Safety Evaluation of Autologous Human Bone Marrow-derived MSCs on Hydroxyapatite-based Scaffold for Congenital Pseudarthrosis of the Tibia: A Pilot Clinical Trial

Leskelä H-V, et al. Congenital pseudarthrosis of neurofibromatosis type 1: impaired osteoblast differentiation and function and altered NF1 gene expression. Bone. 2009;44:243–50.

PubMed  Google Scholar 

Rios JJ, et al. Spatial transcriptomics implicates impaired BMP signaling in NF1 fracture pseudarthrosis in murine and patient tissues. JCI Insight. 2024;9(16):e176802.

PubMed  PubMed Central  Google Scholar 

Zhu G, et al. Identification and characterization of NF1 and non-NF1 congenital pseudarthrosis of the tibia based on germline NF1 variants: genetic and clinical analysis of 75 patients. Orphanet J Rare Dis. 2019;14:1–13.

Google Scholar 

Hardinge K. Congenital anterior bowing of the tibia. The significance of the different types in relation to pseudarthrosis. Ann R Coll Surg Engl. 1972;51:17.

CAS  PubMed  PubMed Central  Google Scholar 

Lee DY, et al. Disturbed osteoblastic differentiation of fibrous hamartoma cell from congenital pseudarthrosis of the tibia associated with neurofibromatosis type I. Clin Orthop Surg. 2011;3:230–7.

PubMed  PubMed Central  Google Scholar 

Madhuri V, Mathew SE, Rajagopal K, Ramesh S, Antonisamy B. Does pamidronate enhance the osteogenesis in mesenchymal stem cells derived from fibrous hamartoma in congenital pseudarthrosis of the tibia? Bone Rep. 2016;5:292–8.

PubMed  PubMed Central  Google Scholar 

Weiland A, Daniel R. Congenital pseudarthrosis of the tibia: treatment with vascularized autogenous fibular grafts. A preliminary report. Johns Hopkins Med J. 1980;147:89–95.

CAS  PubMed  Google Scholar 

Mathieu L, Vialle R, Thevenin-Lemoine C, Mary P, Damsin J-P. Association of Ilizarov’s technique and intramedullary rodding in the treatment of congenital pseudarthrosis of the tibia. J Child’s Orthop. 2008;2:449–55.

Google Scholar 

Charnley J. Congenital Pseudarthrosis of the Tibia Treated by the Intramedullary Nail. JBJS. 1956;38(2):283–90.

Google Scholar 

Umber JS, Moss SW, Coleman SS. Surgical treatment of congenital pseudarthrosis of the tibia. Clin Orthop Relat Res. 1982;166:28–33.

Google Scholar 

Choi IH, Cho T-J, Moon HJ. Ilizarov treatment of congenital pseudarthrosis of the tibia: a multi-targeted approach using the Ilizarov technique. Clin Orthop Surg. 2011;3:1–8.

PubMed  PubMed Central  Google Scholar 

Paley D. Paley cross-union protocol for treatment of congenital pseudarthrosis of the tibia. Oper Tech Orthop. 2021;31:100881.

Google Scholar 

Cho T-J, et al. Biologic characteristics of fibrous hamartoma from congenital pseudarthrosis of the tibia associated with neurofibromatosis type 1. JBJS. 2008;90:2735–44.

Google Scholar 

Khan T, Joseph B. Controversies in the management of congenital pseudarthrosis of the tibia and fibula. Bone Joint j. 2013;95:1027–34.

PubMed  Google Scholar 

Yang G, et al. Serum-derived exosomes from neurofibromatosis type 1 congenital tibial pseudarthrosis impaired bone by promoting osteoclastogenesis and inhibiting osteogenesis. Exp Biol Med. 2021;246:130–41.

CAS  Google Scholar 

Infante A, et al. Reiterative infusions of MSCs improve pediatric osteogenesis imperfecta eliciting a pro-osteogenic paracrine response: TERCELOI clinical trial. Clin Transl Med. 2021;11:e265.

