Unlocking Reishi’s secrets: nutritional and medicinal traits of Ganoderma lucidum isolated from tree bark in Egypt

Abdullah N, Ismail SM, Aminudin N, Shuib AS, Lau BF (2012) Evaluation of selected culinary-medicinal mushrooms for antioxidant and ACE inhibitory activities. Evid Complement Altern Med 2012(1):464238

Google Scholar 

Ahmad R, Riaz M, Khan A, Aljamea A, Algheryafi M, Sewaket D, Alqathama A (2021) Ganoderma lucidum (Reishi) an edible mushroom; a comprehensive and critical review of its nutritional, cosmeceutical, mycochemical, pharmacological, clinical, and toxicological properties. Phyther Res 35(11):6030–6062

Ali NAA, Mothana RAA, Lesnau A, Pilgrim H, Lindequist U (2003) Antiviral activity of Inonotus hispidus. Fitoterapia 74(5):483–485

Google Scholar 

Aslaminabad R, Rahimianshahreza N, Hosseini SA, Armagan G, Khan AK, Özbolat G, Ahmed OS, Mardi Azar A, Adili A, Dağcı T (2022) Regulation of Nrf2 and Nrf2-related proteins by ganoderma lucidum in hepatocellular carcinoma. Mol Biol Rep 49(10):9605–9612

Barros L, Cruz T, Baptista P, Estevinho LM, Ferreira ICFR (2008) Wild and commercial mushrooms as source of nutrients and nutraceuticals. Food Chem Toxicol 46(8):2742–2747

CAS  PubMed  Google Scholar 

Biswal RP, Dandamudi RB, Patnana DP, Pandey M, Vutukuri VNRK (2022) Metabolic fingerprinting of Ganoderma spp. using UHPLC-ESI-QTOF-MS and its chemometric analysis. Phytochemistry 199:113169

Bradford MM (1976) A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72(1–2):248–254

CAS  PubMed  Google Scholar 

Butkhup L, Samappito W, Jorjong S, Reductive MÁ (2018) Evaluation of bioactivities and phenolic contents of wild edible mushrooms from northeastern Thailand. Food Sci Biotechnol 27(1):193–202

CAS  PubMed  Google Scholar 

Cancemi G, Caserta S, Gangemi S, Pioggia G, Allegra A (2024) Exploring the therapeutic potential of ganoderma lucidum in cancer. J Clin Med 13(4):1153

Chang CC, Yang MH, Wen HM, Chern JC (2002) Estimation of total flavonoid content in propolis by two complementary colorimetric methods. J food drug Anal 10(3)

Chang ST, Buswell JA (1996) Mushroom nutriceuticals. World J Microbiol Biotechnol 12(5):473–476

CAS  PubMed  Google Scholar 

Chen C, Chen L, Mao C, Jin L, Wu S, Zheng Y, Cui Z, Li Z, Zhang Y, Zhu S (2024) Natural extracts for antibacterial applications. Small 20(9):2306553

CAS  Google Scholar 

Chen P, Liu Y, Li C, Hua S, Sun C, Huang L (2023) Antibacterial mechanism of vanillin against Escherichia coli O157: H7. Heliyon 9(9):e2306553

Ćilerdžić JL, Sofrenić IV, Tešević VV, Brčeski ID, Duletić-Laušević SN, Vukojević JB, Stajić MM (2018) Neuroprotective potential and chemical profile of alternatively cultivated Ganoderma lucidum basidiocarps. Chem Biodivers 15(5):e1800036

CLSI (2024) M100 performance standards for antimicrobial susceptability testing. 34rd edition

Cör Andrejč D, Knez Ž, Knez Marevci M (2022) Antioxidant, antibacterial, antitumor, antifungal, antiviral, anti-inflammatory, and nevro-protective activity of Ganoderma lucidum: an overview. Front Pharmacol 13:934982

El-Hela AA, Hegazy MM, Bakr MSA, Abbass HS (2020) Profiling of antiviral and antioxidant phytochemicals of Pterocephalus frutescens hochist. using high-resolution ultra-performance liquid chromatography/quadrupole time-of-flight mass spectrometer. Pharmacogn Mag 16(71)

