LncRNAs in hypoxic microenvironment; insight in their impact in cancer biology

Abulihaiti Z, Li W, Yang L, Zhang H, Du A, Tang N et al (2024) Hypoxia-driven lncRNA CTD-2510F5.4: a potential player in hepatocellular carcinoma’s prognostic stratification, cellular behavior, tumor microenvironment, and therapeutic response. Mol Biol Rep 51(1):905

Article  CAS  PubMed  Google Scholar 

Ackerman D, Simon MC (2014) Hypoxia, lipids, and cancer: surviving the harsh tumor microenvironment. Trends Cell Biol 24(8):472–478

Article  CAS  PubMed  PubMed Central  Google Scholar 

Aghdassi A, Sendler M, Guenther A, Mayerle J, Behn CO, Heidecke CD et al (2012) Recruitment of histone deacetylases HDAC1 and HDAC2 by the transcriptional repressor ZEB1 downregulates E-cadherin expression in pancreatic cancer. Gut 61(3):439–448

Article  CAS  PubMed  Google Scholar 

Akamatsu H, Toi Y, Hayashi H, Fujimoto D, Tachihara M, Furuya N et al (2021) Efficacy of osimertinib plus bevacizumab vs osimertinib in patients with EGFR T790M–mutated non–small cell lung cancer previously treated with epidermal growth factor receptor–tyrosine kinase inhibitor: West Japan Oncology Group 8715L Phase 2 randomized clinical trial. JAMA Oncol 7(3):386–394

Article  PubMed  PubMed Central  Google Scholar 

Ala U (2020) Competing endogenous RNAs, non-coding RNAs and diseases: an intertwined story. Cells 9(7):1574

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ali T, Grote P (2020) Beyond the RNA-dependent function of LncRNA genes. Elife 9:e60583

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ally A, Balasundaram M, Carlsen R, Chuah E, Clarke A, Dhalla N, Holt RA, Jones SJ, Lee D, Ma Y, Marra MA (2017) Comprehensive and Integrative Genomic Characterization of Hepatocellular Carcinoma. Cell 169(7):1327–41.e23

Article  Google Scholar 

Batlle R, Andrés E, Gonzalez L, Llonch E, Igea A, Gutierrez-Prat N et al (2019) Regulation of tumor angiogenesis and mesenchymal–endothelial transition by p38α through TGF-β and JNK signaling. Nat Commun 10(1):3071

Article  PubMed  PubMed Central  Google Scholar 

Bhan A, Hussain I, Ansari KI, Kasiri S, Bashyal A, Mandal SS (2013) Antisense transcript long noncoding RNA (lncRNA) HOTAIR is transcriptionally induced by estradiol. J Mol Biol 425(19):3707–3722

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bhaskaran V, Nowicki MO, Idriss M, Jimenez MA, Lugli G, Hayes JL et al (2019) The functional synergism of microRNA clustering provides therapeutically relevant epigenetic interference in glioblastoma. Nat Commun 10(1):442

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bi Y, Ji J, Zhou Y (2021) LncRNA-PVT1 indicates a poor prognosis and promotes angiogenesis via activating the HNF1B/EMT axis in glioma. Journal of Cancer 12(19):5732

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bian Y, Xu S, Gao Z, Ding J, Li C, Cui Z et al (2024) m(6)A modification of lncRNA ABHD11-AS1 promotes colorectal cancer progression and inhibits ferroptosis through TRIM21/IGF2BP2/ FOXM1 positive feedback loop. Cancer Lett 596:217004

Article  CAS  PubMed  Google Scholar 

Bose GS, Jindal S, Landage KG, Jindal A, Mahale MP, Kulkarni AP et al (2024) SMAR1 and p53-regulated lncRNA RP11-431M3.1 enhances HIF1A translation via miR-138 in colorectal cancer cells under oxidative stress. FEBS J 291(21):4696–713

Article  CAS  PubMed  Google Scholar 

Bure IV, Nemtsova MV, Kuznetsova EB (2022) Histone modifications and non-coding RNAs: mutual epigenetic regulation and role in pathogenesis. Int J Mol Sci 23(10):5801

Article  CAS  PubMed  PubMed Central  Google Scholar 

Calvani M, Rapisarda A, Uranchimeg B, Shoemaker RH, Melillo G (2006) Hypoxic induction of an HIF-1α–dependent bFGF autocrine loop drives angiogenesis in human endothelial cells. Blood 107(7):2705–2712