CAS  PubMed  PubMed Central  Google Scholar 

Infante A, Cabodevilla L, Gener B, Rodríguez CI. Circulating TGF-β pathway in osteogenesis imperfecta pediatric patients subjected to MSCs-based cell therapy. Front Cell Dev Biol. 2022;10:830928. https://doi.org/10.3389/fcell.2022.830928.

Hissnauer TN, et al. Bone morphogenetic protein-2 for the treatment of congenital pseudarthrosis of the tibia or persistent tibial nonunion in children and adolescents: a retrospective study with a minimum 2-year follow-up. J Mater Sci Mater Med. 2017;28:1–8.

CAS  Google Scholar 

Kujala S, Vahasarja V, Serlo W, Jalovaara P. Treatment of congenital pseudarthrosis of the tibia with native bovine BMP: a case report. Acta Orthopædica Belgica. 2008;74:132.

PubMed  Google Scholar 

Lee FY-I, et al. Treatment of congenital pseudarthrosis of the tibia with recombinant human bone morphogenetic protein-7 (rhBMP-7): a report of five cases. JBJS. 2006;88:627–33.

Google Scholar 

Tikkanen J, et al. Attempt to treat congenital pseudarthrosis of the tibia with mesenchymal stromal cell transplantation. Cytotherapy. 2010;12:593–604.

PubMed  Google Scholar 

Liu M, Bu J, Yin Y, Wang Y. Case report effect of mesenchymal stromal cell transplantation on congenital pseudarthrosis of the tibia. Int J Clin Exp Med. 2019;12:6177–82.

Google Scholar 

Madhuri V, et al. First report of a tissue-engineered graft for proximal humerus gap non-union after chronic pyogenic osteomyelitis in a child: a case report. JBJS Case Connector. 2020;10:e0031.

PubMed  Google Scholar 

Varma H, Vijayan SP, Babu SS. Transparent hydroxyapatite ceramics through gelcasting and low-temperature sintering. J Am Ceram Soc. 2002;85:493–5.

CAS  Google Scholar 

Sandeep G, Varma H, Kumary T, Babu SS, John A. Characterization of novel bioactive glass coated hydroxyapatite granules in correlation with in vitro and in vivo studies. Trends Biomater Artif Organs. 2006;19:99–107.

Google Scholar 

Pannier S. Congenital pseudarthrosis of the tibia. Orthop Traumatol Surg Res. 2011;97:750–61.

CAS  PubMed  Google Scholar 

El-Hoss J, et al. A murine model of neurofibromatosis type 1 tibial pseudarthrosis featuring proliferative fibrous tissue and osteoclast-like cells. J Bone Miner Res. 2012;27:68–78.

CAS  PubMed  Google Scholar 

Ramanathan M, et al. Utility of Chitra–HASi granules in cystic defects of the maxillofacial region: a pilot study. J Pharm Bioallied Sci. 2021;13:S772–7.

CAS  PubMed  PubMed Central  Google Scholar 

Nair MB, Varma H, John A. Triphasic ceramic coated hydroxyapatite as a niche for goat stem cell-derived osteoblasts for bone regeneration and repair. J Mater Sci Mater Med. 2009;20:251–8.

Google Scholar 

Nair MB, Varma H, Shenoy SJ, John A. Treatment of goat femur segmental defects with silica-coated hydroxyapatite—one-year follow-up. Tissue Eng Part A. 2010;16:385–91.

CAS  PubMed  Google Scholar 

Benson AG, Djalilian HR. Complications of hydroxyapatite bone cement reconstruction of retrosigmoid craniotomy: two cases. Ear Nose Throat J. 2009;88:E1-4.

PubMed  Google Scholar 

Nair MB, Babu SS, Varma H, John A. A triphasic ceramic-coated porous hydroxyapatite for tissue engineering application. Acta Biomater. 2008;4:173–81.

CAS  PubMed  Google Scholar 

Tetsworth K, Woloszyk A, Glatt V. 3D printed titanium cages combined with the Masquelet technique for the reconstruction of segmental femoral defects: preliminary clinical results and molecular analysis of the biological activity of human-induced membranes. OTA Int. 2019;2:e016.

PubMed  PubMed Central  Google Scholar 

Comments (0)

No login
gif