Read SH, Wild SH (2020) Prevention of premature cardiovascular death worldwide. Lancet 395:758–760. https://doi.org/10.1016/s0140-6736(19)32034-3

Article  PubMed  Google Scholar 

Roth GA, Forouzanfar MH, Moran AE et al (2015) Demographic and epidemiologic drivers of global cardiovascular mortality. N Engl J Med 372:1333–1341. https://doi.org/10.1056/NEJMoa1406656

Article  CAS  PubMed  PubMed Central  Google Scholar 

Valtorta NK, Kanaan M, Gilbody S, Ronzi S, Hanratty B (2016) Loneliness and social isolation as risk factors for coronary heart disease and stroke: systematic review and meta-analysis of longitudinal observational studies. Heart 102:1009–1016. https://doi.org/10.1136/heartjnl-2015-308790

Article  CAS  PubMed  Google Scholar 

Hodgson S, Watts I, Fraser S, Roderick P, Dambha-Miller H (2020) Loneliness, social isolation, cardiovascular disease and mortality: a synthesis of the literature and conceptual framework. J R Soc Med 113:185–192. https://doi.org/10.1177/0141076820918236

Article  PubMed  PubMed Central  Google Scholar 

House JS, Landis KR, Umberson D (1988) Social relationships and health. Science 241:540–545. https://doi.org/10.1126/science.3399889

Article  CAS  PubMed  Google Scholar 

Gerlach LB, Solway ES, Malani PN (2024) Social isolation and loneliness in older adults. JAMA 331:2058. https://doi.org/10.1001/jama.2024.3456

Article  PubMed  Google Scholar 

Holt-Lunstad J, Smith TB, Layton JB (2010) Social relationships and mortality risk: a meta-analytic review. PLoS Med 7:e1000316. https://doi.org/10.1371/journal.pmed.1000316

Article  PubMed  PubMed Central  Google Scholar 

National Academies of Sciences, Engineering, and Medicine; Division of Behavioral and Social Sciences and Education; Health and Medicine Division; Board on Behavioral, Cognitive, and Sensory Sciences; Board on Health Sciences Policy; Committee on the Health and Medical Dimensions of Social Isolation and Loneliness in Older Adults (2020) Social Isolation and Loneliness in Older Adults: Opportunities for the Health Care System. National Academies Press, Washington (DC)

Stafford M, von Wagner C, Perman S, Taylor J, Kuh D, Sheringham J (2018) Social connectedness and engagement in preventive health services: an analysis of data from a prospective cohort study. Lancet Public Health 3:e438–e446. https://doi.org/10.1016/s2468-2667(18)30141-5

Article  PubMed  PubMed Central  Google Scholar 

Lakey B, Cohen S (2000) Social support theory and measurement. In: Cohen S, Underwood LG, Gottlieb BH (ed) Social support measurement and intervention: a guide for health and social scientists, edn. Oxford University Press, New York, NY, US, pp 29–52

Chapter  Google Scholar 

Berkman LF, Glass T, Brissette I, Seeman TE (2000) From social integration to health: Durkheim in the new millennium. Soc Sci Med 51:843–857. https://doi.org/10.1016/s0277-9536(00)00065-4

Article  CAS  PubMed  Google Scholar 

Cohen S, Gottlieb BH, Underwood LG (2000) Social relationships and health. In: Cohen S, Underwood LG, Gottlieb BH (ed) Social support measurement and intervention: a guide for health and social scientists, edn. Oxford University Press, New York, NY, US, pp 3–25

Chapter  Google Scholar 

Freak-Poli R, Phyo AZZ, Hu J, Barker SF (2022) Are social isolation, lack of social support or loneliness risk factors for cardiovascular disease in Australia and New Zealand? A systematic review and meta-analysis. Health Promot J Austr 33(Suppl 1):278–315. https://doi.org/10.1002/hpja.592

Article  PubMed  PubMed Central  Google Scholar 

Meng M, Ma Z, Zhou H et al (2024) The impact of social relationships on the risk of stroke and post-stroke mortality: a systematic review and meta-analysis. BMC Public Health 24:2403. https://doi.org/10.1186/s12889-024-19835-6

Article  PubMed  PubMed Central  Google Scholar 

Page MJ, McKenzie JE, Bossuyt PM et al (2021) The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. PLoS Med 18:e1003583. https://doi.org/10.1371/journal.pmed.1003583

