Aye Y, Li M, Long MJC, Weiss RS (2015) Ribonucleotide reductase and cancer: biological mechanisms and targeted therapies. Oncogene 34(16):2011–2021

Article  PubMed  CAS  Google Scholar 

Boison D, Yegutkin GG (2019) Adenosine Metabolism: Emerging Concepts for Cancer Therapy. Cancer Cell 36(6):582–596

Article  PubMed  PubMed Central  CAS  Google Scholar 

Cai J, Sun X, Guo H, Qu X, Huang H, Yu C et al (2020) Non-metabolic role of UCK2 links EGFR-AKT pathway activation to metastasis enhancement in hepatocellular carcinoma. Oncogenesis 9(12):103

Article  PubMed  PubMed Central  CAS  Google Scholar 

Chandel NS. (2021) Nucleotide Metabolism. Cold Spring Harb Perspect Biol 13(7).

Christopherson RI, Lyons SD, Wilson PK (2002) Inhibitors of de novo nucleotide biosynthesis as drugs. Acc Chem Res 35(11):961–971

Article  PubMed  CAS  Google Scholar 

Dong C, Guo Y, Yang Y, Ge X (2024) Comprehensive analysis of PSME3: from pan-cancer analysis to experimental validation. Front Immunol 15:1295693

Article  PubMed  PubMed Central  CAS  Google Scholar 

Fawal MA, Jungas T, Davy A (2021) Inhibition of DHFR targets the self-renewing potential of brain tumor initiating cells. Cancer Lett 503:129–137

Article  PubMed  CAS  Google Scholar 

Fu Y, Wei XD, Guo L, Wu K, Le J, Ma Y et al (2022) The Metabolic and Non-Metabolic Roles of UCK2 in Tumor Progression. Front Oncol 12:904887

Article  PubMed  PubMed Central  CAS  Google Scholar 

Guo Y, Zheng Z, Zhang W, Mao S, Yang F, Li W et al (2022) Gender dimorphism in survival of patients with lymph node metastasis of bladder cancer. Ther Adv Med Oncol 14:17588359221108690

Article  PubMed  PubMed Central  CAS  Google Scholar 

Guo Y, Zheng Z, Mao S, Yang F, Wang R, Wang H et al (2023) Metabolic-associated signature and hub genes associated with immune microenvironment and prognosis in bladder cancer. Mol Carcinog 62(2):185–199

Article  PubMed  CAS  Google Scholar 

Hammond-Thelin LA, Thomas MB, Iwasaki M, Abbruzzese JL, Lassere Y, Meyers CA et al (2012) Phase I and pharmacokinetic study of 3’-C-ethynylcytidine (TAS-106), an inhibitor of RNA polymerase I, II and III, in patients with advanced solid malignancies. Invest New Drugs 30(1):316–326

Article  PubMed  CAS  Google Scholar 

Islam S, Zahid U, Cooke L, Lee YB, Kim DJ, Benaim E et al (2017) RX-3117, a Novel Nucleoside Analog Targeting UCK2 Is Active Alone and Synergistic with Ibrutinib and Bendamustine in ABC and DH/DPDiffuse Large B-Cell Lymphoma. Blood 130(Supplement 1):5196-

Jordan B, Meeks JJ (2019) T1 bladder cancer: current considerations for diagnosis and management. Nat Rev Urol 16(1):23–34

Article  PubMed  Google Scholar 

Li Q, Zhang L, Yang Q, Li M, Pan X, Xu J et al (2023) Thymidine kinase 1 drives hepatocellular carcinoma in enzyme-dependent and -independent manners. Cell Metab 35(6):912–27.e7

Article  PubMed  CAS  Google Scholar 

Liu C, Zhang W, Zhou X, Liu L (2022) IMPDH1, a prognostic biomarker and immunotherapy target that correlates with tumor immune microenvironment in pan-cancer and hepatocellular carcinoma. Front Immunol 13:983490

Article  PubMed  PubMed Central  CAS  Google Scholar 

Liu Y, Sun Y, Guo Y, Shi X, Chen X, Feng W et al (2023) An Overview: The Diversified Role of Mitochondria in Cancer Metabolism. Int J Biol Sci 19(3):897–915

Article  PubMed  PubMed Central  CAS  Google Scholar 

Malami I, Abdul AB, Abdullah R, Kassim NK, Rosli R, Yeap SK et al (2017) Crude Extracts, Flavokawain B and Alpinetin Compounds from the Rhizome of Alpinia mutica Induce Cell Death via UCK2 Enzyme Inhibition and in Turn Reduce 18S rRNA Biosynthesis in HT-29 Cells. PLoS ONE 12(1):e0170233

