Osteocytic vinculin controls bone mass by modulating Mef2c-driven sclerostin expression in mice

Compston, J. E., McClung, M. R. & Leslie, W. D. Osteoporosis. Lancet 393, 364–376 (2019).

Article  CAS  PubMed  Google Scholar 

Feng, X. & McDonald, J. M. Disorders of bone remodeling. Annu. Rev. Pathol. 6, 121–145 (2011).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Einhorn, T. A. & Gerstenfeld, L. C. Fracture healing: mechanisms and interventions. Nat. Rev. Rheumatol. 11, 45–54 (2015).

Article  PubMed  Google Scholar 

Wawrzyniak, A. & Balawender, K. Structural and metabolic changes in bone. Animals 12, 1946 (2022).

Wong, S. K., et al. The relationship between metabolic syndrome and osteoporosis: a review. Nutrients 8, 347 (2016).

Montanez, E. et al. Kindlin-2 controls bidirectional signaling of integrins. Genes Dev. 22, 1325–1330 (2008).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ma, Y. Q. et al. Kindlin-2 (Mig-2): a co-activator of beta3 integrins. J. Cell Biol. 181, 439–446 (2008).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Larjava, H., Plow, E. F. & Wu, C. Kindlins: essential regulators of integrin signalling and cell-matrix adhesion. EMBO Rep. 9, 1203–1208 (2008).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ussar, S. et al. The Kindlins: subcellular localization and expression during murine development. Exp. Cell Res. 312, 3142–3151 (2006).

Article  CAS  PubMed  Google Scholar 

Qin, L. et al. Molecular mechanosensors in osteocytes. Bone Res. 8, 23 (2020).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Xu, H., Cao, H. & Xiao, G. Signaling via PINCH: functions, binding partners and implications in human diseases. Gene 594, 10–15 (2016).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Qin, L. et al. Roles of leader and follower cells in collective cell migration. Mol. Biol. Cell 32, 1267–1272 (2021).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Calderwood, D. A., Campbell, I. D. & Critchley, D. R. Talins and kindlins: partners in integrin-mediated adhesion. Nat. Rev. Mol. Cell Biol. 14, 503–517 (2013).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lin, J. et al. Kindlin-2 promotes hepatocellular carcinoma invasion and metastasis by increasing Wnt/β-catenin signaling. J. Exp. Clin. Cancer Res. 36, 134 (2017).

Article  PubMed  PubMed Central  Google Scholar 

Guo, L. & Wu, C. Mechano-regulation of proline metabolism and cancer progression by kindlin-2. Mol. Cell Oncol. 6, 1596003 (2019).

Article  PubMed  PubMed Central  Google Scholar 

Guo, L. & Wu, C. Mitochondrial dynamics links PINCH-1 signaling to proline metabolic reprogramming and tumor growth. Cell Stress 5, 23–25 (2020).

Article  PubMed  PubMed Central  Google Scholar 

Xue, X. et al. HIF-1α interacts with Kindlin-2 and influences breast cancer elasticity: A study based on shear wave elastography imaging. Cancer Med. 9, 4971–4979 (2020).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zhan, J. & Zhang, H. Kindlins: roles in development and cancer progression. Int. J. Biochem. Cell Biol. 98, 93–103 (2018).

Article  CAS  PubMed  Google Scholar 

Theodosiou, M. et al. Kindlin-2 cooperates with talin to activate integrins and induces cell spreading by directly binding paxillin. Elife 5, e10130 (2016).

Article  PubMed  PubMed Central  Google Scholar 

Wu, C. et al. Kindlin-2 controls TGF-beta signalling and Sox9 expression to regulate chondrogenesis. Nat. Commun. 6, 7531 (2015).

Article  PubMed  Google Scholar 

Wu, X. et al. Kindlin-2 preserves integrity of the articular cartilage to protect against osteoarthritis. Nat. Aging 2, 332–347 (2022).

Article  CAS  PubMed  Google Scholar 

Cao, H. et al. Focal adhesion protein Kindlin-2 regulates bone homeostasis in mice. Bone Res. 8, 2 (2020).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Fu, X. et al. Kindlin-2 regulates skeletal homeostasis by modulating PTH1R in mice. Sig. Transduct. Target Ther. 5, 297 (2020).

Article  CAS  Google Scholar 

Qin, L. et al. Kindlin-2 mediates mechanotransduction in bone by regulating expression of Sclerostin in osteocytes. Commun. Biol. 4, 402 (2021).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lai, Y. et al. Kindlin-2 loss in condylar chondrocytes causes spontaneous osteoarthritic lesions in the temporomandibular joint in mice. Int J. Oral. Sci. 14, 33 (2022).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chen, S. et al. Kindlin-2 inhibits Nlrp3 inflammasome activation in nucleus pulposus to maintain homeostasis of the intervertebral disc. Bone Res. 10, 5 (2022).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wu, X. et al. Kindlin-2 deletion in osteoprogenitors causes severe chondrodysplasia and low-turnover osteopenia in mice. J. Orthop. Transl. 32, 41–48 (2022).

Google Scholar 

Lei, Y. et al. LIM domain proteins Pinch1/2 regulate chondrogenesis and bone mass in mice. Bone Res. 8, 37 (2020).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wang, Y., et al., Focal adhesion proteins Pinch1 and Pinch2 regulate bone homeostasis in mice. JCI Insight 4, e131692 (2019).

Zhang, Z., et al. Postnatal loss of Kindlin-2 leads to progressive heart failure. Circ. Heart Fail. 9, e003129 (2016).

Qi, L. et al. Kindlin-2 suppresses transcription factor GATA4 through interaction with SUV39H1 to attenuate hypertrophy. Cell Death Dis. 10, 890 (2019).

Article  PubMed  PubMed Central  Google Scholar 

Liang, X., Sun, Y. & Chen, J. Particularly interesting cysteine- and histidine-rich protein in cardiac development and remodeling. J. Investig. Med. 57, 842–848 (2009).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Sun, Y. et al. Kindlin-2 association with Rho GDP-dissociation inhibitor α suppresses Rac1 activation and podocyte injury. J. Am. Soc. Nephrol. 28, 3545–3562 (2017).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wei, X. et al. Kindlin-2 mediates activation of TGF-β/Smad signaling and renal fibrosis. J. Am. Soc. Nephrol. 24, 1387–1398 (2013).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lausecker, F. et

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