World Health Organization (2025) Cancer. https://www.who.int/news-room/fact-sheets/detail/cancer. Accessed 26 Mar 2025
National Cancer Institute (2021) What is cancer? https://www.cancer.gov/about-cancer/understanding/what-is-cancer. Accessed 26 Mar 2025
World Health Organization (2024) Breast cancer. https://www.who.int/news-room/fact-sheets/detail/breast-cancer. Accessed 26 Mar 2025
Osborne CK (1998) Tamoxifen in the treatment of breast cancer. New Engl J Med 339(22):1609–1618
Article CAS PubMed Google Scholar
Robinson E, Kimmick GG, Muss HB (1996) Tamoxifen in postmenopausal women: a safety perspective. Drug Aging 5:329–337. https://doi.org/10.2165/00002512-199608050-00002
Craig Jordan V (2007) New insights into the metabolism of tamoxifen and its role in the treatment and prevention of breast cancer. Steroids 13:829–842. https://doi.org/10.1016/j.steroids.2007.07.009
Ahsen NV, Binder C, Brockmoller J, Oellerich M (2009) CYP2D6 and tamoxifen: pharmacogenetic reinvention of an established drug? J Lab Med 33:1–9. https://doi.org/10.1016/j.phrs.2016.03.025
United States Pharmacopeial Convention (2023) tamoxifen tablets. In: USP-NF online. USP Convention, Rockville, MD. https://www.uspnf.com/. Accessed 27 Mar 2025
European Pharmacopoeia (2025) Tamoxifen citrate monograph (reference 07/2024:1046). 11th ed. Council of Europe, Strasburg, Codex: 6045–6046.
British Pharmacopoeia (2023) tamoxifen tablets. The Stationery Office. London. https://www.pharmacopoeia.com/. Accessed 27 Mar 2025
Santiago M, Strobel S (2013) Thin layer chromatography. Methods Enzymol 533:303–324. https://doi.org/10.1016/B978-0-12-420067-8.00024-6
Article CAS PubMed Google Scholar
Ferenczi-Fodor K, Végh Z, Renger B (2011) Impurity profiling of pharmaceuticals by thin-layer chromatography. J Chromatogr A 1218:2722–2731. https://doi.org/10.1016/j.chroma.2010.12.044
Article CAS PubMed Google Scholar
Lim CK, Chow LCL, Yuan ZX, Smith LL (1993) High performance liquid chromatography of tamoxifen and metabolites in plasma and tissues. Biomed Chromatogr 7:311–314. https://doi.org/10.1002/bmc.1130070606
Article CAS PubMed Google Scholar
Armstrong RD, Ward JT, Pattabiraman N, Benz C, Armstrong WD (1987) Separation of tamoxifen geometric isomers and metabolites by bonded-phase β-cyclodextrin chromatography. J Chromatogr A 414:192–196
Lu W, Poon KG, Carmichael LP, Cole BR (1996) Analysis of tamoxifen and its metabolites by on-line capillary electrophoresis-electrospray ionization mass spectrometry employing nonaqueous media containing surfactants. Anal Chem 68:668–674. https://doi.org/10.1021/ac950786x
Article CAS PubMed Google Scholar
Manns JE, Hanks S, Brown JE (1998) Optimised separation of E- and Z- isomers of tamoxifen. and its principal metabolites using reversed-phase high performance liquid chromatography. J Pharm Biomed Anal 16:847–852. https://doi.org/10.1016/s0731-7085(97)00116-7
Article CAS PubMed Google Scholar
Lee K, Ward AB, Desta Z, Flockhart AD, Jones RD (2003) Quantification of tamoxifen and three metabolites in plasma by high-performance liquid chromatography with fluorescence detection: application to a clinical trial. J Chromatogr B Biomed Appl 791:245–253. https://doi.org/10.1016/s1570-0232(03)00218-6