El-Sherbiny GM, Alluqmani AJ, Elsehemy IA, Kalaba MH (2024) Antibacterial, antioxidant, cytotoxicity, and phytochemical screening of Moringa oleifera leaves. Sci Rep 14(1):1–17

El Sayed OH, Asker MMS, Swelim MA, Abbas IH, Attwa AI, El Awady ME (2016) Production of hydroxy marilone C as a bioactive compound from Streptomyces badius. J Genet Eng Biotechnol 14(1):161–168

PubMed  PubMed Central  Google Scholar 

El Sheikha AF (2022) Nutritional profile and health benefits of Ganoderma lucidum “Lingzhi, Reishi, or Mannentake” as functional foods: current scenario and future perspectives. Foods 11(7):1030

Elhusseiny SM, El-Mahdy TS, Awad MF, Elleboudy NS, Farag MMS, Aboshanab KM, Yassien MA (2021) Antiviral, cytotoxic, and antioxidant activities of three edible agaricomycetes mushrooms: Pleurotus columbinus, Pleurotus sajor-caju, and Agaricus bisporus. J Fungi 7(8):645

CAS  Google Scholar 

Erbiai EH, Amina B, Kaoutar A, Saidi R, Lamrani Z, Pinto E, Esteves da Silva JCG, Maouni A, Pinto da Silva L (2023) Chemical characterization and evaluation of antimicrobial properties of the wild medicinal mushroom ganoderma lucidum growing in northern Moroccan forests. Life 13(5):1217

Ferreira ICFR, Dias J, Martins A, Pintado M (2012) A review on antimicrobial activity of mushroom (basidiomycetes) extracts and isolated compounds. Planta Med 78(16):1707–1718

PubMed  Google Scholar 

Gasmi A, Bjørklund G, Peana M, Mujawdiya PK, Pivina L, Ongenae A, Piscopo S, Severin B (2022) Phosphocalcic metabolism and the role of vitamin D, vitamin K2, and nattokinase supplementation. Crit Rev Food Sci Nutr 62(25):7062–7071

CAS  PubMed  Google Scholar 

Girsang E, Lister INE, Ginting CN, Bethasari M, Amalia A, Widowati W (2020) Comparison of antiaging and antioxidant activities of protocatechuic and ferulic acids. Mol Cell Biomed Sci 4(2):68–75

Google Scholar 

González A, Atienza V, Montoro A, Soriano JM (2020) Use of Ganoderma lucidum (Ganodermataceae, Basidiomycota) as radioprotector. Nutrients 12(4):1143

Hapuarachchi KK, Wen TC, Deng CY, Kang JC, Hyde KD (2015) Mycosphere essays 1: taxonomic confusion in the Ganoderma lucidum species complex. Mycosphere 6(5):542–559

Huang F, Wang Z, Wang L, Liu R, Ma C, Che Y, He Y, Ye J (2024) Chemical components characterization and in vivo metabolites profiling of Lingbao Huxin Dan by gas chromatography-mass spectrometry and ultra-high-performance liquid chromatography-tandem quadrupole time-of-flight mass spectrometry. J Sep Sci 47(1):2300233

CAS  Google Scholar 

Ivanov M, Novović K, Malešević M, Dinić M, Stojković D, Jovčić B, Soković M (2022) Polyphenols as inhibitors of antibiotic resistant bacteria—mechanisms underlying Rutin interference with bacterial virulence. Pharmaceuticals 15(3):385

CAS  PubMed  PubMed Central  Google Scholar 

Kalyoncu F, Oskay M, Sağlam H, Erdoğan TF, Tamer AÜ (2010) Antimicrobial and antioxidant activities of mycelia of 10 wild mushroom species. J Med Food 13(2):415–419

CAS  PubMed  Google Scholar 

Kapoor P, Sharma BM (2014) Studies on different growth parameters of Ganoderma lucidum. Int J Sci Environ Tech 3(4):1515–1524

Google Scholar 

Keypour S, Mirzania F, Farimani MM (2019) Antioxidant activity, total flavonoid and phenolic contents of three different extracts of Hyrcanian reishi. Curr Bioact Compd 15(1):109–113

CAS  Google Scholar 

Kozarski M, Klaus A, Nikšić M, Vrvić MM, Todorović N, Jakovljević D, Van Griensven LJLD (2012) Antioxidative activities and chemical characterization of polysaccharide extracts from the widely used mushrooms Ganoderma applanatum, Ganoderma lucidum, Lentinus edodes and Trametes versicolor. J Food Compos Anal 26(1–2):144–153

