Abascal-Saiz A, Duque-Alcorta M, Fioravantti V, Antolin E, Fuente-Luelmo E, Haro M, Ramos-Alvarez MP, Perdomo G, Bartha JL (2022) The Relationship between Angiogenic Factors and Energy Metabolism in Preeclampsia. Nutrients 14

Amaral LM, Wallace K, Owens M, LaMarca B (2017) Pathophysiology and current clinical management of Preeclampsia. Curr Hypertens Rep 19:61

Article  PubMed  PubMed Central  Google Scholar 

Bakrania BA, George EM, Granger JP (2022) Animal models of preeclampsia: investigating pathophysiology and therapeutic targets. Am J Obstet Gynecol 226:S973–S987

Article  CAS  PubMed  Google Scholar 

Carlström M, Wentzel P, Skøtt O, Persson AE, Eriksson UJ (2009) Angiogenesis inhibition causes hypertension and placental dysfunction in a rat model of preeclampsia. J Hypertens 27:829–837

Article  PubMed  Google Scholar 

Chaiworapongsa T, Romero R, Korzeniewski SJ, Cortez JM, Pappas A, Tarca AL, Chaemsaithong P, Dong Z, Yeo L, Hassan SS (2014) Plasma concentrations of angiogenic/anti-angiogenic factors have prognostic value in women presenting with suspected preeclampsia to the obstetrical triage area: a prospective study. J Matern Fetal Neonatal Med 27:132–144

Article  CAS  PubMed  Google Scholar 

Chen X, Chen K, Feng Y, Ren C, Li W, Xiao J, Fan L, Beejadhursing R, Xi L, Chen S (2019) The potential role of pregnancy-associated plasma protein-A2 in angiogenesis and development of preeclampsia. Hypertens Res 42:970–980

Article  CAS  PubMed  Google Scholar 

Chen Q, Jiang S, Liu H, Gao Y, Yang X, Ren Z, Gao Y, Xiao L, Hu H, Yu Y, Yang X, Zhong M (2020) Association of lncRNA SH3PXD2A-AS1 with preeclampsia and its function in invasion and migration of placental trophoblast cells. Cell Death Dis 11:583

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chen Q, He J, Liu H, Huang Q, Wang S, Yin A, Chen S, Shen X, Xiao Y, Hu H, Jiang J, Chen W, Wang S, Huang Z, Li J, Peng Y, Wang X, Yang X, Wang Z, Zhong M (2023a) Small extracellular vesicles-transported lncRNA TDRKH-AS1 derived from AOPPs-treated trophoblasts initiates endothelial cells pyroptosis through PDIA4/DDIT4 axis in preeclampsia. J Transl Med 21:496

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chen Y, Liu X, Li L, He X, Zheng F, Zhang Y, Gao H, Jin Z, Wu D, Wang Q, Tao H, Zhao Y, Liu W, Zou L (2023b) Methyltransferase-like 3 aggravates endoplasmic reticulum stress in preeclampsia by targeting TMBIM6 in YTHDF2-dependent manner. Mol Med 29:19

Article  CAS  PubMed  PubMed Central  Google Scholar 

Cheng L, Zhao L, Wang G (2024) Propofol promoted the Cell Growth and Epithelial Mesenchymal Transformation of the HTR-8/SVneo cells through targeting the METTL3 mediated ZEB2. Reprod Sci 31:687–696

Article  CAS  PubMed  Google Scholar 

Ciavarella C, Motta I, Vasuri F, Fittipaldi S, Valente S, Pollutri D, Ricci F, Gargiulo M, Pasquinelli G (2021) Involvement of miR-30a-5p and miR-30d in Endothelial to Mesenchymal Transition and Early Osteogenic Commitment under Inflammatory Stress in HUVEC. Biomolecules 11

Darden J, Payne LB, Zhao H, Chappell JC (2019) Excess vascular endothelial growth factor-A disrupts pericyte recruitment during blood vessel formation. Angiogenesis 22:167–183

Article  CAS  PubMed  Google Scholar 

de Jager SCA, Meeuwsen JAL, van Pijpen FM, Zoet GA, Barendrecht AD, Franx A, Pasterkamp G, van Rijn BB, Goumans MJ and den, Ruijter HM (2017) Preeclampsia and coronary plaque erosion: Manifestations of endothelial dysfunction resulting in cardiovascular events in women. Eur J Pharmacol 816, 129–137

Du L, Kuang L, He F, Tang W, Sun W, Chen D (2017) Mesenchymal-to-epithelial transition in the placental tissues of patients with preeclampsia. Hypertens Res 40:67–72

Article  CAS  PubMed  Google Scholar 

Dymara-Konopka W, Laskowska M, Oleszczuk J (2018) Preeclampsia - Current Management and Future Approach. Curr Pharm Biotechnol 19:786–796

Article  CAS  PubMed  Google Scholar 

Eremina V, Jefferson JA, Kowalewska J, Hochster H, Haas M, Weisstuch J, Richardson C, Kopp JB, Kabir MG, Backx PH, Gerber HP, Ferrara N, Barisoni L, Alpers CE, Quaggin SE (2008) VEGF inhibition and renal thrombotic microangiopathy. N Engl J Med 358:1129–1136

Article  CAS  PubMed  PubMed Central  Google Scholar 

Fatica A, Bozzoni I (2014) Long non-coding RNAs: new players in cell differentiation and development. Nat Rev Genet 15:7–21