MacCallum J, Cummings J, Dixon JM, Miller WR (1996) Solid-phase extraction and high-performance liquid chromatographic determination of tamoxifen and its major metabolites in plasma. J Chromatogr B Biomed Appl 678:317–323. https://doi.org/10.1016/0378-4347(95)00530-7
Article CAS PubMed Google Scholar
Brown RR, Bain R, Jordan VC (1983) Determination of tamoxifen and metabolites in human serum by high-performance liquid chromatography with post-column fluorescence activation. J Chromatogr 272:351–358
Article CAS PubMed Google Scholar
Teunissen SF, Rosing H, Schinkel AH, Schellens JH, Beijnen JH (2010) Bioanalytical methods for determination of tamoxifen and its phase I metabolites: a review. Anal Chim Acta 683:21–37. https://doi.org/10.1016/j.aca.2010.10.009
Article CAS PubMed Google Scholar
Antunes MV, Rosa DD, Viana Tdos S, Andreolla H, Fontanive TO, Linden R (2013) Sensitive HPLC-PDA determination of tamoxifen and its metabolites N-desmethyltamoxifen, 4-hydroxytamoxifen and endoxifen in human plasma. J Pharm Biomed Anal 76:13–20. https://doi.org/10.1016/j.jpba.2012.12.005
Article CAS PubMed Google Scholar
Antunes MV, Raymundo S, De Oliveira V, Staudt DE, Gössling G, Peteffi GP, Biazús JV, Cavalheiro JA, Tre-Hardy M, Capron A, Haufroid V, Wallemacq P, Schwartsmann G, Linden R (2015) Ultra-high performance liquid chromatography tandem mass spectrometric method for the determination of tamoxifen. N-desmethyltamoxifen, 4-hydroxytamoxifen and endoxifen in dried blood spots-development. Validation and clinical application during breast cancer. Talanta 132:775–784. https://doi.org/10.1016/j.talanta.2014.10.040
Article CAS PubMed Google Scholar
Jager NG, Rosing H, Schellens JH, Beijnen JH (2014) Determination of tamoxifen and endoxifen in dried blood spots using LC-MS/MS and the effect of coated DBS cards on recovery and matrix effects. J Pharm Biomed Anal 100:254–261. https://doi.org/10.1016/j.jpba.2014.07.033
Jager NG, Rosing H, Schellens JH, Beijnen JH, Linn SC (2014) Use of dried blood spots for the determination of serum concentrations of tamoxifen and endoxifen. Breast Cancer Res Treat 146:137–144. https://doi.org/10.1007/s10549-014-2999-2
Article CAS PubMed Google Scholar
Kashtiaray A, Farahani H, Farhadi S, Rochat B, Sobhi HR (2011) Trace determination of Tamoxifen in biological fluids. using hollow fiber liquid-phase microextraction followed by high-performance liquid chromatography-ultraviolet detection. Am J Anal Chem 2:429–436. https://doi.org/10.4236/ajac.2011.24052
Peris-Vicente J, Ochoa-Aranda E, Bose D, Esteve-Romero J (2015) Determination of tamoxifen and its main metabolites in plasma samples from breast cancer patients by micellar liquid chromatography. Talanta 131:535–540. https://doi.org/10.1016/j.talanta.2014.07.093
Article CAS PubMed Google Scholar
Adam HK, Douglas EJ, Kemp JV (1979) The metabolism of tamoxifen in human. Biochem Pharmacol 28:145–147. https://doi.org/10.1016/0006-2952(79)90283-1
Article CAS PubMed Google Scholar
Adam HK, Gay MA, Moore RH (1980) Measurement of tamoxifen in serum by thin-layer densitometry. J Endocrinol 84:35–42. https://doi.org/10.1677/joe.0.0840035
Article CAS PubMed Google Scholar
International Council for Harmonisation (2023) ICH Q2(R2) Guideline on validation of analytical procedures. https://database.ich.org/sites/default/files/ICH_Q2%28R2%29_Guideline_2023_1130.pdf. Accessed 26 Mar 2025
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