Forner A, Reig M, Bruix J. Hepatocellular carcinoma. Lancet. 2018;391(10127):1301–14.

Article  PubMed  Google Scholar 

Huang F, Wang BR, Wang YG. Role of autophagy in tumorigenesis, metastasis, targeted therapy and drug resistance of hepatocellular carcinoma. World J Gastroenterol. 2018;24(41):4643–51.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Han Y, Song L, Lv L, Fan C, Ding H. Unraveling the heterogeneity of tumor immune microenvironment in hepatocellular carcinoma by single cell RNA sequencing and its implications for prognosis and therapeutic response. Turk J Gastroenterol. 2024;35(12):876–88.

Article  PubMed  PubMed Central  Google Scholar 

Xue R, Zhang Q, Cao Q, Kong R, Xiang X, Liu H, Feng M, Wang F, Cheng J, Li Z, et al. Liver tumour immune microenvironment subtypes and neutrophil heterogeneity. Nature. 2022;612(7938):141–7.

Article  CAS  PubMed  Google Scholar 

Zhang W, Hong X, Xiao Y, Wang H, Zeng X. Sorafenib resistance and therapeutic strategies in hepatocellular carcinoma. Biochim Biophys Acta Rev Cancer. 2025;1880(3): 189310.

Article  CAS  PubMed  Google Scholar 

Xin H, Lai Q, Liu Y, Liao N, Wang Y, Liao B, Zhou K, Zhou Y, Bai Y, Chen Z, Zhou Y. Integrative radiomics analyses identify universal signature for predicting prognosis and therapeutic vulnerabilities across primary and secondary liver cancers: a multi-cohort study. Pharmacol Res. 2024;210: 107535.

Article  CAS  PubMed  Google Scholar 

Li M, Qiao C, Qin L, Zhang J, Ling C. Application of traditional Chinese medicine injection in treatment of primary liver cancer: a review. J Tradit Chin Med. 2012;32(3):299–307.

Article  PubMed  Google Scholar 

Chu S, Zhang H, Ding L. Efficiency of Sophora flavescens-fructus ligustri lucidi drug pairs in the treatment of liver fibrosis based on the response surface method. Evid Based Complement Alternat Med. 2019;2019:8609490.

Article  PubMed  PubMed Central  Google Scholar 

Yu B, Wang M, Xu H, Gao R, Zhu Y, Ning H, Dai X. Investigating the role of dahuang in hepatoma treatment using network pharmacology, molecular docking, and survival analysis. Biomed Res Int. 2022;2022:5975223.

Article  PubMed  PubMed Central  Google Scholar 

Shi Q, Chen Z, Yang J, Liu X, Su Y, Wang M, Xi J, Yang F, Li F. Review of codonopsis radix biological activities: a plant of traditional Chinese tonic. J Ethnopharmacol. 2024;332: 118334.

Article  CAS  PubMed  Google Scholar 

Rajavel T, Packiyaraj P, Suryanarayanan V, Singh SK, Ruckmani K, Pandima Devi K. Beta-sitosterol targets Trx/Trx1 reductase to induce apoptosis in A549 cells via ROS mediated mitochondrial dysregulation and p53 activation. Sci Rep. 2018;8(1):2071.

Article  PubMed  PubMed Central  Google Scholar 

Wang X, Li M, Hu M, Wei P, Zhu W. BAMBI overexpression together with beta-sitosterol ameliorates NSCLC via inhibiting autophagy and inactivating TGF-beta/Smad2/3 pathway. Oncol Rep. 2017;37(5):3046–54.

Article  CAS  PubMed  Google Scholar 

Han Y, Xiao Y, Yu L, Chen J, Yang X, Cui H, Liang J. Advances in the mechanism of luteolin against hepatocellular carcinoma based on bioinformatics and network pharmacology. J Cancer. 2023;14(6):966–80.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Tomko AM, Whynot EG, Ellis LD, Dupre DJ. Anti-cancer potential of cannabinoids, terpenes, and flavonoids present in Cannabis. Cancers (Basel). 2020;12(7):1985.

Article  CAS  PubMed  Google Scholar 

Kim HY, Jung SK, Byun S, Son JE, Oh MH, Lee J, Kang MJ, Heo YS, Lee KW, Lee HJ. Raf and PI3K are the molecular targets for the anti-metastatic effect of luteolin. Phytother Res. 2013;27(10):1481–8.

