Briel M, Schwartz GG, Thompson PL, de Lemos JA, Blazing MA, van Es GA, Kayikçioglu M, Arntz HR, den Hartog FR, Veeger NJ et al (2006) Effects of early treatment with statins on short-term clinical outcomes in acute coronary syndromes: a meta-analysis of randomized controlled trials. JAMA 295:2046–2056. https://doi.org/10.1001/jama.295.17.2046

Article  CAS  PubMed  Google Scholar 

Hirsh BJ, Smilowitz NR, Rosenson RS, Fuster V, Sperling LS (2015) Utilization of and adherence to guideline-recommended lipid-lowering therapy after acute coronary syndrome: opportunities for improvement. J Am Coll Cardiol 66:184–192. https://doi.org/10.1016/j.jacc.2015.05.030

Article  PubMed  Google Scholar 

Lopes RD, de Barros e Silva PG, de Andrade Jesuíno I, Santucci EV, Barbosa LM, Damiani LP, Nakagawa Santos RH, Laranjeira LN, Dall Orto FTC, Beraldo de Andrade P et al (2018) Timing of loading dose of atorvastatin in patients undergoing percutaneous coronary intervention for acute coronary syndromes. JAMA Cardiol. https://doi.org/10.1001/jamacardio.2018.3408

Article  PubMed  PubMed Central  Google Scholar 

Andrade RJ, Aithal GP, Björnsson ES, Kaplowitz N, Kullak-Ublick GA, Larrey D, Karlsen TH (2019) EASL clinical practice guidelines: drug-induced liver injury. J Hepatol 70:1222–1261. https://doi.org/10.1016/j.jhep.2019.02.014

Article  Google Scholar 

Björnsson E, Jacobsen EI, Kalaitzakis E (2012) Hepatotoxicity associated with statins: reports of idiosyncratic liver injury post-marketing. J Hepatol 56:374–380. https://doi.org/10.1016/j.jhep.2011.07.023

Article  CAS  PubMed  Google Scholar 

Russo MW, Hoofnagle JH, Gu J, Fontana RJ, Barnhart H, Kleiner DE, Chalasani N, Bonkovsky HL (2014) Spectrum of statin hepatotoxicity: experience of the drug-induced liver injury network. Hepatology 60:679–686. https://doi.org/10.1002/hep.27157

Article  CAS  PubMed  Google Scholar 

Lofthus DM, Stevens SR, Armstrong PW, Granger CB, Mahaffey KW (2012) Pattern of liver enzyme elevations in acute ST-elevation myocardial infarction. Coron Artery Dis 23:22–30. https://doi.org/10.1097/MCA.0b013e32834e4ef1

Article  PubMed  Google Scholar 

Ginès P, Castera L, Lammert F, Graupera I, Serra-Burriel M, Allen AM, Wong VWS, Hartmann P, Thiele M, Caballeria L et al (2021) Population screening for liver fibrosis: toward early diagnosis and intervention for chronic liver diseases. Hepatology 75:219–228. https://doi.org/10.1002/hep.32163

Article  PubMed  Google Scholar 

Grundy SM, Stone NJ, Bailey AL, Beam C, Birtcher KK, Blumenthal RS, Braun LT, de Ferranti S, Faiella-Tommasino J, Forman DE et al (2018) AHA/ACC/AACVPR/AAPA/ABC/ACPM/ADA/AGS/APhA/ASPC/NLA/PCNA guideline on the management of blood cholesterol: a report of the American college of cardiology/American heart association task force on clinical practice guidelines. Circulation 2019:139. https://doi.org/10.1161/cir.0000000000000625

Article  Google Scholar 

Mach F, Baigent C, Catapano AL, Koskinas KC, Casula M, Badimon L, Chapman MJ, De Backer GG, Delgado V, Ference BA et al (2020) 2019 ESC/EAS Guidelines for the management of dyslipidaemias: lipid modification to reduce cardiovascular risk. Eur Heart J 41:111–188. https://doi.org/10.1093/eurheartj/ehz455

Article  PubMed  Google Scholar 

von Elm E, Altman DG, Egger M, Pocock SJ, Gøtzsche PC, Vandenbroucke JP (2007) Strengthening the reporting of observational studies in epidemiology (STROBE) statement: guidelines for reporting observational studies. BMJ 335:806–808. https://doi.org/10.1136/bmj.39335.541782.AD

Article  Google Scholar 

Liu Y, Li L, Li J, Liu H, Geru A, Wang Y, Li Y, Sia C-H, Lip GYH, Yang Q et al (2024) Development and validation of a predictive model for intracranial haemorrhage in patients on direct oral anticoagulants. Clin Appl Thromb/Hemost. https://doi.org/10.1177/10760296241271338

Article  PubMed  Google Scholar 

Li L, Geru A, Guo Y, Liu H, Li J, Jiang S, Zuo L, Sia CH, Zhou X, Sun P et al (2025) Early β-blocker use and clinical outcomes in acute myocardial injury: a retrospective cohort study. Am J Med. https://doi.org/10.1016/j.amjmed.2025.02.029

Article  PubMed  Google Scholar 

Sun P, Liu WN, Qian X, Zhang Z, Liu H, Liu Y, Fonarow G, Foo RS, Chan MY et al (2025) Age-specific prognosis of acute and steady minor elevations in cardiac troponin among non-acute myocardial infarction inpatients: a large real-world cohort study. Heart (British Cardiac Society). https://doi.org/10.1136/heartjnl-2024-325079

