Bray F, Laversanne M, Sung H, Ferlay J, Siegel RL, Soerjomataram I et al (2024) Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin 74:229–263

Article  PubMed  Google Scholar 

Carpanese V, Festa M, Prosdocimi E, Bachmann M, Sadeghi S, Bertelli S et al (2024) Interactomic exploration of LRRC8A in volume-regulated anion channels. Cell Death Discov 10:299

Article  PubMed  PubMed Central  CAS  Google Scholar 

Chen Y, Zuo X, Wei Q, Xu J, Liu X, Liu S et al (2023) Upregulation of LRRC8A by m5C modification-mediated mRNA stability suppresses apoptosis and facilitates tumorigenesis in cervical cancer. Int J Biol Sci 19:691–704

Article  PubMed  PubMed Central  Google Scholar 

Choi H, Miller MR, Nguyen H-N, Rohrbough JC, Koch SR, Boatwright N et al (2023) LRRC8A anion channels modulate vascular reactivity via association with myosin phosphatase rho interacting protein. FASEB J 37:e23028

Article  PubMed  CAS  Google Scholar 

De Silva E, Devine DV, Jan E, Roskelley CD, Kim H (2022) Filamin A regulates caspase-3 cleavage in platelets in a protein kinase C (PKC)-dependent manner. Biochem J 479:2351–2364

Article  PubMed  Google Scholar 

Feng J, Peng Z, Gao L, Yang X, Sun Z, Hou X et al (2021) ClC-3 promotes paclitaxel resistance via modulating tubulins polymerization in ovarian cancer cells. Biomed Pharmacother 138:111407

Article  PubMed  CAS  Google Scholar 

Fife CM, McCarroll JA, Kavallaris M (2014) Movers and shakers: cell cytoskeleton in cancer metastasis. Br J Pharmacol 171:5507–5523

Article  PubMed  PubMed Central  CAS  Google Scholar 

Ganesh K, Massagué J (2021) Targeting metastatic cancer. Nat Med 27:34–44

Article  PubMed  PubMed Central  CAS  Google Scholar 

Henningsen KM, Manzini V, Magerhans A, Gerber S, Dobbelstein M (2021) MDM2-driven ubiquitination rapidly removes p53 from its cognate promoters. Biomol. https://doi.org/10.3390/biom12010022

Hirano T, Hirayama D, Wagatsuma K, Yamakawa T, Yokoyama Y, Nakase H (2020) Immunological mechanisms in inflammation-associated colon carcinogenesis. Int J Mol Sci. https://doi.org/10.3390/ijms21093062

Jordan MA, Wilson L (2004) Microtubules as a target for anticancer drugs. Nat Rev Cancer 4:253–265

Article  PubMed  CAS  Google Scholar 

Kurashima K, Shiozaki A, Kudou M, Shimizu H, Arita T, Kosuga T et al (2021) LRRC8A influences the growth of gastric cancer cells via the p53 signaling pathway. Gastric Cancer 24:1063–1075

Article  PubMed  CAS  Google Scholar 

Lambert IH, Hoffmann EK, Pedersen SF (2008) Cell volume regulation: physiology and pathophysiology. Acta Physiol (Oxf) 194:255–282

Article  PubMed  CAS  Google Scholar 

Li X, Wang J (2020) Mechanical tumor microenvironment and transduction: cytoskeleton mediates cancer cell invasion and metastasis. Int J Biol Sci 16:2014–2028

Article  PubMed  PubMed Central  CAS  Google Scholar 

Luo W (2023) Nasopharyngeal carcinoma ecology theory: cancer as multidimensional spatiotemporal “unity of ecology and evolution” pathological ecosystem. Theranostics 13:1607–1631

Article  PubMed  PubMed Central  CAS  Google Scholar 

Morishita K, Watanabe K, Ichijo H (2019) Cell volume regulation in cancer cell migration driven by osmotic water flow. Cancer Sci 110:2337–2347

Article  PubMed  PubMed Central  CAS  Google Scholar 

Muthusami S, Ramachandran IK, Babu KN, Krishnamoorthy S, Guruswamy A, Queimado L et al (2021) Role of Inflammation in the Development of Colorectal Cancer. Endocr Metab Immune Disord Drug Targets 21:77–90

