Increased CDKN2A expression correlates with resistance to platinum-based therapy and decreased infiltration of B lymphocytes in colon adenocarcinoma

Adams JL, Smothers J, Srinivasan R, Hoos A (2015) Big opportunities for small molecules in immuno-oncology. Nat Rev Drug Discov 14:603–622. https://doi.org/10.1038/nrd4596

Article  CAS  PubMed  Google Scholar 

Adib E, Nassar AH, Akl EW et al (2021) CDKN2A Alterations and Response to Immunotherapy in Solid Tumors. Clin Cancer Res 27:4025–4035. https://doi.org/10.1158/1078-0432.CCR-21-0575

Article  CAS  PubMed  PubMed Central  Google Scholar 

Alvarez-Fernandez M, Malumbres M (2020) Mechanisms of Sensitivity and Resistance to CDK4/6 Inhibition. Cancer Cell 37:514–529. https://doi.org/10.1016/j.ccell.2020.03.010

Article  CAS  PubMed  Google Scholar 

Beihaghi M, Sahebi R, Beihaghi MR et al (2023) Evaluation of rs10811661 polymorphism in CDKN2A/B in colon and gastric cancer. BMC Cancer 23:985. https://doi.org/10.1186/s12885-023-11461-6

Article  CAS  PubMed  PubMed Central  Google Scholar 

Benson AB, Venook AP, Al-Hawary MM et al (2021) Colon Cancer, Version 2.2021, NCCN Clinical Practice Guidelines in Oncology. J Natl Compr Cancer Netw 19:329–359. https://doi.org/10.6004/jnccn.2021.0012

Article  Google Scholar 

Bian Z, Fan R, Xie L (2022) A Novel Cuproptosis-Related Prognostic Gene Signature and Validation of Differential Expression in Clear Cell Renal Cell Carcinoma. Genes 13:851. https://doi.org/10.3390/genes13050851

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chen H, Deng J, Hou TW, Shan YQ (2024b) Villosol reverses 5-FU resistance in colorectal cancer by inhibiting the CDKN2A gene regulated TP53-PI3K/Akt signaling axis. J Ethnopharmacol 325:117907. https://doi.org/10.1016/j.jep.2024.117907

Article  CAS  PubMed  Google Scholar 

Chen L, Min J, Wang F (2022) Copper homeostasis and cuproptosis in health and disease. Sig Transduct Target Ther 7:378. https://doi.org/10.1038/s41392-022-01229-y

Article  CAS  Google Scholar 

Chen SH, Chang JY (2019) New Insights into Mechanisms of Cisplatin Resistance: From Tumor Cell to Microenvironment. Int J Mol Sci 20:4136. https://doi.org/10.3390/ijms20174136

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chen Y, Liao L, Wang B, Wu Z (2024a) Identification and validation of immune and cuproptosis - related genes for diabetic nephropathy by WGCNA and machine learning. Front Immunol 14:1084531. https://doi.org/10.3389/fimmu.2023.1084531

Article  CAS  Google Scholar 

Chung MKY, Gong L, Kwong DL et al (2023) Functions of double-negative B cells in autoimmune diseases, infections, and cancers. EMBO Mol Med 15:e17341. https://doi.org/10.15252/emmm.202217341

Article  CAS  PubMed  PubMed Central  Google Scholar 

Dong Y, Zheng M, Wang X, Yu C, Qin T, Shen X (2023) High expression of CDKN2A is associated with poor prognosis in colorectal cancer and may guide PD-1-mediated immunotherapy. BMC Cancer 23:1097. https://doi.org/10.1186/s12885-023-11603-w

Article  CAS  PubMed  PubMed Central  Google Scholar 

Fu R, Zhao B, Chen M et al (2023) Moving beyond cisplatin resistance: mechanisms, challenges, and prospects for overcoming recurrence in clinical cancer therapy. Med Oncol 41:9. https://doi.org/10.1007/s12032-023-02237-w

Article  CAS  PubMed  Google Scholar 

Han Y, Zhou S, Wang X, Mao E, Huang L (2020) SNHG14 stimulates cell autophagy to facilitate cisplatin resistance of colorectal cancer by regulating miR-186/ATG14 axis. Biomed Pharmacother 121:109580. https://doi.org/10.1016/j.biopha.2019.109580

