CAR T-cell therapy in renal cell carcinoma: opportunities, challenges, and new strategies to overcome

Patel VA, Popat NP. Essentials of Computed Tomography Imaging of Hematuria. Saudi J Kidn Dis Transp. 2023;34(1):61–79.

Article  Google Scholar 

Deleuze A, Saout J, Dugay F, Peyronnet B, Mathieu R, Verhoest G, et al. Immunotherapy in renal cell carcinoma: the future is now. Int J Mol Sci. 2020;21(7):2532.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Singh AK, McGuirk JP. CAR T cells: continuation in a revolution of immunotherapy. Lancet Oncol. 2020;21(3):e168–78.

Article  CAS  PubMed  Google Scholar 

Sakemura R, Can I, Siegler EL, Kenderian SS. In vivo CART cell imaging: paving the way for success in CART cell therapy. Mol Therap-Oncolyt. 2021;20:625–33.

Article  CAS  Google Scholar 

Padala SA, Barsouk A, Thandra KC, Saginala K, Mohammed A, Vakiti A, et al. Epidemiology of renal cell carcinoma. World J Oncol. 2020;11(3):79.

Article  PubMed  PubMed Central  Google Scholar 

Ingels A, Campi R, Capitanio U, Amparore D, Bertolo R, Carbonara U, et al. Complementary roles of surgery and systemic treatment in clear cell renal cell carcinoma. Nat Rev Urol. 2022;19(7):391–418.

Article  CAS  PubMed  Google Scholar 

Yang J, Wang K, Yang Z. Treatment strategies for clear cell renal cell carcinoma: past, present and future. Front Oncol. 2023;13:1133832.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Dahle DO, Skauby M, Langberg CW, Brabrand K, Wessel N, Midtvedt K. Renal cell carcinoma and kidney transplantation: a narrative review. Transplantation. 2022;106(1):e52-63.

Article  CAS  PubMed  Google Scholar 

Kase AM, George DJ, Ramalingam S. Clear cell renal cell carcinoma: from biology to treatment. Cancers. 2023;15(3):665.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wu R, Wang K, Gai Y, Li M, Wang J, Wang C, et al. Nanomedicine for renal cell carcinoma: imaging, treatment and beyond. J Nanobiotechnol. 2023;21(1):3.

Article  CAS  Google Scholar 

Uscanga-Palomeque AC, Chávez-Escamilla AK, Alvizo-Báez CA, Saavedra-Alonso S, Terrazas-Armendáriz LD, Tamez-Guerra RS, et al. CAR-T cell therapy: from the shop to Cancer therapy. Int J Mol Sci. 2023;24(21):15688.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Arı E, Köseoğlu H, Eroğlu T. Predictive value of SIRI and SII for metastases in RCC: a prospective clinical study. BMC Urol. 2024;24(1):14.

Article  PubMed  PubMed Central  Google Scholar 

Korbecki J, Kojder K, Kapczuk P, Kupnicka P, Gawrońska-Szklarz B, Gutowska I, et al. The effect of hypoxia on the expression of CXC chemokines and CXC chemokine receptors—a review of literature. Int J Mol Sci. 2021;22(2):843.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lu Y, Song Y, Xu Y, Ou N, Liang Z, Hu R, et al. The prevalence and prognostic and clinicopathological value of PD-L1 and PD-L2 in renal cell carcinoma patients: a systematic review and meta-analysis involving 3,389 patients. Transl Androl Urol. 2020;9(2):367.

Article  PubMed  PubMed Central  Google Scholar 

Mpakali A, Stratikos E. The role of antigen processing and presentation in cancer and the efficacy of immune checkpoint inhibitor immunotherapy. Cancers. 2021;13(1):134.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Moeckel C, Bakhl K, Georgakopoulos-Soares I, Zaravinos A. The efficacy of tumor mutation burden as a biomarker of response to immune checkpoint inhibitors. Int J Mol Sci. 2023;24(7):6710.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zhou Z, Wang J, Wang J, Yang S, Wang R, Zhang G, et al. Deciphering the tumor immune microenvironment from a multidimensional omics perspective: insight into next-generation CAR-T cell immunotherapy and beyond. Mol Cancer. 2024;23(1):131.

Article  PubMed  PubMed Central  Google Scholar 

Mittal P, Roberts CW. The SWI/SNF complex in cancer—biology, biomarkers and therapy. Nat Rev Clin Oncol. 2020;17(7):435–48.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kim SI, Cassella CR, Byrne KT. Tumor burden and immunotherapy: impact on immune infiltration and therapeutic outcomes. Front Immunol. 2021;11:629722.

Article  PubMed  PubMed Central  Google Scholar 

Hunter P. The four fronts of immunotherapy. EMBO Rep. 2023. https://doi.org/10.15252/embr.202358262.

Article  PubMed  PubMed Central  Google Scholar 

Xu Y, Miller CP, Warren EH, Tykodi SS. Current status of antigen-specific T-cell immunotherapy for advanced renal-cell carcinoma. Hum Vaccin Immunother. 2021;17(7):1882–96.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Righi M. Enhancement of Adoptive Cell Therapies via novel engineered Chimeric Cytokine Receptor: UCL (University College London); 2021.

Kankuri-Tammilehto M, Perasto L, Pyrhonen S, Salminen E. Long-term outcome with prolonged use of interferon-alpha administered intermittently for metastatic renal cell carcinoma: a phase II study. Anticancer Res. 2023;43(6):2645–57.

Article  CAS  PubMed  Google Scholar 

Ayala Ceja M, Khericha M, Harris CM, Puig-Saus C, Chen YY. CAR-T cell manufacturing: major process parameters and next-generation strategies. J Exp Med. 2024;221(2):e20230903.

Article  PubMed  PubMed Central  Google Scholar 

Cesur-Ergün B, Demir-Dora D. Gene therapy in cancer. J Gene Med. 2023;25(11):e3550.

Article  PubMed  Google Scholar 

Song Z, Tao Y, You J. The potential applications of peptide-loading complex in cancer treatment. Front Immunol. 2025;16:1526137.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Asghar MS, Shah SMI, Rani A, Kazmi S, Savul IS, Ukrani J, et al. Toxicities of CAR T-cell therapy: a review of current literature. Ann Med Surg. 2023;85(12):6013–20.

Article  Google Scholar 

Huang R, Li X, He Y, Zhu W, Gao L, Liu Y, et al. Recent advances in CAR-T cell engineering. J Hematol Oncol. 2020;13:1–19.

Article  Google Scholar 

Young RM, Engel NW, Uslu U, Wellhausen N, June CH. Next-generation CAR T-cell therapies. Cancer Discov. 2022;12(7):1625–33.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hiltensperger M, Krackhardt AM. Current and future concepts for the generation and application of genetically engineered CAR-T and TCR-T cells. Front Immunol. 2023;14:1121030.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Barata P, Gulati S, Elliott A, Hammers HJ, Burgess E, Gartrell BA, et al. Renal cell carcinoma histologic subtypes exhibit distinct transcriptional profiles. J Clin Invest. 2024. https://doi.org/10.1172/JCI178915.

Article  PubMed  PubMed Central  Google Scholar 

Panowski SH, Srinivasan S, Tan N, Tacheva-Grigorova SK, Smith B, Mak YS, et al. Preclinical development and evaluation of allogeneic CAR T cells targeting CD70 for the treatment of renal cell carcinoma. Can Res. 2022;82(14):2610–24.

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