PubMed  CAS  Google Scholar 

Nakamura F, Stossel TP, Hartwig JH (2011) The filamins: organizers of cell structure and function. Cell Adh Migr 5:160–169

Article  PubMed  PubMed Central  Google Scholar 

Qiu Z, Dubin AE, Mathur J, Tu B, Reddy K, Miraglia LJ et al (2014) SWELL1, a plasma membrane protein, is an essential component of volume-regulated anion channel. Cell 157:447–458

Article  PubMed  PubMed Central  CAS  Google Scholar 

Schwab A, Fabian A, Hanley PJ, Stock C (2012) Role of ion channels and transporters in cell migration. Physiol Rev 92:1865–1913

Article  PubMed  CAS  Google Scholar 

Shao Q-Q, Zhang T-P, Zhao W-J, Liu Z-W, You L, Zhou L et al (2016) Filamin A: Insights into its Exact Role in Cancers. Pathol Oncol Res 22:245–252

Article  PubMed  Google Scholar 

Solon J, Levental I, Sengupta K, Georges PC, Janmey PA (2007) Fibroblast adaptation and stiffness matching to soft elastic substrates. Biophys J 93:4453–4461

Article  PubMed  PubMed Central  CAS  Google Scholar 

Turner DGP, Tyan L, DeGuire FC, Medvedev RY, Stroebel SJ, Lang D et al (2022) Caveolin-3 prevents swelling-induced membrane damage via regulation of ICl,swell activity. Biophys J 121:1643–1659

Article  PubMed  PubMed Central  CAS  Google Scholar 

Voss FK, Ullrich F, Münch J, Lazarow K, Lutter D, Mah N et al (2014) Identification of LRRC8 heteromers as an essential component of the volume-regulated anion channel VRAC. Science 344:634–638

Article  PubMed  CAS  Google Scholar 

Wade M, Li Y-C, Wahl GM (2013) MDM2, MDMX and p53 in oncogenesis and cancer therapy. Nat Rev Cancer 13:83–96

Article  PubMed  PubMed Central  CAS  Google Scholar 

Wang EJY, Chen IH, Kuo BYT, Yu CC, Lai MT, Lin JT et al (2022) Alterations of cytoskeleton networksin cell fate determination and cancer development. Biomol. https://doi.org/10.3390/biom12121862

Article  Google Scholar 

Xu X, Xu J, Zhao C, Hou X, Li M, Wang L et al (2019) Antitumor effects of disulfiram/copper complex in the poorly-differentiated nasopharyngeal carcinoma cells via activating ClC-3 chloride channel. Biomed Pharmacother 120:109529

Article  PubMed  CAS  Google Scholar 

Yang Y, Li M, Sun X, Zhou C, Wang Y, Wang L et al (2017) The selective cytotoxicity of DSF-Cu attributes to the biomechanical properties and cytoskeleton rearrangements in the normal and cancerous nasopharyngeal epithelial cells. Int J Biochem Cell Biol. https://doi.org/10.1016/j.biocel.2017.01.007

Article  PubMed  PubMed Central  Google Scholar 

Yang H, Ma L, Wang Y, Zuo W, Li B, Yang Y et al (2018) Activation of ClC-3 chloride channel by 17β-estradiol relies on the estrogen receptor α expression in breast cancer. J Cell Physiol 233:1071–1081

Article  PubMed  CAS  Google Scholar 

Zhang H, Li H, Yang L, Deng Z, Luo H, Ye D et al (2013) The ClC-3 chloride channel associated with microtubules is a target of paclitaxel in its induced-apoptosis. Sci Rep 3:2615

Article  PubMed  PubMed Central  Google Scholar 

Zhang Y, Xie L, Gunasekar SK, Tong D, Mishra A, Gibson WJ et al (2017) SWELL1 is a regulator of adipocyte size, insulin signalling and glucose homeostasis. Nat Cell Biol 19:504–517

Article  PubMed  PubMed Central  CAS  Google Scholar 

Zhang H, Deng Z, Zhang D, Li H, Zhang L, Niu J et al (2018) High expression of leucine-rich repeat-containing 8A is indicative of a worse outcome of colon cancer patients by enhancing cancer cell growth and metastasis. Oncol Rep 40:1275–1286

PubMed  PubMed Central  CAS