Article  PubMed  PubMed Central  Google Scholar 

Matchett EC, Ambrose EC, Kornbluth J (2022) Characterization of uridine-cytidine kinase like-1 nucleoside kinase activity and its role in tumor growth. Biochem J 479(11):1149–1164

Article  PubMed  CAS  Google Scholar 

Meeks JJ, Black PC, Galsky M, Grivas P, Hahn NM, Hussain SA et al (2023) Checkpoint Inhibitors in Urothelial Carcinoma—Future Directions and Biomarker Selection. Eur Urol 84(5):473–483

Article  PubMed  CAS  Google Scholar 

Mollick T, Laín S (2020) Modulating pyrimidine ribonucleotide levels for the treatment of cancer. Cancer & Metabolism 8(1):12

Article  Google Scholar 

Mullen NJ, Singh PK (2023) Nucleotide metabolism: a pan-cancer metabolic dependency. Nat Rev Cancer 23(5):275–294

Article  PubMed  PubMed Central  CAS  Google Scholar 

Mullen NJ, Shukla SK, Thakur R, Kollala SS, Wang D, Chaika N et al (2024) DHODH inhibition enhances the efficacy of immune checkpoint blockade by increasing cancer cell antigen presentation. Elife 12

Murata D, Endo Y, Obata T, Sakamoto K, Syouji Y, Kadohira M et al (2004) A crucial role of uridine/cytidine kinase 2 in antitumor activity of 3’-ethynyl nucleosides. Drug Metab Dispos 32(10):1178–1182

Article  PubMed  CAS  Google Scholar 

Naffouje R, Grover P, Yu H, Sendilnathan A, Wolfe K, Majd N et al (2019) Anti-Tumor Potential of IMP Dehydrogenase Inhibitors: A Century-Long Story. Cancers (Basel) 11(9)

Przybyła T, Sakowicz-Burkiewicz M, Maciejewska I, Bielarczyk H, Pawełczyk T (2017) Suppression of ID1 expression in colon cancer cells increases sensitivity to 5-fluorouracil. Acta Biochim Pol 64(2):315–322

Article  PubMed  Google Scholar 

Robinson AD, Eich ML, Varambally S (2020) Dysregulation of de novo nucleotide biosynthetic pathway enzymes in cancer and targeting opportunities. Cancer Lett 470:134–140

Article  PubMed  CAS  Google Scholar 

Sarkisjan D, Julsing JR, Smid K, de Klerk D, van Kuilenburg AB, Meinsma R et al (2016) The Cytidine Analog Fluorocyclopentenylcytosine (RX-3117) Is Activated by Uridine-Cytidine Kinase 2. PLoS ONE 11(9):e0162901

Article  PubMed  PubMed Central  Google Scholar 

Shelton J, Lu X, Hollenbaugh JA, Cho JH, Amblard F, Schinazi RF (2016) Metabolism, Biochemical Actions, and Chemical Synthesis of Anticancer Nucleosides, Nucleotides, and Base Analogs. Chem Rev 116(23):14379–14455

Article  PubMed  PubMed Central  CAS  Google Scholar 

Shen G, He P, Mao Y, Li P, Luh F, Ding G et al (2017) Overexpression of Uridine-Cytidine Kinase 2 Correlates with Breast Cancer Progression and Poor Prognosis. J Breast Cancer 20(2):132–141

Article  PubMed  PubMed Central  Google Scholar 

Shi ZZ, Jin X, Li WT, Tao H, Song SJ, Fan ZW et al (2023) Dihydroorotate dehydrogenase promotes cell proliferation and suppresses cell death in esophageal squamous cell carcinoma and colorectal carcinoma. Transl Cancer Res 12(9):2294–2307

Article  PubMed  PubMed Central  CAS  Google Scholar 

Shimamoto Y, Koizumi K, Okabe H, Kazuno H, Murakami Y, Nakagawa F et al (2002) Sensitivity of human cancer cells to the new anticancer ribo-nucleoside TAS-106 is correlated with expression of uridine-cytidine kinase 2. Jpn J Cancer Res 93(7):825–833

Article  PubMed  PubMed Central  CAS  Google Scholar 

Siddiqui A, Gollavilli PN, Schwab A, Vazakidou ME, Ersan PG, Ramakrishnan M et al (2019) Thymidylate synthase maintains the de-differentiated state of triple negative breast cancers. Cell Death Differ 26(11):2223–2236

Article  PubMed  PubMed Central  CAS  Google Scholar 

Siegel RL, Miller KD, Wagle NS, Jemal A (2023) Cancer statistics, 2023. CA Cancer J Clin 73(1):17–48

Article  PubMed  Google Scholar