Article  CAS  PubMed  Google Scholar 

Gao C, Yang H, Xia F (2021) Increased LINC00922 in preeclampsia regulates the proliferation, invasion, and migration of placental trophoblast cells. Ann Transl Med 9:1553

Article  CAS  PubMed  PubMed Central  Google Scholar 

Germain AM, Romanik MC, Guerra I, Solari S, Reyes MS, Johnson RJ, Price K, Karumanchi SA, Valdés G (2007) Endothelial dysfunction: a link among preeclampsia, recurrent pregnancy loss, and future cardiovascular events? Hypertension 49:90–95

Article  CAS  PubMed  Google Scholar 

Hong K, Kim SH, Cha DH, Park HJ (2021) Defective Uteroplacental Vascular Remodeling in Preeclampsia: key molecular factors leading to Long Term Cardiovascular Disease. Int J Mol Sci 22

Jiang S, Chen Q, Liu H, Gao Y, Yang X, Ren Z, Gao Y, Xiao L, Zhong M, Yu Y, Yang X (2020) Preeclampsia-Associated lncRNA INHBA-AS1 regulates the Proliferation, Invasion, and Migration of placental trophoblast cells. Mol Ther Nucleic Acids 22:684–695

Article  CAS  PubMed  PubMed Central  Google Scholar 

Launay-Vacher V, Deray G (2009) Hypertension and proteinuria: a class-effect of antiangiogenic therapies. Anticancer Drugs 20:81–82

Article  CAS  PubMed  Google Scholar 

Levine RJ, Lam C, Qian C, Yu KF, Maynard SE, Sachs BP, Sibai BM, Epstein FH, Romero R, Thadhani R, Karumanchi SA (2006) Soluble endoglin and other circulating antiangiogenic factors in preeclampsia. N Engl J Med 355:992–1005

Article  CAS  PubMed  Google Scholar 

Lu F, Longo M, Tamayo E, Maner W, Al-Hendy A, Anderson GD, Hankins GD, Saade GR (2007) The effect of over-expression of sFlt-1 on blood pressure and the occurrence of other manifestations of preeclampsia in unrestrained conscious pregnant mice. Am J Obstet Gynecol 196, 396.e391-397; discussion 396.e397.

Ma J, Hu H, Lin M, Chen L, Liu M, Li H, Quan S (2021) ELABELA alleviates syncytiotrophoblast hypoxia/reoxygenation injury and preeclampsia-like symptoms in mice by reducing apoptosis. Placenta 106:30–39

Article  CAS  PubMed  Google Scholar 

Ma’ayeh M, Costantine MM (2020) Prevention of preeclampsia. Semin Fetal Neonatal Med 25:101123

Article  PubMed  PubMed Central  Google Scholar 

McCracken SA, Seeho SKM, Carrodus T, Park JH, Woodland N, Gallery EDM, Morris JM, Ashton AW (2022) Dysregulation of Oxygen Sensing/Response pathways in pregnancies complicated by Idiopathic Intrauterine Growth Restriction and Early-Onset Preeclampsia. Int J Mol Sci 23

Nagano T, Fraser P (2011) No-nonsense functions for long noncoding RNAs. Cell 145:178–181

Article  CAS  PubMed  Google Scholar 

Nezu M, Souma T, Yu L, Sekine H, Takahashi N, Wei AZ, Ito S, Fukamizu A, Zsengeller ZK, Nakamura T, Hozawa A, Karumanchi SA, Suzuki N, Yamamoto M (2017) Nrf2 inactivation enhances placental angiogenesis in a preeclampsia mouse model and improves maternal and fetal outcomes. Sci Signal 10

Poon LC, Shennan A, Hyett JA, Kapur A, Hadar E, Divakar H, McAuliffe F, da Silva Costa F, von Dadelszen P, McIntyre HD, Kihara AB, Di Renzo GC, Romero R, D’Alton M, Berghella V, Nicolaides KH, Hod M (2019) The International Federation of Gynecology and Obstetrics (FIGO) initiative on pre-eclampsia: a pragmatic guide for first-trimester screening and prevention. Int J Gynaecol Obstet 145(Suppl 1):1–33

Article  PubMed  PubMed Central  Google Scholar 

Qin S, Mao Y, Wang H, Duan Y, Zhao L (2021) The interplay between m6A modification and non-coding RNA in cancer stemness modulation: mechanisms, signaling pathways, and clinical implications. Int J Biol Sci 17:2718–2736

Article  CAS  PubMed  PubMed Central  Google Scholar 

Rinn JL, Chang HY (2012) Genome regulation by long noncoding RNAs. Annu Rev Biochem 81:145–166

Article  CAS  PubMed  Google Scholar 

Shen W, Huang Y, Zhang Q, Lin F, Wang X, Ye D, Huang Y (2020) SCH58261, the antagonist of adenosine A2A receptor, alleviates cadmium-induced preeclampsia via sirtiun-1/hypoxia-inducible factor-1α pathway in rats. Eur Rev Med Pharmacol Sci 24:10941–10953

PubMed  Google Scholar 

Staff AC (2019) The two-stage placental model of preeclampsia: an update. J Reprod Immunol 134–135:1–10

Article  PubMed  Google Scholar 

Sun YY, Lu M, Xi XW, Qiao QQ, Chen LL, Xu XM, Feng YJ (2011) Regulation of epithelial-mesenchymal transition by homeobox gene DLX4 in JEG-3 trophoblast cells: a role in preeclampsia. Reprod Sci 18:1138–1145

Article  CAS