Scammell TE. Narcolepsy. N Engl J Med. 2015;373(27):2654–62. https://doi.org/10.1056/nejmra1500587.

Article  CAS  PubMed  Google Scholar 

Bassetti CL, Adamantidis A, Burdakov D, et al. Narcolepsy—clinical spectrum, aetiopathophysiology, diagnosis and treatment. Nat Rev Neurol. 2019;15(9):519–39. https://doi.org/10.1038/s41582-019-0226-9.

Article  PubMed  Google Scholar 

Ruoff C, Rye D. The ICSD-3 and DSM-5 guidelines for diagnosing narcolepsy: clinical relevance and practicality. Curr Med Res Opin. 2016;32(10):1611–22. https://doi.org/10.1080/03007995.2016.1208643.

Article  CAS  PubMed  Google Scholar 

Barateau L, Pizza F, Chenini S, et al. Narcolepsies, update in 2023. Rev Neurol (Paris). 2023. https://doi.org/10.1016/j.neurol.2023.08.001.

Article  PubMed  Google Scholar 

Andlauer O, Moore H IV, Jouhier L, et al. Nocturnal rapid eye movement sleep latency for identifying patients with narcolepsy/hypocretin deficiency. JAMA Neurol. 2013. https://doi.org/10.1001/jamaneurol.2013.1589.

Article  PubMed  PubMed Central  Google Scholar 

Cairns A, Bogan R. Prevalence and clinical correlates of a short onset REM period (SOREMP) during routine PSG. Sleep. 2015;38(10):1575–81. https://doi.org/10.5665/sleep.5050.

Article  PubMed  PubMed Central  Google Scholar 

Reiter J, Katz E, Scammell TE, Maski K. Usefulness of a nocturnal SOREMP for diagnosing narcolepsy with cataplexy in a pediatric population. Sleep. 2015;38(6):859–65. https://doi.org/10.5665/sleep.4728.

Article  PubMed  PubMed Central  Google Scholar 

Ruoff C, Pizza F, Trotti LM, et al. The MSLT is repeatable in narcolepsy type 1 but not narcolepsy type 2: a retrospective patient study. J Clin Sleep Med. 2018;14(1):65–74. https://doi.org/10.5664/jcsm.6882.

Article  PubMed  PubMed Central  Google Scholar 

Aldrich MS, Chervin RD, Malow BA. Value of the multiple sleep latency test (MSLT) for the diagnosis of narcolepsy. Sleep. 1997;20(8):620–9. https://doi.org/10.1093/sleep/20.8.620.

Article  CAS  PubMed  Google Scholar 

Goldbart A, Peppard P, Finn L, et al. Narcolepsy and predictors of positive MSLTs in the Wisconsin Sleep Cohort. Sleep. 2014;37(6):1043–51. https://doi.org/10.5665/sleep.3758.

Article  PubMed  PubMed Central  Google Scholar 

Vernet C, Arnulf I. Idiopathic hypersomnia with and without long sleep time: a controlled series of 75 patients. Sleep. 2009;32(6):753–9. https://doi.org/10.1093/sleep/32.6.753.

Article  PubMed  PubMed Central  Google Scholar 

Trotti LM, Staab BA, Rye DB. Test-retest reliability of the multiple sleep latency test in narcolepsy without cataplexy and idiopathic hypersomnia. J Clin Sleep Med. 2013;9(8):789–95. https://doi.org/10.5664/jcsm.2922.

Article  PubMed  PubMed Central  Google Scholar 

Chun H-S, Kim S-M, Kim T-W, et al. Different course of narcolepsy diagnosed by multiple sleep latency test: a single center experience. Sleep Med Res. 2022;13(3):153–7. https://doi.org/10.17241/smr.2022.01529.

Article  Google Scholar 

Arnulf I, Thomas R, Roy A, Dauvilliers Y. Update on the treatment of idiopathic hypersomnia: progress, challenges, and expert opinion. Sleep Med Rev. 2023;69: 101766. https://doi.org/10.1016/j.smrv.2023.101766.

Article  CAS  PubMed  Google Scholar 

Franceschini C, Pizza F, Cavalli F, Plazzi G. A practical guide to the pharmacological and behavioral therapy of narcolepsy. Neurotherapeutics. 2021;18(1):6–19. https://doi.org/10.1007/s13311-021-01051-4.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lopez R, Doukkali A, Barateau L, et al. Test–retest reliability of the multiple sleep latency test in central disorders of hypersomnolence. Sleep. 2017;40(12):zsx164. https://doi.org/10.1093/sleep/zsx164.

