Bray F, Laversanne M, Weiderpass E, et al. The ever-increasing importance of cancer as a leading cause of premature death worldwide. Cancer. 2021;127:3029–30. https://doi.org/10.1002/cncr.33587.
Banz-Jansen C, Helweg LP, Kaltschmidt B. Endometrial cancer stem cells: Where Do We Stand and Where Should We Go? Int J Mol Sci. 2022. https://doi.org/10.3390/ijms23063412.
Article PubMed PubMed Central Google Scholar
Bray F, Laversanne M, Sung H, et al. Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2024;74:229–63. https://doi.org/10.3322/caac.21834.
Crosbie EJ, Kitson SJ, McAlpine JN, et al. Endometrial cancer. Lancet. 2022;399:1412–28. https://doi.org/10.1016/s0140-6736(22)00323-3.
van den Heerik A, Horeweg N, de Boer SM, et al. Adjuvant therapy for endometrial cancer in the era of molecular classification: radiotherapy, chemoradiation and novel targets for therapy. Int J Gynecol Cancer. 2021;31:594–604. https://doi.org/10.1136/ijgc-2020-001822.
Lorentzen GM, Laniewski P, Cui H, et al. Cervicovaginal metabolome and tumor characteristics for endometrial cancer detection and risk stratification. Clin Cancer Res. 2024;30:3073–87. https://doi.org/10.1158/1078-0432.CCR-23-2934.
Article CAS PubMed PubMed Central Google Scholar
Concin N, Creutzberg CL, Vergote I, et al. ESGO/ESTRO/ESP Guidelines for the management of patients with endometrial carcinoma. Virchows Arch. 2021;478:153–90. https://doi.org/10.1007/s00428-020-03007-z.
Phizicky EM, Hopper AK. The life and times of a tRNA. RNA. 2023;29:898–957. https://doi.org/10.1261/rna.079620.123.
Article CAS PubMed PubMed Central Google Scholar
Orellana EA, Siegal E, Gregory RI. tRNA dysregulation and disease. Nat Rev Genet. 2022;23:651–64. https://doi.org/10.1038/s41576-022-00501-9.
Article CAS PubMed PubMed Central Google Scholar
Zhang Y, Gu X, Li Y, et al. Multiple regulatory roles of the transfer RNA-derived small RNAs in cancers. Genes Dis. 2024;11:597–613. https://doi.org/10.1016/j.gendis.2023.02.053.
Article CAS PubMed Google Scholar
Su Z, Wilson B, Kumar P, et al. Noncanonical Roles of tRNAs: tRNA Fragments and Beyond. Annu Rev Genet. 2020;54:47–69. https://doi.org/10.1146/annurev-genet-022620-101840.
Article CAS PubMed PubMed Central Google Scholar
Lu J, Zhu P, Zhang X, et al. tRNA-derived fragments: Unveiling new roles and molecular mechanisms in cancer progression. Int J Cancer. 2024;155:1347–60. https://doi.org/10.1002/ijc.35041.
Article CAS PubMed Google Scholar
Chen Q, Li D, Jiang L, et al. Biological functions and clinical significance of tRNA-derived small fragment (tsRNA) in tumors: Current state and future perspectives. Cancer Lett. 2024;587:216701. https://doi.org/10.1016/j.canlet.2024.216701.
Article CAS PubMed Google Scholar
Zhang Z, Liu Z, Zhao W, et al. tRF-19-W4PU732S promotes breast cancer cell malignant activity by targeting inhibition of RPL27A (ribosomal protein-L27A). Bioengineered. 2022;13:2087–98. https://doi.org/10.1080/21655979.2021.2023796.
Article CAS PubMed PubMed Central Google Scholar
Mo D, He F, Zheng J, et al. tRNA-derived fragment tRF-17–79MP9PP attenuates cell invasion and migration via THBS1/TGF-β1/Smad3 axis in breast cancer. Front Oncol. 2021;11:656078. https://doi.org/10.3389/fonc.2021.656078.
Article CAS PubMed PubMed Central Google Scholar
Yang W, Gao K, Qian Y, et al. A novel tRNA-derived fragment AS-tDR-007333 promotes the malignancy of NSCLC via the HSPB1/MED29 and ELK4/MED29 axes. J Hematol Oncol. 2022;15:53. https://doi.org/10.1186/s13045-022-01270-y.
Article CAS PubMed PubMed Central Google Scholar
Balatti V, Nigita G, Veneziano D, et al. tsRNA signatures in cancer. Proc Natl Acad Sci U S A. 2017;114:8071–6. https://doi.org/10.1073/pnas.1706908114.
Article CAS PubMed PubMed Central Google Scholar
Zhou SY, Chen W, Yang SJ, et al. Circular RNA circVAPA regulates breast cancer cell migration and invasion via sponging miR-130a-5p. Epigenomics. 2020;12:303–17. https://doi.org/10.2217/epi-2019-0124.
Article CAS PubMed Google Scholar
Qian T, Yu X, Xu A, et al. tRF-20-S998LO9D inhibits endometrial carcinoma by upregulating SESN2. Epigenomics. 2022;14:1563–77. https://doi.org/10.2217/epi-2022-0349.
Article CAS PubMed Google Scholar
Yu X, Xie Y, Zhang S, et al. tRNA-derived fragments: Mechanisms underlying their regulation of gene expression and potential applications as therapeutic targets in cancers and virus infections. Theranostics. 2021;11:461–9. https://doi.org/10.7150/thno.51963.
Article CAS PubMed PubMed Central Google Scholar
Dwivedi SKD, Rao G, Dey A, et al. Small non-coding-RNA in gynecological malignancies. Cancers (Basel). 2021. https://doi.org/10.3390/cancers13051085.
Article PubMed PubMed Central Google Scholar
Gu B, Shang X, Yan M, et al. Variations in incidence and mortality rates of endometrial cancer at the global, regional, and national levels, 1990–2019. Gynecol Oncol. 2021;161:573–80. https://doi.org/10.1016/j.ygyno.2021.01.036.
Makker V, MacKay H, Ray-Coquard I, et al. Endometrial cancer. Nat Rev Dis Primers. 2021;7:88. https://doi.org/10.1038/s41572-021-00324-8.
Article PubMed PubMed Central Google Scholar
Morice P, Leary A, Creutzberg C, et al. Endometrial cancer. Lancet. 2016;387:1094–108. https://doi.org/10.1016/s0140-6736(15)00130-0.
Erickson BK, Slomovitz B, Powell M, et al. Top advances of the year: Uterine cancer. Cancer. 2024;130:2409–12. https://doi.org/10.1002/cncr.35321.
Xu W, Zhou B, Wang J, et al. tRNA-derived fragment tRF-Glu-TTC-027 regulates the progression of gastric carcinoma via MAPK signaling pathway. Front Oncol. 2021;11:733763. https://doi.org/10.3389/fonc.2021.733763.
Article CAS PubMed PubMed Central Google Scholar
Han Y, Peng Y, Liu S, et al. tRF3008A suppresses the progression and metastasis of colorectal cancer by destabilizing FOXK1 in an AGO-dependent manner. J Exp Clin Cancer Res. 2022;41:32. https://doi.org/10.1186/s13046-021-02190-4.
Article CAS PubMed PubMed Central Google Scholar
Kim HK, Fuchs G, Wang S, et al. A transfer-RNA-derived small RNA regulates ribosome biogenesis. Nature. 2017;552:57–62. https://doi.org/10.1038/nature25005.
Comments (0)