Article  PubMed  Google Scholar 

Li Z, Sun H, Hao Y, Liu H, Jin Z, Li L, Zhang C, Ma M, Teng T, Chen X et al (2023) Renin-angiotensin system inhibition and in-hospital mortality in acute coronary syndrome patients with advanced renal dysfunction: findings from CCC-ACS project and a nationwide electronic health record-based cohort in China. Eur Heart J Qual Care Clin Outcomes 9:785–795. https://doi.org/10.1093/ehjqcco/qcad006

Article  PubMed  Google Scholar 

Hicks KA, Tcheng JE, Bozkurt B, Chaitman BR, Cutlip DE, Farb A, Fonarow GC, Jacobs JP, Jaff MR, Lichtman JH et al (2015) 2014 ACC/AHA key data elements and definitions for cardiovascular endpoint events in clinical trials. Circulation 132:302–361. https://doi.org/10.1161/cir.0000000000000156

Article  PubMed  Google Scholar 

Seo YG, Polyzos SA, Park KH, Mantzoros CS (2023) Fibrosis-4 index predicts long-term all-cause, cardiovascular and liver-related mortality in the adult korean population. Clin Gastroenterol Hepatol : Off Clin Pract J Am Gastroenterol Assoc 21:3322–3335. https://doi.org/10.1016/j.cgh.2023.04.026

Article  CAS  Google Scholar 

VanderWeele TJ, Ding P (2017) Sensitivity analysis in observational research: introducing the E-value. Ann Internal Med. https://doi.org/10.7326/m16-2607

Article  Google Scholar 

Groenwold RH (2013) Falsification end points for observational studies. JAMA 309:1769–1770. https://doi.org/10.1001/jama.2013.3089

Article  CAS  PubMed  Google Scholar 

Xanthopoulos A, Starling RC, Kitai T, Triposkiadis F (2019) Heart failure and liver disease. JACC: Heart Fail. 7:87–97. https://doi.org/10.1016/j.jchf.2018.10.007

Article  PubMed  Google Scholar 

Zhou S, Chen R, Liu J, Guo Z, Su L, Li Y, Zhang X, Luo F, Gao Q, Lin Y et al (2024) Comparative effectiveness and safety of atorvastatin versus rosuvastatin. Ann Intern Med 177:1641–1651. https://doi.org/10.7326/m24-0178

Article  PubMed  Google Scholar 

Lee Y-J, Hong S-J, Kang WC, Hong B-K, Lee J-Y, Lee J-B, Cho H-J, Yoon J, Lee S-J, Ahn C-M et al (2023) Rosuvastatin versus atorvastatin treatment in adults with coronary artery disease: secondary analysis of the randomised LODESTAR trial. BMJ. https://doi.org/10.1136/bmj-2023-075837

Article  PubMed  PubMed Central  Google Scholar 

Istvan ES, Deisenhofer J (2001) Structural mechanism for statin inhibition of HMG-CoA reductase. Science 292:1160–1164. https://doi.org/10.1126/science.1059344

Article  CAS  PubMed  Google Scholar 

Newman CB, Preiss D, Tobert JA, Jacobson TA, Page RL, Goldstein LB, Chin C, Tannock LR, Miller M, Raghuveer G et al (2019) Statin safety and associated adverse events: a scientific statement from the american heart association. Arterioscler Thromb Vasc Biol. https://doi.org/10.1161/atv.0000000000000073

Article  PubMed  Google Scholar 

Cao Y, Wang Y, Zhou Z, Pan C, Jiang L, Zhou Z, Meng Y, Charugundla S, Li T, Allayee H et al (2022) Liver-heart cross-talk mediated by coagulation factor XI protects against heart failure. Science 377:1399–1406. https://doi.org/10.1126/science.abn0910

Article  CAS  PubMed  PubMed Central  Google Scholar 

Xie W, Gan J, Zhou X, Tian H, Pan X, Liu W, Li X, Du J, Xu A, Zheng M et al (2024) Myocardial infarction accelerates the progression of MASH by triggering immunoinflammatory response and induction of periostin. Cell Metab 36:1269-1286.e1269. https://doi.org/10.1016/j.cmet.2024.04.020

Article  CAS  PubMed  Google Scholar 

Luther J, Garber JJ, Khalili H, Dave M, Bale SS, Jindal R, Motola DL, Luther S, Bohr S, Jeoung SW et al (2015) Hepatic injury in nonalcoholic steatohepatitis contributes to altered intestinal permeability. Cell Mol Gastroenterol Hepatol 1:222-232.e222. https://doi.org/10.1016/j.jcmgh.2015.01.001

Article  PubMed  PubMed Central  Google Scholar 

Zhou X, Li J, Guo J, Geng B, Ji W, Zhao Q, Li J, Liu X, Liu J, Guo Z et al (2018) Gut-dependent microbial translocation induces inflammation and cardiovascular events after ST-elevation myocardial infarction. Microbiome. https://doi.org/10.1186/s40168-018-0441-4

Article  PubMed  PubMed Central  Google Scholar 

Goldstein JA, Lerakis S, Moreno PR (2024) Right ventricular myocardial infarction—a tale of two ventricles. J Am Coll Cardiol 83:1779–1798. https://doi.org/10.1016/j.jacc.2023.09.839

Article