;8(69):114300–13. https://doi.org/10.18632/oncotarget.23259.

Article  PubMed  PubMed Central  Google Scholar 

Li L, Wang H, Zhang J, Chen X, Zhang Z, Li Q. Effect of endothelial progenitor cell-derived extracellular vesicles on endothelial cell ferroptosis and atherosclerotic vascular endothelial injury. Cell Death Discov. 2021;7(1):235. https://doi.org/10.1038/s41420-021-00610-0.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ward Z, Schmeier S, Pearson J, Cameron VA, Frampton CM, Troughton RW, Doughty RN, Richards AM, Pilbrow AP. Identifying candidate circulating RNA markers for coronary artery disease by deep RNA-sequencing in human plasma. Cells. 2022;11(20): 3191. https://doi.org/10.3390/cells11203191.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Yousefzadeh N, Jeddi S, Zarkesh M, Kashfi K, Ghasemi A. Altered sialin mRNA gene expression in type 2 diabetic male Wistar rats: implications for nitric oxide deficiency. Sci Rep. 2023;13(1):4013. https://doi.org/10.1038/s41598-023-31240-4.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Akhtar S, Sagar K, Singh A, Hote MP, Roy A, Sharma A. Inflammation-induced sialin mediates nitrate efflux in dysfunctional endothelium affecting NO bioavailability. Nitric Oxide Biol Chem. 2024;146:37–47. https://doi.org/10.1016/j.niox.2024.04.002.

Article  CAS  Google Scholar 

Théry C, Amigorena S, Raposo G, Clayton A (2006) Isolation and characterization of exosomes from cell culture supernatants and biological fluids. Curr Protoc Cell Biol Chapter 3, Unit 3.22. https://doi.org/10.1002/0471143030.cb0322s30

Tang Y-T, Huang Y-Y, Zheng L, Qin S-H, Xu X-P, An T-X, Xu Y, Wu Y-S, Hu X-M, Ping B-H, Wang Q. Comparison of isolation methods of exosomes and exosomal RNA from cell culture medium and serum. Int J Mol Med. 2017;40(3):834–44. https://doi.org/10.3892/ijmm.2017.3080.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Pan X, Fang Y, Li X, Yang Y, Shen H-B. RBPsuite: RNA-protein binding sites prediction suite based on deep learning. BMC Genomics. 2020;21(1):884. https://doi.org/10.1186/s12864-020-07291-6.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Szklarczyk D, Kirsch R, Koutrouli M, Nastou K, Mehryary F, Hachilif R, Gable AL, Fang T, Doncheva N, Pyysalo S, Bork P, Jensen L, von Mering C. The STRING database in 2023: protein–protein association networks and functional enrichment analyses for any sequenced genome of interest. Nucleic Acids Res. 2023;51(D1):D638–46. https://doi.org/10.1093/nar/gkac1000.

Article  CAS  PubMed  Google Scholar 

Deanfield JE, Halcox JP, Rabelink TJ. Endothelial function and dysfunction: testing and clinical relevance. Circulation. 2007;115(10):1285–95. https://doi.org/10.1161/CIRCULATIONAHA.106.652859.

Article  PubMed  Google Scholar 

Rathcke CN, Vestergaard H. YKL-40–an emerging biomarker in cardiovascular disease and diabetes. Cardiovasc Diabetol. 2009;8: 61. https://doi.org/10.1186/1475-2840-8-61.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Vita JA, Brennan M-L, Gokce N, Mann SA, Goormastic M, Shishehbor MH, Penn MS, Keaney JF, Hazen SL. Serum myeloperoxidase levels independently predict endothelial dysfunction in humans. Circulation. 2004;110(9):1134–9. https://doi.org/10.1161/01.CIR.0000140262.20831.8F.

Arti

Comments (0)

No login
gif