Article  CAS  PubMed  Google Scholar 

Ru J, Li P, Wang J, Zhou W, Li B, Huang C, Li P, Guo Z, Tao W, Yang Y, et al. TCMSP: a database of systems pharmacology for drug discovery from herbal medicines. J Cheminform. 2014;6:13.

Article  PubMed  PubMed Central  Google Scholar 

Daina A, Michielin O, Zoete V. SwissADME: a free web tool to evaluate pharmacokinetics, drug-likeness and medicinal chemistry friendliness of small molecules. Sci Rep. 2017;7:42717.

Article  PubMed  PubMed Central  Google Scholar 

Li AP. Screening for human ADME/Tox drug properties in drug discovery. Drug Discov Today. 2001;6(7):357–66.

Article  CAS  PubMed  Google Scholar 

Kim S, Thiessen PA, Bolton EE, Chen J, Fu G, Gindulyte A, Han L, He J, He S, Shoemaker BA, et al. PubChem Substance and Compound databases. Nucleic Acids Res. 2016;44(D1):D1202-1213.

Article  CAS  PubMed  Google Scholar 

Gfeller D, Grosdidier A, Wirth M, Daina A, Michielin O, Zoete V. SwissTargetPrediction: a web server for target prediction of bioactive small molecules. Nucleic Acids Res. 2014;42(Web Server Issue):W32-38.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Safran M, Dalah I, Alexander J, Rosen N, Iny Stein T, Shmoish M, Nativ N, Bahir I, Doniger T, Krug H, et al. GeneCards Version 3: the human gene integrator. Database (Oxford). 2010;2010:baq020.

Article  PubMed  Google Scholar 

Amberger JS, Bocchini CA, Scott AF, Hamosh A. OMIM.org: leveraging knowledge across phenotype-gene relationships. Nucleic Acids Res. 2019;47(D1):D1038-1043.

Article  CAS  PubMed  Google Scholar 

Apweiler R, Bairoch A, Wu CH, Barker WC, Boeckmann B, Ferro S, Gasteiger E, Huang H, Lopez R, Magrane M, et al. UniProt: the Universal Protein knowledgebase. Nucleic Acids Res. 2004;32(Database issue):D115-119.

Article  CAS  PubMed  PubMed Central  Google Scholar 

von Mering C, Huynen M, Jaeggi D, Schmidt S, Bork P, Snel B. STRING: a database of predicted functional associations between proteins. Nucleic Acids Res. 2003;31(1):258–61.

Article  Google Scholar 

Shannon P, Markiel A, Ozier O, Baliga NS, Wang JT, Ramage D, Amin N, Schwikowski B, Ideker T. Cytoscape: a software environment for integrated models of biomolecular interaction networks. Genome Res. 2003;13(11):2498–504.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Sherman BT, Hao M, Qiu J, Jiao X, Baseler MW, Lane HC, Imamichi T, Chang W. DAVID: a web server for functional enrichment analysis and functional annotation of gene lists (2021 update). Nucleic Acids Res. 2022;50(W1):W216–21.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Barrett T, Wilhite SE, Ledoux P, Evangelista C, Kim IF, Tomashevsky M, Marshall KA, Phillippy KH, Sherman PM, Holko M, et al. NCBI GEO: archive for functional genomics data sets—update. Nucleic Acids Res. 2013;41(Database issue):D991-995.

CAS  PubMed  Google Scholar 

Lamb J, Crawford ED, Peck D, Modell JW, Blat IC, Wrobel MJ, Lerner J, Brunet JP, Subramanian A, Ross KN, et al. The Connectivity Map: using gene-expression signatures to connect small molecules, genes, and disease. Science. 2006;313(5795):1929–35.

Article  CAS  PubMed  Google Scholar 

Tang Z, Kang B, Li C, Chen T, Zhang Z. GEPIA2: an enhanced web server for large-scale expression profiling and interactive analysis. Nucleic Acids Res. 2019;47(W1):W556–60.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Yu P, Cao WY, Yang SL, Wang Y, Xia AX, Tan XL, Wang LY. Design, synthesis and antitumor evaluation of novel quinazoline analogs in hepatocellular carcinoma cell. J Mol Struct. 2022;1268:133718.

Article  CAS