Unveiling a novel ellagic acid derivative as a potent lipoxygenase (LOX) inhibitor: integration of computational modeling and experimental validation

Cuzzocrea S (2005) Shock, inflammation and PARP. Pharmacol Res 52:2–82

Article  Google Scholar 

Liu Q, Suzuki K, Kudo S, Yamada M, Kowatari K, Umeda T, Nakaji S, Sugawara K (2000) Effect of decaglycerol monooleate on phagocytosis and respiratory burst activity of human neutrophils: an in vitro study. Food Chem Toxicol 38:423–428

Article  CAS  PubMed  Google Scholar 

Roussin A, Le Cabec V, Lonchampt M, De Nadai J, Canet E, Maridonneau-Parini I (1997) Neutrophil-associated inflammatory responses in rats are inhibited by phenylarsine oxide. Eur J Pharmacol 322:91–96

Article  CAS  PubMed  Google Scholar 

Tan AS, Berridge MV (2000) Superoxide produced by activated neutrophils efficiently reduces the tetrazolium salt, WST-1 to produce a soluble formazan: a simple colorimetric assay for measuring respiratory burst activation and for screening anti-inflammatory agents. J Immunol Methods 238:59–68

Article  CAS  PubMed  Google Scholar 

Costantino G, Cuzzocrea S, Mazzon E, Caputi AP (1998) Protective effects of melatonin in zymosan-activated plasma-induced paw inflammation. Eur J Pharmacol 363:57–63. https://doi.org/10.1016/S0014-2999(98)00673-6

Article  CAS  PubMed  Google Scholar 

Kulkarni AP (2001) Lipoxygenase-a versatile biocatalyst for biotransformation of endobiotics and xenobiotics. Cell Mol Life Sci CMLS 58:1805–1825. https://doi.org/10.1007/PL00000820

Article  CAS  PubMed  Google Scholar 

Kolar D, Wimmerova L, Kadek R (2010) Acetylcholinesterase and butyrylcholinesterase inhibitory activities of Berberis vulgaris. Phytopharmacol 1:7–11

Google Scholar 

Rioux N, Castonguay A (1998) Inhibitors of lipoxygenase: a new class of cancer chemopreventive agents. Carcinogenesis 19:1393–1400. https://doi.org/10.1093/carcin/19.8.1393

Article  CAS  PubMed  Google Scholar 

Chan MM (1995) Inhibition of tumor necrosis factor by curcumin, a phytochemical. Biochem Pharmacol 49:1551–1556. https://doi.org/10.1016/0006-2952(95)00171-U

Article  CAS  PubMed  Google Scholar 

Viji V, Helen A (2008) Inhibition of lipoxygenases and cyclooxygenase-2 enzymes by extracts isolated from Bacopa monniera (L.) Wettst. J Ethnopharmacol 118:305–311. https://doi.org/10.1016/j.jep.2008.04.017

Article  CAS  PubMed  Google Scholar 

Ali SI (1975) Flora of west pakisatan. Fakhri Printing Press, Karachi

Google Scholar 

Fan C, Xiang QY (2001) Phylogenetic relationships within Cornus (Cornaceae) based on 26S rDNA sequences. Am J Bot 88:1131–1138. https://doi.org/10.2307/2657096

Article  CAS  PubMed  Google Scholar 

Lee DY, Lyu HN, Kwak HY, Jung LK, Lee YH, Kim DK, Chung IS, Kim SH, Baek NI (2007) Isolation of flavonoids from the fruits of Cornus kousa Burg. J Appl Biol Chem 50:144–147

CAS  Google Scholar 

Stermitz FR, Krull RE (1998) Iridoid glycosides of Cornus canadensis: a comparison with some other Cornus species. Biochem Syst Ecol 26:845–849

Article  CAS  Google Scholar 

Seeram NP, Schutzki R, Chandra A, Nair MG (2002) Characterization, quantification, and bioactivities of anthocyanins in Cornus species. J Agric Food Chem 50:2519–2523

Article  CAS  PubMed  Google Scholar 

Tanaka N, Tanaka T, Fujioka T, Fujii H, Mihashi K, Shimomura K, Ishimaru K (2001) An ellagic compound and iridoids from Cornus capitata root cultures. Phytochemistry 57:1287–1291

Article  CAS  PubMed  Google Scholar 

Kim DK, Kwak JH (1998) A furan derivative from Cornus officinalis. Arch Pharmacal Res 21:787–789

Article  CAS  Google Scholar 

Khan KM, Ambreen N, Mughal UR, Jalil S, Perveen S, Choudhary MI (2010) 3-Formylchromones: potential antiinflammatory agents. Eur J Med Chem 45:4058–4064