Article  Google Scholar 

Huang YS, Guilleminault C, Lin CH, et al. Multiple sleep latency test in narcolepsy type 1 and narcolepsy type 2: a 5-year follow-up study. J Sleep Res. 2018;27: e12700. https://doi.org/10.1111/jsr.12700.

Article  PubMed  Google Scholar 

Dietmann A, Gallino C, Wenz E, et al. Multiple sleep latency test and polysomnography in patients with central disorders of hypersomnolence. Sleep Med. 2021;79:6–10. https://doi.org/10.1016/j.sleep.2020.12.037.

Article  PubMed  Google Scholar 

Pizza F, Vandi S, Iloti M, et al. Nocturnal sleep dynamics identify narcolepsy type 1. Sleep. 2015;38(8):1277–84. https://doi.org/10.5665/sleep.4908.

Article  PubMed  PubMed Central  Google Scholar 

Zeng S, Feng F, Li W, et al. Exploring sleep characteristics in Chinese patients with narcolepsy: insights from the nocturnal sleep onset rapid eye movement period (nSOREMP). J Clin Sleep Med. 2024. https://doi.org/10.5664/jcsm.11168.

Article  PubMed  Google Scholar 

Thorpy MJ, Siegel JM, Dauvilliers Y. REM sleep in narcolepsy. Sleep Med Rev. 2024. https://doi.org/10.1016/j.smrv.2024.101976.

Article  PubMed  Google Scholar 

Nishino S, Riehl J, Hong J, et al. Is narcolepsy a REM sleep disorder? Analysis of sleep abnormalities in narcoleptic Dobermans. Neurosci Res. 2000;38(4):437–46. https://doi.org/10.1016/s0168-0102(00)00195-4.

Article  CAS  PubMed  Google Scholar 

Drakatos P, Suri A, Higgins SE, et al. Sleep stage sequence analysis of sleep onset REM periods in the hypersomnias. J Neurol Neurosurg Psychiatry. 2013;84(2):223–7. https://doi.org/10.1136/jnnp-2012-303578.

Article  PubMed  Google Scholar 

Sampat AC, Avidan AY. Multiple sleep latency test/maintenance of wakefulness test and central hypersomnias: evolving diagnostic and therapeutic approaches. J Clin Neurophysiol. 2023;40(3):203–14. https://doi.org/10.1097/WNP.0000000000000786.

Article  PubMed  Google Scholar 

Baumann CR, Mignot E, Lammers GJ, et al. Challenges in diagnosing narcolepsy without cataplexy: a consensus statement. Sleep. 2014;37(6):1035–42. https://doi.org/10.5665/sleep.3756.

Article  PubMed  PubMed Central  Google Scholar 

Johns MW. Sensitivity and specificity of the multiple sleep latency test (MSLT), the maintenance of wakefulness test and the Epworth sleepiness scale: failure of the MSLT as a gold standard. J Sleep Res. 2000;9(1):5–11. https://doi.org/10.1046/j.1365-2869.2000.00177.x.

Article  CAS  PubMed  Google Scholar 

Mignot E, Lin L, Finn L, et al. Correlates of sleep-onset REM periods during the Multiple Sleep Latency Test in community adults. Brain. 2006;129(6):1609–23. https://doi.org/10.1093/brain/awl079.

Article  PubMed  Google Scholar 

Singh M, Drake CL, Roth T. The prevalence of multiple sleep-onset REM periods in a population-based sample. Sleep. 2006;29(7):890–5. https://doi.org/10.1093/sleep/29.7.890.

Article  PubMed  Google Scholar 

Marti I, Valko PO, Khatami R, et al. Multiple sleep latency measures in narcolepsy and behaviourally induced insufficient sleep syndrome. Sleep Med. 2009;10(10):1146–50. https://doi.org/10.1016/j.sleep.2009.03.008.

Article  PubMed  Google Scholar 

Wang Z, Wu H, Stone WS, et al. Body weight and basal metabolic rate in childhood narcolepsy: a longitudinal study. Sleep Med. 2016;25:139–44. https://doi.org/10.1016/j.sleep.2016.06.019.

Article  PubMed  Google Scholar 

Tsujino N, Sakurai T. Role of orexin in modulating arousal, feeding, and motivation. Front Behav Neurosci. 2013;7:28. https://doi.org/10.3389/fnbeh.2013.00028.