Article  CAS  PubMed  Google Scholar 

Hausser-Kinzel S, Weber MS (2019) The Role of B Cells and Antibodies in Multiple Sclerosis, Neuromyelitis Optica, and Related Disorders. Front Immunol 10:201. https://doi.org/10.3389/fimmu.2019.00201

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hayward NK, Wilmott JS, Waddell N et al (2017) Whole-genome landscapes of major melanoma subtypes. Nature 545:175–180. https://doi.org/10.1038/nature22071

Article  CAS  PubMed  Google Scholar 

Huang D, Savage SR, Calinawan AP et al (2021) A highly annotated database of genes associated with platinum resistance in cancer. Oncogene 40:6395–6405. https://doi.org/10.1038/s41388-021-02055-2

Article  CAS  PubMed  PubMed Central  Google Scholar 

Inoue S, Ito H, Tsunoda T et al (2019) CD70 expression in tumor-associated fibroblasts predicts worse survival in colorectal cancer patients. Virchows Arch 475:425–434. https://doi.org/10.1007/s00428-019-02565-1

Article  CAS  PubMed  Google Scholar 

Jacobs J, Deschoolmeester V, Zwaenepoel K et al (2015) CD70: An emerging target in cancer immunotherapy. Pharmacol Ther 155:1–10. https://doi.org/10.1016/j.pharmthera.2015.07.007

Article  CAS  PubMed  Google Scholar 

Jendzelovsky R, Jendzelovska Z, Hilovska L, Koval J, Mikes J, Fedorocko P (2016) Proadifen sensitizes resistant ovarian adenocarcinoma cells to cisplatin. Toxicol Lett 243:56–56. https://doi.org/10.1016/j.toxlet.2015.12.002

Article  CAS  PubMed  Google Scholar 

Jiang X, Ke J, Jia L, An X, Ma H, Li Z, Yuan W (2023) A novel cuproptosis-related gene signature of prognosis and immune microenvironment in head and neck squamous cell carcinoma cancer. J Cancer Res Clin Oncol 149:203–218. https://doi.org/10.1007/s00432-022-04471-7

Article  CAS  PubMed  Google Scholar 

Laumont CM, Banville AC, Gilardi M, Hollern DP, Nelson BH (2022) Tumour-infiltrating B cells: immunological mechanisms, clinical impact and therapeutic opportunities. Nat Rev Cancer 22:414–430. https://doi.org/10.1038/s41568-022-00466-1

Article  CAS  PubMed  PubMed Central  Google Scholar 

Liu FT, Stowell SR (2023) The role of galectins in immunity and infection. Nat Rev Immunol 23:479–494. https://doi.org/10.1038/s41577-022-00829-7

Article  CAS  PubMed  Google Scholar 

Liu H, Tang T (2022) Pan-cancer genetic analysis of cuproptosis and copper metabolism-related gene set. Front Oncol 12:952290. https://doi.org/10.3389/fonc.2022.952290

Article  CAS  PubMed  PubMed Central  Google Scholar 

Liu WQ, Lin WR, Yan L, Xu WH, Yang J (2024) Copper homeostasis and cuproptosis in cancer immunity and therapy. Immunol Rev 321:211–227. https://doi.org/10.1111/imr.13276

Article  CAS  PubMed  Google Scholar 

Maeser D, Gruener RF, Huang RS (2021) oncoPredict: an R package for predicting in vivo or cancer patient drug response and biomarkers from cell line screening data. Brief Bioinform 22, bbab260. https://doi.org/10.1093/bib/bbab260

Mayakonda A, Lin DC, Assenov Y, Plass C, Koeffler HP (2018) Maftools: efficient and comprehensive analysis of somatic variants in cancer. Genome Res 28:1747–1756. https://doi.org/10.1101/gr.239244.118

Article  CAS  PubMed  PubMed Central  Google Scholar 

Pan C, Liu H, Robins E, Song W, Liu D, Li Z, Zheng L (2020) Next-generation immuno-oncology agents: current momentum shifts in cancer immunotherapy. J Hematol Oncol 13:29. https://doi.org/10.1186/s13045-020-00862-w

Article  PubMed  PubMed Central  Google Scholar 

Qin Y, Liu Y, Xiang X et al (2023) Cuproptosis correlates with immunosuppressive tumor microenvironment based on pan-cancer multiomics and single-cell sequencing analysis. Mol Cancer 22:59.

Comments (0)

No login
gif