Article  CAS  PubMed  PubMed Central  Google Scholar 

Cao J, Yang Y, Duan B, Zhang H, Xu Q, Han J et al (2024) LncRNA PCED1B-AS1 mediates miR-3681-3p/MAP2K7 axis to promote metastasis, invasion and EMT in gastric cancer. Biol Direct 19(1):34

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chen C, Liu Y, Lu C, Cross JR, Morris JP, Shroff AS et al (2013) Cancer-associated IDH2 mutants drive an acute myeloid leukemia that is susceptible to Brd4 inhibition. Genes Dev 27(18):1974–1985

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chen X, Liu M, Meng F, Sun B, Jin X, Jia C (2019) The long noncoding RNA HIF1A-AS2 facilitates cisplatin resistance in bladder cancer. J Cell Biochem 120(1):243–52

Article  CAS  PubMed  Google Scholar 

Chen L, Wang Y, Jiang W, Ni R, Wang Y, Ni S (2019) CDK14 involvement in proliferation migration and invasion of esophageal cancer. Annal Transl Med 7(22):681

Article  CAS  Google Scholar 

Chen F, Chen J, Yang L, Liu J, Zhang X, Zhang Y et al (2019) Extracellular vesicle-packaged HIF-1α-stabilizing lncRNA from tumour-associated macrophages regulates aerobic glycolysis of breast cancer cells. Nat Cell Biol 21(4):498–510

Article  CAS  PubMed  Google Scholar 

Chen Q-H, Li B, Liu D-G, Zhang B, Yang X, Tu Y-L (2020) LncRNA KCNQ1OT1 sponges miR-15a to promote immune evasion and malignant progression of prostate cancer via up-regulating PD-L1. Cancer Cell Int 20:1–15

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chen Q, Huang X, Dong X, Wu J, Teng F, Xu HJP (2020) Long non-coding RNA ERICH3-AS1 is an unfavorable prognostic factor for gastric cancer. PeerJ 8:e8050

Article  PubMed  PubMed Central  Google Scholar 

Chen H, Chu LY, Li XH, Peng YH, Liu CT, Tian LR et al (2020) ApoB/ApoA-1 Ratio as a Novel Prognostic Predictor in Patients With Primary Small Cell Carcinoma of the Esophagus. Front Oncol 10:610

Article  PubMed  PubMed Central  Google Scholar 

Chen Y, Li Z, Chen X, Zhang S (2021) Long non-coding RNAs: From disease code to drug role. Acta Pharmaceutica Sinica b 11(2):340–354

Article  CAS  PubMed  Google Scholar 

Chen L, Bao L, Niu Y, Wang JE, Kumar A, Xing C et al (2021) Lncihat is induced by hypoxia-inducible factor 1 and promotes breast cancer progression. Mol Cancer Res 19(4):678–87

Article  CAS  PubMed  Google Scholar 

Chen L, Bao L, Niu Y, Wang JE, Kumar A, Xing C et al (2021) LncIHAT Is Induced by Hypoxia-Inducible Factor 1 and Promotes Breast Cancer Progression. Mol Cancer Res : MCR 19(4):678–687

Article  CAS  PubMed  Google Scholar 

Chen Z, Zhong T, Li T, Zhong J, Tang Y, Liu Z, et al (2021) LncRNA SNHG15 modulates gastric cancer tumorigenesis by impairing miR-506–5p expression. Biosci Rep 41(7):BSR20204177. https://doi.org/10.1042/BSR20204177

Chen Y, Ma F, Zhang Z, Guo Y, Shen H, Chen H (2023) LncRNA-PVT1 was identified as a key regulator for TMZ resistance and STAT-related pathway in glioma. BMC Cancer 23(1):455

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chen J, Li L, Feng Y, Zhao Y, Sun F, Zhou X et al (2024) MKLN1-AS promotes pancreatic cancer progression as a crucial downstream mediator of HIF-1α through miR-185-5p/TEAD1 pathway. Cell Biol Toxicol 40(1):30

Article  PubMed  PubMed Central  Google Scholar 

Chen Y, Cui F, Wu X, Zhao W, Xia Q (2025) The expression and clinical significance of serum exosomal-long non-coding RNA DLEU1 in patients with cervical cancer. Ann Med 57(1):2442537

Article  PubMed 

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