Identification of a novel tRNA-derived small RNA fragment, tRF-16-2YU04DE, with the potential of inhibiting endometrial cancer progression

Bray F, Laversanne M, Weiderpass E, et al. The ever-increasing importance of cancer as a leading cause of premature death worldwide. Cancer. 2021;127:3029–30. https://doi.org/10.1002/cncr.33587.

Article  PubMed  Google Scholar 

Banz-Jansen C, Helweg LP, Kaltschmidt B. Endometrial cancer stem cells: Where Do We Stand and Where Should We Go? Int J Mol Sci. 2022. https://doi.org/10.3390/ijms23063412.

Article  PubMed  PubMed Central  Google Scholar 

Bray F, Laversanne M, Sung H, et al. Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2024;74:229–63. https://doi.org/10.3322/caac.21834.

Article  PubMed  Google Scholar 

Crosbie EJ, Kitson SJ, McAlpine JN, et al. Endometrial cancer. Lancet. 2022;399:1412–28. https://doi.org/10.1016/s0140-6736(22)00323-3.

Article  PubMed  Google Scholar 

van den Heerik A, Horeweg N, de Boer SM, et al. Adjuvant therapy for endometrial cancer in the era of molecular classification: radiotherapy, chemoradiation and novel targets for therapy. Int J Gynecol Cancer. 2021;31:594–604. https://doi.org/10.1136/ijgc-2020-001822.

Article  PubMed  Google Scholar 

Lorentzen GM, Laniewski P, Cui H, et al. Cervicovaginal metabolome and tumor characteristics for endometrial cancer detection and risk stratification. Clin Cancer Res. 2024;30:3073–87. https://doi.org/10.1158/1078-0432.CCR-23-2934.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Concin N, Creutzberg CL, Vergote I, et al. ESGO/ESTRO/ESP Guidelines for the management of patients with endometrial carcinoma. Virchows Arch. 2021;478:153–90. https://doi.org/10.1007/s00428-020-03007-z.

Article  PubMed  Google Scholar 

Phizicky EM, Hopper AK. The life and times of a tRNA. RNA. 2023;29:898–957. https://doi.org/10.1261/rna.079620.123.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Orellana EA, Siegal E, Gregory RI. tRNA dysregulation and disease. Nat Rev Genet. 2022;23:651–64. https://doi.org/10.1038/s41576-022-00501-9.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zhang Y, Gu X, Li Y, et al. Multiple regulatory roles of the transfer RNA-derived small RNAs in cancers. Genes Dis. 2024;11:597–613. https://doi.org/10.1016/j.gendis.2023.02.053.

Article  CAS  PubMed  Google Scholar 

Su Z, Wilson B, Kumar P, et al. Noncanonical Roles of tRNAs: tRNA Fragments and Beyond. Annu Rev Genet. 2020;54:47–69. https://doi.org/10.1146/annurev-genet-022620-101840.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lu J, Zhu P, Zhang X, et al. tRNA-derived fragments: Unveiling new roles and molecular mechanisms in cancer progression. Int J Cancer. 2024;155:1347–60. https://doi.org/10.1002/ijc.35041.

Article  CAS  PubMed  Google Scholar 

Chen Q, Li D, Jiang L, et al. Biological functions and clinical significance of tRNA-derived small fragment (tsRNA) in tumors: Current state and future perspectives. Cancer Lett. 2024;587:216701. https://doi.org/10.1016/j.canlet.2024.216701.

Article  CAS  PubMed  Google Scholar 

Zhang Z, Liu Z, Zhao W, et al. tRF-19-W4PU732S promotes breast cancer cell malignant activity by targeting inhibition of RPL27A (ribosomal protein-L27A). Bioengineered. 2022;13:2087–98. https://doi.org/10.1080/21655979.2021.2023796.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Mo D, He F, Zheng J, et al. tRNA-derived fragment tRF-17–79MP9PP attenuates cell invasion and migration via THBS1/TGF-β1/Smad3 axis in breast cancer. Front Oncol. 2021;11:656078. https://doi.org/10.3389/fonc.2021.656078.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Yang W, Gao K, Qian Y, et al. A novel tRNA-derived fragment AS-tDR-007333 promotes the malignancy of NSCLC via the HSPB1/MED29 and ELK4/MED29 axes. J Hematol Oncol. 2022;15:53. https://doi.org/10.1186/s13045-022-01270-y.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Balatti V, Nigita G, Veneziano D, et al. tsRNA signatures in cancer. Proc Natl Acad Sci U S A. 2017;114:8071–6. https://doi.org/10.1073/pnas.1706908114.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zhou SY, Chen W, Yang SJ, et al. Circular RNA circVAPA regulates breast cancer cell migration and invasion via sponging miR-130a-5p. Epigenomics. 2020;12:303–17. https://doi.org/10.2217/epi-2019-0124.

Article  CAS  PubMed  Google Scholar 

Qian T, Yu X, Xu A, et al. tRF-20-S998LO9D inhibits endometrial carcinoma by upregulating SESN2. Epigenomics. 2022;14:1563–77. https://doi.org/10.2217/epi-2022-0349.

Article  CAS  PubMed  Google Scholar 

Yu X, Xie Y, Zhang S, et al. tRNA-derived fragments: Mechanisms underlying their regulation of gene expression and potential applications as therapeutic targets in cancers and virus infections. Theranostics. 2021;11:461–9. https://doi.org/10.7150/thno.51963.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Dwivedi SKD, Rao G, Dey A, et al. Small non-coding-RNA in gynecological malignancies. Cancers (Basel). 2021. https://doi.org/10.3390/cancers13051085.

Article  PubMed  PubMed Central  Google Scholar 

Gu B, Shang X, Yan M, et al. Variations in incidence and mortality rates of endometrial cancer at the global, regional, and national levels, 1990–2019. Gynecol Oncol. 2021;161:573–80. https://doi.org/10.1016/j.ygyno.2021.01.036.

Article  PubMed  Google Scholar 

Makker V, MacKay H, Ray-Coquard I, et al. Endometrial cancer. Nat Rev Dis Primers. 2021;7:88. https://doi.org/10.1038/s41572-021-00324-8.

Article  PubMed  PubMed Central  Google Scholar 

Morice P, Leary A, Creutzberg C, et al. Endometrial cancer. Lancet. 2016;387:1094–108. https://doi.org/10.1016/s0140-6736(15)00130-0.

Article  PubMed  Google Scholar 

Erickson BK, Slomovitz B, Powell M, et al. Top advances of the year: Uterine cancer. Cancer. 2024;130:2409–12. https://doi.org/10.1002/cncr.35321.

Article  PubMed  Google Scholar 

Xu W, Zhou B, Wang J, et al. tRNA-derived fragment tRF-Glu-TTC-027 regulates the progression of gastric carcinoma via MAPK signaling pathway. Front Oncol. 2021;11:733763. https://doi.org/10.3389/fonc.2021.733763.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Han Y, Peng Y, Liu S, et al. tRF3008A suppresses the progression and metastasis of colorectal cancer by destabilizing FOXK1 in an AGO-dependent manner. J Exp Clin Cancer Res. 2022;41:32. https://doi.org/10.1186/s13046-021-02190-4.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kim HK, Fuchs G, Wang S, et al. A transfer-RNA-derived small RNA regulates ribosome biogenesis. Nature. 2017;552:57–62. https://doi.org/10.1038/nature25005.

Article  CAS  PubMed  PubMed Central 

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