Article  PubMed  PubMed Central  Google Scholar 

Wang F, Gao Y, Han Z et al (2023) A systematic review and meta-analysis of 90 cohort studies of social isolation, loneliness and mortality. Nat Hum Behav 7:1307–1319. https://doi.org/10.1038/s41562-023-01617-6

Article  PubMed  Google Scholar 

Gunnes M, Løe IC, Kalseth J (2024) Exploring the impact of information and communication technologies on loneliness and social isolation in community-dwelling older adults: a scoping review of reviews. BMC Geriatr 24:215. https://doi.org/10.1186/s12877-024-04837-1

Article  PubMed  PubMed Central  Google Scholar 

Kuiper JS, Zuidersma M, Oude Voshaar RC et al (2015) Social relationships and risk of dementia: a systematic review and meta-analysis of longitudinal cohort studies. Ageing Res Rev 22:39–57. https://doi.org/10.1016/j.arr.2015.04.006

Article  PubMed  Google Scholar 

Wang S, Molassiotis A, Guo C, Leung ISH, Leung AYM (2023) Association between social integration and risk of dementia: a systematic review and meta-analysis of longitudinal studies. J Am Geriatr Soc 71:632–645. https://doi.org/10.1111/jgs.18094

Article  PubMed  Google Scholar 

Zhao YL, Qu Y, Ou YN, Zhang YR, Tan L, Yu JT (2021) Environmental factors and risks of cognitive impairment and dementia: a systematic review and meta-analysis. Ageing Res Rev 72:101504. https://doi.org/10.1016/j.arr.2021.101504

Article  PubMed  Google Scholar 

Pan A, Sun Q, Okereke OI, Rexrode KM, Hu FB (2011) Depression and risk of stroke morbidity and mortality: a meta-analysis and systematic review. JAMA 306:1241–1249. https://doi.org/10.1001/jama.2011.1282

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kim Y, Je Y (2018) Meat consumption and risk of metabolic syndrome: results from the Korean population and a meta-analysis of observational studies. Nutrients. https://doi.org/10.3390/nu10040390

Article  PubMed  PubMed Central  Google Scholar 

Higgins JP, Thompson SG (2004) Controlling the risk of spurious findings from meta-regression. Stat Med 23:1663–1682. https://doi.org/10.1002/sim.1752

Article  PubMed  Google Scholar 

Duval S, Tweedie R (2000) Trim and fill: a simple funnel-plot-based method of testing and adjusting for publication bias in meta-analysis. Biometrics 56:455–463. https://doi.org/10.1111/j.0006-341x.2000.00455.x

Article  CAS  PubMed  Google Scholar 

Rosengren A, Wilhelmsen L, Orth-Gomér K (2004) Coronary disease in relation to social support and social class in Swedish men. A 15 year follow-up in the study of men born in 1933. Eur Heart J 25:56–63. https://doi.org/10.1016/j.ehj.2003.10.005

Article  PubMed  Google Scholar 

Gronewold J, Kropp R, Lehmann N et al (2020) Association of social relationships with incident cardiovascular events and all-cause mortality. Heart 106:1317–1323. https://doi.org/10.1136/heartjnl-2019-316250

Article  PubMed  Google Scholar 

Freeborne N, Simmens SJ, Manson JE et al (2019) Perceived social support and the risk of cardiovascular disease and all-cause mortality in the women’s health initiative observational study. Menopause 26:698–707. https://doi.org/10.1097/gme.0000000000001297

Article  PubMed  Google Scholar 

Liang YY, Chen Y, Feng H et al (2023) Association of social isolation and loneliness with incident heart failure in a population-based cohort study. JACC: Heart Failure 11:334–344. https://doi.org/10.1016/j.jchf.2022.11.028

Article  CAS  PubMed  Google Scholar 

Chang SC, Glymour M, Cornelis M et al (2017) Social integration and reduced risk of coronary heart disease in women: the role of lifestyle behaviors. Circ Res 120:1927–1937. https://doi.org/10.1161/circresaha.116.309443

Article  CAS  PubMed  PubMed Central  Google Scholar 

Nagayoshi M, Everson-Rose SA, Iso H, Mosley TH Jr., Rose KM, Lutsey PL (2014) Social network, social support, and risk of incident stroke: atherosclerosis risk in communities study. Stroke 45:2868–2873. https://doi.org/10.1161/strokeaha.114.005815

Article  CAS  PubMed  PubMed Central