CAS  Google Scholar 

Lambert JD, Elias RJ (2010) The antioxidant and pro-oxidant activities of green tea polyphenols: a role in cancer prevention. Arch Biochem Biophys 501(1):65–72

CAS  PubMed  PubMed Central  Google Scholar 

Lee SH, Hwang HS, Yun JW (2009) Antitumor activity of water extract of a mushroom, Inonotus obliquus, against HT-29 human colon cancer cells. Phyther Res 23(12):1784–1789

Lazić V, Klaus A, Kozarski M, Doroški A, Tosti T, Simić S, Vunduk J (2024) The effect of green extraction technologies on the chemical composition of medicinal Chaga mushroom extracts. J Fungi 10(3):225

Lesa KN, Khandaker MU, Mohammad Rashediqbal F, Sharma R, Islam F, Mitra S, Emran TB (2022) Nutritional value, medicinal importance, and health-promoting effects of dietary mushroom Pleurotus ostreatus. J Food Qual 2022(1):2454180

Google Scholar 

Li Y, Xiao J, Dong H, Li L, Dong J, Huang D (2024) Enhanced chalcopyrite-catalyzed heterogeneous Fenton oxidation of diclofenac by ABTS. J Hazard Mater 463:132908

CAS  PubMed  Google Scholar 

Lian W, Yang X, Duan Q, Li J, Zhao Y, Yu C, He T, Sun T, Zhao Y, Wang W (2024) The biological activity of Ganoderma lucidum on neurodegenerative diseases: the interplay between different active compounds and the pathological hallmarks. Molecules 29(11):2516

Lima VN, Oliveira-Tintino CDM, Santos ES, Morais LP, Tintino SR, Freitas TS, Geraldo YS, Pereira RLS, Cruz RP, Menezes IRA (2016) Antimicrobial and enhancement of the antibiotic activity by phenolic compounds: gallic acid, caffeic acid and pyrogallol. Microb Pathog 99:56–61

CAS  PubMed  Google Scholar 

Liu F, Luo K, Yu Z, Co N, Wu S, Wu P, Fung K, Kwok T (2009) Suillin from the mushroom Suillus placidus as potent apoptosis inducer in human hepatoma HepG2 cells. Chem Biol Interact 181(2):168–174

Liu Y, Liu Y, Qiu F, Di X (2011) Sensitive and selective liquid chromatography–tandem mass spectrometry method for the determination of five ganoderic acids in Ganoderma lucidum and its related species. J Pharm Biomed Anal 54(4):717–721

Maeda H, Fukuda S, Izumi H, Saga N (2018) Anti-oxidant and fucoxanthin contents of brown alga Ishimozuku (Sphaerotrichia divaricata) from the West Coast of Aomori. Japan Mar Drugs 16(8):255

Marzougui N, Guasmi F, Mkaddem M, Boubaya A, Mrabet A, Elfalleh W, Ferchichi A, Beji M (2009) Assessment of Tunisian Trigonella foenum graecum diversity using seed vitamin B6, B1, B9 and C contents. J Food Agric Environ 7(1):56–61

Mohsin M, Negi PS, Ahmed Z (2011) Determination of the antioxidant activity and polyphenol contents of wild Lingzhi or Reishi medicinal mushroom, Ganoderma lucidum (W. Curt. Fr.) P. Karst. (higher Basidiomycetes) from central Himalayan hills of India. Int J Med Mushrooms 13(6)

Mothana RAA, Ali NAA, Jansen R, Wegner U, Mentel R, Lindequist U (2003) Antiviral lanostanoid triterpenes from the fungus Ganoderma pfeifferi. Fitoterapia 74(1–2):177–180

CAS  PubMed  Google Scholar 

Muscolo A, Mariateresa O, Giulio T, Mariateresa R (2024) Oxidative stress: the role of antioxidant phytochemicals in the prevention and treatment of diseases. Int J Mol Sci 25(6):3264

CAS  PubMed  PubMed Central  Google Scholar 

Naim MJ (2024) A review on mushrooms as a versatile therapeutic agent with emphasis on its bioactive constituents for anticancer and antioxidant potential. Explor Med 5:312–330