Article  CAS  PubMed  Google Scholar 

Mau JL, Chen CP, Hsieh PC (2001) Antimicrobial effect of extracts from Chinese chive, cinnamon, and corni fructus. J Agric Food Chem 49:183–188

Article  CAS  PubMed  Google Scholar 

Wang H, Nair MG, Strasburg GM, Chang YC, Booren AM, Gray JI, DeWitt DL (1999) Antioxidant and antiinflammatory activities of anthocyanins and their aglycon, cyanidin, from tart cherries. J Nat Prod 62:294–296

Article  CAS  PubMed  Google Scholar 

Jayaprakasam B, Vareed SK, Olson LK, Nair MG (2005) Insulin secretion by bioactive anthocyanins and anthocyanidins present in fruits. J Agric Food Chem 53:28–31

Article  CAS  PubMed  Google Scholar 

Kamei H, Kojima T, Hasegawa M, Koide T, Umeda T, Yukawa T, Terabe K (1995) Suppression of tumor cell growth by anthocyanins in vitro. Cancer Invest 13:590–594

Article  CAS  PubMed  Google Scholar 

Vareed SK, Reddy MK, Schutzki RE, Nair MG (2006) Anthocyanins in Cornus alternifolia, Cornus controversa, Cornus kousa, and Cornus florida fruits with health benefits. Life Sci 78:777–784

Article  CAS  PubMed  Google Scholar 

Johns T, Windust A, Jurgens T, Mansor SM (2011) Antimalarial alkaloids isolated from Annona squamosa. Phytopharmacology 1:49–53

Google Scholar 

Song MJ, Lee SM, Kim DK (2011) Antidiabetic effect of Chenopodium ambrosioides. Phytopharmacology 1:12–15

Google Scholar 

White G, Bourbonnais-Spear N, Garner F (2011) Antibacterial constituents from Uncaria tomentosa. Phytopharmacology 1:16–19

Google Scholar 

Hussain M, Perveen R, Lateef M, Akram Z, Azhar I, Saleem S (2021) In-vitro dose response effect of bergenin on platelet aggregation by inhibiting inducers (collagen and ADP) and lipoxygenase. Health Biotechnol Biopharma 5:24–38

Google Scholar 

Akram Z, Perveen R, Saleem S, Siddiqui R, Hussain M, Shaukat S, Yusuf MZ (2021) Novel target of the 4-piperidone thiazole derivative for platelet inhibitions by using inducers collagen and ADP. Health Biotechnol Biopharma 5:1–6

Google Scholar 

Khan I, Nisar M, Ebad F, Nadeem S, Saeed M, Khan H, Khuda F, Karim N, Ahmad Z (2009) Anti-inflammatory activities of Sieboldogenin from Smilax china Linn.: experimental and computational studies. J Ethnopharmacol 121:175–177

Article  CAS  PubMed  Google Scholar 

Khallouki F, Haubner R, Hull WE, Erben G, Spiegelhalder B, Bartsch H, Owen RW (2007) Isolation, purification, and identification of ellagic acid derivatives, catechins, and procyanidins from the root bark of Anisophyllea dichostyla R. Br. Food Chem Toxicol 45:472–485

Article  CAS  PubMed  Google Scholar 

Kobe MJ, Neau DB, Mitchell CE, Bartlett SG, Newcomer ME (2014) The structure of human 15-lipoxygenase-2 with a substrate mimic. J Biol Chem 289:8562–8569

Article  CAS  PubMed  PubMed Central  Google Scholar 

Mishra A, Mulpuru V, Mishra N (2023) An interaction network-driven approach for identifying cervical, endometrial, vulvar carcinomic biomarkers and their multi-targeted inhibitory agents from few widely available medicinal plants. J Mol Biol 195:6893–6912

CAS  Google Scholar 

Akbar S, Das S, Iqubal A, Ahmed B (2022) Synthesis, biological evaluation, and molecular dynamics studies of oxadiazine derivatives as potential anti-hepatotoxic agents. J Biomol Struct Dyn 40:9974–9991

Article  CAS  PubMed  Google Scholar 

Seeliger D, de Groot BL (2010) Conformational transitions upon ligand binding: holo structure prediction from apo conformations. Biophys J 98:428a

Article  Google Scholar 

Daina A, Michielin O, Zoete V (2017) SwissADME: a free web tool to evaluate pharmacokinetics, drug-likeness, and medicinal chemistry friendliness of small molecules. Sci Rep 7:42717

Article  PubMed  PubMed Central  Google Scholar 

Banerjee P, Kemmler E, Dunkel M, Preissner R (2024) ProTox 3.0: a webserver for the prediction of toxicity of chemicals. Nucleic Acids Res 52:W513–W520

Article 

Comments (0)

No login
gif