CAS  Google Scholar 

Niedermeyer THJ, Lindequist U, Mentel R, Gördes D, Schmidt E, Thurow K, Lalk M (2005) Antiviral terpenoid constituents of Ganoderma pfeifferi. J Nat Prod 68(12):1728–1731

CAS  PubMed  Google Scholar 

Nielsen SS (2024) Total carbohydrate by phenol-sulfuric acid method. In: Nielsen’s food analysis laboratory manual. Springer, pp 147–151

Ninfali P, Antonelli A, Magnani M, Scarpa ES (2020) Antiviral properties of flavonoids and delivery strategies. Nutrients 12(9):2534

CAS  PubMed  PubMed Central  Google Scholar 

Oke MA, Afolabi FJ, Oyeleke OO, Kilani TA, Adeosun AR, Olanbiwoninu AA, Adebayo EA (2022) Ganoderma lucidum: unutilized natural medicine and promising future solution to emerging diseases in Africa. Front Pharmacol 13(August):1–26

Ozen T, Darcan C, Aktop O, Turkekul I (2011) Screening of antioxidant, antimicrobial activities and chemical contents of edible mushrooms wildly grown in the black sea region of Turkey. Comb Chem High Throughput Screen 14(2):72–84

CAS  PubMed  Google Scholar 

Özkütük AS (2022) Antimicrobial effects of carnosic acid, kaempferol and luteolin on biogenic amine production by spoilage and food-borne pathogenic bacteria. Food Biosci 46:101588

Google Scholar 

Öztürk M, Duru ME, Kivrak Ş, Mercan-Doğan N, Türkoglu A, Özler MA (2011) In vitro antioxidant, anticholinesterase and antimicrobial activity studies on three Agaricus species with fatty acid compositions and iron contents: a comparative study on the three most edible mushrooms. Food Chem Toxicol 49(6):1353–1360

PubMed  Google Scholar 

Park Y-J, Kwon O-C, Son E-S, Yoon D-E, Han W, Nam J-Y, Yoo Y-B, Lee C-S (2012) Genetic diversity analysis of Ganoderma species and development of a specific marker for identification of medicinal mushroom Ganoderma lucidum. African J Microbiol Res 6(25):5417–5425

CAS  Google Scholar 

Petricevich VL, Mendonça RZ (2003) Inhibitory potential of Crotalus durissus terrificus venom on measles virus growth. Toxicon 42(2):143–153

Prinsloo G, Marokane CK, Streat RA (2018) Anti-HIV activity of southern African plants: current developments, phytochemistry and future research. J Ethnopharmacol 210:133–155

CAS  PubMed  Google Scholar 

Priya RR, Bhaduhsha N, Manivannan V, Gunasekaran T (2021) Evaluation of in-vitro antioxidant activity in Senna alata of hydroalcoholic extract and methanolic extract. Ann Roman Soc Cell Biol 25(4):5291–5303

Qi J, Duan Y, Li Z, Gao J, Qi J, Liu C (2023) The alkynyl-containing compounds from mushrooms and their biological activities. Nat Products Bioprospect 13(1):50

CAS  Google Scholar 

Qin Y, Li S, Zhao J (2024) HPLC and HPLC–MS for qualitative and quantitative analysis of chinese medicines. In: Quality control of chinese medicines: strategies and methods. Springer, pp 475–577

Rašeta M, Kebert M, Mišković J, Kostić S, Kaišarević S, Stilinović N, Vukmirović S, Karaman M (2024) Ganoderma pfeifferi. Bres and Ganoderma resinaceum Boud as potential therapeutic agents: a comparative study on antiproliferative and lipid-lowering properties. J Fungi. 10(7):501

Rhee CM, Ahmadi S, Kovesdy CP, Kalantar-Zadeh K (2018) Low-protein diet for conservative management of chronic kidney disease: a systematic review and meta-analysis of controlled trials. J Cachexia Sarcopenia Muscle 9(2):235–245

PubMed  Google Scholar 

Salehi B, Martorell M, Arbiser JL, Sureda A, Martins N, Maurya PK, Sharifi-Rad M, Kumar P, Sharifi-Rad J (2018) Antioxidants: positive or negat

Comments (0)

No login
gif